TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D0Q9HF	Acetylcholine	Approved	187	C7H16NO2+	146.21	CC(=O)OCC[N+](C)(C)C	EC50 = 127000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D0T8GD	Nicotine	Approved	89594	C10H14N2	162.23	CN1CCC[C@H]1C2=CN=CC=C2	EC50 = 51000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D01MAU	AZD-1446	Phase 2	24795080	C11H13ClN2O2	240.68	C1C2CN(CC2CN1)C(=O)C3=CC=C(O3)Cl	EC50 = 70000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D00EZO	TC-2216	Phase 1	10176607	C12H17N3	203.28	C1CC2(CCN(C2)C3=CN=CC=C3)NC1	EC50 = 55000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D09ADT	ABT-418	Discontinued in Phase 2	119380	C9H14N2O	166.22	CC1=NOC(=C1)[C@@H]2CCCN2C	EC50 = 64000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D06LKM	PNU-282987	Terminated	9795278	C14H17ClN2O	264.75	C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl	Ki ~ 60000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B0PD5Z	2-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-N-(1H-pyrazol-5-yl)acetamide	Investigative	56926498	C15H18FN5O3S	367.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B0PKX8	(3R)-N-(6-Methylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137649484	C14H19N5O	273.33	CC1=CC(=NC=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B14CFB	N-(1H-Pyrazol-5-yl)-2-(4-pyridin-3-ylsulfonylpiperazin-1-yl)acetamide	Investigative	56926723	C14H18N6O3S	350.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B1H0ZR	N-(6-Chloropyridin-2-yl)-4-propoxybenzamide	Investigative	71727772	C15H15ClN2O2	290.74	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B1J3FS	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(pyridin-2-yl)methanone	Investigative	66211794	C12H15N3O	217.27	C1C2CN(CC2CN1)C(=O)C3=CC=CC=N3	EC50 = 51000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B1N2UF	(1R,5S)-6-(5-Ethynylpyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane	Investigative	9877653	C12H13N3	199.25	C#CC1=CC(=CN=C1)N2C[C@@H]3[C@H]2CNC3	EC50 = 77624.71 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B1Y4VL	(3S)-5-Chloro-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1-prop-2-enylindol-2-one	Investigative	7582345	C17H14ClNO4	331.7	C=CCN1C2=C(C=C(C=C2)Cl)[C@](C1=O)(CC(=O)C3=CC=CO3)O	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B20HDJ	2-(6-Chloropyridin-3-yl)-2,7-diazaspiro[4.4]nonane	Investigative	22291236	C12H16ClN3	237.73	C1CNCC12CCN(C2)C3=CN=C(C=C3)Cl	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B20WLE	N-[6-(3-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727900	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC(=CC=C3)F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2B5QC	Pyridine, 3-ethynyl-5-[(2R)-1-methyl-2-pyrrolidinyl]-	Investigative	10559473	C12H14N2	186.25	CN1CCC[C@@H]1C2=CN=CC(=C2)C#C	EC50 = 68000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2I6CX	2-(2-Methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)xanthen-9-one	Investigative	11461365	C20H20N2O2	320.4	CN1CC2CN(CC2C1)C3=CC4=C(C=C3)OC5=CC=CC=C5C4=O	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2IVQ3	O-3-(Dimethylamino)butyl dimethylcarbamothioate	Investigative	44570056	C9H20N2OS	204.34	CC(CCOC(=S)N(C)C)N(C)C	EC50 = 50118.72 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2MHT9	N-(6-Anilinopyridin-2-yl)-4-propoxybenzamide	Investigative	71727898	C21H21N3O2	347.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2P6QG	(1S,2R,4S)-N-(Isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'-oxazol]-2'-amine	Investigative	44247585	C18H20N4O	308.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC5=CC=CC=C5C=N4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B2VB8U	(3R)-N-(5-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	58081856	C14H19N5O	273.33	CC1=CN=C(C=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B38UAB	4-[[2-[4-(2-Fluorophenyl)sulfonylpiperazin-1-yl]acetyl]amino]benzoic acid	Investigative	56926617	C19H20FN3O5S	421.4	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)C(=O)O)S(=O)(=O)C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B3AGF6	(3R)-N-(5-Methoxypyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660090	C14H19N5O2	289.33	COC1=NC=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B3K0NP	