TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61683	Inhibitor of apoptosis protein 3	D0R1CR	L-Phenylalanine	Approved	6140	C9H11NO2	165.19	C1=CC=C(C=C1)C[C@@H](C(=O)O)N	IC50 = 80200 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B04HKV	4-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide	Investigative	90060653	C33H32N4O4S	580.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=C(C=C5)C(=O)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B05MNR	(2S)-N-(2-Benzoylphenyl)-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide	Investigative	117886634	C31H34N4O4	526.6	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NC3=CC=CC=C3C(=O)C4=CC=CC=C4)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0AZ8I	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8,9-difluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	73056901	C29H30BrF2N3O5	618.5	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=C(C(=C(C=C2)F)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0B3YE	(2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	72712342	C25H29N5O6S	527.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=CC=CC=C43)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0NB9A	1-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide	Investigative	118586095	C32H39N5O3S	573.8	C[C@@H](C(=O)N[C@@H]1CN(C2=CC=CC(=C2SC1)NC(=O)C3CCN(CC3)C(=O)C)CC4=CC=CC5=CC=CC=C54)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0U7NP	1-(6-Methylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	71471946	C16H23N3O	273.37	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C	IC50 = 51000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B0U7NP	1-(6-Methylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	71471946	C16H23N3O	273.37	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C	IC50 = 95000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0UX9S	(2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylsulfonyl-1,3-dihydroisoindol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide	Investigative	90060610	C23H28N4O5S	472.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC4=C3CN(C4)S(=O)(=O)C)NC	IC50 = 53210 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B0Y8CE	3-Cyano-N-ethyl-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzamide	Investigative	90060740	C32H33N7O4	579.6	CCNC(=O)C1=CC(=C(C=C1)N2C3=CC=CC(=C3C=N2)CN4C5=CC=CC=C5O[C@H]([C@@H](C4=O)NC(=O)[C@H](C)NC)C)C#N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B16VZM	(2S)-N-[(3S)-5-[[2-Cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	73053618	C34H33ClN6O4	625.1	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(N(C5=CC=CC=C54)C6=CC=CC=C6C#N)C#N)NC.Cl	IC50 ~ 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B17BLA	(3S,8As)-6-[[(2S)-2-aminopropanoyl]amino]-5-oxo-N-phenyl-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride	Investigative	45265687	C18H25ClN4O3	380.9	C[C@@H](C(=O)NC1CC[C@H]2CC[C@H](N2C1=O)C(=O)NC3=CC=CC=C3)N.Cl	Ki ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1C8WY	(2S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide	Investigative	90060665	C28H30BrN3O5	568.5	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1CO5T	(2S)-N-[(3S,4S)-7-Cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(ethylamino)propanamide	Investigative	73425764	C31H35N5O5S	589.7	CCN[C@@H](C)C(=O)N[C@H]1[C@@H](N(C2=C(C=CC(=C2)C#N)N(C1=O)CC3=C(C=CC4=CC=CC=C43)C)C(=O)CS(=O)(=O)C)C	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1E2KU	(2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712130	C29H35ClN4O6S	603.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)OC)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1R3HC	(2S,3S)-2-Amino-N-((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-hydroxybutanamide hydrochloride	Investigative	72712566	C26H29BrClN3O4	562.9	C[C@@H]([C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)N)O.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1S3JT	(2S)-N-[(3S)-5-Benzyl-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72711020	C25H33ClN4O3	473	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1SHL3	(2S)-N-(5-Benzyl-1,1,4-trioxo-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl)-2-(methylamino)propanamide	Investigative	73056593	C20H23N3O4S	401.5	C[C@@H](C(=O)NC1CS(=O)(=O)C2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC	IC50 ~ 54200 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1SP9Y	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxetane]-3-yl]-2-(methylamino)propanamide	Investigative	118586124	C27H28BrN3O5	554.4	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13COC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B1TMJ6	(2S)-N-[(3S,4S)-1-[(7-Chloro-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425989	C27H29ClN4O7S	589.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC(=O)OC4=C3C=CC(=C4)Cl)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B1UCB6	N,N-Dimethyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide	Investigative	71472076	C17H26N4O3S	366.5	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)S(=O)(=O)N(C)C	IC50 = 57000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B21SWQ	(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(7-phenylthiazolo[5,4-c]pyridin-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide	Investigative	46884023	C28H35N5O2S	505.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(S3)C=NC=C4C5=CC=CC=C5)NC	Ki = 73000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B28OTN	(2S)-N-[(2S,3S)-5-[[2-Cyano-1-(2-cyanophenyl)indol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide	Investigative	90060675	C32H30N6O3	546.6	CCN[C@@H](C)C(=O)N[C@H]1[C@@H](OC2=CC=CC=C2N(C1=O)CC3=C4C=C(N(C4=CC=C3)C5=CC=CC=C5C#N)C#N)C	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B29EDT	(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-3-phenylbutanoyl]-1,3-dihydroisoindole-1-carboxamide	Investigative	73294887	C29H30F2N4O3	520.6	C[C@@H](C1=CC=CC=C1)[C@@H](C(=O)N2CC3=CC=CC=C3[C@H]2C(=O)NC4=C(C=CC=C4F)F)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2CTK8	(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-(2-phenylphenyl)-2,3-dihydroindole-2-carboxamide	Investigative	117872952	C33H32N4O3	532.6	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4C5=CC=CC=C5)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2FG8H	1-(5-Fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone	Investigative	71471949	C15H20FN3O	277.34	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=CC(=C3)F	IC50 = 130000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B2FG8H	1-(5-Fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone	Investigative	71471949	C15H20FN3O	277.34	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=CC(=C3)F	IC50 = 170000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2FIH5	(2S)-N-[(3S,4S)-1-[(7-Methoxy-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73427177	C28H32N4O8S	584.