TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86437	HUMAN janus kinase 1	B0NZT4	4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide	Investigative	46917073	C18H16ClN3O	325.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCCl	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B18GAM	2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46917070	C18H18N4O	306.4	CN(C)CC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B1E3KY	Disodium;2-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	76325323	C19H16FN6Na2O3P	472.3	CN1C(=C(N=C1C2=CN(N=N2)CCP(=O)([O-])[O-])C3=CC=C(C=C3)F)C4=CC=NC=C4.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B1NM0O	3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide	Investigative	46916410	C17H14ClN3O	311.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCl	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B24FDH	Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate	Investigative	118707523	C21H14FN8NaO2S	484.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CC(=O)[O-])C5=CC=C(C=C5)F.[Na+]	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B28CHV	N-[3-(2-Quinoxalinyl)phenyl]methanesulfonamide	Investigative	1485426	C15H13N3O2S	299.3	CS(=O)(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B2DO4T	4-[5-(4-Fluorophenyl)-3-methyl-2-(2H-triazol-4-yl)imidazol-4-yl]pyridine	Investigative	76325315	C17H13FN6	320.32	CN1C(=C(N=C1C2=NNN=C2)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B2X6MP	N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide	Investigative	46917074	C18H14N6O	330.3	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CN4C=NC=N4	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B3H7WV	2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine	Investigative	9798589	C17H13FN6S	352.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)N)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B4K3YE	N-[3-(2-Quinoxalinyl)phenyl]-2-furamide	Investigative	1485419	C19H13N3O2	315.3	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)C4=CC=CO4	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B64LHM	(2R,3R,4R,5S,6R)-3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]-6-(hydroxymethyl)oxane-2,4,5-triol	Investigative	118707521	C23H23FN6O5	482.5	CN1C(=C(N=C1C2=CN(N=N2)[C@@H]3[C@H]([C@@H]([C@H](O[C@H]3O)CO)O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B73IWP	2-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethanol	Investigative	76314414	C19H17FN6O	364.4	CN1C(=C(N=C1C2=CN(N=N2)CCO)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B7LQ4K	2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46916408	C21H23N5O	361.4	CN1CCN(CC1)CC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	B81JYI	Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	118707526	C21H16FN8Na2O3PS	556.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CCP(=O)([O-])[O-])C5=CC=C(C=C5)F.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B82CPS	4-[4-(4-Fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazol-2-yl]phenol	Investigative	136987005	C20H15FN4OS	378.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	B97OTQ	7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707522	C19H12FN5S	361.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BB5A6N	N-[4-(2-Quinoxalinyl)phenyl]cyclopropanecarboxamide	Investigative	45588498	C18H15N3O	289.3	C1CC1C(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BB7T4M	4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine	Investigative	118707543	C22H15FN4S	386.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BC34WF	N-Methyl-N'-[3-(2-quinoxalinyl)phenyl]thiourea	Investigative	1485416	C16H14N4S	294.4	CNC(=S)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BCVE73	N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide	Investigative	1485420	C18H13N3O2S2	367.4	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BD5O9Y	2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine	Investigative	44124695	C24H20FN7	425.5	C[C@@H](C1=CC=CC=C1)NC2=NC=CC(=N2)C3=C(N=C4N3C=CC(=N4)N)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BDM21A	4-[5-(4-Fluorophenyl)-2-[1-[(3S,4S)-3-fluoropiperidin-4-yl]triazol-4-yl]-3-methylimidazol-4-yl]pyridine;hydrochloride	Investigative	76317978	C22H22ClF2N7	457.9	CN1C(=C(N=C1C2=CN(N=N2)[C@H]3CCNC[C@@H]3F)C4=CC=C(C=C4)F)C5=CC=NC=C5.Cl	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BGD0S5	3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76332540	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=CC(=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BKG16O	4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine	Investigative	76310785	C23H26FN6O3P	484.5	CCOP(=O)(CCN1C=C(N=N1)C2=NC(=C(N2C)C3=CC=NC=C3)C4=CC=C(C=C4)F)OCC	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BMJZ59	2-Morpholino-N-(3-(quinoxalin-2-yl)phenyl)acetamide	Investigative	46916411	C20H20N4O2	348.4	C1COCCN1CC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BNK7H2	7-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707525	C25H26FN8O3PS	568.6	CCOP(=O)(CCN1C=C(N=N1)C2=NC3=NC(=C(N3C=C2)C4=NC(=NC=C4)SC)C5=CC=C(C=C5)F)OCC	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BPD53O	Chembl4289149	Investigative	145987719	C18H14F3N7O	401.3	C1CC1NC2=CC(=NN3C2=NC=C3C(=O)N)NC4=CC(=CC(=C4)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BRQ36B	2-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide	Investigative	58200382	C17H14ClN3O	311.8	CC(C(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2)Cl	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BSH4V3	N-(3-Quinoxalin-2-ylphenyl)propanamide	Investigative	952076	C17H15N3O	277.32	CCC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	BWV26C	N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea	Investigative	1485415	C22H18N4O2	370.4	COC1=CC=C(C=C1)NC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T86437	HUMAN janus kinase 1	BYZ38E	4-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76310788	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=C(C=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T86437	HUMAN janus kinase 1	D0VC0I	Oxindole 94	Investigative	5169	C20H14FN3O	331.3	C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O	IC50 ~ 100000 nM	Poor binder