TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61622	Angiotensinogenase renin	D0J2VB	Iboctadekin + rituximab	Phase 1	5478883	C34H63N5O9	685.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O	IC50 = 92000 nM	Poor binder
T61622	Angiotensinogenase renin	B08HIO	2-Amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one	Investigative	11517020	C22H20FN5O2	405.4	CC1=C(C=CC(=C1)C2(C(=O)N(C(=N2)N)C)C3=CC(=C(C=C3)F)C4=CN=CN=C4)OC	IC50 = 57600 nM	Poor binder
T61622	Angiotensinogenase renin	B0VB4E	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;dihydrochloride	Investigative	90664759	C33H53Cl2N7O6	714.7	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CN=CN2)N.Cl.Cl	Ki = 80000 nM	Poor binder
T61622	Angiotensinogenase renin	B0X6DV	(3S)-3-Hydroxy-6-methyl-N-[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]-4-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]heptanamide	Investigative	44340366	C26H50N4O5	498.7	C[C@@H](C(=O)NCCC(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)CC(C)C)O	IC50 = 140000 nM	Poor binder
T61622	Angiotensinogenase renin	B0Z1CJ	(2R,4S,5S)-5-Amino-4-hydroxy-2,7-dimethyl-octanoic acid butylamide	Investigative	44287451	C14H30N2O2	258.399	CCCCNC(=O)[C@H](C)C[C@@H]([C@H](CC(C)C)N)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B18MZT	4-Methoxy-5-[1-(3-methoxypropyl)-3,4-dihydro-2H-quinolin-7-yl]pyridin-2-amine	Investigative	137650764	C19H25N3O2	327.4	COCCCN1CCCC2=C1C=C(C=C2)C3=CN=C(C=C3OC)N	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B1E8BQ	N-Ethyl-4-(furan-2-ylmethylamino)-2-methyl-N-piperidin-4-ylpyrimidine-5-carboxamide;dihydrochloride	Investigative	134144122	C18H27Cl2N5O2	416.3	CCN(C1CCNCC1)C(=O)C2=CN=C(N=C2NCC3=CC=CO3)C.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B2M6WX	1-N-[(2S,3R)-4-Amino-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide	Investigative	11376341	C28H33FN4O5S	556.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CN)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	B39KDI	1-N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylpropane-2-sulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	Investigative	11342476	C33H42N4O5S	606.8	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C(C)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	B3EGZ6	1-N-[(2S,3R)-4-(Ethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide	Investigative	11421906	C30H37FN4O5S	584.7	CCNC[C@H]([C@H](CC1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C(=O)N[C@H](C)C3=CC=C(C=C3)F)N(C)S(=O)(=O)C)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	B3J2LG	N-(4-{[4-(Cyclohexylamino)-1-(3-Fluorophenyl)-2-Oxo-1,3,8-Triazaspiro[4.5]dec-3-En-8-Yl]methyl}phenyl)acetamide	Investigative	135875806	C28H34FN5O2	491.6	CC(=O)NC1=CC=C(C=C1)CN2CCC3(CC2)C(=NC4CCCCC4)NC(=O)N3C5=CC(=CC=C5)F	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B4A2VQ	4-{(2R,3S,4S)-4-[(S)-2-((S)-2-Tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-2,3-dihydroxy-6-methyl-heptanoylamino}-butyric acid	Investigative	44384916	C32H48N6O9	660.8	CC(C)C[C@@H]([C@@H]([C@H](C(=O)NCCCC(=O)O)O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C	IC50 = 63000 nM	Poor binder
T61622	Angiotensinogenase renin	B4A3SR	2-Oxo-4-cyclohexyl-3-[[N-(benzyloxycarbonyl)-L-leucyl]amino]butanoic acid ethyl ester	Investigative	44460211	C26H38N2O6	474.6	CCOC(=O)C(=O)C(CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)OCC2=CC=CC=C2	IC50 = 52000 nM	Poor binder
T61622	Angiotensinogenase renin	B4EZK1	CID 56834949	Investigative	56834949	C30H38ClN3O	492.1	C1CCC(CC1)[C@@H]2C[C@@H](CCN2C(=O)[C@@H]3CNC[C@]34CCCC5=C4C=CC(=N5)Cl)C6=CC=CC=C6	IC50 = 106000 nM	Poor binder
T61622	Angiotensinogenase renin	B4HS8N	N-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide	Investigative	44441703	C31H37N3O5S	563.7	CCCN(C1=CC2=CC(=C1)C(=O)N[C@H](CCC3=CC(=CC=C3)C[C@@](C(=O)OC2)(C)N)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 169000 nM	Poor binder
