TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86385	Cathepsin G	D0FT4R	Sivelestat	Phase 4	107706	C20H22N2O7S	434.5	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	D0A5BT	Camostat mesylate	Phase 2/3	5284360	C21H26N4O8S	494.5	CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B0HLO3	2-Allyl-1-hydroxy-8-methoxy-anthraquinone	Investigative	10517868	C18H14O4	294.3	COC1=CC=CC2=C1C(=O)C3=C(C2=O)C=CC(=C3O)CC=C	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	B15JUI	(3Ar,6S,6aS)-4-methylsulfonyl-6-propan-2-yl-1-[2-(pyrrolidin-1-ylmethyl)-1,3-oxazole-4-carbonyl]-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	10322033	C19H29ClN4O5S	461	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3=COC(=N3)CN4CCCC4)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B1Q9MT	(2S,3S)-N-[(1R)-1-[[3-(Butylamino)-3-oxopropyl]-diphenylsilyl]-3-methylbutyl]-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]pentanamide	Investigative	46221636	C42H55N3O3Si	678	CCCCNC(=O)CC[Si](C1=CC=CC=C1)(C2=CC=CC=C2)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CC3=CC4=CC=CC=C4C=C3	IC50 = 120000 nM	Poor binder
T86385	Cathepsin G	B1QW9S	Benzyl (3aS,6aR)-6-allyl-4-(methylsulfonyl)-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate	Investigative	54132077	C18H22N2O5S	378.4	CS(=O)(=O)N1[C@H]2CCN([C@@H]2[C@H](C1=O)CC=C)C(=O)OCC3=CC=CC=C3	IC50 = 53000 nM	Poor binder
T86385	Cathepsin G	B29LPH	2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561932	C13H8F5NO3S	353.27	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C(=C(C(=C3F)F)F)F)F	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B2MIZ5	(3Ar,6S,6aS)-1-[1-(2,2-dimethylpropyl)azetidine-3-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	10455658	C19H34ClN3O4S	436	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3CN(C3)CC(C)(C)C)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B2UKI6	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3-hydroxy-phenyl)-propionamide	Investigative	44303391	C19H20ClNO3	345.8	C1=CC=C(C=C1)C[C@@H](C(=O)CCl)NC(=O)CCC2=CC(=CC=C2)O	IC50 = 58000 nM	Poor binder
T86385	Cathepsin G	B36ZIR	2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561892	C12H11BrN2O3S	343.2	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Br	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B3KYM0	4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide	Investigative	44561930	C10H6F4N2O3S	310.23	CC1=C(S(=O)(=O)N(C1=O)C2=C(C(=NC(=C2F)F)F)F)C	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B45OVK	2-Hexyl-1-hydroxy-8-methoxy-anthraquinone	Investigative	44287881	C21H22O4	338.4	CCCCCCC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C(=CC=C3)OC)O	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	B4ADZ2	2-(2,3,5,6-Tetrafluoropyridin-4-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	25141405	C12H8F4N2O3S	336.26	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C(=NC(=C3F)F)F)F	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B4UJA1	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137637214	C117H160N32O28S3	2558.9	C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](CSCC3=CC4=CC(=C3)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@@H](CSC4)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC7=CNC8=CC=CC=C87)CC9=CNC1=CC=CC=C19)CC(=O)N)CC1=CNC2=CC=CC=C21)[C@@H](C)O)CC(=O)N)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)CC(C)C	Ki ~ 50000 nM	Poor binder