(4-Bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Investigative	59268939	C12H15BrN2O2	299.16	C1C2CNCC1CN(C2)C(=O)C3=CC(=CO3)Br	EC50 = 50000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B46SDE	(3R)-N-(6-Propan-2-ylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137633214	C16H23N5O	301.39	CC(C)C1=CC(=NC=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B47CBX	N-(Naphthylmethyl)(2-phenylphenyl)carboxamide	Investigative	17384430	C24H19NO	337.4	C1=CC=C(C=C1)C2=CC=CC=C2C(=O)NCC3=CC=CC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B4EF2W	3,7-Diazabicyclo[3.3.1]nonan-3-yl(phenyl)methanone	Investigative	18177037	C14H18N2O	230.31	C1C2CNCC1CN(C2)C(=O)C3=CC=CC=C3	Ki = 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B4EFA7	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-5-carboxamide	Investigative	9943346	C16H18N2O2	270.33	C1CN2CCC1[C@H](C2)NC(=O)C3=CC4=C(C=C3)OC=C4	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B4OJD5	2alpha-[[[2-Methyl-5-(cyclopropylethynyl)-3-pyridinyl]oxy]methyl]azetidine	Investigative	71584828	C15H18N2O	242.32	CC1=C(C=C(C=N1)C#CC2CC2)OC[C@@H]3CCN3	Ki = 150000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B5FQV1	CID 52920236	Investigative	52920236	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=NC(=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B5LF7Y	Altinicline	Investigative	3036156	C12H14N2	186.25	CN1CCC[C@H]1C2=CN=CC(=C2)C#C	EC50 = 52000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B5UZY1	(1R,5S)-N-Methyl-3-azabicyclo[3.3.1]nonane-7-carboxamide	Investigative	71682974	C10H18N2O	182.26	CNC(=O)C1C[C@H]2C[C@@H](C1)CNC2	EC50 = 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B65QUB	6-[5-[(Azetidine-2alpha-yl)methoxy]-6-methyl-3-pyridinyl]-5-hexyne-1-ol	Investigative	71584824	C16H22N2O2	274.36	CC1=C(C=C(C=N1)C#CCCCCO)OC[C@@H]2CCN2	IC50 = 50000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B6DLS9	7-(6-Chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane	Investigative	11715647	C12H16ClN3	237.73	C1CC2(CCN(C2)C3=CN=C(C=C3)Cl)NC1	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B6L4QY	N-Pyrimidin-4-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137635141	C13H17N5O	259.31	C1CN2CCC1C3(C2)CN=C(O3)NC4=NC=NC=C4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B6LN1M	2-(4-Morpholinyl)-5-[(2-thienylmethyl)amino]benzoic acid	Investigative	666124	C16H18N2O3S	318.4	C1COCCN1C2=C(C=C(C=C2)NCC3=CC=CS3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B6WY0G	2alpha-[[[2-Methyl-5-(6-chloro-1-hexynyl)-3-pyridinyl]oxy]methyl]azetidine	Investigative	71584826	C16H21ClN2O	292.8	CC1=C(C=C(C=N1)C#CCCCCCl)OC[C@@H]2CCN2	Ki = 86000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B6YEV5	3,7-Diazabicyclo[3.3.1]nonan-3-yl(pyridin-4-yl)methanone	Investigative	24945542	C13H17N3O	231.29	C1C2CNCC1CN(C2)C(=O)C3=CC=NC=C3	EC50 = 54000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B71WQT	3-(Dimethylamino)-4-hydroxybutyl dimethylcarbamate	Investigative	44570100	C9H20N2O3	204.27	CN(C)C(CCOC(=O)N(C)C)CO	Ki = 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B76FWO	3-(Dimethylamino)Butyl Methylcarbamate	Investigative	44593550	C8H18N2O2	174.24	CC(CCOC(=O)NC)N(C)C	EC50 = 158489.32 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B7Y1GK	2-Pyridin-3-yl-2,7-diazaspiro[4.4]nonane	Investigative	10262309	C12H17N3	203.28	C1CNCC12CCN(C2)C3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B86FPX	N-(2-Fluorophenyl)-2-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]acetamide	Investigative	3691150	C18H19F2N3O3S	395.4	C1CN(CCN1CC(=O)NC2=CC=CC=C2F)S(=O)(=O)C3=CC=CC=C3F	IC50 = 99800 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B90HMU	5-(Dimethylamino)-N-methylhex-2-enamide	Investigative	44570054	C9H18N2O	170.25	CC(C/C=C/C(=O)NC)N(C)C	EC50 = 150000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	B9VEY0	(3R)-N-(4-Propan-2-ylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137655697	C16H23N5O	301.39	CC(C)C1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BA0O3M	N-[6-(Pentylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727896	C20H27N3O2	341.4	CCCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BA35PX	(R)-N-(5-Chloropyrazin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	52920234	C13H16ClN5O	293.75	