TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T64553	Tyrosine-protein kinase ZAP-70	D0LF1U	Flavopiridol	Phase 2	5287969	C21H20ClNO5	401.8	CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O	IC50 ~ 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B0G8SO	3-({4-[(2,2-Dimethylpropyl)(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl}amino)-N-methoxy-4-methylbenzamide	Investigative	11454205	C24H38N8O2	470.6	CC1=C(C=C(C=C1)C(=O)NOC)NC2=NC(=NC(=N2)N(C)CC(C)(C)C)N3CCCN(CC3)C	IC50 ~ 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B1JLM9	3,10,13,16,23-Pentaazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(23),2,4(9),5,7,11(15),17(22),18,20-nonaen-12-one	Investigative	45482637	C18H11N5O	313.3	C1C2=C(C(=O)N1)N3C4=CC=CC=C4N=C3C5=NC6=CC=CC=C6N25	IC50 = 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B28IBR	{4-[({[{[{[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-(3-phenyl-propyl)-carbamoyl]-methyl}-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid	Investigative	44353160	C49H64N5O8P	882	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CCCC2=CC=CC=C2)CC(=O)N(CCCC3=CC=CC=C3)CC(=O)N(CCCC4=CC=CC=C4)CC(=O)N	IC50 = 100000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B2BI5Q	1,2,4-Oxadiazole Analogue 4g	Investigative	5329183	C24H26Cl2N5O8P	614.4	CC(=O)N[C@@H](CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)N[C@@H](CCC(=O)N)C2=NC(=NO2)CC3=C(C=C(C=C3)Cl)Cl	IC50 = 184000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B2N7EA	3-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol	Investigative	22736235	C23H22N4O2	386.4	C1CC(CC1N2C=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B2XAR6	1,2,4-Oxadiazole Analogue 4i	Investigative	5329185	C28H30N5O8P	595.5	CC(=O)N[C@@H](CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)N[C@@H](CCC(=O)N)C2=NC(=NO2)CC3=CC=CC4=CC=CC=C43	IC50 = 55000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B4TYS9	Benzeneacetamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-(((2-hydroxy-1-(hydroxymethyl)ethyl)amino)methyl)-	Investigative	5282335	C23H30N4O4S2	490.6	CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)CC3=CC=C(C=C3)CNC(CO)CO	IC50 ~ 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B52CIH	{4-[({[({[(Carbamoylmethyl-ethyl-carbamoyl)-methyl]-ethyl-carbamoyl}-methyl)-isobutyl-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid	Investigative	44353601	C30H50N5O8P	639.7	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CC(C)C)CC(=O)N(CC)CC(=O)N(CC)CC(=O)N	IC50 = 63000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B62LBZ	1,2,4-Oxadiazole Analogue 5g	Investigative	5329189	C23H24F3N4O7P	556.4	C[C@@H](C1=NC(=NO1)CC2=CC(=CC=C2)C(F)(F)F)NC(=O)[C@H](CC3=CC=C(C=C3)OP(=O)(O)O)NC(=O)C	IC50 = 96000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B6OY8V	{4-[({[[({[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-ethyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid	Investigative	44353525	C42H58N5O8P	791.9	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CCCC2=CC=CC=C2)CC(=O)N(CC)CC(=O)N(CCCC3=CC=CC=C3)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B7GT4L	N-[(S)-1-[3-(3,4-Dichlorobenzyl)-1,2,4-oxadiazole-5-yl]ethyl]-4-(phosphonooxy)benzenepropanamide	Investigative	12968819	C20H20Cl2N3O6P	500.3	C[C@@H](C1=NC(=NO1)CC2=CC(=C(C=C2)Cl)Cl)NC(=O)CCC3=CC=C(C=C3)OP(=O)(O)O	IC50 = 198000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B8BI0C	5-(3-Aminopropylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[4,3-c]pyrimidine-8-carboxamide	Investigative	44578626	C17H22N8O3	386.4	COC1=CC(=CC(=C1)NC2=C(C3=NN=CN3C(=N2)NCCCN)C(=O)N)OC	IC50 = 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B8QY4O	1,2,4-Oxadiazole Analogue 4b	Investigative	5329179	C25H30N5O8P	559.5	