TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67102	Cathepsin D	D0R4KK	verubecestat	Phase 3	51352361	C17H17F2N5O3S	409.4	C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	D0U3EP	Resveratrol	Phase 3	445154	C14H12O3	228.24	C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O	IC50 = 138000 nM	Poor binder
T67102	Cathepsin D	D0D8II	TMB-607	Phase 1	513956	C33H44N4O6S	624.8	CC(C)CN([C@@H](CCCCNC(=O)[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC(=O)OC)CO)S(=O)(=O)C3=CC=C(C=C3)N	IC50 ~ 50000 nM	Poor binder
T67102	Cathepsin D	D0J2VB	Iboctadekin + rituximab	Phase 1	5478883	C34H63N5O9	685.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	D0Y5NA	PF-06751979	Phase 1	118435360	C18H19F2N5O3S2	455.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N	IC50 ~ 95300 nM	Poor binder
T67102	Cathepsin D	D0U2SS	MDL-2170	Terminated	11199915	C22H26N2O4	382.5	CC(C)[C@@H](C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B01NQS	Tricyclic hydroxyethylamine (HEA) derivative, 8f	Investigative	11785880	C25H32N4O4S	484.6	CCC1=CN2CCS(=O)(=O)N(C3=CC(=CC1=C32)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC)O)C	IC50 = 58880 nM	Poor binder
T67102	Cathepsin D	B04VPK	Chembl4217023	Investigative	145971666	C19H22N4O3S2	418.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=CC=C(C=C4)OC)N	IC50 ~ 97000 nM	Poor binder
T67102	Cathepsin D	B05IUA	(4As,10R,10aS)-8-(5-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	76336403	C20H20FN3O3	369.4	C[C@]12CCOC[C@@H]1[C@]3(COC(=N3)N)C4=C(O2)C=CC(=C4)C5=CC(=CN=C5)F	IC50 = 160000 nM	Poor binder
T67102	Cathepsin D	B0AI2N	(4S)-4-[5-(Ethylaminomethyl)-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137637780	C14H19F2N3S	299.38	CCNCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B0GWI3	Chembl4225481	Investigative	145970582	C21H21N3O4	379.4	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B0IU6P	8-(4-Methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11711024	C23H22N6O	398.5	COC1=CC=C(C=C1)C2(C3=NCCCN3C(=N2)N)C4=CC=CC(=C4)C5=CN=CN=C5	IC50 = 69500 nM	Poor binder
T67102	Cathepsin D	B0J8IS	N-[(2S)-5-(Diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(2-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]benzamide;2,2,2-trifluoroacetic acid	Investigative	118717662	C34H48F3N7O7	723.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B0MA5D	Chembl4209994	Investigative	145966369	C15H17F3N2OS	330.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B0NFG9	1-[(1R,3S)-3-[[(4R)-2-Amino-4-(2-cyclohexylethyl)-1-methyl-5-oxoimidazol-4-yl]methyl]cyclohexyl]-3-(4-chlorophenyl)urea	Investigative	59262280	C26H38ClN5O2	488.1	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@H]3CCC[C@H](C3)NC(=O)NC4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	B0QOH2	3-[(4As,10R,10aS)-2'-amino-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-8-yl]benzonitrile	Investigative	67950181	C22H21N3O3	375.4	C[C@]12CCOC[C@@H]1[C@]3(COC(=N3)N)C4=C(O2)C=CC(=C4)C5=CC=CC(=C5)C#N	IC50 = 69000 nM	Poor binder
T67102	Cathepsin D	B10EDM	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90414821	C18H14BrF3N4O2	455.2	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)F)F)N	IC50 = 109250 nM	Poor binder
T67102	Cathepsin D	B12ZTF	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(2-cyclopropylethynyl)pyrazine-2-carboxamide	Investigative	90413025	C22H18F3N5O2	441.4	C1CC1C#CC2=CN=C(C=N2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 169850 nM	Poor binder
T67102	Cathepsin D	B1CU9N	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90413403	C17H12ClF6N5O2	467.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C(=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)F)C(F)F)N	IC50 = 158500 nM	Poor binder
T67102	Cathepsin D	B1D0YW	(1R,5S,6R)-5-(5-((Cyclobutylmethyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	118232920	C17H20F3N3O	339.35	C1CC(C1)CNC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 121000 nM	Poor binder
T67102	Cathepsin D	B1D4GU	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90413383	C20H17ClFN5O3	429.8	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 123500 nM	Poor binder
T67102	Cathepsin D	B1DR0B	(4S)-4-[5-[(Cyclopropylmethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137637375	C16H21F2N3S	325.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCC3CC3)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B1J9ZU	(1R,2S,6R)-2-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441949	C19H15ClF2N6O	416.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC4=NC=NC5=C4N=CC(=C5)Cl)F)N	IC50 = 105750 nM	Poor binder
T67102	Cathepsin D	B1K3YM	(8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11655737	C24H19F4N5O	469.4	C1CN=C2[C@](N=C(N2C1)N)(C3=CC=C(C=C3)OC(F)(F)F)C4=CC=CC(=C4)C5=C(N=CC=C5)F	IC50 = 56900 nM	Poor binder
T67102	Cathepsin D	B1L0NT	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-1-(2,3-dihydro-1H-inden-2-ylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717654	C36H50F3N7O8	765.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CC2=CC=CC=C2C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B1LQ6F	[4-[3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-2-(5-prop-1-ynylpyridin-3-yl)phenyl]methanol	Investigative	118796793	C21H19F2N3O2	383.4	CC#CC1=CC(=CN=C1)C2=CC(=C(C=C2CO)F)C3(C4CC4OC(=N3)N)CF	IC50 = 177690 nM	Poor binder
T67102	Cathepsin D	B1SX9D	(1R,2S,6R)-2-[5-[[(7S)-3-Bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90412343	C20H18BrF3N4O	467.3	C1CC2=C([C@H]1NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=CC(=C2)Br	IC50 = 83300 nM	Poor binder
T67102	Cathepsin D	B1Z0QA	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	78105160	C24H18ClFN6O4	508.9	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)Cl)F	IC50 = 151500 nM	Poor binder
T67102	Cathepsin D	B24QCO	(7R)-7-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile	Investigative	90401359	C21H18F3N5O	413.4	C1CC2=C([C@@H]1NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=CC(=C2)C#N	IC50 = 131500 nM	Poor binder
T67102	Cathepsin D	B26OTZ	Chembl4229013	Investigative	145988827	C26H23N3O4	441.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CC(=CC=C5)C(=O)O	IC50 = 98000 nM	Poor binder
T67102	Cathepsin D	B2ID7S	(4S)-4-[5-[(1-Bicyclo[1.1.1]pentanylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137656577	C17H21F2N3S	337.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC34CC(C3)C4)F)F	IC50 = 95300 nM	Poor binder
T67102	Cathepsin D	B2JKI8	(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-(6-prop-1-ynylpyridin-3-yl)phenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373311	C20H16F5N3O	409.4	CC#CC1=NC=C(C=C1)C2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 = 170000 nM	Poor binder
T67102	Cathepsin D	B2U5PC	(1R,5S,6R)-5-[5-[(6-Chloro-1-benzofuran-3-yl)amino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	118796789	C20H15ClF3N3O2	421.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=COC5=C4C=CC(=C5)Cl)F)C(F)F)N	IC50 = 153000 nM	Poor binder
T67102	Cathepsin D	B2WC5P	1-[[5-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]methylamino]cyclopropane-1-carbonitrile	Investigative	137651451	C16H18F2N4S	336.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC3(CC3)C#N)F)F	IC50 = 71800 nM	Poor binder
