TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T87166	Glucokinase	B14BFY	N,N-Dimethyl-5-[[2-methyl-6-(pyrimidin-2-ylcarbamoyl)-1-benzofuran-4-yl]oxy]pyrazine-2-carboxamide	Investigative	90665757	C21H18N6O4	418.4	CC1=CC2=C(O1)C=C(C=C2OC3=NC=C(N=C3)C(=O)N(C)C)C(=O)NC4=NC=CC=N4	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	B1L9CV	1,1,1,3,3,3-Hexafluoro-2-{4-[4-(Thiophen-2-Ylsulfonyl)piperazin-1-Yl]phenyl}propan-2-Ol	Investigative	56832521	C17H16F6N2O3S2	474.4	C1CN(CCN1C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C3=CC=CS3	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	B3O9PW	N-[1-[2-(Diethylamino)ethyl]pyrazol-3-yl]-3-(3-methylpyridin-2-yl)-5-(4-methylsulfonylphenoxy)benzamide	Investigative	77107274	C29H33N5O4S	547.7	CCN(CC)CCN1C=CC(=N1)NC(=O)C2=CC(=CC(=C2)C3=C(C=CC=N3)C)OC4=CC=C(C=C4)S(=O)(=O)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	B51IBR	1-[3-(2-Ethylpyridin-3-yl)oxy-5-pyridin-2-ylsulfanylpyridin-2-yl]-3-propan-2-ylurea	Investigative	118715095	C21H23N5O2S	409.5	CCC1=C(C=CC=N1)OC2=C(N=CC(=C2)SC3=CC=CC=N3)NC(=O)NC(C)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	B80RCS	N-(5-Chloro-1,3-thiazol-2-yl)-2-(6-cyclopropylsulfonylindazol-1-yl)-3-(oxan-4-yl)propanamide	Investigative	57964003	C21H23ClN4O4S2	495	C1CC1S(=O)(=O)C2=CC3=C(C=C2)C=NN3C(CC4CCOCC4)C(=O)NC5=NC=C(S5)Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	B8SNY2	3-(3-Methylpyridin-2-yl)-5-(4-methylsulfonylphenoxy)-N-[4-(piperazin-1-ylmethyl)-1,3-thiazol-2-yl]benzamide	Investigative	77105088	C28H29N5O4S2	563.7	CC1=C(N=CC=C1)C2=CC(=CC(=C2)OC3=CC=C(C=C3)S(=O)(=O)C)C(=O)NC4=NC(=CS4)CN5CCNCC5	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	B8XQ2D	2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]sulfanyl-N-pyrimidin-2-ylacetamide	Investigative	71454226	C17H12ClN7OS	397.8	C1=CC=C(C(=C1)N2C3=C(C=N2)C(=NC=N3)SCC(=O)NC4=NC=CC=N4)Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	B9GC7H	(2r)-1,1,1-Trifluoro-2-{4-[(2s)-2-{[(3s)-3-Methylmorpholin-4-Yl]methyl}-4-(Thiophen-2-Ylsulfonyl)piperazin-1-Yl]phenyl}propan-2-Ol	Investigative	66582747	C23H30F3N3O4S2	533.6	C[C@H]1COCCN1C[C@H]2CN(CCN2C3=CC=C(C=C3)[C@](C)(C(F)(F)F)O)S(=O)(=O)C4=CC=CS4	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BBD26L	2-(4-Tert-butylsulfonylpyrazol-1-yl)-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide	Investigative	44513475	C18H25FN4O4S2	444.5	CC(C)(C)S(=O)(=O)C1=CN(N=C1)C(CC2CCOCC2)C(=O)NC3=NC=C(S3)F	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BD9OK8	N-[1-(Ethoxymethyl)pyrazol-3-yl]-3-(3-methylpyridin-2-yl)-5-(4-methylsulfonylphenoxy)benzamide	Investigative	77107471	C26H26N4O5S	506.6	CCOCN1C=CC(=N1)NC(=O)C2=CC(=CC(=C2)C3=C(C=CC=N3)C)OC4=CC=C(C=C4)S(=O)(=O)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BEG59M	N-[4-(Diethylaminomethyl)-1,3-thiazol-2-yl]-3-(3-methylpyridin-2-yl)-5-(4-methylsulfonylphenoxy)benzamide	Investigative	90655315	C28H30N4O4S2	550.7	CCN(CC)CC1=CSC(=N1)NC(=O)C2=CC(=CC(=C2)C3=C(C=CC=N3)C)OC4=CC=C(C=C4)S(=O)(=O)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BFP7A8	4-Methyl-2-(4-methylsulfonylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)pentanamide	Investigative	71579463	C14H24N4O3S2	360.5	CC(C)CC(C(=O)NC1=NC=CS1)N2CCN(CC2)S(=O)(=O)C	