TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88975	Phosphodiesterase 3A	D0R4UW	Roflumilast	Approved	449193	C17H14Cl2F2N2O3	403.2	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	D0A0ZU	AC1MOZOL	Patented	3403301	C16H18N2OS2	318.5	CCC(C)SC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	D0SG9Q	US9388139, 12	Patented	60194756	C20H20Cl2N2O2	391.3	CC(C)(C)C1=NN(C(C1)C2=C(C=C(C=C2)Cl)Cl)C3=CC=C(C=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T88975	Phosphodiesterase 3A	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	D0Z7YQ	AC1M1SP5	Patented	2155273	C16H18N2O2S2	334.5	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	B05TXO	5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968471	C17H24ClN3O3	353.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCOCCN	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B0KS7F	N-(3,5-Dichloropyridin-4-yl)-7-methylsulfanyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-4-carboxamide	Investigative	59227413	C15H9Cl2F3N4OS	421.2	CSC1=CC=C(C2=CC(=NN12)C(F)(F)F)C(=O)NC3=C(C=NC=C3Cl)Cl	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	B1C0EV	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	9859898	C14H16N4O	256.3	CC(C)C1=NN2C=CC=CC2=C1C3=NNC(=O)CC3	IC50 = 110000 nM	Poor binder
T88975	Phosphodiesterase 3A	B1O7SK	(2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087052	C21H19ClN6O3	438.9	C[C@@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T88975	Phosphodiesterase 3A	B21MFB	4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9836643	C15H12ClN3OS	317.8	CN1C(=NC2=CC=C(C=C2)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B38LGJ	6-Methoxy-2-[[4-[4-(4-pyridyl)-1-methyl-1H-pyrazole-3-yl]phenoxy]methyl]quinoline	Investigative	68578314	C26H22N4O2	422.5	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=C(C=C3)C=C(C=C4)OC)C5=CC=NC=C5	IC50 = 78000 nM	Poor binder
T88975	Phosphodiesterase 3A	B3VWM4	4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193709	C31H31FN4O4	542.6	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C(=C3)OCCOCCOCCF)C5=CC=NC=C5	IC50 = 116000 nM	Poor binder
T88975	Phosphodiesterase 3A	B45PMI	2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetonitrile	Investigative	9922545	C15H16ClN3O2	305.76	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC#N	IC50 = 94000 nM	Poor binder
T88975	Phosphodiesterase 3A	B4G9AQ	8-Chloro-5-(2-morpholin-4-ylethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	6918800	C19H26ClN3O3	379.9	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCN4CCOCC4	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B4GU0D	2-[2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetic acid	Investigative	10270352	C17H22ClN3O4	367.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCNCC(=O)O	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B4JF8H	8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9880288	C16H22ClN3O2	323.82	CNCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B4PA8F	3-Methoxy-2-[[4-[4-(4-pyridyl)-1-methyl-1H-pyrazole-3-yl]phenoxy]methyl]quinoline	Investigative	90665374	C26H22N4O2	422.5	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3OC)C5=CC=NC=C5	IC50 = 123000 nM	Poor binder
T88975	Phosphodiesterase 3A	B51NBE	(5Z)-5-(3,4-Diethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one	Investigative	1232680	C14H15NO3S2	309.4	CCOC1=C(C=C(C=C1)/C=C\\2/C(=O)NC(=S)S2)OCC	IC50 = 80000 nM	Poor binder
T88975	Phosphodiesterase 3A	B57NKZ	2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9880010	C15H12ClN3OS	317.8	CN1C(=NC2=CC=CC=C2O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B5AIE1	7-Methoxy-4-[(E)-2-pyridin-4-ylethenyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine	Investigative	24798187	C16H12F3N3O	319.28	COC1=CC=C(C2=CC(=NN12)C(F)(F)F)/C=C/C3=CC=NC=C3	IC50 = 67100 nM	Poor binder
T88975	Phosphodiesterase 3A	B5JKC7	CID 16666618	Investigative	16666618	C15H19N5O	285.34	CCC1=NN2C(=CC=C(C2=C1)C3=NNC(=O)C3(C)C)NC	IC50 = 75550 nM	Poor binder
T88975	Phosphodiesterase 3A	B5XLR9	6-Phenyl-8-chlorospiro[quinazoline-4(3H),1'-cyclohexane]-2(1H)-one	Investigative	6918667	C19H19ClN2O	326.8	C1CCC2(CC1)C3=C(C(=CC(=C3)C4=CC=CC=C4)Cl)NC(=O)N2	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B5YFU2	Chembl4127641	Investigative	44180409	C17H21N5O2	327.4	CC1=CC(=NN1)CC(C)NC2=NC=NC3=C2C=CC(=C3OC)OC	IC50 = 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B6X2RI	3,5-Dichloro-N-[[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]methyl]pyridin-4-amine	Investigative	72192868	C15H11Cl2F3N4O	391.2	COC1=CC=C(C2=CC(=NN12)C(F)(F)F)CNC3=C(C=NC=C3Cl)Cl	IC50 = 71400 nM	Poor binder