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CN=C(C=N4)Cl	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BB51GT	CID 24945124	Investigative	24945124	C10H13N3O2	207.23	C1C2CN(CC2CN1)C(=O)C3=NC=CO3	EC50 = 79000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BB7Y1T	(R)-N-(6-Methoxypyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	52920232	C14H19N5O2	289.33	COC1=NC=NC(=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BBO7Z1	(3R)-N-(6-Chloropyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660174	C13H16ClN5O	293.75	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC(=NC=N4)Cl	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BBV1E8	N-(6-Bromopyridin-2-yl)-4-prop-2-enoxybenzamide	Investigative	47461992	C15H13BrN2O2	333.18	C=CCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Br	IC50 = 65500 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BCK4E8	(3R)-N-Pyrimidin-5-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137654434	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CN=CN=C4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BD18MS	5-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-2-carbonitrile	Investigative	68024820	C12H13N3O2	231.25	C1C2CN(CC2CN1)C(=O)C3=CC=C(O3)C#N	EC50 = 61000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BD7CI3	3-(Dimethylamino)butyl carbamate	Investigative	44570009	C7H16N2O2	160.21	CC(CCOC(=O)N)N(C)C	EC50 = 57000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BDTG17	(3R)-N-(5-Phenylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137654242	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=C(N=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BDV4S2	[1-(3-Phenylpropyl)piperidin-3-yl]methyl 2-naphthalen-1-ylbenzoate	Investigative	57397988	C32H33NO2	463.6	C1CC(CN(C1)CCCC2=CC=CC=C2)COC(=O)C3=CC=CC=C3C4=CC=CC5=CC=CC=C54	IC50 = 63095.73 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BE4WL1	Furan-2-yl(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone	Investigative	24945028	C11H14N2O2	206.24	C1C2CN(CC2CN1)C(=O)C3=CC=CO3	Ki = 72000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BE5Z9R	(4-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Investigative	59268918	C12H15ClN2O2	254.71	C1C2CNCC1CN(C2)C(=O)C3=CC(=CO3)Cl	EC50 = 54000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BEI4K8	N-[6-(4-Chloroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728020	C21H20ClN3O2	381.9	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BET93F	2-[4-(2-Fluorophenyl)sulfonylpiperazin-1-yl]-N-(1H-pyrazol-5-yl)acetamide	Investigative	56926722	C15H18FN5O3S	367.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BETD61	(3R)-N-(5-Methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137644928	C14H19N5O2	289.33	COC1=CN=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BEU60O	N-[6-(Butylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727895	C19H25N3O2	327.4	CCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 = 77800 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BFK97P	3-(Dimethylamino)butyl methyl(phenyl)carbamate	Investigative	44570105	C14H22N2O2	250.34	CC(CCOC(=O)N(C)C1=CC=CC=C1)N(C)C	EC50 = 50118.72 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BG18OB	(3R)-N-(1,7-Naphthyridin-6-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137659736	C17H19N5O	309.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=C5C(=C4)C=CC=N5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BG4P6Z	CID 24945129	Investigative	24945129	C10H13N3O2	207.23	C1C2CN(CC2CN1)C(=O)C3=CC=NO3	EC50 = 66000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BG9LK0	N-((3-(2-Chlorophenyl)isoxazol-5-yl)methyl)-N-methylpiperidine-4-carboxamide	Investigative	44580251	C17H20ClN3O2	333.8	CN(CC1=CC(=NO1)C2=CC=CC=C2Cl)C(=O)C3CCNCC3	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BGAR81	Biphenyl-2-carboxylic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	Investigative	44348296	C28H31NO2	413.5	C1CC(CN(C1)CCCC2=CC=CC=C2)COC(=O)C3=CC=CC=C3C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BGC84S	[1-(3-Phenylpropanoyl)piperidin-3-yl]methyl 2-phenylbenzoate	Investigative	57392658	C28H29NO3	427.5	C1CC(CN(C1)C(=O)CCC2=CC=CC=C2)COC(=O)C3=CC=CC=C3C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BGH80W	3,5,5-Trimethyl-2-(pyridin-3-yl)morpholin-2-ol	