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC(=O)OC4=C3C=CC(=C4)OC)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2IPM7	(S)-N-((S)-2-((S)-2-(4-(Benzo[d]isoxazol-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46884477	C26H33N5O3S	495.6	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=NOC5=CC=CC=C54)NC	Ki = 120000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2P8LY	(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73056915	C22H21F3N4O4	462.4	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=NOC4=CC=CC=C43)C(F)(F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2QD5S	(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(3-hydroxypropyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73055136	C32H38BrN5O5	652.6	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)N5CCN(CC5)CCCO)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2TP9F	(S)-N-((S)-2-((S)-2-(4-(Benzofuran-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46884476	C27H34N4O3S	494.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=COC5=CC=CC=C54)NC	Ki = 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B2UI1E	N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide	Investigative	129012534	C30H33BrFN3O5	614.5	CCC(C(=O)N[C@@H]1C(=O)N(C2=C(C=C(C=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B36EFZ	4-Methoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide	Investigative	90060651	C32H32N4O4S	568.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=C(C=C5)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B39QTD	(S)-1-[(S)-3-Methyl-2-((S)-2-methylamino-propionylamino)-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid (2,6-difluoro-phenyl)-amide	Investigative	117887617	C24H28F2N4O3	458.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NC3=C(C=CC=C3F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B3QW1S	(2R)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide	Investigative	25241676	C27H36N4O3	464.6	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC	Ki ~ 56000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B3VT6Y	(2S)-N-[(3S,4S)-5-(4-Acetylbenzoyl)-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	90082539	C38H35N7O4	653.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C3=CC=C(C=C3)C(=O)C)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B3X2IW	(2S)-N-[(3S)-1-Acetyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72714287	C26H29ClN4O3	481	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C(=O)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B3YD1Z	(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid	Investigative	73057219	C26H27N3O6	477.5	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)C(=O)O)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B47KQO	(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid	Investigative	73054593	C26H26BrN3O6	556.4	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)O)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B48SYE	3-[[6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carbonyl]amino]propanoic acid	Investigative	118586143	C29H32N4O7	548.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)NCCC(=O)O)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4J9GQ	N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-6-oxoheptanamide	Investigative	73058099	C31H36N4O4S	560.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CCCCC(=O)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4P0SA	N-(2-Hydroxyethyl)-6-methoxy-N-methyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide	Investigative	118586168	C29H34N4O6	534.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)N(C)CCO)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4QA6Y	(2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	90060661	C25H27N3O4	433.5	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4R3JD	(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-isopropylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46883882	C26H38N4O2S	470.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C(C)C)NC	Ki = 190000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4U8AL	(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	90060659	C24H24BrN3O3	482.4	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B4UZ8J	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)-6-fluoroindazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide	Investigative	90060671	C29H27FN6O3	526.6	CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC(=C3)F)C5=CC=CC=C5C#N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B50EOF	6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylic acid	Investigative	73053728	C26H27N3O6	477.5	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B51HND	(2S)-N-(2-Methoxyphenyl)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide	Investigative	117886657	C28H30N4O4	486.6	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B51UXN	(2S)-2-(Methylamino)-N-[(3S)-1-[(4-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride	Investigative	72712337	C26H30ClN3O2	452	CC1=CC=C(C2=CC=CC=C12)CN3C4=CC=CC=C4CC[C@@H](C3=O)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B53IUD	(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(oxane-4-carbonyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	90082360	C35H37N7O4	619.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C3CCOCC3)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B57KTU	(2S)-N-Benzyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide	Investigative	117870989	C25H32N4O3	436.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NCC3=CC=CC=C3)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5EBT8	3-[[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carbonyl]amino]propanoic acid	Investigative	73054852	C29H31BrN4O7	627.5	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)NCCC(=O)O)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5JUX9	(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-6-yl)propanamide	Investigative	70980464	C11H15N5O2	249.27	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)NC2)NC	IC50 = 200000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B5JUX9	(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-6-yl)propanamide	Investigative	70980464	C11H15N5O2	249.27	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)NC2)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5KV1M	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide	Investigative	129012535	C29H28N6O3	508.6	CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5NRX7	(2S)-N-((1S)-2-((2S)-2-(4-(2-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46883923	C29H35ClN4O2S	539.1	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=CC=C5Cl)NC	Ki = 160000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5O8CT	(1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295055	C25H30F2N4O3	472.