T86385	Cathepsin G	B4YPJ2	N-{4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-phenyl}-acetamide	Investigative	10811389	C17H14ClN3O5S	407.8	CC(=O)NC1=CC=C(C=C1)N2CC(=O)N(C2=O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B5A6OV	(3R,6As)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester	Investigative	9972080	C17H19NO4	301.34	C=CC[C@@H]1C2[C@H](CCN2C(=O)OCC3=CC=CC=C3)OC1=O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B5B7YV	Trifluoroethylamine inhibitor, 2	Investigative	23648277	C16H17BrF3N3O3S	468.3	CS(=O)(=O)C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)Br)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T86385	Cathepsin G	B5I6RB	(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797572	C19H18F3N3O3S	425.4	C1[C@H]([C@@]1(C#N)NC(=O)[C@@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T86385	Cathepsin G	B5L2WV	3-(4-Chloro-benzenesulfonyl)-1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-imidazolidine-2,4-dione	Investigative	44308976	C21H21ClN4O5S	476.9	CN1CCN(CC1)C(=O)C2=CC=C(C=C2)N3CC(=O)N(C3=O)S(=O)(=O)C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B69HKU	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3,4-dimethoxy-phenyl)-propionamide	Investigative	44303536	C21H24ClNO4	389.9	COC1=C(C=C(C=C1)CCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl)OC	IC50 = 140000 nM	Poor binder
T86385	Cathepsin G	B6IPT8	3-(4-Chloro-benzenesulfonyl)-1-cyclohexyl-imidazolidine-2,4-dione	Investigative	10642042	C15H17ClN2O4S	356.8	C1CCC(CC1)N2CC(=O)N(C2=O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 = 75000 nM	Poor binder
T86385	Cathepsin G	B6NB3X	(4-Carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoate;methanesulfonic acid	Investigative	6442224	C26H31N3O8S	545.6	CCOC(=O)CN(CC=C)C(=O)/C(=C/C1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C(=N)N)/C.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B6PSY3	4-(4-Guanidinobenzoyloxy)phenylacetic acid	Investigative	130394	C17H19N3O7S	409.4	CS(=O)(=O)O.C1=CC(=CC=C1CC(=O)O)OC(=O)C2=CC=C(C=C2)N=C(N)N	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B75VTC	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-phenyl-propionamide	Investigative	12043588	C19H20ClNO2	329.8	C1=CC=C(C=C1)CCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl	IC50 = 63000 nM	Poor binder
T86385	Cathepsin G	B7PMG1	2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561891	C12H11ClN2O3S	298.75	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B8AL5U	1-Hydroxy-8-methoxy-2-propyl-anthraquinone	Investigative	15743471	C18H16O4	296.3	CCCC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C(=CC=C3)OC)O	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	B8RS5T	1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid	Investigative	49797481	C12H13ClN2O7S	364.76	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=CC=NC=C3.OCl(=O)(=O)=O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	B9FUP5	1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dione	Investigative	10616405	C16H14N2O4S	330.4	C1C(=O)N(C(=O)N1C2=CC=CC=C2)S(=O)(=O)CC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T86385	Cathepsin G	B9RI7L	(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797573	C19H18F3N3O3S	425.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T86385	Cathepsin G	BB1XC3	(3S,6As)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester	Investigative	44351104	C17H19NO4	301.34	C=CC[C@H]1C2[C@H](CCN2C(=O)OCC3=CC=CC=C3)OC1=O	IC50 = 67000 nM	Poor binder
T86385	Cathepsin G	BB74AC	2-Butyl-1-hydroxy-8-methoxyanthracene-9,10-dione	Investigative	44287910	C19H18O4	310.3	CCCCC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C(=CC=C3)OC)O	IC50 = 55000 nM	Poor binder