T67102	Cathepsin D	B36FAN	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90373228	C18H16ClF4N5O3	461.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OC)F)Cl	IC50 = 194000 nM	Poor binder
T67102	Cathepsin D	B3BEJ6	3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2R,3S)-2-hydroxy-1-[(3-methoxyphenyl)methylamino]-4-methylpentan-3-yl]benzamide	Investigative	44447299	C27H40N4O5S	532.7	CCNC1=CC(=CC(=C1)C(=O)N[C@H]([C@@H](CNCC2=CC(=CC=C2)OC)O)C(C)C)N3CCCCS3(=O)=O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B3INY4	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[[1-(trifluoromethyl)cyclopropyl]methylamino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441973	C17H17F6N3O	393.33	C1CC1(CNC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C(F)(F)F	IC50 = 52900 nM	Poor binder
T67102	Cathepsin D	B3J2LG	N-(4-{[4-(Cyclohexylamino)-1-(3-Fluorophenyl)-2-Oxo-1,3,8-Triazaspiro[4.5]dec-3-En-8-Yl]methyl}phenyl)acetamide	Investigative	135875806	C28H34FN5O2	491.6	CC(=O)NC1=CC=C(C=C1)CN2CCC3(CC2)C(=NC4CCCCC4)NC(=O)N3C5=CC(=CC=C5)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B3LYN5	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-(fluoromethyl)pyridine-2-carboxamide	Investigative	90412817	C19H15ClF4N4O2	442.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)CF)F)C(F)F)N	IC50 = 186000 nM	Poor binder
T67102	Cathepsin D	B3NR9U	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide	Investigative	78105119	C27H21FN6O4	512.5	C1COCC(=C1)C2=NC(=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)C#N)F	IC50 = 132000 nM	Poor binder
T67102	Cathepsin D	B3T5GJ	(S)-2-Amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one	Investigative	46231555	C24H24FN5O	417.5	CCC1=CC(=CC(=N1)CC)[C@]2(C(=O)N(C(=N2)N)C)C3=CC=CC(=C3)C4=C(N=CC=C4)F	IC50 = 54000 nM	Poor binder
T67102	Cathepsin D	B41OWS	(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67971363	C19H18FN3O3	355.4	C1COC[C@@H]2[C@@H]1OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=C(N=CC=C5)F	IC50 = 170000 nM	Poor binder
T67102	Cathepsin D	B42ZIH	2-Amino-7-[4-(3-methylbutyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one	Investigative	127028386	C30H33N3O2	467.6	CC(C)CCC1=CC=C(C=C1)C2=CC3=C(C=C2)C(=O)N(C(=N3)N)C[C@@H]4CC[C@@H](O4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B47BTQ	(4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	Investigative	71268741	C14H15F3N2OS	316.34	C1[C@H]2CSC(=N[C@]2(CO[C@H]1CF)C3=C(C=C(C=C3)F)F)N	IC50 ~ 81000 nM	Poor binder
T67102	Cathepsin D	B49LHS	N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	71542622	C27H24FN5O5	517.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4[C@]35CCOC(=N5)N)C6=CCOCC6)F	IC50 = 184000 nM	Poor binder
T67102	Cathepsin D	B4E5SR	(1R,2S,6R)-2-[5-(6-Chloro-1,3-benzoxazol-2-yl)-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413705	C19H13ClF3N3O2	407.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)C4=NC5=C(O4)C=C(C=C5)Cl)F)C(F)F)N	IC50 = 195650 nM	Poor binder
T67102	Cathepsin D	B4G9XS	(4S,5R)-4-(2,4-Difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	118732789	C13H16F2N2OS	286.34	C[C@]1([C@@H](CSC(=N1)N)COC)C2=C(C=C(C=C2)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B4HS8N	N-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide	Investigative	44441703	C31H37N3O5S	563.7	CCCN(C1=CC2=CC(=C1)C(=O)N[C@H](CCC3=CC(=CC=C3)C[C@@](C(=O)OC2)(C)N)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 97000 nM	Poor binder
T67102	Cathepsin D	B4LT3Q	(3S,4S)-4-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[(2-phenylmethoxyacetyl)amino]pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717663	C36H52F3N7O8	767.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)COCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B4N1UL	(4Ar,8aS)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	Investigative	71268850	C13H14F2N2OS	284.33	C1COC[C@]2([C@@H]1CSC(=N2)N)C3=C(C=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B4N9PI	8-(3-Benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11710655	C25H24N4	380.5	C1CN=C2C(N=C(N2C1)N)(C3=CC=CC=C3)C4=CC=CC(=C4)CC5=CC=CC=C5	IC50 = 52500 nM	Poor binder
T67102	Cathepsin D	B4U8LM	Chembl4204215	Investigative	145977049	C12H16N2OS2	268.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CS3)N	IC50 ~ 98000 nM	Poor binder
T67102	Cathepsin D	B4V7CW	4-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]pyrido[3,2-d]pyrimidine-7-carbonitrile	Investigative	90418607	C20H15F2N7O	407.4	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC4=NC=NC5=C4N=CC(=C5)C#N)F)N	IC50 = 147000 nM	Poor binder
T67102	Cathepsin D	B4X0NB	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90412211	C20H16ClF2N5O3	447.8	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F	IC50 = 65800 nM	Poor binder
T67102	Cathepsin D	B52ZAL	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,3,3-trifluoropropanamide	Investigative	90413219	C15H13F6N3O2	381.27	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)CC(F)(F)F)F)C(F)F)N	IC50 = 190000 nM	Poor binder
T67102	Cathepsin D	B57UJA	(4S)-4-[2,4-Difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137646316	C15H18F5N3S	367.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCC(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B5DBM8	3-Acetyl-5,8-dibromo-2-(4-bromophenylamino)quinolin-4(1H)-one	Investigative	44565900	C17H11Br3N2O2	515	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Br)Br)NC3=CC=C(C=C3)Br	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B5DEP4	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90372825	C21H18F5N5O3	483.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=CN=C(C=N3)OCC#C	IC50 = 188500 nM	Poor binder
T67102	Cathepsin D	B5HCQ7	(4S)-4-[2,4-Difluoro-5-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137640486	C17H23F2N3OS	355.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN3CC[C@H](C3)OC)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B5JBZ4	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-4-chloro-2-(fluoromethyl)benzamide	Investigative	90412339	C21H18ClF4N3O2	455.8	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=C(C=C(C=C4)Cl)CF	IC50 = 171000 nM	Poor binder
T67102	Cathepsin D	B5KR7M	CID 73507165	Investigative	73507165	C14H14F4N2OS	334.33	C1[C@H]2CSC(=N[C@]2(CO[C@H]1C(F)F)C3=C(C=C(C=C3)F)F)N	IC50 = 83100 nM	Poor binder
T67102	Cathepsin D	B5KT2V	Chembl4225038	Investigative	145970804	C26H23N3O4	441.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CC=C(C=C5)C(=O)O	IC50 = 100000 nM	Poor binder
T67102	Cathepsin D	B5P2HQ	(1R,2S,6R)-2-[5-[[(1R)-1-(5-Chloropyridin-2-yl)ethyl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413328	C19H18ClF3N4O	410.8	C[C@H](C1=NC=C(C=C1)Cl)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 77400 nM	Poor binder
T67102	Cathepsin D	B5RW9X	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78105032	C27H24FN5O4S	533.6	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCOCC6)F	IC50 = 197600 nM	Poor binder
T67102	Cathepsin D	B60UJH	Chembl4214785	Investigative	145974600	C11H15N3OS2	269.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC=CS3)N	IC50 ~ 64000 nM	Poor binder
T67102	Cathepsin D	B60XCS	(4S)-4-[2,4-Difluoro-5-[[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137653545	C16H20F5N3S	381.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC(C)(C)C(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B63VMU	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	77846098	C20H16F3N5O3	431.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 143000 nM	Poor binder