T88975	Phosphodiesterase 3A	B76FCU	7-(1-Hydroxyethyl)-2-trifluoromethylpyrazolo[1,5-a]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide	Investigative	24772513	C16H11Cl2F3N4O2	419.2	CC(C1=CC=C(C2=CC(=NN12)C(F)(F)F)C(=O)NC3=C(C=NC=C3Cl)Cl)O	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	B7H3NC	5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9966830	C15H11ClFN3S	319.8	CN1C(=NC2=CC(=CC=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B7HX1A	2-Cyclopropyl-N-(3,5-dichloropyridin-4-yl)-7-methoxypyrazolo[1,5-a]pyridine-4-carboxamide	Investigative	24772445	C17H14Cl2N4O2	377.2	COC1=CC=C(C2=CC(=NN12)C3CC3)C(=O)NC4=C(C=NC=C4Cl)Cl	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	B8OSL6	5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9901606	C15H11ClFN3S	319.8	CN1C(=NC2=CC=C(C=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	B97HAY	6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	662965	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC)OC	IC50 ~ 50000 nM	Poor binder
T88975	Phosphodiesterase 3A	B9B6QD	3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[3-(dimethylamino)propyl]benzamide	Investigative	6918668	C25H31ClN4O2	455	CN(C)CCCNC(=O)C1=CC=CC(=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 = 78100 nM	Poor binder
T88975	Phosphodiesterase 3A	B9FXI0	4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193931	C31H31FN4O4	542.6	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)OCCOCCOCCF	IC50 = 62200 nM	Poor binder
T88975	Phosphodiesterase 3A	B9P6JX	N-(2-Fluoroethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolin-4-amine	Investigative	122193933	C27H24FN5O	453.5	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)NCCF	IC50 = 78800 nM	Poor binder
T88975	Phosphodiesterase 3A	B9V3TH	N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide	Investigative	2409032	C23H24N4OS	404.5	CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	B9W7HS	5-(2-Aminoethoxy)-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9922691	C15H20ClN3O2	309.79	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCN	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	BAR03O	Ethyl 5-[(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylate	Investigative	44394047	C21H23ClN2O5	418.9	CCOC(=O)C1=CC=C(O1)COC2=C3C(=C(C=C2)Cl)NC(=O)NC34CCCCC4	IC50 = 78000 nM	Poor binder
T88975	Phosphodiesterase 3A	BBZS05	8-Chloro-6-[2-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	44393651	C25H29ClN4O2	453	CN1CCN(CC1)C(=O)C2=CC=CC=C2C3=CC4=C(C(=C3)Cl)NC(=O)NC45CCCCC5	IC50 ~ 92000 nM	Poor binder
T88975	Phosphodiesterase 3A	BC3MU2	3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[2-(dimethylamino)ethyl]benzamide	Investigative	6918796	C24H29ClN4O2	441	CN(C)CCNC(=O)C1=CC=CC(=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 ~ 79900 nM	Poor binder
T88975	Phosphodiesterase 3A	BD0XY9	8-Chloro-5-[2-hydroxy-3-(methylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9924709	C17H24ClN3O3	353.8	CNCC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	BF48VA	8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10109572	C18H26ClN3O3	367.9	CN(C)CC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	BFDA41	4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193932	C33H35FN4O5	586.7	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)OCCOCCOCCOCCF	IC50 = 58710 nM	Poor binder
T88975	Phosphodiesterase 3A	BG87XN	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one	Investigative	24751843	C14H14N4O	254.29	CC(C)C1=NN2C=CC=CC2=C1C3=NNC(=O)C=C3	IC50 = 72000 nM	Poor binder
T88975	Phosphodiesterase 3A	BGM86U	(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylate	Investigative	57385767	C21H20O6	368.4	COC1=CC(=CC(=C1OC)OC)COC(=O)C2=CC=C(O2)C3=CC=CC=C3	IC50 = 54600 nM	Poor binder
T88975	Phosphodiesterase 3A	BGP76O	8-Chloro-5-[2-(dimethylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9967652	C17H24ClN3O2	337.8	CN(C)CCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	BH4JT6	8-Chloro-5-[3-(dimethylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968370	C18H26ClN3O2	351.9	CN(C)CCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 ~ 101000 nM	Poor binder