T61622	Angiotensinogenase renin	B52TOV	4-(Furan-2-ylmethylamino)-N,2-dimethyl-N-piperidin-3-ylpyrimidine-5-carboxamide;dihydrochloride	Investigative	134141867	C17H25Cl2N5O2	402.3	CC1=NC=C(C(=N1)NCC2=CC=CO2)C(=O)N(C)C3CCCNC3.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B5ZL2G	Propan-2-yl 2-hydroxy-3-[[3-(1H-imidazol-5-yl)-2-[[4-morpholin-4-yl-2-(naphthalen-1-ylmethyl)-4-oxobutanoyl]amino]propanoyl]amino]-5-methylhexanoate	Investigative	129717	C35H47N5O7	649.8	CC(C)CC(C(C(=O)OC(C)C)O)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CC=CC3=CC=CC=C32)CC(=O)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B62ZIR	2-[2-(2-{[7-(2-Tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-methyl-5-oxo-1-oxa-4,7-diaza-cyclododecane-3-carbonyl]-amino}-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester	Investigative	44331191	C43H66N8O10	855	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)OC)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2COCCCCCN([C@@H](C(=O)N2)C)C(=O)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 = 69000 nM	Poor binder
T61622	Angiotensinogenase renin	B6I7GJ	Methyl (3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[[(2R)-3-(1H-indol-3-yl)-2-[[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]propanoyl]amino]-6-methylheptanoate	Investigative	13384519	C47H67N7O10	890.1	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)OC)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B6L0HQ	Phe-Statine-Ile-Phe-NH2	Investigative	44459674	C32H47N5O5	581.7	CC[C@H](C)[C@@H](C(=O)NC(=O)[C@H](CC1=CC=CC=C1)N)NC(=O)CC(C(CC(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B6NH3I	(2S,3R,5S)-5-((1S,3R)-3-Butylcarbamoyl-1-hydroxy-butyl)-3-methyl-2-phenyl-pyrrolidine-1-carboxylic acid benzyl ester	Investigative	44292211	C28H38N2O4	466.6	CCCCNC(=O)[C@H](C)C[C@@H]([C@@H]1C[C@H]([C@H](N1C(=O)OCC2=CC=CC=C2)C3=CC=CC=C3)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B7IQL9	5-(1-Adamantyl)-2-amino-5-(4-methoxyphenyl)-3-methylimidazol-4-one	Investigative	16050550	C21H27N3O2	353.5	CN1C(=O)C(N=C1N)(C2=CC=C(C=C2)OC)C34CC5CC(C3)CC(C5)C4	IC50 = 53300 nM	Poor binder
T61622	Angiotensinogenase renin	B8N4WP	(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-9-[4-(hydroxymethyl)phenyl]-2,7,7-trimethylnonanamide	Investigative	44287870	C23H40N2O3	392.6	CCCCNC(=O)[C@H](C)C[C@@H]([C@H](CC(C)(C)CCC1=CC=C(C=C1)CO)N)O	IC50 = 79000 nM	Poor binder
T61622	Angiotensinogenase renin	B90GPA	(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-6-[(4-methoxyphenyl)sulfonyl-propan-2-ylamino]-2-methylhexanamide	Investigative	45271101	C21H37N3O5S	443.6	CCCCNC(=O)[C@H](C)C[C@@H]([C@H](CN(C(C)C)S(=O)(=O)C1=CC=C(C=C1)OC)N)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B95PSJ	Pro-Phe-His-Phe-Phe-Val-Tyr-Lys-NH2	Investigative	44459577	C58H74N12O9	1083.3	CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@@H]6CCCN6	IC50 = 100000 nM	Poor binder
T61622	Angiotensinogenase renin	B98GOX	N-[(1S,2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]isophthalamide	Investigative	5287532	C31H38N4O5S	578.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BBH6S9	1-N-[(2S,3R)-4-(Tert-butylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide	Investigative	11342515	C32H41FN4O5S	612.8	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC(C)(C)C)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BC1AX7	Ac-Ftr-Pro-Phe-His-Phe-Phe-NH2	Investigative	44332789	C52H56N10O8	949.1	CC(=O)N[C@@H](CC1=CN(C2=CC=CC=C21)C=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)N	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BC3KU7	N-[(1R,2S)-1,3-Dicyclohexyl-1-hydroxypropan-2-yl]-2-[8-(2-methylpropyl)-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]acetamide	Investigative	14775318	C32H45N5O2	531.7	CC(C)CC1=NC(=CN2C1=NN=C2CC(=O)N[C@@H](CC3CCCCC3)[C@@H](C4CCCCC4)O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BC7I3P	2-Amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one	Investigative	11516577	C23H22N4O2	386.4	CC1=C(C=CC(=C1)C2(C(=O)N(C(=N2)N)C)C3=CC=CC(=C3)C4=CN=CC=C4)OC	IC50 = 93400 nM	Poor binder