T67102	Cathepsin D	B6FIV2	(4Ar,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine	Investigative	76311037	C19H18ClN3O2S	387.9	C1COC[C@@H]2[C@@H]1OC3=C([C@@]24CSC(=N4)N)C=C(C=C3)C5=CC(=CN=C5)Cl	IC50 = 57000 nM	Poor binder
T67102	Cathepsin D	B6H5XD	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717658	C35H49ClF3N7O8	788.3	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=C(C=C1)Cl)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B6MO2T	(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]pentanediamide	Investigative	118717559	C24H45N9O7	571.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N[C@@H](CCC(=O)N)C(=O)N)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B6R5EH	Benzyl N-[(2S)-6-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamate;hydrochloride	Investigative	118717568	C31H52ClN5O6	626.2	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCCN)NC(=O)OCC2=CC=CC=C2.Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B6S8KE	(E)-N-((1S,3S)-1-Benzyl-2-hydroxy-3-{(2-pyridin-2-yl-ethyl)-[2-(2,4,6-trichloro-phenoxy)-acetyl]-amino}-propyl)-3-(2,6-dichloro-phenyl)-acrylamide	Investigative	44280079	C34H30Cl5N3O4	721.9	C1=CC=C(C=C1)C[C@@H]([C@H](CN(CCC2=CC=CC=N2)C(=O)COC3=C(C=C(C=C3Cl)Cl)Cl)O)NC(=O)/C=C/C4=C(C=CC=C4Cl)Cl	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	B6Y3QG	CID 56682314	Investigative	56682314	C22H19FN4O2S	422.5	CCC(=O)C1=CC(=CS1)[C@@]2(C(=O)N(C(=N2)N)C)C3=CC=CC(=C3)C4=C(N=CC=C4)F	IC50 = 78400 nM	Poor binder
T67102	Cathepsin D	B70BHN	Chembl4214603	Investigative	145974594	C13H16FN3OS	281.35	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC=N3)F)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B75VWL	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-oxocyclobutane-1-carboxamide	Investigative	90413255	C17H16F3N3O3	367.32	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4CC(=O)C4)F)C(F)F)N	IC50 = 117000 nM	Poor binder
T67102	Cathepsin D	B78OPG	(4S)-4-[2,4-Difluoro-5-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137645221	C16H18F5N3OS	395.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC3(COC3)C(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B79QAX	Hydroxyethylamine derivative, 16	Investigative	44143262	C32H34F3N5O3	593.6	CCN1C=NC2=C1C=C(C=C2N3CCCC3=O)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNCC5=CC(=CC=C5)C(F)(F)F)O	IC50 = 53700 nM	Poor binder
T67102	Cathepsin D	B7F1KU	N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide	Investigative	90413734	C18H15FN6O2	366.3	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=N3)NC(=O)C4=NC=C(C=C4)C#N)F	IC50 = 182000 nM	Poor binder
T67102	Cathepsin D	B7LT8H	(4S,6S)-4-[2-Fluoro-5-(6-fluoroquinolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373268	C21H15F6N3O	439.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C3=NC4=C(C=C3)C=C(C=C4)F)F)N)C(F)(F)F	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	B7W2MA	2-Amino-4-(4-methoxyphenyl)-4-[3-(3-pyridinyl)phenyl]-2-oxazoline	Investigative	57825223	C21H19N3O2	345.4	COC1=CC=C(C=C1)C2(COC(=N2)N)C3=CC=CC(=C3)C4=CN=CC=C4	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B7Y9XS	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90417533	C20H16F6N4O2	458.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C(F)(F)F	IC50 = 113000 nM	Poor binder
T67102	Cathepsin D	B7Z1WD	CID 73507384	Investigative	73507384	C15H18F2N2O2S	328.4	COC[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=C(C=C(C=C3)F)F)N	IC50 ~ 91400 nM	Poor binder
T67102	Cathepsin D	B80GJU	(1R,2S,6R)-2-[5-[[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413473	C21H19BrF3N3O	466.3	C1CC2=C([C@@H]1NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)C=CC(=C2)Br	IC50 = 82550 nM	Poor binder
T67102	Cathepsin D	B86THV	8-(3-Tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	44478657	C22H26N4	346.5	CC(C)(C)C1=CC=CC(=C1)C2(C3=NCCCN3C(=N2)N)C4=CC=CC=C4	IC50 = 150100 nM	Poor binder
T67102	Cathepsin D	B89QYX	Benzyl N-[(2S)-5-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;hydrochloride	Investigative	118717566	C30H50ClN5O6	612.2	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN)NC(=O)OCC2=CC=CC=C2.Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8A9YJ	US9315520, Example 7	Investigative	118435407	C17H18ClN5O2S2	423.9	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)Cl)N	IC50 ~ 97000 nM	Poor binder
T67102	Cathepsin D	B8DS9E	Chembl4203347	Investigative	145977020	C12H16N2OS2	268.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CSC=C3)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8FIS1	(4S,5S)-4-(2,4-Difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	118732788	C13H16F2N2OS	286.34	C[C@]1([C@H](CSC(=N1)N)COC)C2=C(C=C(C=C2)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8JEL1	(1R,2S,6R)-2-[5-[[(1R)-1-(5-Chloropyridin-2-yl)-2,2,2-trifluoroethyl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90401361	C19H15ClF6N4O	464.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)N[C@H](C4=NC=C(C=C4)Cl)C(F)(F)F)F)C(F)F)N	IC50 = 68200 nM	Poor binder
T67102	Cathepsin D	B8KR1Q	US9315520, Example 45	Investigative	118435524	C19H21F2N5O3S2	469.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4C)OC(F)F)N	IC50 ~ 70300 nM	Poor binder
T67102	Cathepsin D	B8LG9R	N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-methoxypyridine-2-carboxamide	Investigative	118435601	C18H21N5O3S2	419.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC)N	IC50 ~ 95000 nM	Poor binder
T67102	Cathepsin D	B8M7VD	(4S)-4-[2,4-Difluoro-5-[[[(2R)-1,1,1-trifluoropropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137635011	C15H18F5N3S	367.4	C[C@H](C(F)(F)F)NCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8OJ7Q	(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3R)-1-pentylpiperidin-3-yl]methyl]imidazol-4-one	Investigative	118719667	C23H42N4O	390.6	CCCCCN1CCC[C@@H](C1)C[C@@]2(C(=O)N(C(=N2)N)C)CCC3CCCCC3	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8PS0F	(4As,10R,10aS)-8-(5-chloropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67950202	C20H20ClN3O3	385.8	C[C@]12CCOC[C@@H]1[C@]3(COC(=N3)N)C4=C(O2)C=CC(=C4)C5=CC(=CN=C5)Cl	IC50 = 140000 nM	Poor binder
T67102	Cathepsin D	B8SK0D	8-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	44478660	C24H18F3N5O2	465.4	C1CN=C2C(N=C(N2C1)N)(C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC=CC(=C5)C6=C(N=CC=C6)F	IC50 = 95300 nM	Poor binder
T67102	Cathepsin D	B8TZW1	(4s,6r)-4-[2,4-Difluoro-5-({[1-(Trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-Dimethyl-5,6-Dihydro-4h-1,3-Thiazin-2-Amine	Investigative	123132915	C17H20F5N3S	393.4	C[C@@H]1C[C@@](N=C(S1)N)(C)C2=C(C=C(C(=C2)CNC3(CC3)C(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B8ZEV6	(4S,6S)-4-(5-((3-Chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732113	C20H15ClF5N5O	471.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=NC=CC4=CC(=CN=C43)Cl)F)N)C(F)(F)F	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	B90TOX	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide	Investigative	118796783	C21H17ClF2N4O3	446.8	C#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 86900 nM	Poor binder
T67102	Cathepsin D	B93SYJ	(4S)-4-[2,4-Difluoro-5-[(2,2,2-trifluoroethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137643369	C14H16F5N3S	353.36	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCC(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B94TIS	(4S)-4-[2,4-Difluoro-5-[(3-methoxypropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137635828	C16H23F2N3OS	343.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCCOC)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9BEM7	8-(3-(Pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11510740	C23H19F3N6O	452.4	C1CN=C2C(N=C(N2C1)N)(C3=CC=C(C=C3)OC(F)(F)F)C4=CC=CC(=C4)C5=CN=CN=C5	IC50 = 78700 nM	Poor binder
T67102	Cathepsin D	B9E6HX	8-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	90401372	C21H13F5N6O	460.4	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C(=CC(=C3)NC4=NC=C(C5=C4N=CC(=C5)C#N)F)F)F)C(F)F)N	IC50 = 127610 nM	Poor binder
T67102	Cathepsin D	B9FQ1S	Chembl4209354	Investigative	145965420	C15H20N2O2S	292.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3OC)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9GHI3	(4S)-4-[2,4-Difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137654633	C18H20F2N4S	362.4	CC1=CN=C(C=C1)NCC2=CC(=C(C=C2F)F)[C@@]3(CCSC(=N3)N)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9GP7S	2-Amino-4-(4-methoxyphenyl)-4-[3-(5-pyrimidinyl)phenyl]-2-oxazoline	Investigative	57825229	C20H18N4O2	346.4	COC1=CC=C(C=C1)C2(COC(=N2)N)C3=CC=CC(=C3)C4=CN=CN=C4	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9IOX8	(4As,7aS)-7a-(2,4-difluorophenyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine	Investigative	118732790	C12H12F2N2OS	270.3	C1[C@H]2CSC(=N[C@]2(CO1)C3=C(C=C(C=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9JRI8	8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	90441956	C21H14F4N6O	442.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=C(C5=C4N=CC(=C5)C#N)F)F)C(F)F)N	IC50 = 192210 nM	Poor binder
T67102	Cathepsin D	B9JY8N	(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl) 3-chlorobenzoate;2,2,2-trifluoroacetic acid	Investigative	122180112	C17H18ClF3N2O4S	438.8	C1CC2C(CC1OC(=O)C3=CC(=CC=C3)Cl)CSC(=N2)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9SI2G	Chembl4226994	Investigative	118440826	C19H18F5N5O3	459.4	C[C@]1([C@H]([C@H](OC(=N1)N)C(C)(F)F)F)C2=C(C=CC(=C2)NC(=O)C3=CN=C(C=N3)OCF)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	B9T8CD	8-(3-Propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11683112	C22H23F3N4O	416.4	CCCC1=CC(=CC=C1)C2(C3=NCCCN3C(=N2)N)C4=CC=C(C=C4)OC(F)(F)F	IC50 = 93700 nM	Poor binder
T67102	Cathepsin D	B9W3ZB	(4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1,3-oxazol-2-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	Investigative	72547065	C16H15F2N3O2S	351.4	C1[C@H]2CSC(=N[C@]2(CO[C@H]1C3=NC=CO3)C4=C(C=C(C=C4)F)F)N	IC50 = 74900 nM	Poor binder
T67102	Cathepsin D	B9Y1AV	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide	Investigative	90373216	C19H16F7N5O3	495.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=NC=C(C=C3)OCC(F)(F)F)F	IC50 = 150000 nM	Poor binder
T67102	Cathepsin D	BA1F9C	2-Amino-7-[4-(2-cyclohexylethyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one	Investigative	127028384	C33H37N3O2	507.7	C1CCC(CC1)CCC2=CC=C(C=C2)C3=CC4=C(C=C3)C(=O)N(C(=N4)N)C[C@@H]5CC[C@@H](O5)C6=CC=CC=C6	IC50 = 100000 nM	Poor binder
T67102	Cathepsin D	BA4E7V	(4S)-4-[2,4-Difluoro-5-[[methyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137657646	C15H18F5N3S	367.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN(C)CC(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BA4Y7V	2-Tert-butyl-4-(furan-2-ylmethylamino)-N-(2-methylpropyl)-N-[(3S)-piperidin-3-yl]pyrimidine-5-carboxamide;dihydrochloride	Investigative	68432286	C23H37Cl2N5O2	486.5	CC(C)CN([C@H]1CCCNC1)C(=O)C2=CN=C(N=C2NCC3=CC=CO3)C(C)(C)C.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BAC8B9	Sulfonamide tricyclic analogue, 12	Investigative	11168125	C27H32N4O4S	508.6	CCC1=CN2CCS(=O)(=O)N(C3=CC(=CC1=C32)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNCC#C)O)C	IC50 = 75500 nM	Poor binder
T67102	Cathepsin D	BAG3X7	(1R,2S,6R)-2-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441953	C19H14ClF3N6O	434.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=NC5=C4N=CC(=C5)Cl)F)C(F)F)N	IC50 = 141050 nM	Poor binder
T67102	Cathepsin D	BAY85C	(S)-3-((4-(6-Methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	Investigative	50898620	C25H23N5O	409.5	COC1=CC2=C(C=C1)C=C(C=C2)C3=CN(N=N3)C[C@@H]4CC5=C(CN4)NC6=CC=CC=C56	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BB13WD	CID 66683659	Investigative	66683659	C18H20N4O	308.4	CC1(CC2=C(C=C(C=C2)C3=CN=CN=C3)[C@]4(C1)COC(=N4)N)C	IC50 = 88464 nM	Poor binder
T67102	Cathepsin D	BB2LP0	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[[7-(trifluoromethyl)pyrido[3,2-d]pyrimidin-4-yl]amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441972	C20H14F6N6O	468.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=NC5=C4N=CC(=C5)C(F)(F)F)F)C(F)F)N	IC50 = 79350 nM	Poor binder
T67102	Cathepsin D	BBK83C	Chembl4226007	Investigative	126693206	C19H19F4N5O3	441.4	C[C@H]([C@@H]1[C@@H]([C@@](N=C(O1)N)(C)C2=C(C=CC(=C2)NC(=O)C3=CN=C(C=N3)OCF)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BBX89R	8-(3,4-Diethoxyphenyl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	44478656	C27H28FN5O2	473.5	CCOC1=C(C=C(C=C1)C2(C3=NCCCN3C(=N2)N)C4=CC=CC(=C4)C5=C(N=CC=C5)F)OCC	IC50 = 63400 nM	Poor binder
T67102	Cathepsin D	BBX93T	3-Acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroquinolin-4(1H)-one	Investigative	44566187	C17H11Cl2N3O4	392.2	CC(=O)C1=C(NC2=C(C1=O)C=C(C=C2Cl)[N+](=O)[O-])NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BBXV19	(2e,5r)-5-(2-Cyclohexylethyl)-5-{[(1s,3r)-3-(Cyclopentylamino)cyclohexyl]methyl}-2-Imino-3-Methylimidazolidin-4-One	Investigative	57844200	C24H42N4O	402.6	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@H]3CCC[C@H](C3)NC4CCCC4	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	BC1QT7	Z-FF-Fmk	Investigative	11705307	C27H27FN2O4	462.5	C1=CC=C(C=C1)C[C@@H](C(=O)CF)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BC4B8R	(4S,6S)-4-[2-Fluoro-5-(7-fluoroquinolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373074	C21H15F6N3O	439.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C3=NC4=C(C=CC(=C4)F)C=C3)F)N)C(F)(F)F	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	BC5MR0	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	124222814	C27H23ClFN5O3S	552	CC1=CC(=CN=C1C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCOCC6)F)Cl	IC50 = 133000 nM	Poor binder
T67102	Cathepsin D	BD46KS	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-phenylpyridine-2-carboxamide	Investigative	90414603	C24H19F3N4O2	452.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C5=CC=CC=C5)F)C(F)F)N	IC50 = 148000 nM	Poor binder
T67102	Cathepsin D	BD7BZ3	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78104986	C27H20F2N6O3S	546.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CC(=NC=C6)F)F	IC50 = 162100 nM	Poor binder
T67102	Cathepsin D	BD89TV	Chembl4211913	Investigative	118435403	C18H18N6O2S2	414.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)C#N)N	IC50 = 197600 nM	Poor binder