Investigative	49799236	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CN=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BGR3E1	N-(4-Methoxyphenyl)-2-(4-pyridin-3-ylsulfonylpiperazin-1-yl)acetamide	Investigative	39010244	C18H22N4O4S	390.5	COC1=CC=C(C=C1)NC(=O)CN2CCN(CC2)S(=O)(=O)C3=CN=CC=C3	IC50 = 95000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BGWD67	Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)	Investigative	11243536	C14H18Cl2N2O	301.2	C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl.Cl	IC50 ~ 60000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BH6IB2	N-(6-Chloropyridin-2-yl)-4-prop-2-enoxybenzamide	Investigative	71727769	C15H13ClN2O2	288.73	C=CCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BH9B6C	(3R)-N-Pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137657023	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CN=C4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BHK10J	4-Allyloxy-N-pyridin-2-yl-benzamide	Investigative	2268445	C15H14N2O2	254.28	C=CCOC1=CC=C(C=C1)C(=O)NC2=CC=CC=N2	IC50 = 61400 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BHZS95	3-(Dimethylamino)butyl 2-hydroxyethyl(methyl)carbamate	Investigative	44570104	C10H22N2O3	218.29	CC(CCOC(=O)N(C)CCO)N(C)C	EC50 = 158489.32 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BJ5VE7	(3R)-N-(5-Methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137635902	C14H19N5O	273.33	CC1=CN=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BK53FO	CID 58088118	Investigative	58088118	C14H18N4O	258.32	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC=CC=N4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BKJ0Z8	3-[[(2R)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Investigative	71584830	C16H22N2O	258.36	CCCCC#CC1=CC(=C(N=C1)C)OC[C@H]2CCN2	Ki = 200000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BKY57C	5-(Dimethylamino)-N,N-dimethylhex-2-enamide	Investigative	44570055	C10H20N2O	184.28	CC(C/C=C/C(=O)N(C)C)N(C)C	EC50 = 91000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BL4R5B	3-(2-Chlorophenyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole	Investigative	44580252	C17H17ClN4O	328.8	C1CNCCC1N2C=C(C=N2)C3=CC(=NO3)C4=CC=CC=C4Cl	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BL9B3C	(3R)-N-(4-Methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137647317	C14H19N5O	273.33	CC1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BLP30N	3-(1,4-Diazabicyclo[3.2.2]nonane-4-yl)dibenzothiophene 5,5-dioxide	Investigative	57334716	C19H20N2O2S	340.4	C1CN2CCC1N(CC2)C3=CC4=C(C=C3)C5=CC=CC=C5S4(=O)=O	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BLSE56	1,6-Diazaspiro[3.4]octane, 6-(3-pyridinyl)-	Investigative	11528487	C11H15N3	189.26	C1CNC12CCN(C2)C3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BML9B7	(R)-N-(5-m-Tolylpyrimidin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	58081870	C20H23N5O	349.4	CC1=CC(=CC=C1)C2=CN=C(N=C2)NC3=NC[C@]4(O3)CN5CCC4CC5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BMT2L8	3-(Dimethylamino)butyl ethylcarbamate	Investigative	44570010	C9H20N2O2	188.27	CCNC(=O)OCCC(C)N(C)C	EC50 = 50118.72 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BMU41A	1-[3-(Dimethylamino)propyl]-2-oxo-4-phenylquinoline-3-carbonitrile	Investigative	23332842	C21H21N3O	331.4	CN(C)CCCN1C2=CC=CC=C2C(=C(C1=O)C#N)C3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BMX5B2	N-[6-(Hexylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727897	C21H29N3O2	355.5	CCCCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BN7D6E	(3R)-N-(4-Methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137649905	C14H19N5O2	289.33	COC1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BNS60U	(3R)-N-(6-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137645815	C14H19N5O	273.33	CC1=CN=CC(=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BQ2FC1	(3R)-N-(4-Phenylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660214	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CC(=N4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BR7EK6	N-[6-(4-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727901	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BRB3Z9	S-3-(Dimethylamino)butyl dimethylcarbamothioate	Investigative	44570097	C9H20N2OS	204.34	CC(CCSC(=O)N(C)C)N(C)C	Ki = 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BRF3D5	CID 58088056	Investigative	58088056	C17H19N5O	309.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC5=CC=CC=C5C=N4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BRM3E9	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-(trifluoromethyl)pyridine	Investigative	71584827	C16H19F3N2O	312.33	CCCCC#CC1=CC(=C(N=C1)C(F)(F)F)OC[C@@H]2CCN2	Ki ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BS2WB7	N-[6-(4-Methoxyanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728021	C22H23N3O3	377.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BS3G1O	(R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide	Investigative	9930121	C15H17N3O2	271.31	C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BS6VY1	(3R)-N-(3-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137644763	C14H19N5O	273.33	CC1=NC=CN=C1NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BT7D1M	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide	Investigative	10445840	C16H18N2O2	270.33	C1CN2CCC1[C@H](C2)NC(=O)C3=CC4=C(C=C3)C=CO4	IC50 = 81000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BT7PS4	(3R)-N-Pyrimidin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137659815	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CC=N4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BTW79U	N-(6-Bromopyridin-2-yl)-4-propoxybenzamide	Investigative	71727771	C15H15BrN2O2	335.2	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Br	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BTW7M6	3-(Dimethylamino)butyl propylcarbamate	Investigative	44570011	C10H22N2O2	202.29	CCCNC(=O)OCCC(C)N(C)C	EC50 = 95000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BV0E5X	N-(6-Piperidin-1-ylpyridin-2-yl)-4-propoxybenzamide	Investigative	71728023	C20H25N3O2	339.4	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)N3CCCCC3	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BV2UL1	3,5,5-Trimethyl-2-(pyridin-2-yl)morpholin-2-ol	Investigative	49799237	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CC=CC=N2)O	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BW93XK	2alpha-[[[2-Methyl-5-(1-hexynyl)-3-pyridinyl]oxy]methyl]pyrrolidine	Investigative	71584829	C17H24N2O	272.4	CCCCC#CC1=CC(=C(N=C1)C)OC[C@@H]2CCCN2	Ki = 94000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BW9L6R	Dendocarbin A	Investigative	10911949	C15H22O3	250.33	C[C@]12CCCC([C@@H]1CC=C3[C@@H]2[C@@H](OC3=O)O)(C)C	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BWET24	2alpha-[[[2-Methyl-5-(6-fluoro-1-hexynyl)-3-pyridinyl]oxy]methyl]azetidine	Investigative	71584798	C16H21FN2O	276.35	CC1=C(C=C(C=N1)C#CCCCCF)OC[C@@H]2CCN2	Ki = 130000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BX6KB4	5'-Phenylspiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]	Investigative	10085732	C19H20N2O	292.4	C1CN2CCC1C3(C2)CC4=C(O3)N=CC(=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BY3M0U	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-chlorofuran-2-yl)methanone	Investigative	59268936	C11H13ClN2O2	240.68	C1C2CN(CC2CN1)C(=O)C3=CC(=CO3)Cl	EC50 = 56000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BY71GF	(1R,6S)-8-(5-Methoxy-pyridin-3-yl)-3,8-diaza-bicyclo[4.2.0]octane	Investigative	9942613	C12H17N3O	219.28	COC1=CN=CC(=C1)N2C[C@H]3[C@@H]2CNCC3	EC50 = 63095.73 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BY7JG4	N-Pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137643408	C13H17N5O	259.31	C1CN2CCC1C3(C2)CN=C(O3)NC4=NC=CN=C4	EC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BY8V5O	N-[6-(2-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727899	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BZ3HW7	N-[6-(Benzylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728022	C22H23N3O2	361.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	BZ5R7V	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-methylfuran-2-yl)methanone	Investigative	24945030	C12H16N2O2	220.27	CC1=CC=C(O1)C(=O)N2CC3CNCC3C2	EC50 = 57000 nM	Poor binder
T74166	Neuronal acetylcholine receptor alpha-3/beta-4	D0IP9V	PH-709829	Investigative	10107234	C15H17N3O2	271.31	C1CN2C[C@H]1C[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4	IC50 ~ 100000 nM	Poor binder