T86385	Cathepsin G	BBT7Q4	(3Ar,6S,6aS)-1-[5-[(cyclopropylamino)methyl]pyrazine-2-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	45261824	C19H28ClN5O4S	458	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3=NC=C(N=C3)CNC4CC4)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BDK70S	4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid	Investigative	10572734	C16H11ClN2O6S	394.8	C1C(=O)N(C(=O)N1C2=CC=C(C=C2)C(=O)O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BDN93P	1,8-Dihydroxy-2-methylanthracene-9,10-dione	Investigative	11253808	C15H10O4	254.24	CC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O	IC50 = 55000 nM	Poor binder
T86385	Cathepsin G	BE9IJ3	1-Hydroxy-2-methylanthraquinone	Investigative	160817	C15H10O3	238.24	CC1=C(C2=C(C=C1)C(=O)C3=CC=CC=C3C2=O)O	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	BEB9O5	5-Methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide	Investigative	44561931	C15H8F4N2O3S	372.3	CC1=C(C(=O)N(S1(=O)=O)C2=C(C(=NC(=C2F)F)F)F)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BHAG94	(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid	Investigative	137654508	C76H105N19O19S3	1685	C[C@H]1CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSC3)C(=O)N1)CCCCNC(=N)N)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)CO)NC(=O)C)C(=O)O)CC(C)C)CC(=O)O)CCC(=O)N)CC7=CN=CN7	Ki ~ 50000 nM	Poor binder
T86385	Cathepsin G	BI7MJ1	6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile	Investigative	44143089	C14H8F4N6	336.25	C1=C(C=C(C=C1F)F)NC2=C3C(=NC(=N2)C#N)N(C=N3)CC(F)F	IC50 = 147910.84 nM	Poor binder
T86385	Cathepsin G	BJ6K8F	2-Allyl-1,8-dimethoxy-anthraquinone	Investigative	5013064	C19H16O4	308.3	COC1=CC=CC2=C1C(=O)C3=C(C2=O)C=CC(=C3OC)CC=C	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T86385	Cathepsin G	BLZX12	2-(Benzothiazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one	Investigative	72793747	C18H17NO4S2	375.5	CC(C)(C)C(=O)OC1=COC(=CC1=O)CSC2=NC3=CC=CC=C3S2	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BM0XI7	2-(5-Carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one	Investigative	72793776	C19H17NO7S	403.4	CC(C)(C)C(=O)OC1=COC(=CC1=O)CSC2=NC3=C(O2)C=CC(=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BMX70R	2-[[(E)-3-[4-(4-Carbamimidoylphenoxy)carbonylphenyl]-2-methylprop-2-enoyl]-prop-2-enylamino]acetic acid;methanesulfonic acid	Investigative	44318819	C24H27N3O8S	517.6	C/C(=C\\C1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C(=N)N)/C(=O)N(CC=C)CC(=O)O.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BNHQ54	cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide	Investigative	24822701	C17H17N3OS	311.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T86385	Cathepsin G	BPV54Q	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-fluoro-phenyl)-propionamide	Investigative	44303534	C19H19ClFNO2	347.8	C1=CC=C(C=C1)C[C@@H](C(=O)CCl)NC(=O)CCC2=CC=C(C=C2)F	IC50 = 130000 nM	Poor binder
T86385	Cathepsin G	BQ6KW7	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-hydroxy-phenyl)-propionamide	Investigative	44303240	C19H20ClNO3	345.8	C1=CC=C(C=C1)C[C@@H](C(=O)CCl)NC(=O)CCC2=CC=C(C=C2)O	IC50 = 91000 nM	Poor binder
T86385	Cathepsin G	BQD61L	2-[(5-Amino-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dichlorophenyl)-2-phenylacetamide	Investigative	5236960	C16H13Cl2N5OS	394.3	C1=CC=C(C=C1)C(C(=O)NC2=CC(=CC(=C2)Cl)Cl)SC3=NNC(=N3)N	IC50 ~ 139000 nM	Poor binder