T67102	Cathepsin D	BD8UG7	3-Acetyl-6-chloro-2-(2-chloro-4-methylphenylamino)-8-nitroquinolin-4(1H)-one	Investigative	44566195	C18H13Cl2N3O4	406.2	CC1=CC(=C(C=C1)NC2=C(C(=O)C3=C(N2)C(=CC(=C3)Cl)[N+](=O)[O-])C(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BD96YX	2-Amino-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]-7-[4-(5-phenylpentyl)phenyl]quinazolin-4-one	Investigative	127040014	C36H37N3O2	543.7	C1C[C@@H](O[C@@H]1CN2C(=O)C3=C(C=C(C=C3)C4=CC=C(C=C4)CCCCCC5=CC=CC=C5)N=C2N)C6=CC=CC=C6	IC50 = 52000 nM	Poor binder
T67102	Cathepsin D	BDG9N6	(1R,5S,6R)-5-(5-(((5-Chloropyridin-2-yl)methyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	118232935	C18H16ClF3N4O	396.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NCC4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 = 177000 nM	Poor binder
T67102	Cathepsin D	BDGC07	(4Ar,6R,8aS)-8a-(2,4-difluoro-5-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	Investigative	86762648	C17H19F6N3OS	427.4	C1[C@H]2CSC(=N[C@]2(CO[C@H]1CF)C3=C(C=C(C(=C3)CNCC(F)(F)F)F)F)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BDO7H1	Chembl4212046	Investigative	145967429	C18H21N5O3S2	419.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC=C(S3)C(=O)NC4=NC(=CC=C4)OC)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BDQR73	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-cyclohexyl-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717564	C27H48F3N7O7	639.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BDR30N	Chembl4203860	Investigative	145978250	C19H22N4O3S2	418.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC=C(S3)C(=O)NC4=CC(=CC=C4)OC)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BDT4G9	(5R)-2-Amino-5-[[(1S,3R)-3-(cyclohexylamino)cyclohexyl]methyl]-5-(2-cyclohexylethyl)-3-methylimidazol-4-one	Investigative	57844562	C25H44N4O	416.6	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@H]3CCC[C@H](C3)NC4CCCCC4	Ki = 63500 nM	Poor binder
T67102	Cathepsin D	BE0V4N	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90413697	C19H18F3N5O3	421.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F)OC	IC50 = 191000 nM	Poor binder
T67102	Cathepsin D	BE1HT7	2-Amino-7-[4-(4-phenylbutyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one	Investigative	127039677	C35H35N3O2	529.7	C1C[C@@H](O[C@@H]1CN2C(=O)C3=C(C=C(C=C3)C4=CC=C(C=C4)CCCCC5=CC=CC=C5)N=C2N)C6=CC=CC=C6	IC50 = 91000 nM	Poor binder
T67102	Cathepsin D	BE1IP9	Chembl4229080	Investigative	145987742	C26H24N4O3	440.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CC=C(C=C5)C(=O)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BE4WB0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(3-cyclopropylprop-2-ynoxy)pyridine-2-carboxamide	Investigative	90412656	C24H21F3N4O3	470.4	C1CC1C#CCOC2=CN=C(C=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 77500 nM	Poor binder
T67102	Cathepsin D	BE5Q1O	Chembl4288556	Investigative	86658490	C19H12ClFN4O2	382.8	C1[C@]2(C3=CC(=NC=C3OC4=C2C=C(C=C4)C5=CC(=CN=C5)F)Cl)N=C(O1)N	IC50 = 130000 nM	Poor binder
T67102	Cathepsin D	BE79FP	(4S,6S)-4-(5-((3-Chloro-1,7-naphthyridin-8-yl)amino)-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732245	C20H15ClF5N5O	471.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC3=NC=CC4=CC(=CN=C43)Cl)F)F	IC50 = 104000 nM	Poor binder
T67102	Cathepsin D	BE8LY5	(4As,10R,10aS)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67971920	C18H18N4O3	338.4	C1COC[C@H]2[C@H]1OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=CN=CN=C5	IC50 = 76000 nM	Poor binder
T67102	Cathepsin D	BE9V1A	(4S)-4-[5-[(Dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137662127	C14H19F2N3S	299.38	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN(C)C)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BEK87S	3-Acetyl-8-bromo-5-chloro-2-(4-chlorophenylamino)quinolin-4(1H)-one	Investigative	44565901	C17H11BrCl2N2O2	426.1	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Cl)Br)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BEQL32	(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-(4-phenylpyridin-2-yl)oxyphenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372794	C23H18F5N3O2	463.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CC(=C3)C4=CC=CC=C4)F)N)C(F)(F)F	IC50 = 114000 nM	Poor binder
T67102	Cathepsin D	BEU49N	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78104939	C27H20F2N6O3S	546.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CC(=CN=C6)F)F	IC50 = 120100 nM	Poor binder
T67102	Cathepsin D	BEWI47	(4r)-2'-Amino-6-Bromo-1',2,2-Trimethyl-2,3-Dihydrospiro[chromene-4,4'-Imidazol]-5'(1'h)-One	Investigative	58423762	C14H16BrN3O2	338.2	CC1(CC2(C3=C(O1)C=CC(=C3)Br)C(=O)N(C(=N2)N)C)C	IC50 = 97740 nM	Poor binder
T67102	Cathepsin D	BEY9A1	(S)-2-Amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one	Investigative	16113753	C17H15F2N3O2	331.32	CN1C(=O)[C@](N=C1N)(C2=CC=CC=C2)C3=CC=C(C=C3)OC(F)F	IC50 = 53000 nM	Poor binder
T67102	Cathepsin D	BF0QY3	8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine	Investigative	11543843	C18H18N4	290.4	C1CN=C2C(N=C(N2C1)N)(C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BF24AY	Chembl4228400	Investigative	145970255	C24H22N4O2	398.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BF9A8H	(2S,4S,5S)-5-[[(2S)-2-[(3R)-3-Benzyl-4-(4-methylpiperazine-1-carbonyl)-2-oxopiperazin-1-yl]hexanoyl]amino]-6-cyclohexyl-N-[2-(dimethylamino)ethyl]-4-hydroxy-2-propan-2-ylhexanamide	Investigative	44342415	C42H71N7O5	754.1	CCCC[C@@H](C(=O)N[C@@H](CC1CCCCC1)[C@H](C[C@@H](C(C)C)C(=O)NCCN(C)C)O)N2CCN([C@@H](C2=O)CC3=CC=CC=C3)C(=O)N4CCN(CC4)C	IC50 = 58000 nM	Poor binder
T67102	Cathepsin D	BF9K5B	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78104985	C26H21ClFN5O3S	538	C1COCC=C1C2=NC(=C3C(=C2)C4(CCSC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl)F	IC50 = 133000 nM	Poor binder
T67102	Cathepsin D	BFL8Y4	(S)-2-Amino-4-(4-(2-fluoroethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one	Investigative	52942291	C18H18FN3O2	327.4	CN1C(=O)[C@](N=C1N)(C2=CC=CC=C2)C3=CC=C(C=C3)OCCF	IC50 = 116710 nM	Poor binder
T67102	Cathepsin D	BFLK57	N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide	Investigative	11290116	C19H18N4O	318.4	C1=CC=C(C=C1)C2=CC=C(N2CC(=O)N=C(N)N)C3=CC=CC=C3	IC50 = 60000 nM	Poor binder
T67102	Cathepsin D	BG51RJ	(4S,6S)-4-(5-((6-Chloro-4-phenylpyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732267	C23H17ClF5N3O2	497.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC(=CC(=C3)C4=CC=CC=C4)Cl)F)N)C(F)(F)F	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	BG5XY3	8-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	90441950	C21H14ClF3N6O	458.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC4=NC=C(C5=C4N=CC(=C5)C#N)F)Cl)C(F)F)N	IC50 = 88357 nM	Poor binder
T67102	Cathepsin D	BGE3F5	N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)-3-chlorobenzamide;hydrochloride	Investigative	122180107	C15H19Cl2N3OS	360.3	C1CC2C(CC1NC(=O)C3=CC(=CC=C3)Cl)CSC(=N2)N.Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BGJ52C	(1R,4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67970433	C20H20FN3O3	369.4	C[C@@H]1[C@@H]2[C@@H](CCO1)OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=C(N=CC=C5)F	IC50 = 57000 nM	Poor binder
T67102	Cathepsin D	BGY6U3	2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-(N'-cyclohexylcarbamimidoyl)acetamide	Investigative	44455733	C29H38N4O	458.6	C1CCC(CC1)N=C(N)NC(=O)CN2C(=CC=C2C34CC5CC(C3)CC(C5)C4)C6=CC=CC=C6	IC50 = 54200 nM	Poor binder