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5Q3DF	(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl)propanamide	Investigative	70981492	C11H15N5O2	249.27	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)CN2)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B5Q3DF	(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl)propanamide	Investigative	70981492	C11H15N5O2	249.27	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)CN2)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B5USN8	(2S)-N-[(3S)-1-Benzyl-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712329	C21H26ClN3O2	387.9	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B61BEO	(1R)-6-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070355	C25H29ClF2N4O3	507	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B62KFS	(2S)-N-[(3R)-9-[[2-(2-Methoxyethoxy)acetyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide	Investigative	118586094	C29H36N4O4S	536.7	C[C@@H](C(=O)N[C@@H]1CN(C2=CC=CC(=C2SC1)NC(=O)COCCOC)CC3=CC=CC4=CC=CC=C43)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B69GCY	(2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72711026	C30H37ClN4O4	553.1	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B6P2ES	Methyl 6-methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylate	Investigative	73058107	C27H29N3O6	491.5	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)OC)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B6R7QP	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1'-methylsulfonyl-4-oxospiro[3H-1,5-benzoxazepine-2,4'-piperidine]-3-yl]-2-(methylamino)propanamide	Investigative	118586228	C30H35BrN4O6S	659.6	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCN(CC3)S(=O)(=O)C)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B6ZVY3	N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]pyridine-4-carboxamide	Investigative	90060638	C30H29N5O3S	539.6	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=NC=C5)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B70TXM	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72712343	C26H33ClN6O5S	577.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B72FRA	(1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295060	C26H32F2N4O3	486.6	C[C@@H](C(=O)N[C@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)C(C)(C)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B73LYF	1-[6-(N-Methylanilino)-2,3-dihydroindol-1-yl]-2-[(3R)-3-methylpiperazin-1-yl]ethanone	Investigative	70980699	C22H28N4O	364.5	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)N(C)C4=CC=CC=C4	IC50 = 79000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B79MSQ	(2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-1-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride	Investigative	72712335	C25H28ClN3O2	438	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7D2XB	Formic acid;(2S)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-(6-methylquinolin-5-yl)pyrrolidine-2-carboxamide	Investigative	44182262	C23H31N5O3	425.5	CC[C@@H](C(=O)N1CCC[C@H]1C(=O)NC2=C(C=CC3=C2C=CC=N3)C)NC(=O)[C@H](C)NC	Ki = 56130 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7DIS4	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-1-(quinolin-4-ylmethyl)-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide	Investigative	73427183	C27H31N5O5S	537.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC=NC4=CC=CC=C34)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7FH5T	(2S)-N-(1,3-Dimethyl-2-oxo-4H-pyrido[3,2-d]pyrimidin-6-yl)-2-(methylamino)propanamide	Investigative	70980168	C13H19N5O2	277.32	C[C@@H](C(=O)NC1=NC2=C(C=C1)N(C(=O)N(C2)C)C)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7FVA5	(2S,4S)-1-[(2S)-2-[2-(Dimethylamino)propanoylamino]-3,3-dimethylbutanoyl]-4-phenoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide	Investigative	44396367	C32H44N4O4	548.7	CC(C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC2CCCC3=CC=CC=C23)OC4=CC=CC=C4)C(C)(C)C)N(C)C	EC50 ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 1	B7JH4N	(5S,8S,10Ar)-N-benzhydryl-5-[[(2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide	Investigative	25173661	C40H48N6O4	676.8	CC(C)CC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC)C(=O)NC(C5=CC=CC=C5)C6=CC=CC=C6	IC50 = 75000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7JH4N	(5S,8S,10Ar)-N-benzhydryl-5-[[(2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide	Investigative	25173661	C40H48N6O4	676.8	CC(C)CC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC)C(=O)NC(C5=CC=CC=C5)C6=CC=CC=C6	Ki = 67300 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7JPK4	(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide	Investigative	46884474	C28H35N5O2S	505.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=NC5=CC=CC=C45)NC	Ki = 75000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7LD0Y	Nvp-cgm097	Investigative	53240420	C38H47ClN4O4	659.3	CC(C)OC1=C(C=C2CC(=O)N([C@H](C2=C1)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)N(C)CC5CCC(CC5)N6CCN(C(=O)C6)C)OC	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B7LD0Y	Nvp-cgm097	Investigative	53240420	C38H47ClN4O4	659.3	CC(C)OC1=C(C=C2CC(=O)N([C@H](C2=C1)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)N(C)CC5CCC(CC5)N6CCN(C(=O)C6)C)OC	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B7MH5Z	N-Methyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide	Investigative	71471885	C16H24N4O3S	352.5	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)S(=O)(=O)NC	IC50 = 59000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7R6JM	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72712132	C29H35ClN4O5S	587.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7SUF8	(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-3-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide	Investigative	46883921	C28H35N5O2S	505.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CN=CC=C5)NC	Ki = 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7UCG9	(2S)-N-[(2S,3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide	Investigative	118586173	C30H30N6O3	522.6	CCN[C@@H](C)C(=O)N[C@H]1[C@@H](OC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)C	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B7UOM0	(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72713609	C30H37ClN4O3	537.1	CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4N(C[C@@H](C3=O)NC(=O)[C@H](C)NC)C(=O)CC(C)C.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B83VQI	2-((R)-3-Methyl-piperazin-1-yl)-1-(6-phenylamino-2,3-dihydro-indol-1-yl)-ethanone	Investigative	86723980	C21H26N4O	350.5	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)NC4=CC=CC=C4	IC50 = 79000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B83WCN	(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72713168	C25H29ClN4O5	501	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NOC5=CC=CC=C54)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B87IOZ	(2S)-N-[(3R)-5-[[2-(Difluoromethoxy)naphthalen-1-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	90060686	C29H31F2N3O5	539.6	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=CC=CC=C54)OC(F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B8C7EU	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	73356962	C32H33ClN6O4	601.1	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B8DF3G	(2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73427080	C27H31N5O3	473.