T86385	Cathepsin G	BQT4D3	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-p-tolyl-propionamide	Investigative	11725023	C20H22ClNO2	343.8	CC1=CC=C(C=C1)CCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl	IC50 = 80000 nM	Poor binder
T86385	Cathepsin G	BTL95I	Tosylphenylalanyl chloromethyl ketone	Investigative	439647	C17H18ClNO3S	351.8	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl	IC50 = 110000 nM	Poor binder
T86385	Cathepsin G	BTW8U0	3-(4-Chlorophenyl)sulfonyl-1-(3,4-dimethoxyphenyl)imidazolidine-2,4-dione	Investigative	10764081	C17H15ClN2O6S	410.8	COC1=C(C=C(C=C1)N2CC(=O)N(C2=O)S(=O)(=O)C3=CC=C(C=C3)Cl)OC	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BV06PE	1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-2,9-dihydro-1H-beta-carboline-8-carboxylic acid	Investigative	10048700	C20H18F3N3O5	437.4	CC(C)C(C(=O)C(F)(F)F)NC(=O)CN1C=CC2=C(C1=O)NC3=C2C=CC=C3C(=O)O	Ki = 130000 nM	Poor binder
T86385	Cathepsin G	BVD2P6	3-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid	Investigative	10739429	C16H11ClN2O6S	394.8	C1C(=O)N(C(=O)N1C2=CC=CC(=C2)C(=O)O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BVP1Q6	(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanone	Investigative	102323332	C12H13IN4O2	372.16	C1=CC(=CC=C1C[C@@H](C(=O)C=[N+]=[N-])NC(=O)CN)I	IC50 ~ 50000 nM	Poor binder
T86385	Cathepsin G	BW7A8K	1-Hydroxy-8-methoxy-2-pentyl-anthraquinone	Investigative	44288060	C20H20O4	324.4	CCCCCC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C(=CC=C3)OC)O	IC50 ~ 60000 nM	Poor binder
T86385	Cathepsin G	BWCN26	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137639385	C114H161N29O28S3	2481.9	CC[C@H](C)[C@H]1C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSC3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N1)CC(=O)O)CC6=CC=C(C=C6)O)CC7=CC=C(C=C7)O)C(C)C)CCCCNC(=N)N)CC8=CC=C(C=C8)O)CC9=CC=CC=C9)CO)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T86385	Cathepsin G	BWDO61	3-(3,4-Dimethoxyphenyl)sulfonyl-1-(3,4-dimethylphenyl)imidazolidine-2,4-dione	Investigative	10431323	C19H20N2O6S	404.4	CC1=C(C=C(C=C1)N2CC(=O)N(C2=O)S(=O)(=O)C3=CC(=C(C=C3)OC)OC)C	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BX0G5F	2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561893	C12H10F2N2O3S	300.28	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C=C(C=N3)F)F	IC50 ~ 100000 nM	Poor binder
T86385	Cathepsin G	BX43VG	2-Benzyl-1,8-dihydroxy-anthraquinone	Investigative	44287670	C21H14O4	330.3	C1=CC=C(C=C1)CC2=C(C3=C(C=C2)C(=O)C4=C(C3=O)C(=CC=C4)O)O	IC50 = 56000 nM	Poor binder
T86385	Cathepsin G	BXE4I2	(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-heptanoylamino]-3-phenyl-propionic acid ethyl ester	Investigative	10504812	C28H35N3O4	477.6	CCCCC(C(C)(C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC)NC(=O)C2=CC=C(C=C2)C#N	IC50 = 83000 nM	Poor binder
T86385	Cathepsin G	BY0W3I	N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-isopropyl-phenyl)-propionamide	Investigative	44303218	C22H26ClNO2	371.9	CC(C)C1=CC=C(C=C1)CCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl	IC50 = 65000 nM	Poor binder
T86385	Cathepsin G	BZ9P3H	6-(((5-(Cyclopropanecarboxamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-fluorobenzoate	Investigative	18572952	C19H14FN3O5S2	447.5	C1CC1C(=O)NC2=NN=C(S2)SCC3=CC(=O)C(=CO3)OC(=O)C4=CC(=CC=C4)F	IC50 ~ 134000 nM	Poor binder
T86385	Cathepsin G	D0F3CA	3,4-dichloroisocoumarin	Investigative	1609	C9H4Cl2O2	215.03	C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl	IC50 = 93000 nM	Poor binder