T67102	Cathepsin D	BH0GR4	N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethoxy)pyridine-2-carboxamide	Investigative	118435414	C18H18F3N5O3S2	473.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)(F)F)N	IC50 = 163600 nM	Poor binder
T67102	Cathepsin D	BH3T2E	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717570	C33H52F3N7O8	731.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BH48WS	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90412982	C19H18F3N5O3	421.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC	IC50 = 99750 nM	Poor binder
T67102	Cathepsin D	BH6EC0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(fluoromethyl)-1,3-oxazole-4-carboxamide	Investigative	90413296	C17H14F4N4O3	398.31	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=COC(=N4)CF)F)C(F)F)N	IC50 = 56750 nM	Poor binder
T67102	Cathepsin D	BH8CF5	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90372869	C19H14ClF4N5O2	455.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F)Cl	IC50 = 131000 nM	Poor binder
T67102	Cathepsin D	BHD7A5	Chembl4227851	Investigative	118441142	C20H19F4N5O3	453.4	C[C@]1([C@H]([C@H](OC(=N1)N)C2(CC2)F)F)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCF)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BI87ER	Tert-butyl (3R)-3-[[(4R)-2-amino-4-(2-cyclohexylethyl)-1-methyl-5-oxoimidazol-4-yl]methyl]piperidine-1-carboxylate	Investigative	118719664	C23H40N4O3	420.6	CC(C)(C)OC(=O)N1CCC[C@@H](C1)C[C@@]2(C(=O)N(C(=N2)N)C)CCC3CCCCC3	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	BI8JY9	(4S)-4-[5-[(2,2-Difluoroethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137633017	C14H17F4N3S	335.37	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCC(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BIPF08	(3R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]oxolane-3-carboxamide	Investigative	90413132	C17H18F3N3O3	369.34	C1COC[C@@H]1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 188000 nM	Poor binder
T67102	Cathepsin D	BIRH41	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105199	C26H23FN6O4S	534.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCOCC6)F	IC50 = 159800 nM	Poor binder
T67102	Cathepsin D	BIUT74	(4S)-4-[2,4-Difluoro-5-[(propan-2-ylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137648425	C15H21F2N3S	313.4	CC(C)NCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BIV94K	(4Ar,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67971614	C19H18ClN3O3	371.8	C1COC[C@@H]2[C@@H]1OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=CC(=CN=C5)Cl	IC50 = 120000 nM	Poor binder
T67102	Cathepsin D	BIXS84	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-(5-prop-1-ynylpyridin-3-yl)phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413015	C20H16F3N3O	371.4	CC#CC1=CC(=CN=C1)C2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 72850 nM	Poor binder
T67102	Cathepsin D	BJBF71	(1R,2S,6R)-2-[5-(Cyclopropylmethylamino)-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90414259	C16H18F3N3O	325.33	C1CC1CNC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 188500 nM	Poor binder
T67102	Cathepsin D	BJGS53	(4S)-4-[5-[[[1-(Difluoromethyl)cyclopropyl]amino]methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137634377	C16H19F4N3S	361.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC3(CC3)C(F)F)F)F	IC50 = 65500 nM	Poor binder
T67102	Cathepsin D	BJP9V8	N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-methoxypyrazine-2-carboxamide	Investigative	118435506	C17H20N6O3S2	420.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=CN=C(C=N4)OC)N	IC50 ~ 96700 nM	Poor binder
T67102	Cathepsin D	BK0V8D	2-Amino-3-[[(2S)-oxolan-2-yl]methyl]-7-phenylquinazolin-4-one	Investigative	127026505	C19H19N3O2	321.4	C1C[C@H](OC1)CN2C(=O)C3=C(C=C(C=C3)C4=CC=CC=C4)N=C2N	IC50 = 53400 nM	Poor binder
T67102	Cathepsin D	BK4S3Q	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90413699	C20H17ClF4N4O3	472.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)OC(F)F	IC50 = 164500 nM	Poor binder
T67102	Cathepsin D	BK89BZ	5-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile	Investigative	86732149	C18H13F5N4O	396.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C3=CN=CC(=C3)C#N)F)N)C(F)(F)F	IC50 = 129000 nM	Poor binder
T67102	Cathepsin D	BK8IW1	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-(hydroxymethyl)pyridine-2-carboxamide	Investigative	90411892	C20H16F3N5O3	431.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)CO)F)C(F)F)N	IC50 = 197500 nM	Poor binder
T67102	Cathepsin D	BKQ3X4	4-Acetamido-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	44454542	C28H38N4O4	494.6	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC=C(C=C3)NC(=O)C)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BKVN04	(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3R)-piperidin-3-yl]methyl]imidazol-4-one	Investigative	118719666	C18H32N4O	320.5	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@H]3CCCNC3	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	BKVT70	3-Acetyl-5,8-dichloro-2-(2,4-dichlorophenylamino)quinolin-4(1H)-one	Investigative	44219712	C17H10Cl4N2O2	416.1	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Cl)Cl)NC3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BLB0U9	(1R,2S,6R)-2-[5-[[1-(4-Chlorophenyl)cyclopropyl]methylamino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441966	C22H21ClF3N3O	435.9	C1CC1(CNC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C5=CC=C(C=C5)Cl	IC50 = 63600 nM	Poor binder
T67102	Cathepsin D	BLQ0F6	US9085576, 2b-rac	Investigative	90411856	C18H18FN5O3	371.4	C[C@@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 = 81300 nM	Poor binder
T67102	Cathepsin D	BM0FD8	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-cyanopyridine-2-carboxamide	Investigative	124222793	C24H18FN5O4	459.4	COC1=CC2=C(C(=C1)F)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=NC=C(C=C5)C#N	IC50 = 147000 nM	Poor binder
T67102	Cathepsin D	BM67RS	2-Amino-5-(1-ethylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one	Investigative	56682567	C19H19N7O	361.4	CCN1C=C(C=N1)C2(C(=O)N(C(=N2)N)C)C3=CC=CC(=C3)C4=CN=CN=C4	IC50 = 75800 nM	Poor binder
T67102	Cathepsin D	BN03VI	(4S)-4-[5-[(Cyclopropylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137641491	C15H19F2N3S	311.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC3CC3)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BN3ZO8	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-bromo-3-methylpyridine-2-carboxamide	Investigative	124222812	C27H23BrFN5O3S	596.5	CC1=CC(=CN=C1C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCOCC6)F)Br	IC50 = 88300 nM	Poor binder
T67102	Cathepsin D	BN7X0K	2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-[(2S)-2-hydroxypropyl]carbamimidoyl]acetamide	Investigative	11618935	C26H34N4O2	434.6	C[C@@H](CN=C(N)NC(=O)CN1C(=CC=C1C23CC4CC(C2)CC(C4)C3)C5=CC=CC=C5)O	IC50 = 54100 nM	Poor binder
T67102	Cathepsin D	BO3AI5	3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide;formic acid	Investigative	11785879	C26H34N4O6S	530.6	CCC1=CN2CCS(=O)(=O)N(C3=CC(=CC1=C32)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC)O)C.C(=O)O	IC50 = 58880 nM	Poor binder
T67102	Cathepsin D	BO3N5Q	2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2,3-dihydroxypropyl)carbamimidoyl]acetamide	Investigative	11604834	C26H34N4O3	450.6	C1C2CC3CC1CC(C2)(C3)C4=CC=C(N4CC(=O)NC(=NCC(CO)O)N)C5=CC=CC=C5	IC50 = 73500 nM	Poor binder
T67102	Cathepsin D	BO4BC3	Hydroxy ethylamine (HEA), 19	Investigative	25190497	C28H38N6O5S	570.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CN2C=CC=N2)[C@@H](CNCC3=CC(=CC=C3)OC)O)N4CCCCS4(=O)=O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BOI7A4	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413581	C18H14ClF3N4O2	410.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)F)N	IC50 = 154000 nM	Poor binder
T67102	Cathepsin D	BOU4B5	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-(4-amino-4-oxobutyl)-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717562	C25H45F3N8O8	642.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCCC(=O)N)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BOVY74	Chembl4227924	Investigative	145969327	C24H22N4O2	398.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CN=CC=C5	IC50 = 71000 nM	Poor binder
T67102	Cathepsin D	BOXY01	Chembl4225394	Investigative	145970818	C28H29N3O2	439.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3)C4=CC=C(C=C4)CCCC5=CC=CC=C5)N=C2N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BPC3A4	(1R,2R,6R)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90412775	C21H20FN5O2	393.4	C[C@@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)OC)F	IC50 = 56550 nM	Poor binder
T67102	Cathepsin D	BPT6Z0	Hydroxy ethylamine (HEA), 22	Investigative	25190500	C29H39FN6O4S	586.7	CCNC1=CC(=C(C(=C1)N2CCCCS2(=O)=O)F)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNCC4=CN(N=C4)CC)O	IC50 = 87100 nM	Poor binder
T67102	Cathepsin D	BPU2B9	(5R)-2-Amino-5-(2-cyclohexylethyl)-5-[[(1S,3R)-3-(cyclopropylmethylamino)cyclohexyl]methyl]-3-methylimidazol-4-one	Investigative	57843652	C23H40N4O	388.6	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@H]3CCC[C@H](C3)NCC4CC4	Ki = 53300 nM	Poor binder
T67102	Cathepsin D	BPV4E8	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-1,3-benzoxazol-2-amine	Investigative	90373205	C19H15ClF4N4O2	442.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC3=NC4=C(O3)C=CC(=C4)Cl)F	IC50 = 162000 nM	Poor binder
T67102	Cathepsin D	BQ04SZ	2,2-Dimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine	Investigative	53494150	C18H20N4O	308.4	CC1(CC2=C(C=C(C=C2)C3=CN=CN=C3)C4(C1)COC(=N4)N)C	IC50 = 59798 nM	Poor binder
T67102	Cathepsin D	BQ34BW	6-o-Tolylquinolin-2-amine	Investigative	53465787	C16H14N2	234.29	CC1=CC=CC=C1C2=CC3=C(C=C2)N=C(C=C3)N	IC50 = 108000 nM	Poor binder
T67102	Cathepsin D	BQ3DJ6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90413190	C20H16F6N4O2	458.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C(F)(F)F	IC50 = 159000 nM	Poor binder
T67102	Cathepsin D	BQ4L2T	(4S,6S)-4-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372932	C19H14ClF5N6O	472.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=NC=NC4=C3N=CC(=C4)Cl)F)N)C(F)(F)F	IC50 = 54400 nM	Poor binder
T67102	Cathepsin D	BQ5T0M	3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]benzamide;hydrochloride	Investigative	24878947	C24H35ClN4O4S	511.1	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNC)O)N3CCCCS3(=O)=O.Cl	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BQ8IP0	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	78105196	C21H16ClFN6O3S	486.9	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)Cl)F	IC50 = 69900 nM	Poor binder
T67102	Cathepsin D	BQ97RM	(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(1R,2R)-2-phenylcyclopropyl]methylamino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90441968	C22H22F3N3O	401.4	C1[C@H]([C@@H]1C2=CC=CC=C2)CNC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 102350 nM	Poor binder
T67102	Cathepsin D	BQIF83	2-Amino-3-methyl-5-(1-methylpyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one	Investigative	56679262	C18H17N7O	347.4	CN1C=C(C=N1)C2(C(=O)N(C(=N2)N)C)C3=CC=CC(=C3)C4=CN=CN=C4	IC50 = 54400 nM	Poor binder
T67102	Cathepsin D	BS40WZ	N-[2-Amino-7'-(3,6-dihydro-2H-pyran-5-yl)-5'-fluorospiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	124222807	C27H24FN5O5	517.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4F)C6=CCCOC6	IC50 = 106500 nM	Poor binder
T67102	Cathepsin D	BS48ER	Chembl4228633	Investigative	145968904	C25H24N4O2	412.5	C1CC(OC1)CN2C(=O)C3=C(C=C(C=C3N=C2N)C4=CC=CC=C4)C5=CC(=CC=C5)N	IC50 = 93000 nM	Poor binder
T67102	Cathepsin D	BS4OK1	N-[2-Amino-7'-(3,6-dihydro-2H-pyran-4-yl)-5'-fluorospiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105291	C27H24FN5O4S	533.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)C6=CCOCC6	IC50 = 173600 nM	Poor binder
T67102	Cathepsin D	BS9Q2R	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90412198	C20H16F3N5O3	431.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 116000 nM	Poor binder
T67102	Cathepsin D	BSH9Z6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90412908	C19H17ClF2N4O3	422.8	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 190500 nM	Poor binder
T67102	Cathepsin D	BSIB13	CID 73507167	Investigative	73507167	C14H16F2N2OS	298.35	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=C(C=C(C=C3)F)F)N	IC50 ~ 72000 nM	Poor binder
T67102	Cathepsin D	BSN5D6	3-Acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-one	Investigative	44565925	C18H13Br2ClN2O2	484.6	CC1=C2C(=C(C=C1)Cl)NC(=C(C2=O)C(=O)C)NC3=C(C=C(C=C3)Br)Br	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BSPE91	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide	Investigative	78105229	C27H17F2N7O3	525.5	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)C#N)F)C6=CC(=CN=C6)F)N	IC50 = 133000 nM	Poor binder
T67102	Cathepsin D	BT07UD	(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2,3-difluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90418855	C20H15ClF3N5O	433.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC4=NC=CC5=CC(=CN=C54)Cl)F)F)N	IC50 = 50550 nM	Poor binder
T67102	Cathepsin D	BT23ZP	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethyl-methylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717660	C36H51ClF3N7O8	802.3	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N(C)CCC1=CC=C(C=C1)Cl)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BT4OX2	(4S)-4-[2,4-Difluoro-5-[[[(2R)-1-methoxypropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137646126	C16H23F2N3OS	343.4	C[C@H](COC)NCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BT50NK	Hydroxy ethylamine (HEA), 15	Investigative	25190493	C29H40N6O4S	568.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CN(N=C3)CC)O)N4CCCCS4(=O)=O	IC50 = 56230 nM	Poor binder
T67102	Cathepsin D	BT7N4A	4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-oxo-butyramide	Investigative	9853618	C39H55N7O5	701.9	C1CCC(CC1)C[C@@H]([C@H]([C@H](CCC2=CC=CC=N2)O)O)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](CC4=CC=CC=C4)CC(=O)N5CCC(CC5)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BT8H2D	(4S,6S)-4-[5-[[3-(2-Cyclopropylethynyl)-5-fluoro-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90380057	C25H19F6N5O	519.4	C1CC1C#CC2=CC3=C(C(=NC=C3F)NC4=CC(=C(C=C4)F)[C@@]5(C[C@H](OC(=N5)N)C(F)(F)F)CF)N=C2	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	BTQL60	(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(1S,2R)-2-phenylcyclopropyl]methylamino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90441974	C22H22F3N3O	401.4	C1[C@@H]([C@@H]1C2=CC=CC=C2)CNC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 85450 nM	Poor binder