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=C(C=NC4=CC=CC=C43)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B8IBD4	(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-4-oxo-5-(2-phenylethyl)-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72711022	C26H35ClN4O3	487	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CCC3=CC=CC=C3)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B8TG3S	(S)-N-((S)-2-((S)-2-(4-Benzylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46883883	C30H38N4O2S	518.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)CC5=CC=CC=C5)NC	Ki = 150000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B8XPK2	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide	Investigative	72712344	C26H32N6O5S	540.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9AEG0	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	118586164	C29H32BrN3O5	582.5	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9AFE6	(2S)-2-(Methylamino)-N-[(3S)-2-oxo-1-(2-phenylethyl)-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride	Investigative	72712331	C22H28ClN3O2	401.9	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CCC3=CC=CC=C3)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9CBL2	(2S)-N-[(3S)-5-[(1-Ethyl-2-oxo-3H-indol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73055432	C24H28N4O4	436.5	CCN1C(=O)CC2=C(C=CC=C21)CN3C4=CC=CC=C4OC[C@@H](C3=O)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9DVE8	(2S,3R)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide	Investigative	90060723	C26H28BrN3O5	542.4	CC1=CC2=C(C=C1)N(C(=O)[C@H](CO2)NC(=O)[C@H]([C@@H](C)O)N)CC3=C(C=CC4=C3C=CC(=C4)Br)OC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9FIL0	(2S)-N-[(3S,4S)-7-Cyano-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73426205	C33H32N8O5S	652.7	C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)CS(=O)(=O)C)C=C(C=C2)C#N)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	B9JP0D	5-Bromo-N-methyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide	Investigative	90231905	C16H23BrN4O3S	431.4	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=CC(=C(C=C32)S(=O)(=O)NC)Br	IC50 = 60000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9K3RF	5-[[(3S)-9-[2-Hydroxyethyl(methyl)carbamoyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]-6-methoxynaphthalene-2-carboxylic acid	Investigative	73054857	C30H34N4O8	578.6	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)C(=O)N(C)CCO)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9MB6Q	(2S)-N-[(3S,4S)-1-[(5-Chloro-2-methoxyphenyl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425995	C25H31ClN4O6S	551.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC(=C3)Cl)OC)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9RA7N	(S)-N-((S)-2-((S)-2-(4-(4-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46883992	C29H35ClN4O2S	539.1	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=C(C=C5)Cl)NC	Ki = 58000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9WA7J	Afzelin	Investigative	5316673	C21H20O10	432.4	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	B9ZPC8	(2S)-N-[(3S)-5-[(4-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054591	C20H22ClN3O3	387.9	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=C(C=C3)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BA3O4D	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(oxetan-3-ylamino)propanamide	Investigative	73055732	C30H28N6O4	536.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC6COC6	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BADF58	Smac AVPI Mimetic 3	Investigative	11280887	C19H26N4O3	358.4	C[C@@H](C(=O)N[C@H]1CC[C@@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N	Ki ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BADP15	(2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	72712131	C29H34N4O6S	566.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)OC)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BARB97	(3S,8Ar)-6-[[(2S)-2-aminopropanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride	Investigative	45263222	C19H27ClN4O3	394.9	C[C@@H](C(=O)NC1CC[C@@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N.Cl	Ki ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BAU3Y4	1-(6-Isopropylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	71471953	C18H27N3O	301.4	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C(C)C	IC50 = 63000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BAU3Y4	1-(6-Isopropylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	71471953	C18H27N3O	301.4	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C(C)C	IC50 = 59000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BAV6G8	(2S)-2-(Methylamino)-N-[(3S)-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride	Investigative	72712339	C26H30ClN3O2	452	CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4CC[C@@H](C3=O)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BAZV04	(2S)-N-[(3S)-5-[(6-Fluoro-1-methyl-2-oxoquinolin-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73055430	C24H25FN4O4	452.5	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC(=O)N(C4=C3C=C(C=C4)F)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BB04AQ	(1S)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070333	C25H29F3N4O3	490.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BB4AL9	(1R)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070354	C25H29F3N4O3	490.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BB97XD	3,4,5-Trimethoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide	Investigative	73057823	C34H36N4O6S	628.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC(=C(C(=C5)OC)OC)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BB98PJ	(S)-N-[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride	Investigative	72711028	C30H36BrClN4O4	632	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BBP4Y6	(2S)-N-[(3S,4S)-1-[(6-Bromo-1,2-benzoxazol-3-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425991	C25H28BrN5O6S	606.5	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=C3C=CC(=C4)Br)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BBRW91	(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide	Investigative	117870970	C21H24N4O3	380.4	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)N)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BC15KN	(2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide	Investigative	117872371	C26H33FN4O3	468.6	CC1=C(C=C(C=C1)F)CNC(=O)[C@@H]2CC3=CC=CC=C3N2C(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BC6YR1	(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]pentanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295053	C26H32F2N4O3	486.6	CC[C@H](C)[C@@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BC9KY7	1-(6-Methoxyindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	90254453	C16H23N3O2	289.37	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)OC	IC50 = 78000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BCG8E5	(3S)-5-[(6-Carboxy-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid	Investigative	73054855	C27H27N3O8	521.5	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)C(=O)O)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BCOX92	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)butanamide	Investigative	73056601	C27H30BrN3O5	556.4	CC[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NCCO	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BD1J2B	(2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-[[2-(2,2,2-trifluoroethoxy)naphthalen-1-yl]methyl]spiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide	Investigative	90060717	C30H32F3N3O5	571.6	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=CC=CC=C54)OCC(F)(F)F)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BDI4Y1	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,2-dimethyl-4-oxo-3H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide	Investigative	90060685	C27H30BrN3O3S	556.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2SC1(C)C)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BDM21Y	(2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide	Investigative	73054588	C25H27N3O3	417.5	CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4OC[C@@H](C3=O)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BDYU40	(3S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride	Investigative	45263207	C21H31ClN4O3	422.9	CCC[C@@H](C(=O)NC1CC[C@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N.Cl	Ki ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BE2Z4K	(S)-N-(6-Amino-2-pyridyl)-2-aminopropanamide	Investigative	91826683	C8H12N4O	180.21	C[C@@H](C(=O)NC1=CC=CC(=N1)N)N	IC50 = 110000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BE9JM6	(1R)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide	Investigative	90070352	C24H28F2N4O3	458.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2[C@@H]1C(=O)NC3=C(C=CC=C3F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BEAQ57	(2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,8-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054024	C27H30BrN3O4	540.4	C[C@H]1[C@@H](C(=O)N(C2=C(O1)C=C(C=C2)C)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BF1HM6	(2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425660	C28H32N4O3	472.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BF3YD9	Smac peptido-mimetic 12d	Investigative	23646339	C22H34N4O3	402.5	CCC[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC2=CC=CC=C2)N	Ki = 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BF5XW0	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide	Investigative	73427179	C28H33N5O5S	551.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=NC4=CC=CC=C43)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BFD13V	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(2-methylsulfonylacetyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72711931	C28H32BrClN4O6S	668	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)CS(=O)(=O)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BFU10L	(S)-N-((S)-2-((S)-2-(4-(3-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46883924	C29H35ClN4O2S	539.1	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC(=CC=C5)Cl)NC	Ki = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BG2A8E	N,N-Dimethyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-carboxamide	Investigative	71472006	C18H26N4O2	330.4	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C(=O)N(C)C	IC50 = 110000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BG3IK1	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	90060670	C32H32N6O4	564.6	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C5C=NN(C5=CC=C4)C6=CC=CC=C6C#N)NC	IC50 ~ 53100 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BG3ZK1	6-Methoxy-N,N-dimethyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide	Investigative	90060696	C28H32N4O5	504.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)N(C)C)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BG4J7W	(2S)-N-[(3S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712558	C26H30ClN3O3	468	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BG75YW	(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	72713169	C25H28N4O5	464.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NOC5=CC=CC=C54)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BGH52F	(2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-2-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride	Investigative	72712333	C25H28ClN3O2	438	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC4=CC=CC=C4C=C3)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BH6P2S	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclopentane]-3-yl]-2-(methylamino)propanamide	Investigative	118586161	C29H32BrN3O4	566.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BH7JT9	(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(5-methyl-7-phenylthiazolo[5,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide	Investigative	46884084	C28H36N6O2S	520.7	CC1=NC(=C2C(=N1)SC(=N2)[C@@H]3CCCN3C(=O)[C@H](C4CCCCC4)NC(=O)[C@H](C)NC)C5=CC=CC=C5	Ki = 51000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BHD2I5	(2S)-N-[(3S)-5-[(3-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054590	C20H22ClN3O3	387.9	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC(=CC=C3)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BHFE58	(2S)-N-[(3S)-1-Acetyl-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72711929	C27H30BrClN4O4	589.9	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BHW16K	3-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]butanamide	Investigative	90060635	C29H34N4O3S	518.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CC(C)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BI2HS0	(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72714294	C29H37ClN4O2	509.1	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)CCC(C)C)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BI43NJ	N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-5-oxohexanamide	Investigative	73057825	C30H34N4O4S	546.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CCCC(=O)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BI4Y7G	(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide	Investigative	73056905	C29H31BrFN3O5	600.5	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=C(C(=CC=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BI6X7Y	(S)-N-((S)-3,3-Dimethyl-1-oxo-1-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)butan-2-yl)-2-(methylamino)propanamide	Investigative	46884475	C26H33N5O2S	479.6	C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C2=NC(=CS2)C3=CC=NC4=CC=CC=C34)C(C)(C)C)NC	Ki = 130000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BIA15Y	(1S)-N-(2-Fluoro-6-methylphenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide	Investigative	73294889	C25H31FN4O3	454.5	CC1=C(C(=CC=C1)F)NC(=O)[C@@H]2C3=CC=CC=C3CN2C(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BIN51D	(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid	Investigative	73055134	C25H24BrN3O5	526.4	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)O)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BITH41	(2S)-N-[(3S,4S)-5-Acetyl-1-[(5-bromo-2-methoxyphenyl)methyl]-7-cyano-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425879	C25H28BrN5O4	542.4	C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)C)C=C(C=C2)C#N)CC3=C(C=CC(=C3)Br)OC)NC(=O)[C@H](C)NC	IC50 = 53050 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJ4HI2	(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-phenyl-2,3-dihydroindole-2-carboxamide	Investigative	117872174	C27H28N4O3	456.5	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJ85NB	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73055138	C29H27N5O3	493.