TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T68967	Sphingomyelin synthase 2	B0MJA9	2-(Furan-2-ylmethylamino)-2-(2-phenylmethoxyphenyl)acetonitrile	Investigative	76336086	C20H18N2O2	318.4	C1=CC=C(C=C1)COC2=CC=CC=C2C(C#N)NCC3=CC=CO3	IC50 = 71000 nM	Poor binder
T68967	Sphingomyelin synthase 1	B1HV2I	N-[(4-Chlorophenyl)methyl]-2-[4-(3-phenylpropylsulfamoyl)phenoxy]acetamide	Investigative	122189457	C24H25ClN2O4S	473	C1=CC=C(C=C1)CCCNS(=O)(=O)C2=CC=C(C=C2)OCC(=O)NCC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 1	B1Y5VG	Chembl4207944	Investigative	139409737	C20H14F3N3O3	401.3	C1=CC=C(C(=C1)COC2=CC=CC3=C2C(=NO3)NC4=CN=CC=C4)OC(F)(F)F	IC50 = 67000 nM	Poor binder
T68967	Sphingomyelin synthase 2	B3UNX7	2-(2-Hydroxyphenyl)-3-phenyl-2,4-dihydro-1,3-benzoxazine-4-carbonitrile	Investigative	437002	C21H16N2O2	328.4	C1=CC=C(C=C1)N2C(C3=CC=CC=C3OC2C4=CC=CC=C4O)C#N	IC50 = 75000 nM	Poor binder
T68967	Sphingomyelin synthase 1	B4G3HB	Chembl4202973	Investigative	139409692	C19H14ClN3O2	351.8	C1=CC=C(C(=C1)COC2=CC=CC3=C2C(=NO3)NC4=CN=CC=C4)Cl	IC50 = 79000 nM	Poor binder
T68967	Sphingomyelin synthase 1	B5E9TX	4-[2-[(4-Chlorophenyl)methylamino]-2-oxoethoxy]-N-(2-phenylethyl)benzamide	Investigative	122189455	C24H23ClN2O3	422.9	C1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)OCC(=O)NCC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 1	B6O5CL	Chembl4217676	Investigative	139409724	C20H17N3O2	331.4	CC1=CC=CC=C1COC2=CC=CC3=C2C(=NO3)NC4=CN=CC=C4	IC50 = 70000 nM	Poor binder
T68967	Sphingomyelin synthase 2	BAJL23	2-Anilino-2-(2-phenylmethoxyphenyl)acetamide	Investigative	76328785	C21H20N2O2	332.4	C1=CC=C(C=C1)COC2=CC=CC=C2C(C(=O)N)NC3=CC=CC=C3	IC50 = 135300 nM	Poor binder
T68967	Sphingomyelin synthase 1	BB5D4U	Sms2-IN-2	Investigative	134813905	C19H13ClFN3O2	369.8	C1=CC2=C(C(=C1)OCC3=C(C=CC(=C3)F)Cl)C(=NO2)NC4=CN=CC=C4	IC50 = 56000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BC0A3V	N-(2-Methylphenyl)-2-{4-[(2-phenylethyl)sulfamoyl]phenoxy}acetamide	Investigative	2193570	C23H24N2O4S	424.5	CC1=CC=CC=C1NC(=O)COC2=CC=C(C=C2)S(=O)(=O)NCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 2	BE01LA	4-[[Cyano-(2-phenylmethoxyphenyl)methyl]amino]benzamide	Investigative	76321599	C22H19N3O2	357.4	C1=CC=C(C=C1)COC2=CC=CC=C2C(C#N)NC3=CC=C(C=C3)C(=O)N	IC50 = 80500 nM	Poor binder
T68967	Sphingomyelin synthase 1	BEM2S1	Chembl4214637	Investigative	139409693	C19H14ClN3O2	351.8	C1=CC(=CC(=C1)Cl)COC2=CC=CC3=C2C(=NO3)NC4=CN=CC=C4	IC50 = 80000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BEPZ87	4-[2-[(4-Chlorophenyl)methylamino]-2-oxoethoxy]-N-pyridin-4-ylbenzamide	Investigative	122189456	C21H18ClN3O3	395.8	C1=CC(=CC=C1CNC(=O)COC2=CC=C(C=C2)C(=O)NC3=CC=NC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BHUV16	N-(4-Fluoro-2-methoxyphenyl)-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide	Investigative	122189468	C23H23FN2O5S	458.5	