T88975	Phosphodiesterase 3A	BJ69KQ	2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetic acid	Investigative	6918798	C15H17ClN2O4	324.76	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC(=O)O	IC50 ~ 68000 nM	Poor binder
T88975	Phosphodiesterase 3A	BK1ZJ6	N-(3,5-Dichloropyridin-4-yl)-2-[(E)-hydroxyiminomethyl]-7-methoxypyrazolo[1,5-a]pyridine-4-carboxamide	Investigative	136260531	C15H11Cl2N5O3	380.2	COC1=CC=C(C2=CC(=NN12)/C=N/O)C(=O)NC3=C(C=NC=C3Cl)Cl	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BLR0D8	[4-(1-Methylimidazole-4-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone	Investigative	73388373	C24H22N10O2	482.5	CN1C=C(N=C1)C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC5=CC=CC=C5N6C4=NN=N6	IC50 = 50118.72 nM	Poor binder
T88975	Phosphodiesterase 3A	BM51NR	4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193710	C33H35FN4O5	586.7	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C(=C3)OCCOCCOCCOCCF)C5=CC=NC=C5	IC50 = 144400 nM	Poor binder
T88975	Phosphodiesterase 3A	BNP6R8	(1-Methylbenzimidazol-2-yl)-[4-(3-pyridin-3-ylpyridin-2-yl)oxyphenyl]methanone	Investigative	118725368	C25H18N4O2	406.4	CN1C2=CC=CC=C2N=C1C(=O)C3=CC=C(C=C3)OC4=C(C=CC=N4)C5=CN=CC=C5	IC50 = 167000 nM	Poor binder
T88975	Phosphodiesterase 3A	BNU4B7	5-Methyl-6-(2-isopropylpyrazolo[1,5-a]pyridine-3-yl)-4,5-dihydropyridazine-3(2H)-one	Investigative	10221093	C15H18N4O	270.33	CC1CC(=O)NN=C1C2=C3C=CC=CN3N=C2C(C)C	IC50 = 89000 nM	Poor binder
T88975	Phosphodiesterase 3A	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BP6X7D	2-Cyano-N-(3,5-dichloropyridin-4-yl)-7-methoxypyrazolo[1,5-a]pyridine-4-carboxamide	Investigative	24772511	C15H9Cl2N5O2	362.2	COC1=CC=C(C2=CC(=NN12)C#N)C(=O)NC3=C(C=NC=C3Cl)Cl	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BQI63Y	6-Fluoro-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193935	C25H19FN4O	410.4	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=C(C=C4)C=C(C=C5)F	IC50 = 111000 nM	Poor binder
T88975	Phosphodiesterase 3A	BQIK50	4-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193703	C25H19FN4O	410.4	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C(=C3)F)C5=CC=NC=C5	IC50 = 199000 nM	Poor binder
T88975	Phosphodiesterase 3A	BQP08U	7-Methoxy-4-(pyridin-4-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine	Investigative	72193179	C15H12F3N3O	307.27	COC1=CC=C(C2=CC(=NN12)C(F)(F)F)CC3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 = 51000 nM	Poor binder
T88975	Phosphodiesterase 3A	BRJ8Q5	(5-Phenylfuran-2-yl)methyl 3,4,5-triethoxybenzoate	Investigative	57385526	C24H26O6	410.5	CCOC1=CC(=CC(=C1OCC)OCC)C(=O)OCC2=CC=C(O2)C3=CC=CC=C3	IC50 = 104200 nM	Poor binder
T88975	Phosphodiesterase 3A	BVA87L	2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136217455	C21H19ClN6O3	438.9	CC(C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T88975	Phosphodiesterase 3A	BW7G6L	N-Benzyl-5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazole-2-carboxamide	Investigative	70685361	C24H22N4O3S	446.5	COC1=C(C=C2C(=C1)CCN3C2=C(N=C3)C4=CN=C(S4)C(=O)NCC5=CC=CC=C5)OC	Ki ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BXB1Y0	N-(3,5-Dichloropyridin-4-yl)-2-ethyl-7-methoxypyrazolo[1,5-a]pyridine-4-carboxamide	Investigative	24772447	C16H14Cl2N4O2	365.2	CCC1=NN2C(=CC=C(C2=C1)C(=O)NC3=C(C=NC=C3Cl)Cl)OC	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BXVA98	8-Chloro-5-(2-hydroxyethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	6918799	C15H19ClN2O3	310.77	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCO	IC50 ~ 73000 nM	Poor binder
T88975	Phosphodiesterase 3A	BY16BA	4-Benzyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,6,10,13,15-hexaen-5-one	Investigative	54587404	C20H16N4O	328.4	C1CC2=NN3C=CC=CC3=C2C4=NN(C(=O)C=C41)CC5=CC=CC=C5	IC50 = 69000 nM	Poor binder
T88975	Phosphodiesterase 3A	BYGM62	7-Methoxypyrazolo[1,5-a]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide	Investigative	59227421	C14H10Cl2N4O2	337.2	COC1=CC=C(C2=CC=NN21)C(=O)NC3=C(C=NC=C3Cl)Cl	IC50 ~ 100000 nM	Poor binder
T88975	Phosphodiesterase 3A	BZ5MY4	4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193930	C29H27FN4O3	498.5	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)OCCOCCF	IC50 = 66400 nM	Poor binder
T88975	Phosphodiesterase 3A	BZ70CK	2-Acetyl-7-methoxypyrazolo[1,5-a]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide	Investigative	59227406	C16H12Cl2N4O3	379.2	CC(=O)C1=NN2C(=CC=C(C2=C1)C(=O)NC3=C(C=NC=C3Cl)Cl)OC	IC50 ~ 100000 nM	Poor binder