TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T78198	Purine nucleoside phosphorylase	D0B5MP	Aciclovir	Approved	135398513	C8H11N5O3	225.2	C1=NC2=C(N1COCCO)N=C(NC2=O)N	Ki = 180000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B0SPI6	8-Amino-3-benzyl-1,9-dihydro-purine-6-thione	Investigative	44282426	C12H11N5S	257.32	C1=CC=C(C=C1)CN2C=NC(=S)C3=C2N=C(N3)N	IC50 = 131000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B1N5PB	3-Benzylhypoxanthine	Investigative	250702	C12H10N4O	226.23	C1=CC=C(C=C1)CN2C=NC(=O)C3=C2N=CN3	IC50 = 112000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B2JQG9	2,5-Diaminothiazolo(5,4-d)pyrimidin-7(6H)-one	Investigative	147047	C5H5N5OS	183.19	C12=C(N=C(NC1=O)N)SC(=N2)N	IC50 = 142500 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B3R0JU	8-Amino-3-benzyl-2-methylthio-9H-purin-6(3H)-one	Investigative	15741996	C13H13N5OS	287.34	CSC1=NC(=O)C2=C(N1CC3=CC=CC=C3)N=C(N2)N	IC50 ~ 75000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B5V8JS	9-(5-Phosphonopentyl)Guanine	Investigative	135410344	C10H16N5O4P	301.24	C1=NC2=C(N1CCCCCP(=O)(O)O)N=C(NC2=O)N	Ki = 170000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B67GDN	Dezaguanine	Investigative	55710	C6H6N4O	150.14	C1=C(NC(=O)C2=C1NC=N2)N	IC50 = 77000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	B6C5BH	beta-(3-Chlorophenyl)-2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-propanoic acid methyl ester	Investigative	136054568	C16H15ClN4O3	346.77	COC(=O)CC(C1=CC(=CC=C1)Cl)C2=CNC3=C2N=C(NC3=O)N	IC50 = 80000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BJG7W5	9-(3,3-Dimethyl-pentyl)-1,9-dihydro-purin-6-one	Investigative	136074301	C12H18N4O	234.3	CCC(C)(C)CCN1C=NC2=C1N=CNC2=O	Ki = 110000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BNB56U	3-Benzyl-7H-purin-3-ium-6-amine;chloride	Investigative	15741979	C12H12ClN5	261.709	C1=CC=C(C=C1)C[N+]2=C3C(=C(N=C2)N)NC=N3.[Cl-]	IC50 = 95000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BOM1J8	5-Amino-1-[(3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-1,2,4-triazole-3-carboximidamide	Investigative	46875976	C8H14N6O3	242.24	C[C@@H]1[C@H]([C@H](C(O1)N2C(=NC(=N2)C(=N)N)N)O)O	Ki = 80000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BT24QE	1-[(2-Methylthiazol-4-yl)methyl]-1H-benzimidazole-4,7-dione	Investigative	493150	C12H9N3O2S	259.29	CC1=NC(=CS1)CN2C=NC3=C2C(=O)C=CC3=O	Ki = 100000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BT2U6W	2-Amino-3-benzyl-8-formylamino-9H-purin-6(3H)-one	Investigative	15741997	C13H12N6O2	284.27	C1=CC=C(C=C1)CN2C3=C(C(=O)N=C2N)NC(=N3)NC=O	IC50 ~ 150000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BUE02M	[(2R,3S,4R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 4-fluorosulfonylbenzoate	Investigative	135976355	C17H16FN5O8S	469.4	C1=CC(=CC=C1C(=O)OC[C@@H]2[C@H]([C@H](C(O2)N3C=NC4=C3N=C(NC4=O)N)O)O)S(=O)(=O)F	Ki = 93000 nM	Poor binder
T78198	Purine nucleoside phosphorylase	BWZP64	3-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,7a-dihydropyrazolo[4,3-d]pyrimidin-7-one	Investigative	90663688	C10H12N4O5	268.23	C1=NC(=O)C2C(=N1)C(=NN2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O	Ki = 100000 nM	Poor binder