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=CN(C4=CC=C3)C5=CC=CC=C5C#N)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJCV98	(S)-N-((S)-2-((S)-2-(4-(4-Fluoronaphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide	Investigative	11497354	C28H33FN4O3S	524.7	C[C@@H](C(=O)N[C@@H](C1CCOCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=C(C5=CC=CC=C54)F)NC	Ki = 140000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJF8I5	(2S)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2R)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide	Investigative	56666366	C27H36N4O3	464.6	C[C@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC	Ki ~ 56000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJG83V	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(4-nitrobenzoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72711484	C32H31BrClN5O6	697	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)C5=CC=C(C=C5)[N+](=O)[O-])NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BJR64G	(2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide	Investigative	90060715	C20H29N3O4	375.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)C(C)C)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BK02LQ	(2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide	Investigative	90060699	C26H28BrN3O5	542.4	CC1=CC2=C(C=C1)N(C(=O)[C@H](CO2)NC(=O)[C@H]([C@H](C)O)N)CC3=C(C=CC4=C3C=CC(=C4)Br)OC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BK58GW	(2S)-N-(1,3-Dimethyl-2-oxobenzimidazol-5-yl)-2-(methylamino)propanamide	Investigative	89970323	C13H18N4O2	262.31	C[C@@H](C(=O)NC1=CC2=C(C=C1)N(C(=O)N2C)C)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BK58GW	(2S)-N-(1,3-Dimethyl-2-oxobenzimidazol-5-yl)-2-(methylamino)propanamide	Investigative	89970323	C13H18N4O2	262.31	C[C@@H](C(=O)NC1=CC2=C(C=C1)N(C(=O)N2C)C)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BL30OR	(2S,3S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide	Investigative	118582223	C29H32BrN3O6	598.5	C[C@@H]([C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N)O	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BL5RB6	(2R)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712562	C26H29BrClN3O3	546.9	C[C@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BL68TM	(1S)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070353	C25H29ClF2N4O3	507	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BLO4C5	(2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide	Investigative	118582222	C29H32BrN3O6	598.5	C[C@@H]([C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N)O	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BLX4S3	Smac peptido-mimetic 12a	Investigative	23646336	C20H30N4O3	374.5	CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NCCC2=CC=CC=C2)NC(=O)CN	Ki = 68000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BM0L3N	(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-hydroxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide	Investigative	73294730	C23H26F2N4O4	460.5	C[C@H]([C@@H](C(=O)N1CC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)O	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BM4PK5	(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295228	C25H30F2N4O4	488.5	C[C@H]([C@@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)OC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BME0D6	(2S)-2-Amino-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide	Investigative	118582224	C19H27N3O4	361.4	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)C(C)C)N	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BMK1Q7	(1S)-N-(2,6-Dichlorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295057	C25H30Cl2N4O3	505.4	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3Cl)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BMQ59X	(1R)-2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-naphthalen-1-yl-1,3-dihydroisoindole-1-carboxamide	Investigative	73297144	C28H32N4O3	472.6	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2[C@@H]1C(=O)NC3=CC=CC4=CC=CC=C43)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BMR54A	(2S)-N-[(1S)-1-(Anilinocarbamoyl)-2-methyl-propyl]-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butyramide;formic acid	Investigative	44176339	C20H33N5O3	391.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NNC1=CC=CC=C1)NC	Ki = 65620 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BMX6D9	(3S,6S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-1,2,3,5,6,7,8,8a-octahydroindolizine-3-carboxamide	Investigative	44590212	C21H32N4O2	372.5	CCC[C@@H](C(=O)N[C@H]1CC[C@H]2CC[C@H](N2C1)C(=O)NCC3=CC=CC=C3)N	Ki ~ 100000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BN03AF	Methanoic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-1-oxidanylidene-1-(2-phenylhydrazinyl)propan-2-yl]butanamide	Investigative	44176335	C18H29N5O3	363.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)NNC1=CC=CC=C1)NC	Ki = 51790 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BN1XU9	3-Cyano-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzoic acid	Investigative	90060674	C30H28N6O5	552.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2O1)CC3=C4C=NN(C4=CC=C3)C5=C(C=C(C=C5)C(=O)O)C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BN35CM	(1R)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070358	C25H29ClF2N4O3	507	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BO08LJ	(S)-2-Methylamino-N-((S)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride	Investigative	72713605	C24H27ClN4O2	438.9	C[C@@H](C(=O)N[C@H]1CNC2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BO5ML4	(1R)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070335	C25H29F3N4O3	490.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BOS19I	(2S)-2-(Methylamino)-N-[(3S)-3-methyl-2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl]propanamide	Investigative	70980028	C12H17N5O2	263.3	C[C@H]1C(=O)NC2=C(N1)N=C(C=C2)NC(=O)[C@H](C)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BOS19I	(2S)-2-(Methylamino)-N-[(3S)-3-methyl-2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl]propanamide	Investigative	70980028	C12H17N5O2	263.3	C[C@H]1C(=O)NC2=C(N1)N=C(C=C2)NC(=O)[C@H](C)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BOW01N	(2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	73352496	C25H30ClN5O6S	564.1	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=CC=CC=C43)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BP02YB	N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide	Investigative	73058103	C31H30N4O3S	538.