TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77796	Thyrotropin-releasing hormone receptor	B2Z4LH	(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Investigative	44422111	C21H31N5O4	417.5	CC(C)(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@H]3CCC(=O)C3	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	B40SIE	(2S)-N-[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Investigative	44422169	C24H30N6O4	466.5	C1C[C@H](NC(=O)C1)C(=O)N[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)C(=O)N4CCC[C@H]4C(=O)N	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	B4AV2M	N-[(1R)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide	Investigative	44422092	C20H29N5O4	403.5	CCCC1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@@H]3CCC(=O)C3	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	B5PK3E	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(2-cyclohexyl-1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Investigative	44422091	C23H34N6O4	458.6	C1CCC(CC1)C2=NC=C(N2)C[C@@H](C(=O)N3CCC[C@H]3C(=O)N)NC(=O)[C@@H]4CCCC(=O)N4	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	B7YFX1	(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Investigative	44422115	C23H33N5O4	443.5	C1CCC(CC1)C2=NC=C(N2)C[C@@H](C(=O)N3CCC[C@H]3C(=O)N)NC(=O)[C@H]4CCC(=O)C4	EC50 ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	B8NY9O	(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Investigative	44422105	C23H33N5O4	443.5	C1CCC(CC1)C2=NC=C(N2)C[C@@H](C(=O)N3CCC[C@H]3C(=O)N)NC(=O)[C@@H]4CCC(=O)C4	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BDC60S	(2S)-1-[(2S)-2-[[(1S)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide	Investigative	44422110	C20H29N5O4	403.5	CC(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@H]3CCC(=O)C3	EC50 ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BHV7S9	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propan-2-yl-1H-imidazol-5-yl)propan-2-yl]-6-oxopiperidine-2-carboxamide	Investigative	44422085	C20H30N6O4	418.5	CC(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@@H]3CCCC(=O)N3	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BI89PC	N-[(1S)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide	Investigative	44422106	C20H29N5O4	403.5	CCCC1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@H]3CCC(=O)C3	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BKRT49	(2S)-1-[(2S)-2-[[(1R)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide	Investigative	44422097	C20H29N5O4	403.5	CC(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@@H]3CCC(=O)C3	EC50 ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BM6GW3	(2S)-N-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Investigative	44422086	C21H32N6O4	432.5	CC(C)(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@@H]3CCCC(=O)N3	Ki ~ 100000 nM	Poor binder
T77796	Thyrotropin-releasing hormone receptor	BPE4V2	(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Investigative	44422098	C21H31N5O4	417.5	CC(C)(C)C1=NC=C(N1)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N)NC(=O)[C@@H]3CCC(=O)C3	EC50 ~ 100000 nM	Poor binder