COC1=C(C=CC(=C1)F)NC(=O)COC2=CC=C(C=C2)S(=O)(=O)NCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 2	BITS76	Tricyclo-decan-9-yl-xanthogenate (racemate)	Investigative	2941	C11H16OS2	228.4	C1CC2C(C1)C3CC2CC3OC(=S)S	IC50 = 56000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BITS76	Tricyclo-decan-9-yl-xanthogenate (racemate)	Investigative	2941	C11H16OS2	228.4	C1CC2C(C1)C3CC2CC3OC(=S)S	IC50 = 86000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BJBQ41	N-[(4-Chlorophenyl)methyl]-2-[4-[(4-chlorophenyl)methylsulfamoyl]phenoxy]acetamide	Investigative	122189458	C22H20Cl2N2O4S	479.4	C1=CC(=CC=C1CNC(=O)COC2=CC=C(C=C2)S(=O)(=O)NCC3=CC=C(C=C3)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BK79AN	N-(4-Methoxyphenyl)-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide	Investigative	122189463	C23H24N2O5S	440.5	COC1=CC=C(C=C1)NC(=O)COC2=CC=C(C=C2)S(=O)(=O)NCCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BKI04Q	2-[4-(2-Phenylethylsulfamoyl)phenoxy]-N-[2-(trifluoromethoxy)phenyl]acetamide	Investigative	122189466	C23H21F3N2O5S	494.5	C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)OCC(=O)NC3=CC=CC=C3OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BLE73I	Chembl4203399	Investigative	139409534	C19H13Cl2N3O2	386.2	C1=CC2=C(C(=C1)OCC3=C(C=CC=C3Cl)Cl)C(=NO2)NC4=CN=CC=C4	IC50 = 70000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BPE43L	N-[(4-Chlorophenyl)methyl]-2-[4-(phenylsulfamoyl)phenoxy]acetamide	Investigative	4028251	C21H19ClN2O4S	430.9	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCC(=O)NCC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 2	BQA2D5	2-Anilino-2-(3-phenylmethoxyphenyl)acetonitrile	Investigative	76325210	C21H18N2O	314.4	C1=CC=C(C=C1)COC2=CC=CC(=C2)C(C#N)NC3=CC=CC=C3	IC50 = 50700 nM	Poor binder
T68967	Sphingomyelin synthase 1	BR12CA	N-(2-Nitrophenyl)-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide	Investigative	122189464	C22H21N3O6S	455.5	C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)OCC(=O)NC3=CC=CC=C3[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 2	BR7Q2Y	[2-(Benzyloxy)phenyl][(2-methylphenyl)amino]acetonitrile	Investigative	45067779	C22H20N2O	328.4	CC1=CC=CC=C1NC(C#N)C2=CC=CC=C2OCC3=CC=CC=C3	IC50 = 67200 nM	Poor binder
T68967	Sphingomyelin synthase 1	BSTA40	N-(2-Cyanophenyl)-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide	Investigative	122189465	C23H21N3O4S	435.5	C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)OCC(=O)NC3=CC=CC=C3C#N	IC50 ~ 100000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BUK29R	N-(2-Phenylethyl)-2-[4-(2-phenylethylsulfamoyl)phenoxy]acetamide	Investigative	122189459	C24H26N2O4S	438.5	C1=CC=C(C=C1)CCNC(=O)COC2=CC=C(C=C2)S(=O)(=O)NCCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T68967	Sphingomyelin synthase 1	BV2A5R	Chembl4162182	Investigative	145960205	C25H23F6N3O2	511.5	CN1C2=CC=CC=C2C(=C(C1=O)C(=O)N(C)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCCC4	IC50 ~ 100000 nM	Poor binder