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=CC=C5)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BP0J3I	(1S)-2-[(2S)-2-Cyclopentyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(2,6-difluorophenyl)-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	73295404	C27H32F2N4O3	498.6	C[C@@H](C(=O)N[C@@H](C1CCCC1)C(=O)N2CCC3=CC=CC=C3[C@H]2C(=O)NC4=C(C=CC=C4F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BP6T7Y	(2S)-N-Benzhydryl-1-[(2R)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide	Investigative	25241691	C27H36N4O3	464.6	C[C@@H](C(=O)N[C@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC	Ki ~ 56000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BP8N0H	(2S)-N-[(3S)-5-[(2-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054589	C20H22ClN3O3	387.9	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3Cl)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BPI2M6	(S)-N-((S)-3,3-Dimethyl-1-((S)-2-(4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-(methylamino)propanamide	Investigative	46884410	C27H34N4O2S	478.7	C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C2=NC(=CS2)C3=CC=CC4=CC=CC=C43)C(C)(C)C)NC	Ki = 68000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BPQZ07	(2S)-1-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide	Investigative	117871469	C18H26N4O3	346.4	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)N)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BPT34E	(2S)-N-(2,6-Difluorophenyl)-3,3-dimethyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2H-indole-2-carboxamide	Investigative	73442923	C26H32F2N4O3	486.6	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](C(C2=CC=CC=C21)(C)C)C(=O)NC3=C(C=CC=C3F)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BPZ81V	(2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide	Investigative	117871180	C29H31FN4O3	502.6	CC1=C(C=C(C=C1)F)CNC(=O)[C@@H]2CC3=CC=CC=C3N2C(=O)[C@H](C4=CC=CC=C4)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BQ3HE5	(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73055135	C31H36BrN5O5	638.6	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)N5CCN(CC5)CCO)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BR2N6T	1-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide	Investigative	90060632	C31H37N5O3S	559.7	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5CCN(CC5)C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BREB57	(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide	Investigative	72712133	C29H34N4O5S	550.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BRN4J1	(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide	Investigative	90070334	C24H28F2N4O4	474.5	C[C@H]([C@@H](C(=O)N1CC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)OC	IC50 = 51740 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BRS9F8	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(2-hydroxyethylamino)propanamide	Investigative	73057217	C30H34BrN3O6	612.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NCCO	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BRT79A	(2S)-N-[(3S)-5-[[6-Bromo-1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide	Investigative	90060741	C29H27BrN6O3	587.5	CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC(=C3)Br)C5=CC=CC=C5C#N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BS3Z5X	1-(4-Chloro-3,3-dimethyl-2H-indol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone	Investigative	71472008	C17H24ClN3O	321.8	C[C@@H]1CN(CCN1)CC(=O)N2CC(C3=C2C=CC=C3Cl)(C)C	IC50 = 150000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BS7YV4	(S)-N-((3S,4S)-5-Acetyl-7-cyano-4-methyl-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1, 4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride	Investigative	72714057	C29H32ClN5O3	534	C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)C)C=C(C=C2)C#N)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BS9N7U	(1S)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide	Investigative	90070337	C25H29F3N4O3	490.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)F)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BS9TM1	N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide	Investigative	129012532	C30H33BrFN3O5	614.5	CCC(C(=O)N[C@H]1C(=O)N(C2=C(C(=CC=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BSC76E	(2S)-N-[(2S,3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxolane]-3-yl]-2-(methylamino)propanamide	Investigative	90060712	C28H30BrN3O5	568.5	C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2O[C@@]13CCOC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BSDP36	(2S)-N-(3-Benzyl-2-oxo-1H-imidazo[4,5-b]pyridin-5-yl)-2-(methylamino)propanamide	Investigative	71003452	C17H19N5O2	325.4	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)N2CC3=CC=CC=C3)NC	IC50 = 200000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BSDP36	(2S)-N-(3-Benzyl-2-oxo-1H-imidazo[4,5-b]pyridin-5-yl)-2-(methylamino)propanamide	Investigative	71003452	C17H19N5O2	325.4	C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)N2CC3=CC=CC=C3)NC	IC50 = 55000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BSGZ13	(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72714289	C29H35ClN4O3	523.1	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BSNR67	(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-phenylthiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide	Investigative	46884409	C25H34N4O2S	454.6	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=CC=C4)NC	Ki = 190000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BST6W7	(2S)-2-(Methylamino)-N-[1,1,4-trioxo-5-(4-phenylbutyl)-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl]propanamide	Investigative	73056595	C23H29N3O4S	443.6	C[C@@H](C(=O)NC1CS(=O)(=O)C2=CC=CC=C2N(C1=O)CCCCC3=CC=CC=C3)NC	IC50 ~ 54200 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BSZ0U2	(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712345	C32H34ClN7O5S	664.2	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BT8QD1	(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide	Investigative	24754961	C80H94N16O8	1407.7	CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H]3CCCC[C@H]4CC[C@H](N4C3=O)C(=O)N[C@@H](C5=CC=CC=C5)C6=CN(N=N6)CCCCC7=CC=C(C=C7)CCCCN8C=C(N=N8)[C@H](C9=CC=CC=C9)NC(=O)[C@@H]1CC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 1	BT8QD1	(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide	Investigative	24754961	C80H94N16O8	1407.7	CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H]3CCCC[C@H]4CC[C@H](N4C3=O)C(=O)N[C@@H](C5=CC=CC=C5)C6=CN(N=N6)CCCCC7=CC=C(C=C7)CCCCN8C=C(N=N8)[C@H](C9=CC=CC=C9)NC(=O)[C@@H]1CC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 2	BT8QD1	(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide	Investigative	24754961	C80H94N16O8	1407.7	CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H]3CCCC[C@H]4CC[C@H](N4C3=O)C(=O)N[C@@H](C5=CC=CC=C5)C6=CN(N=N6)CCCCC7=CC=C(C=C7)CCCCN8C=C(N=N8)[C@H](C9=CC=CC=C9)NC(=O)[C@@H]1CC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C	IC50 ~ 50000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BUE72Y	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)propanamide	Investigative	90060578	C29H28N6O4	524.