CC1=CC=C(C=C1)CC2=NOC(=N2)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)OP(=O)(O)O)NC(=O)C	IC50 = 65000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B93ILO	9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-	Investigative	10248747	C18H14Cl2N4O	373.2	CC1=C(NC(=O)C2=C1C=CC3=C2N=C(N3)NC4=C(C=CC=C4Cl)Cl)C	IC50 = 80000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	B9OES1	1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	11755812	C26H20F3N7O	503.5	C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5	IC50 = 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BAEM98	[4-({[({[[(Carbamoylmethyl-ethyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-ethyl-carbamoyl)-methyl]-hexanoyl-amino}-methyl)-benzyl]-phosphonic acid	Investigative	44353260	C35H52N5O8P	701.8	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CC)CC(=O)N(CCCC2=CC=CC=C2)CC(=O)N(CC)CC(=O)N	IC50 = 100000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BALX83	1-[(1-{2-[(3-Chloro-1,2-Dimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-3-Methyl-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol	Investigative	71698376	C22H24ClN7O	437.9	CC1=C(C2=C(N1C)C=CC(=C2)NC3=NC=CC(=N3)N4C=C(C(=N4)C)CN5CC(C5)O)Cl	IC50 = 53850 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BAT5O1	{4-[({[[({[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-isobutyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid	Investigative	44353173	C44H62N5O8P	820	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CCCC2=CC=CC=C2)CC(=O)N(CC(C)C)CC(=O)N(CCCC3=CC=CC=C3)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BB2PT6	1,2,4-Oxadiazole Analogue 7	Investigative	5329199	C22H22F3N4O7P	542.4	CC(=O)N[C@@H](CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)NCC2=NC(=NO2)CC3=CC=C(C=C3)C(F)(F)F	IC50 = 128000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BDA7S1	1,2,4-Oxadiazole Analogue 4e	Investigative	5329182	C24H27ClN5O8P	579.9	CC(=O)N[C@@H](CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)N[C@@H](CCC(=O)N)C2=NC(=NO2)CC3=CC(=CC=C3)Cl	IC50 = 94000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BI19TQ	N-(3,4-Dimethoxyphenyl)-6-(morpholin-4-yl)-9H-purin-2-amine	Investigative	45493316	C17H20N6O3	356.4	COC1=C(C=C(C=C1)NC2=NC3=C(C(=N2)N4CCOCC4)NC=N3)OC	IC50 = 62000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BJ3X7A	1,2,4-Oxadiazole Analogue 5h	Investigative	6326456	C22H24FN4O7P	506.4	C[C@@H](C1=NC(=NO1)CC2=CC=C(C=C2)F)NC(=O)[C@H](CC3=CC=C(C=C3)OP(=O)(O)O)NC(=O)C	IC50 = 72000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BQJ5M6	1,2,4-Oxadiazole Analogue 5c	Investigative	6326458	C22H24ClN4O7P	522.9	C[C@@H](C1=NC(=NO1)CC2=CC(=CC=C2)Cl)NC(=O)[C@H](CC3=CC=C(C=C3)OP(=O)(O)O)NC(=O)C	IC50 = 61000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BU8V1Y	(3R)-1-[[1-[2-[(3-Chloro-1,2-dimethylindol-5-yl)amino]pyrimidin-4-yl]-3-methylpyrazol-4-yl]methyl]pyrrolidin-3-ol	Investigative	89708625	C23H26ClN7O	452	CC1=C(C2=C(N1C)C=CC(=C2)NC3=NC=CC(=N3)N4C=C(C(=N4)C)CN5CC[C@H](C5)O)Cl	IC50 = 73420 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	BUNT46	{4-[({[({[(Carbamoylmethyl-isobutyl-carbamoyl)-methyl]-ethyl-carbamoyl}-methyl)-isobutyl-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid	Investigative	44353421	C32H54N5O8P	667.8	CCCCCC(=O)N(CC1=CC=C(C=C1)CP(=O)(O)O)CC(=O)N(CC(C)C)CC(=O)N(CC)CC(=O)N(CC(C)C)CC(=O)N	IC50 = 100000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	D04PEI	BMS-509744	Investigative	11467730	C32H41N5O4S2	623.8	CC1=CC(=C(C=C1SC2=CN=C(S2)NC(=O)C3=CC=C(C=C3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC	IC50 ~ 50000 nM	Poor binder
T64553	Tyrosine-protein kinase ZAP-70	D0OZ2S	Lck inhibitor	Investigative	6603792	C23H22N4O	370.4	C1CCC(C1)N2C=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder