TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T93145	Pyruvate dehydrogenase kinase	D00YWP	Nandrolone	Approved	9904	C18H26O2	274.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@H]34	IC50 = 120000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	D01FQV	Dichloroacetate sodium	Phase 1	517326	C2HCl2NaO2	150.92	C(C(=O)[O-])(Cl)Cl.[Na+]	EC50 = 130000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	B3HVP2	(2S)-N-Cyclohexyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide	Investigative	10681448	C10H16F3NO2	239.23	C[C@](C(=O)NC1CCCCC1)(C(F)(F)F)O	IC50 = 200000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	B56BWJ	3,3,3-Trifluoro-2-hydroxy-N-[2-(hydroxymethyl)phenyl]-2-methylpropanamide	Investigative	44312085	C11H12F3NO3	263.21	CC(C(=O)NC1=CC=CC=C1CO)(C(F)(F)F)O	IC50 = 145000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	B5BCH3	N-[(3E)-17beta-Hydroxyestra-4-ene-3-ylidene]glycine	Investigative	44311110	C20H29NO3	331.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=NCC(=O)O)CC[C@H]34	IC50 = 56000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	BGR0A4	3,3,3-Trifluoro-2-hydroxy-N-[3-(hydroxymethyl)phenyl]-2-methylpropanamide	Investigative	44312073	C11H12F3NO3	263.21	CC(C(=O)NC1=CC=CC(=C1)CO)(C(F)(F)F)O	IC50 = 80000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	BM1UH0	N-(2-Chloro-6-methylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide	Investigative	44312513	C11H11ClF3NO2	281.66	CC1=C(C(=CC=C1)Cl)NC(=O)C(C)(C(F)(F)F)O	IC50 = 60000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	BO8LC3	3,3,3-Trifluoro-2-hydroxy-N-(2-methoxyphenyl)-2-methylpropanamide	Investigative	22287193	C11H12F3NO3	263.21	CC(C(=O)NC1=CC=CC=C1OC)(C(F)(F)F)O	IC50 = 61500 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	BUK13V	17beta-Hydroxy-5alpha-androstan-3-one oxime	Investigative	9922541	C19H31NO2	305.5	C[C@]12CC/C(=N\\O)/C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C	IC50 = 51000 nM	Poor binder
T93145	Pyruvate dehydrogenase kinase	BV5Z6B	N-(3-Acetylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide	Investigative	44312049	C12H12F3NO3	275.22	CC(=O)C1=CC(=CC=C1)NC(=O)C(C)(C(F)(F)F)O	IC50 = 170000 nM	Poor binder