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)NCCO	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BV25KB	(2S)-N-[5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-(2-methoxyethyl)-2-methyl-4-oxo-3H-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	118586166	C29H34BrN3O5	584.5	C[C@@H](C(=O)NC1C(=O)N(C2=CC=CC=C2OC1(C)CCOC)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BVL51G	(2S)-N-[(3S)-5-[(2-Methoxyphenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	90060664	C21H25N3O4	383.4	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BVP34Y	4-({[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-7-((S)-2-methylamino-propionylamino)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester	Investigative	73054853	C35H35BrN4O7	703.6	C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)NCC5=CC=C(C=C5)C(=O)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BW1XJ9	(2S)-N-[(3S,9S,12S,18S,24S,27S)-9,24-Dibenzyl-18-[[(2S)-2-(methylamino)propanoyl]amino]-2,8,11,17,23,26-hexaoxo-1,7,10,16,22,25-hexazatricyclo[25.3.0.012,16]triacontan-3-yl]-2-(methylamino)propanamide	Investigative	46888403	C46H66N10O8	887.1	C[C@@H](C(=O)N[C@H]1CCCNC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C1=O)CC4=CC=CC=C4)NC(=O)[C@H](C)NC)CC5=CC=CC=C5)NC	IC50 = 53900 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BW4DQ2	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054296	C26H25BrF3N3O4	580.4	C[C@@H](C(=O)N[C@H]1COC2=C(C=C(C=C2)C(F)(F)F)N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BW8VT4	1-(6-Fluoroindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone	Investigative	71471950	C15H20FN3O	277.34	C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)F	IC50 = 51000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BWB92O	(2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(ethylamino)propanamide;hydrochloride	Investigative	72712768	C27H31BrClN3O3	560.9	CCN[C@@H](C)C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BWD3M0	(2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride	Investigative	72712560	C26H29BrClN3O3	546.9	C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BWK7Y5	(2S)-N-[(3R)-9-Amino-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73058101	C24H26N4O2S	434.6	C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)N)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BX04QZ	2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-phenyl-1,3-dihydroisoindole-1-carboxamide	Investigative	73296972	C24H30N4O3	422.5	C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2C1C(=O)NC3=CC=CC=C3)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BX0ER3	(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	72712346	C32H33N7O5S	627.7	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BX1CK2	(2S)-2-(Methylamino)-N-[(3S)-1-methyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72714292	C25H29ClN4O2	453	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C)NC.Cl	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BXF7I6	(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(1-naphthalen-1-ylethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride	Investigative	72711024	C30H37ClN4O3	537.1	C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)C(C)C3=CC=CC4=CC=CC=C43)C(=O)CC(C)C)NC.Cl	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BXH4S6	(2S)-N-[(3S,4S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-5-(2-methoxyacetyl)-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	90089029	C29H33BrN4O5	597.5	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)COC)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC	IC50 = 50260 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BXQD72	(2S)-N-[(3S,4S)-5-Acetyl-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide	Investigative	73425656	C31H31N7O3	549.6	C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BXYW79	(2S)-2-Amino-N-[(3S)-5-[[1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide	Investigative	90060606	C27H24N6O3	480.5	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)N	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BY1XS0	(S)-2-Amino-N-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[D]azepin-1-YL)propanamide	Investigative	44178407	C14H19N3O2	261.32	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)N	IC50 ~ 54200 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BY7Q3N	(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-[(2-hydroxy-2-methylpropyl)amino]propanamide	Investigative	90060724	C31H32N6O4	552.6	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)NCC(C)(C)O	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BYK54J	(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-4-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide	Investigative	46883922	C28H35N5O2S	505.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=NC=C5)NC	Ki = 60000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BZ98KP	(2S)-N-(5-Benzyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl)-2-(methylamino)propanamide	Investigative	73056591	C20H23N3O2S	369.5	C[C@@H](C(=O)NC1CSC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC	IC50 ~ 54200 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BZD7K3	(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclohexane]-3-yl]-2-(methylamino)propanamide	Investigative	73056304	C30H34BrN3O4	580.5	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCCCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC	IC50 = 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BZP97N	(S)-N-[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-2-methylamino-propionamide trifluoroacetate	Investigative	72712770	C27H27BrF3N3O6	626.4	C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.C(=O)(C(F)(F)F)O	IC50 ~ 54000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BZWE03	N-{(1s)-1-Cyclohexyl-2-[(2s)-2-(4-Naphthalen-1-Yl-1,3-Thiazol-2-Yl)pyrrolidin-1-Yl]-2-Oxoethyl}-N~2~-Methyl-L-Alaninamide	Investigative	44820626	C29H36N4O2S	504.7	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=CC5=CC=CC=C54)NC	Ki = 68000 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	BZX1T5	(2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-methyl-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide	Investigative	73054298	C27H27BrF3N3O4	594.4	C[C@H]1[C@@H](C(=O)N(C2=C(O1)C=CC(=C2)C(F)(F)F)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC	IC50 ~ 54800 nM	Poor binder
T61683	Inhibitor of apoptosis protein 3	D0G3TK	KAEMPFEROL	Investigative	5280863	C15H10O6	286.24	C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 ~ 100000 nM	Poor binder