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BHD56X	2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]sulfanyl-N-phenylacetamide	Investigative	1445399	C19H14ClN5OS	395.9	C1=CC=C(C=C1)NC(=O)CSC2=NC=NC3=C2C=NN3C4=CC=CC=C4Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BJ8CX6	2-[4-(3-Chlorophenyl)sulfonylpyrazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide	Investigative	137634006	C20H20ClFN4O4S2	499	C1COCCC1CC(C(=O)NC2=NC=C(S2)F)N3C=C(C=N3)S(=O)(=O)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BNI47T	(2S)-2-(2,4-Dioxo-1H-quinazolin-3-yl)-3-phenyl-N-(1,3-thiazol-2-yl)propanamide	Investigative	71579465	C20H16N4O3S	392.4	C1=CC=C(C=C1)C[C@@H](C(=O)NC2=NC=CS2)N3C(=O)C4=CC=CC=C4NC3=O	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BO8BI7	2-(1,3-Dihydroisoindol-2-yl)-4-methyl-N-(1,3-thiazol-2-yl)pentanamide	Investigative	71579462	C17H21N3OS	315.4	CC(C)CC(C(=O)NC1=NC=CS1)N2CC3=CC=CC=C3C2	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BP12ID	(2S)-2-(2,4-Dioxo-1H-quinazolin-3-yl)-4-methyl-N-(1,3-thiazol-2-yl)pentanamide	Investigative	24745013	C17H18N4O3S	358.4	CC(C)C[C@@H](C(=O)NC1=NC=CS1)N2C(=O)C3=CC=CC=C3NC2=O	EC50 = 50000 nM	Poor binder
T87166	Glucokinase	BPE8B3	3-(3-Methylpyridin-2-yl)-5-(4-methylsulfonylphenoxy)-N-[4-(propylaminomethyl)-1,3-thiazol-2-yl]benzamide	Investigative	77105468	C27H28N4O4S2	536.7	CCCNCC1=CSC(=N1)NC(=O)C2=CC(=CC(=C2)C3=C(C=CC=N3)C)OC4=CC=C(C=C4)S(=O)(=O)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BRIG72	N-(4-Methylthiazol-2-yl)-2-((1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)thio)acetamide	Investigative	1172823	C17H14N6OS2	382.5	CC1=CSC(=N1)NC(=O)CSC2=NC=NC3=C2C=NN3C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BT5BO8	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-[(2S)-1-hydroxypropan-2-yl]oxypropanamide	Investigative	57482815	C22H19ClN8O4	494.9	C[C@@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)C#N)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BUY26O	6-[3-(4-Methylsulfonylphenoxy)-5-propan-2-yloxyphenyl]-1H-pyrimidin-2-one	Investigative	71813504	C20H20N2O5S	400.4	CC(C)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)S(=O)(=O)C)C3=CC=NC(=O)N3	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BV6U8O	N-[3-(2-Ethylpyridin-3-yl)oxy-5-pyridin-2-ylsulfanylpyridin-2-yl]acetamide	Investigative	118715091	C19H18N4O2S	366.4	CCC1=C(C=CC=N1)OC2=C(N=CC(=C2)SC3=CC=CC=N3)NC(=O)C	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BW2YM4	Ethyl N-[3-(2-ethylpyridin-3-yl)oxy-5-pyridin-2-ylsulfanylpyridin-2-yl]carbamate	Investigative	118715092	C20H20N4O3S	396.5	CCC1=C(C=CC=N1)OC2=C(N=CC(=C2)SC3=CC=CC=N3)NC(=O)OCC	EC50 ~ 50000 nM	Poor binder
T87166	Glucokinase	BWG3K1	2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]sulfanyl-N-(4-methyl-1,3-thiazol-2-yl)-2-phenylacetamide	Investigative	71450638	C23H17ClN6OS2	493	CC1=CSC(=N1)NC(=O)C(C2=CC=CC=C2)SC3=NC=NC4=C3C=NN4C5=CC=CC=C5Cl	EC50 ~ 100000 nM	Poor binder
T87166	Glucokinase	BZ0KW4	N-[1-Benzofuran-2-yl(phenyl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide	Investigative	16349380	C24H21NO5S	435.5	C1COC2=C(C=C(C=C2)S(=O)(=O)NC(C3=CC=CC=C3)C4=CC5=CC=CC=C5O4)OC1	EC50 ~ 100000 nM	Poor binder