TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T84472	Geranylgeranyl transferase type I beta subunit	B38PQH	4-(5-{[1-(2-Mercapto-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	10862667	C22H22N6OS	418.5	C1CN(C[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=CC=CNC4=S	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	B94BRS	4-(5-{[1-(2-Methyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	10949393	C23H24N6O	400.5	CC1=C(C=CC=N1)C(=O)N2CC[C@@H](C2)NCC3=CN=CN3CC4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	B9JS3N	2-(8-Quinolinyl)-4-[1-hydroxy-1-(1-methyl-1H-imidazole-5-yl)-3-(4-cyanophenyl)-2-propynyl]benzonitrile	Investigative	44459800	C30H19N5O	465.5	CN1C=NC=C1C(C#CC2=CC=C(C=C2)C#N)(C3=CC(=C(C=C3)C#N)C4=CC=CC5=C4N=CC=C5)O	IC50 = 83000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BG65YR	(S)-4-((5-(((1-Benzyl-2-oxopyrrolidin-3-yl)(pyridin-3-ylmethyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile	Investigative	10950878	C29H28N6O	476.6	C1CN(C(=O)[C@H]1N(CC2=CN=CC=C2)CC3=CN=CN3CC4=CC=C(C=C4)C#N)CC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BH7Q8Z	4-[5-[[3-Aminopropyl[(3S)-1-(3-chlorobenzyl)-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile	Investigative	9912881	C26H29ClN6O	477	C1CN(C(=O)[C@H]1N(CCCN)CC2=CN=CN2CC3=CC=C(C=C3)C#N)CC4=CC(=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BHUZ73	4-[5-[[2-Piperazinoethyl[(3S)-1-(3-chlorobenzyl)-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile	Investigative	9807068	C29H34ClN7O	532.1	C1CN(C(=O)[C@H]1N(CCN2CCNCC2)CC3=CN=CN3CC4=CC=C(C=C4)C#N)CC5=CC(=CC=C5)Cl	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BIG3C4	4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	10938254	C22H23N7O	401.5	C1CN(C[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=C(N=CC=C4)N	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BK2M4I	4-[5-[[3-Aminopropyl[(3S)-1-benzyl-2-oxo-3-pyrrolidinyl]amino]methyl]-1H-imidazole-1-ylmethyl]benzonitrile	Investigative	9824630	C26H30N6O	442.6	C1CN(C(=O)[C@H]1N(CCCN)CC2=CN=CN2CC3=CC=C(C=C3)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BL3U9D	4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	11732162	C22H22N6O2	402.4	C1CN(C[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=CC=CNC4=O	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BMO5D7	4-(5-{[1-(2-Methoxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	10993420	C23H24N6O2	416.5	COC1=C(C=CC=N1)C(=O)N2CC[C@@H](C2)NCC3=CN=CN3CC4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T84472	Geranylgeranyl transferase type I beta subunit	BV19ZO	4-(5-{[1-(Pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile	Investigative	11728765	C22H22N6O	386.4	C1CN(C[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=CN=CC=C4	IC50 ~ 50000 nM	Poor binder