T67102	Cathepsin D	BTV2J4	8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	90413556	C21H13F5N6O	460.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C(=CC(=C3)NC4=NC=C(C5=C4N=CC(=C5)C#N)F)F)F)C(F)F)N	IC50 = 102630 nM	Poor binder
T67102	Cathepsin D	BTW3D7	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90415722	C18H13BrF4N4O2	473.2	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)F)F)C(F)F)N	IC50 = 81884 nM	Poor binder
T67102	Cathepsin D	BU3Y5N	Chembl4213486	Investigative	71466345	C19H15F2N5O2	383.4	C[C@]1(C=C(OC(=N1)N)CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BU8C2G	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105232	C26H23FN6O4S	534.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCCOC6)F	IC50 = 179300 nM	Poor binder
T67102	Cathepsin D	BU92GS	(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3S)-piperidin-3-yl]methyl]imidazol-4-one	Investigative	118719665	C18H32N4O	320.5	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@@H]3CCCNC3	Ki ~ 100000 nM	Poor binder
T67102	Cathepsin D	BUVJ40	(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzenesulfonamido)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717664	C33H48F3N7O8S	759.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BV0F6Q	(4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylamino)-propionylamino]-6-hydroxy-4-isobutylcarbamoyl-8-phenyl-octanoic acid	Investigative	11757267	C28H43N3O8	549.7	CC(C)CC(=O)N[C@@H](CC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](C[C@@H](CCC(=O)O)C(=O)NCC(C)C)O)C(=O)O	Ki = 79700 nM	Poor binder
T67102	Cathepsin D	BV3T9J	(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717665	C34H50F3N7O8S	773.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)CC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BV4XL3	2-Amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one	Investigative	45488113	C16H14ClN3O	299.75	CN1C(=O)C(N=C1N)(C2=CC=CC=C2)C3=CC(=CC=C3)Cl	IC50 = 69180 nM	Poor binder
T67102	Cathepsin D	BV8US5	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(3-methylidenecyclobutyl)methylamino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441970	C18H20F3N3O	351.4	C=C1CC(C1)CNC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 78850 nM	Poor binder
T67102	Cathepsin D	BVB4T1	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441962	C21H17F4N5O2	447.4	COC1=CC2=C(C(=NC=C2F)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=C1	IC50 = 169000 nM	Poor binder
T67102	Cathepsin D	BVKR62	3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one	Investigative	44566188	C21H20ClN3O4	413.9	CC(=O)C1=C(NC2=C(C1=O)C=C(C=C2Cl)[N+](=O)[O-])NC3=CC=C(C=C3)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BVS84J	N-[6-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoropyridin-2-yl]-5-isocyanopyridine-2-carboxamide	Investigative	118796785	C18H13F3N6O2	402.3	[C-]#[N+]C1=CN=C(C=C1)C(=O)NC2=NC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 139000 nM	Poor binder
T67102	Cathepsin D	BVX0E3	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxy-3-methylpyridine-2-carboxamide	Investigative	124222813	C28H26FN5O4S	547.6	CC1=CC(=CN=C1C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCOCC6)F)OC	IC50 = 158800 nM	Poor binder
T67102	Cathepsin D	BVZ0O7	Chembl4207711	Investigative	145978628	C14H18N2OS	262.37	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BWD1J2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]cyclopropanecarboxamide	Investigative	90413093	C16H16F3N3O2	339.31	C1CC1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 103950 nM	Poor binder
T67102	Cathepsin D	BWD1X0	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(benzylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717650	C34H48F3N7O8	739.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BWE97M	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide	Investigative	78322708	C19H13ClF5N5O2	473.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)C#N)Cl)F)F	IC50 = 113000 nM	Poor binder
T67102	Cathepsin D	BWN2Q0	(4Ar,6S,8aS)-8a-(2,4-difluorophenyl)-6-ethyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	118732791	C15H18F2N2OS	312.4	CC[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=C(C=C(C=C3)F)F)N	IC50 = 63000 nM	Poor binder
T67102	Cathepsin D	BX21JP	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90412206	C17H13ClF5N5O2	449.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)F)N	IC50 = 173500 nM	Poor binder
T67102	Cathepsin D	BX5GQ6	CID 9821383	Investigative	9821383	C18H29N3O6	383.4	CCCNC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BX65LE	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(1-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717656	C35H50F3N7O8	753.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC(C)C1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BXF04Q	Chembl4280656	Investigative	145981023	C22H15ClN4O2	402.8	CC#CC1=CC(=CN=C1)C2=CC3=C(C=C2)OC4=CN=C(C=C4[C@]35COC(=N5)N)Cl	IC50 = 72000 nM	Poor binder
T67102	Cathepsin D	BY25OL	(1R,2S,6R)-2-[5-[[3-(5-Chloropyridin-2-yl)oxetan-3-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441943	C20H18ClF3N4O2	438.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4(COC4)C5=NC=C(C=C5)Cl)F)C(F)F)N	IC50 = 163000 nM	Poor binder
T67102	Cathepsin D	BY2M9J	(4S,6S)-4-[5-[(3-Chloro-5-fluoro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372925	C20H14ClF6N5O	489.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=NC=C(C4=C3N=CC(=C4)Cl)F)F)N)C(F)(F)F	IC50 ~ 133000 nM	Poor binder
T67102	Cathepsin D	BY7H9O	(4S)-4-[2,4-Difluoro-5-[(2-methoxyethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137652983	C15H21F2N3OS	329.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCOC)F)F	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BY7ZR0	(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine	Investigative	76332783	C19H18FN3O2S	371.4	C1COC[C@@H]2[C@@H]1OC3=C([C@@]24CSC(=N4)N)C=C(C=C3)C5=C(N=CC=C5)F	IC50 = 96000 nM	Poor binder
T67102	Cathepsin D	BYOQ41	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-[(2S)-1-amino-1-oxopropan-2-yl]-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717560	C24H43F3N8O8	628.6	C[C@@H](C(=O)N)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T67102	Cathepsin D	BYZ5I7	N-(2'-Amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)-5-methylfuran-2-carboxamide	Investigative	71624580	C20H22N4O4	382.4	CC1=CC=C(O1)C(=O)NC2=CC3=C(C=C2)OC(CC34C(=O)N(C(=N4)N)C)(C)C	IC50 = 180420 nM	Poor binder
T67102	Cathepsin D	BZ5K4P	(1R,5S,6R)-5-[5-[[4-Chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90441975	C17H15ClF5N5O	435.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NCC4=NN(C=C4Cl)C(F)F)F)C(F)F)N	IC50 = 115500 nM	Poor binder
T67102	Cathepsin D	BZM07P	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90413090	C20H16ClF2N5O3	447.8	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 51050 nM	Poor binder
T67102	Cathepsin D	D09SOY	5,5-Diphenyl-2-iminohydantoin	Investigative	15054176	C16H15N3O	265.31	CN1C(=O)C(N=C1N)(C2=CC=CC=C2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder