TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T69612	G protein-coupled receptor kinase 5	D06VML	Seroxat	Approved	43815	C19H20FNO3	329.4	C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B1DX2Z	Chembl4227754	Investigative	145969093	C27H29FN6O4	520.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CCC(=O)NCC3(CC3)CO)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B39BXS	Chembl4228575	Investigative	145970038	C29H33FN6O4	548.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)N3CCCCC3CCCOC)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B3LRF7	4-[3-[(2,6-Dichlorophenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888909	C27H21Cl2FN6O3	567.4	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=C(C=CC=C3Cl)Cl)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B4WZ1D	Chembl4229149	Investigative	145987049	C28H33FN6O3	520.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NC(C)CCCC(C)C)C(=O)NC3=CC4=C(C=C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B5DWI4	4-[3-[2-[(2,6-Dimethoxyphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888916	C30H29FN6O5	572.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CC(=O)NCC3=C(C=CC=C3OC)OC)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B65MLT	2-Fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoic acid	Investigative	118875292	C20H16FN5O4	409.4	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)O)C(=O)NC3=CC4=C(C=C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B9PZD4	N-(1,3-Benzodioxol-5-yl)-4-[4-fluoro-3-(pyridin-2-ylmethylcarbamoyl)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	127044089	C26H22FN5O5	503.5	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=CC=CC=N3)C(=O)NC4=CC5=C(C=C4)OCO5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	B9WA0M	4-[4-Fluoro-3-[(3-methylpyridin-2-yl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888918	C27H24FN7O3	513.5	CC1=C(N=CC=C1)CNC(=O)C2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F	IC50 = 68000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BAB3Y4	4-(6-Benzylimidazo[1,2-b]pyridazin-3-yl)benzamide	Investigative	90480122	C20H16N4O	328.4	C1=CC=C(C=C1)CC2=NN3C(=NC=C3C4=CC=C(C=C4)C(=O)N)C=C2	IC50 = 80000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BC95QY	4-[3-[2-[[2,6-Bis(trifluoromethyl)phenyl]methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888915	C30H23F7N6O3	648.5	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CC(=O)NCC3=C(C=CC=C3C(F)(F)F)C(F)(F)F)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BCL1P6	Chembl4224950	Investigative	130338701	C30H33FN6O3	544.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NC3CC4CCC3(C4(C)C)C)C(=O)NC5=CC6=C(C=C5)NN=C6	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BD18EM	4-[3-[(2,6-Dimethylphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	77105902	C29H27FN6O3	526.6	CC1=C(C(=CC=C1)C)CNC(=O)C2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F	IC50 = 63000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BE1HP7	Chembl4229210	Investigative	118888938	C30H29FN6O3	540.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CCC(=O)NCCC3=CC=CC=C3)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BE5M7Z	4-[3-[2-(2,6-Dimethylphenyl)ethylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888910	C30H29FN6O3	540.6	CC1=C(C(=CC=C1)C)CCNC(=O)C2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F	IC50 = 58000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BF7J1I	Chembl4226551	Investigative	145971104	C29H33FN6O4	548.6	CCC1(CCCN(C1)C(=O)CCC2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F)O	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BFWO97	Chembl4225012	Investigative	118888931	C29H34FN7O3	547.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC(C)N3CCCCCC3)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 = 71000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BH7K9I	(2S)-6-Amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acid	Investigative	134133467	C113H183N29O32	2459.8	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)N	IC50 = 61300 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BJ14WL	4-(3-((2,6-Dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide	Investigative	118888904	C29H27FN6O5	558.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=C(C=CC=C3OC)OC)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BKRN73	4-[4-Fluoro-3-(methylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888903	C21H19FN6O3	422.4	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NC)C(=O)NC3=CC4=C(C=C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BL26WK	4-[3-[[2,6-Bis(trifluoromethyl)phenyl]methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	118888933	C29H21F7N6O3	634.5	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=C(C=CC=C3C(F)(F)F)C(F)(F)F)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BLO12S	Chembl4228524	Investigative	145968197	C28H33FN6O3	520.6	CCCCCCC(C)NC(=O)C1=C(C=CC(=C1)C2C(=C(NC(=O)N2)C)C(=O)NC3=CC4=C(C=C3)NN=C4)F	IC50 = 77000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BN6IF1	Chembl4226760	Investigative	118888936	C25H27FN6O3	478.5	CCC(C)N(C)C(=O)C1=C(C=CC(=C1)C2C(=C(NC(=O)N2)C)C(=O)NC3=CC4=C(C=C3)NN=C4)F	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BNA1Z8	Chembl4225310	Investigative	145970814	C31H37FN6O3	560.7	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CC(=O)N3CCCC(CC3)C(C)(C)C)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BNZ2S7	4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide	Investigative	11233873	C19H16FN5O2	365.4	CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BPXZ60	Chembl4228117	Investigative	145970244	C30H35FN6O3	546.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CCC(=O)NCC3(CCCCC3)C)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BTB6C4	4-[3-[(2,6-Dimethylphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-N,6-dimethyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	Investigative	127044088	C30H29FN6O3	540.6	CC1=C(C(=CC=C1)C)CNC(=O)C2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)N(C)C4=CC5=C(C=C4)NN=C5)F	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BTV76M	Chembl4224914	Investigative	145969653	C30H29FN6O3	540.6	CC1=CC(=C(C=C1)C)CNC(=O)CC2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BUY3Q7	Chembl4227413	Investigative	118888926	C27H26FN7O4	531.5	CC1=CN=C(O1)CNC(=O)CCC2=C(C=CC(=C2)C3C(=C(NC(=O)N3)C)C(=O)NC4=CC5=C(C=C4)NN=C5)F	IC50 = 66000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BX83SE	Chembl4228272	Investigative	145969342	C29H35FN6O3	534.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)CCC(=O)N(CC(C)C)C(C)C)C(=O)NC3=CC4=C(C=C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BY8OH5	Chembl4226879	Investigative	118888930	C27H29FN6O4	520.6	CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)N(C)CC3CCCCO3)C(=O)NC4=CC5=C(C=C4)NN=C5	IC50 ~ 100000 nM	Poor binder
T69612	G protein-coupled receptor kinase 5	BZ7FV4	6-(1-Methylpyrazol-4-yl)-3-thiophen-2-ylimidazo[1,2-b]pyridazine	Investigative	90480124	C14H11N5S	281.34	CN1C=C(C=N1)C2=NN3C(=NC=C3C4=CC=CS4)C=C2	IC50 = 80000 nM	Poor binder