TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	D06IAR	Adenosine	Approved	60961	C10H13N5O4	267.24	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B0HBE5	(E)-6-(4-Hydroxy-6-methoxy-2,7-dimethyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl)-4-methyl-hex-4-enoic acid	Investigative	10759053	C18H23NO5	333.4	CC1=C2CN(C(=O)C2=C(C(=C1OC)C/C=C(\\C)/CCC(=O)O)O)C	IC50 ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B1R7CB	(E)-6-(6-Hydroxy-2-methoxy-3,4-dimethyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10492850	C16H22O4	278.34	CC1=CC(=C(C(=C1C)OC)C/C=C(\\C)/CCC(=O)O)O	IC50 = 51800 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B26LVE	(E)-6-(5-Hydroxy-2-methoxy-3,4-dimethyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10826452	C16H22O4	278.34	CC1=C(C=C(C(=C1C)OC)C/C=C(\\C)/CCC(=O)O)O	IC50 ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B27GIR	Adenosine 5''-methylenebis(sulfonamide)	Investigative	44578789	C11H17N7O7S2	423.4	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CNS(=O)(=O)CS(=O)(=O)N)O)O)N	Ki ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B3AF8U	(E)-6-(2,5-Dimethoxy-3,4-dimethyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10685057	C17H24O4	292.4	CC1=C(C=C(C(=C1C)OC)C/C=C(\\C)/CCC(=O)O)OC	IC50 = 50000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B4C3LG	N-(4-Chlorophenyl)-2-phenoxypropanamide	Investigative	3140491	C15H14ClNO2	275.73	CC(C(=O)NC1=CC=C(C=C1)Cl)OC2=CC=CC=C2	EC50 ~ 50000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B4DF3G	6-(2-Methoxy-3,4-dimethyl-5-methylsulfenyloxy-phenyl)-4-methyl-hex-4-enoic acid	Investigative	44354730	C17H24O4S	324.4	CC1=C(C=C(C(=C1C)OC)C/C=C(\\C)/CCC(=O)O)OSC	IC50 ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B4FW1T	7-(Benzo[d]oxazol-2-ylamino)-1-methyl-1H-indole-3-carbonitrile	Investigative	44410732	C17H12N4O	288.3	CN1C=C(C2=C1C(=CC=C2)NC3=NC4=CC=CC=C4O3)C#N	IC50 = 58400 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B4SFE0	(E)-6-[2-Hydroxy-6-methoxy-3-(methoxyimino-methyl)-4,5-dimethyl-phenyl]-4-methyl-hex-4-enoic acid	Investigative	135419254	C18H25NO5	335.4	CC1=C(C(=C(C(=C1/C=N/OC)O)C/C=C(\\C)/CCC(=O)O)OC)C	IC50 = 52800 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B8YCX5	6-(Benzyloxy)-1H-indole-3-carbonitrile	Investigative	44410469	C16H12N2O	248.28	C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CN3)C#N	IC50 = 71800 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B9BN1T	2-[5-O-[(5'-Adenylyloxy)phosphonyl]-beta-D-ribofuranosyl]-4-carbamoylfuran	Investigative	10841975	C20H26N6O15P2	652.4	C1=C(OC=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O	Ki = 57900 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	B9CW6B	(E)-6-(7-Carbamoyl-4-hydroxy-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enoic acid	Investigative	10593915	C17H19NO7	349.3	C/C(=C\\CC1=C(C2=C(COC2=O)C(=C1OC)C(=O)N)O)/CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BD1YJ8	(E)-6-(2-Methoxy-3,4-dimethyl-5-methylsulfanyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10709955	C17H24O3S	308.4	CC1=C(C=C(C(=C1C)OC)C/C=C(\\C)/CCC(=O)O)SC	IC50 = 52300 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BH0F3L	[(2S,3R,4S)-3,4-Dihydroxy-5-[2-(hydroxymethyl)-6-oxo-1H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate	Investigative	135976471	C11H15N4O9P	378.23	C1=NC2=C(N1C3[C@H]([C@H]([C@@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)CO	IC50 = 132000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BNB62G	6-(2,4-Dimethoxy-3-methyl-5-(oxazol-5-yl)phenyl)-4-methylhex-4-enoic acid	Investigative	44589785	C19H23NO5	345.4	CC1=C(C(=CC(=C1OC)C2=CN=CO2)C/C=C(\\C)/CCC(=O)O)OC	Ki ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BRT6X9	(4E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid	Investigative	44433349	C18H22O6	334.4	CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\\C)/CCC(=O)O)OC	IC50 = 72000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BU6AS5	N-(4-Methoxyphenyl)-2-(2-thiazol-4-ylbenzimidazol-1-yl)acetamide	Investigative	6618978	C19H16N4O2S	364.4	COC1=CC=C(C=C1)NC(=O)CN2C3=CC=CC=C3N=C2C4=CSC=N4	IC50 ~ 50000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BWI21J	Penicacid C	Investigative	59053798	C17H22O9	370.4	CC1=C2COC(=O)C2=C(C(=C1OC)CC(C(C)(C(CC(=O)O)O)O)O)O	IC50 = 73240 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BXP79E	(E)-6-(6-Hydroxy-2,3,4-trimethyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10515627	C16H22O3	262.34	CC1=CC(=C(C(=C1C)C)C/C=C(\\C)/CCC(=O)O)O	IC50 ~ 100000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BXQ97I	(E)-6-(6-Amino-2,3,4-trimethyl-phenyl)-4-methyl-hex-4-enoic Acid	Investigative	10682843	C16H23NO2	261.36	CC1=CC(=C(C(=C1C)C)C/C=C(\\C)/CCC(=O)O)N	IC50 = 90800 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BY53XA	[(2S,3S,4R,5S)-5-(6-Aminopurin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl]phosphinic acid	Investigative	90663712	C23H29FN6O12P2	662.5	C1=CC(=CC(=C1)C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(CP(=O)(O)OC[C@H]3[C@@H]([C@H]([C@H](O3)N4C=NC5=C(N=CN=C54)N)F)O)O)O)O	IC50 = 175000 nM	Poor binder
T86573	HUMAN inosine-5'-monophosphate dehydrogenase 2	BY8BN4	(E)-6-(7-Cyano-4-hydroxy-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enoic acid	Investigative	10687933	C17H17NO6	331.32	C/C(=C\\CC1=C(C(=C2COC(=O)C2=C1O)C#N)OC)/CCC(=O)O	IC50 ~ 100000 nM	Poor binder