T61622	Angiotensinogenase renin	BC91TD	1-N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[(dimethylsulfamoyl)(methyl)amino]-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	Investigative	11410903	C32H41N5O5S	607.8	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)N(C)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BCW36O	(S)-N-[(S)-4-((S,R)-Butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-2-(2-phenyl-ethanesulfonylamino)-propionamide	Investigative	44325449	C29H47N5O7S2	641.8	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CN=CN2)NS(=O)(=O)CCC3=CC=CC=C3)O)O	IC50 = 140000 nM	Poor binder
T61622	Angiotensinogenase renin	BFV1T6	3-N-[(2S)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(methanesulfonamido)benzene-1,3-dicarboxamide	Investigative	44421347	C30H35FN4O5S	582.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)NS(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)C(CNC4CC4)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BGQ9C4	Pro-Phe-His-Statine-NH2	Investigative	44459672	C28H41N7O5	555.7	CC(C)CC(C(CC(=O)N)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]3CCCN3	IC50 = 68000 nM	Poor binder
T61622	Angiotensinogenase renin	BGW94V	Pro-His-Pro-Phe-Arg-Phe-Phe-Val-Tyr-Lys	Investigative	44274654	C69H92N16O12	1337.6	CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CC6=CN=CN6)NC(=O)[C@@H]7CCCN7	IC50 = 200000 nM	Poor binder
T61622	Angiotensinogenase renin	BHD10G	Acetyl-NH-val-cyclohexyl-CH2[nch2choh]CH2-benzyl-val-NH-acetyl	Investigative	65023	C31H51N5O5	573.8	CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2CCCCC2)NC(=O)[C@H](C(C)C)NC(=O)C)O)NC(=O)C	IC50 ~ 58000 nM	Poor binder
T61622	Angiotensinogenase renin	BIA19Q	Di-Tert-Butyl {iminobis[(2s,3s)-3-Hydroxy-1-Phenylbutane-4,2-Diyl]}biscarbamate	Investigative	447617	C30H45N3O6	543.7	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](CNC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C)O)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BJG58A	Methyl (2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[(3R,6S)-6-methyl-7-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]-5-oxo-1,4,7-oxadiazecan-3-yl]methylamino]butanoyl]amino]pentanoyl]amino]propanoate	Investigative	71455790	C41H64N8O9	813	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)OC)NC(=O)[C@H](C(C)C)NC[C@@H]2COCCCN([C@H](C(=O)N2)C)C(=O)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BJP1A7	Boc-Pro[CH2O]Phe-His-Sta-Ile-AMP	Investigative	44373947	C45H67N9O8	862.1	CC[C@H](C)[C@@H](C(=O)NCC1=CC=CC=N1)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)OC(C)(C)C)N)O	IC50 = 140000 nM	Poor binder
T61622	Angiotensinogenase renin	BJS98L	3-N-[(2S)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	Investigative	44421346	C31H38N4O5S	578.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)C(CNC4CC4)O	IC50 ~ 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BK61EA	Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-4-cyclohexyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	15601558	C27H41N3O5	487.6	C[C@@H](C(=O)N[C@@H](CCC1CCCCC1)C=O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C	IC50 = 55000 nM	Poor binder
T61622	Angiotensinogenase renin	BL6MB2	Boc-His-Pro[CH2O]Phe-His-Sta-Ile-AMP	Investigative	44373944	C51H74N12O9	999.2	CC[C@H](C)[C@@H](C(=O)NCC1=CC=CC=N1)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)[C@H](CC5=CN=CN5)NC(=O)OC(C)(C)C)N)O	IC50 = 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BLVG61	Hexanoic acid, 2-hydroxy-3-((3-(1H-imidazol-4-yl)-2-((2-(1-naphthalenylmethyl)-1,4-dioxo-4-((2-phenylethyl)amino)butyl)amino)-1-oxopropyl)amino)-5-methyl-, methyl ester	Investigative	147073	C37H45N5O6	655.8	CC(C)CC(C(C(=O)OC)O)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CC=CC3=CC=CC=C32)CC(=O)NCCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BM2WS5	Ac-His-Phe-Ftr-Phe-Phe-Val-Ftr-NH2	Investigative	73346989	C64H68N12O10	1165.3	CC(C)[C@@H](C(=O)N[C@@H](CC1=CN(C2=CC=CC=C21)C=O)C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CN(C6=CC=CC=C65)C=O)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BM42SQ	5-(1-Adamantyl)-2-amino-5-(4-methoxy-3-methylphenyl)-3-methylimidazol-4-one	Investigative	45488102	C22H29N3O2	367.5	CC1=C(C=CC(=C1)C2(C(=O)N(C(=N2)N)C)C34CC5CC(C3)CC(C5)C4)OC	IC50 = 59500 nM	Poor binder
T61622	Angiotensinogenase renin	BM6CI8	5-(1H-Indol-7-yl)-4,6-dimethylpyridin-2-amine	Investigative	137654249	C15H15N3	237.3	CC1=CC(=NC(=C1C2=CC=CC3=C2NC=C3)C)N	IC50 = 124000 nM	Poor binder
T61622	Angiotensinogenase renin	BMR35K	Pro-Phe-His-delta-ornithine-Val-Tyr-Lys-NH2	Investigative	73347122	C45H66N12O8	903.1	CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H]4CCCN4	IC50 = 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BMS2A1	4-(4-Chloro-phenyl)-3-(4-methoxy-benzyloxy)-piperidine	Investigative	22126742	C19H22ClNO2	331.8	COC1=CC=C(C=C1)COC2CNCCC2C3=CC=C(C=C3)Cl	IC50 = 50000 nM	Poor binder
T61622	Angiotensinogenase renin	BPLX72	N-[(5R,14R)-5-Amino-5-methyl-16-oxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide	Investigative	44441701	C31H39N3O4S	549.7	CCCN(C1=CC2=CC(=C1)C(=O)N[C@H](CCC3=CC(=CC=C3)C[C@@](COC2)(C)N)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 144000 nM	Poor binder
T61622	Angiotensinogenase renin	BQ0HB7	Methyl (2S)-2-[[(2S)-2-[(5-amino-3-hydroxy-7-methyloctanoyl)amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	45259745	C24H40ClN3O5	486	CC(C)CC(CC(CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N.Cl	Ki = 95000 nM	Poor binder
T61622	Angiotensinogenase renin	BQ15IE	(2R)-6-Amino-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2R)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2R)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoic acid	Investigative	56661194	C67H87N17O11	1306.5	CC[C@@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CCCCN)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]6CCCN6C(=O)[C@H](CC7=CN=CN7)NC(=O)[C@H]8CCCN8	IC50 = 170000 nM	Poor binder
T61622	Angiotensinogenase renin	BQ6GR3	2-[2-(2-{[7-(2-Tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-methyl-5-oxo-[1,4,7]oxadiazecane-3-carbonyl]-amino}-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester	Investigative	44331135	C41H62N8O10	827	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)OC)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2COCCCN([C@@H](C(=O)N2)C)C(=O)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BQAV03	N-(3-{1-Hydroxy-2-[1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-ethylamino}-1-isopropyl-2-oxo-3-phenyl-propyl)-3-methyl-butyramide	Investigative	44340274	C28H46N4O5	518.7	C[C@@H](C(=O)NCCC(C)C)NC(=O)C[C@@H](NC(C1=CC=CC=C1)C(=O)[C@@H](C(C)C)NC(=O)CC(C)C)O	IC50 = 140000 nM	Poor binder
T61622	Angiotensinogenase renin	BR87EB	Methyl (3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[[(2S)-3-(1H-indol-3-yl)-2-[[(2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]propanoyl]amino]-6-methylheptanoate	Investigative	13384520	C47H67N7O10	890.1	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)OC)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BR9GL1	(2R)-N-[(2R)-1-[[(2R)-1-(2,2-Dimethylpropylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-(hydroxymethyl)-4-methylpentanamide	Investigative	44267838	C27H41N5O4	499.6	CC(C)C[C@H](CO)C(=O)N[C@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)NCC(C)(C)C	IC50 = 80000 nM	Poor binder
T61622	Angiotensinogenase renin	BRPQ09	{1-[3-({1-[2-(1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-methyl)-oxiranyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester	Investigative	44380693	C38H56N4O7	680.9	CC(C)C[C@@H](C(CC(=O)N[C@@H](CC(C)C)C(=O)NCC1=CC=CC=C1)O)NC(=O)CC2C(O2)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BS08IL	Methyl (2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[(3R,6S)-6-methyl-7-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]-5-oxo-1-oxa-4,7-diazacyclododec-3-yl]methylamino]butanoyl]amino]pentanoyl]amino]propanoate	Investigative	71450425	C43H68N8O9	841	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)OC)NC(=O)[C@H](C(C)C)NC[C@@H]2COCCCCCN([C@H](C(=O)N2)C)C(=O)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 = 69000 nM	Poor binder
T61622	Angiotensinogenase renin	BS9X1I	Tert-butyl N-[(Z,2S)-6-[[(4S)-1-[[(2S)-1-(benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-6-oxo-1-phenylhex-3-en-2-yl]carbamate	Investigative	44380670	C38H56N4O6	664.9	CC(C)C[C@@H](C(CC(=O)N[C@@H](CC(C)C)C(=O)NCC1=CC=CC=C1)O)NC(=O)C/C=C\\[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BSIG34	[(1S,2S,4R)-4-Butylcarbamoyl-2-hydroxy-1-((S)-2-methyl-3-phenyl-propyl)-pentyl]-carbamic acid tert-butyl ester	Investigative	9910816	C25H42N2O4	434.6	CCCCNC(=O)[C@H](C)C[C@@H]([C@H](C[C@@H](C)CC1=CC=CC=C1)NC(=O)OC(C)(C)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BT08PR	(2S)-1-[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1-formylindol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide	Investigative	44332881	C48H56N10O8	901	CC(C)[C@@H](C(=O)N[C@@H](CC1=CN(C2=CC=CC=C21)C=O)C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]5CCCN5C(=O)[C@@H](CC6=CN=CN6)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BU1ZW3	[(S)-1-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester	Investigative	44325179	C29H49N3O7S	583.8	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)OCC2=CC=CC=C2)O)O	IC50 = 52000 nM	Poor binder
T61622	Angiotensinogenase renin	BV0F6Q	(4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylamino)-propionylamino]-6-hydroxy-4-isobutylcarbamoyl-8-phenyl-octanoic acid	Investigative	11757267	C28H43N3O8	549.7	CC(C)CC(=O)N[C@@H](CC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](C[C@@H](CCC(=O)O)C(=O)NCC(C)C)O)C(=O)O	Ki = 73600 nM	Poor binder
T61622	Angiotensinogenase renin	BV3H4G	2-(2-{5-[2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-7-methyl-oct-3-enoylamino}-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester	Investigative	44276707	C30H44N6O5	568.7	CC(C)C[C@@H](/C=C/CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CN=CN2)N	Ki = 146000 nM	Poor binder
T61622	Angiotensinogenase renin	BVX07U	Boc-Trp-Trp-Sta-Ala-Sta-OMe	Investigative	13384518	C47H67N7O10	890.1	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)OC)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C)O	IC50 = 150000 nM	Poor binder
T61622	Angiotensinogenase renin	BWD39J	(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-9-[3-(hydroxymethyl)phenyl]-2,7,7-trimethylnonanamide	Investigative	44287804	C23H40N2O3	392.6	CCCCNC(=O)[C@H](C)C[C@@H]([C@H](CC(C)(C)CCC1=CC(=CC=C1)CO)N)O	IC50 = 58000 nM	Poor binder
T61622	Angiotensinogenase renin	BWRU86	His-Leu-Leu-Val-Phe-OCH3	Investigative	44276708	C33H51N7O6	641.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CN=CN2)N	Ki = 80000 nM	Poor binder
T61622	Angiotensinogenase renin	BX26SO	(2S,3R)-5-((1S,3R)-3-Butylcarbamoyl-1-hydroxy-butyl)-3-methyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester	Investigative	44292210	C25H40N2O4	432.6	CCCCNC(=O)[C@H](C)C[C@@H](C1C[C@H]([C@H](N1C(=O)OC(C)(C)C)C2=CC=CC=C2)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	BX6OQ3	N-[(2S)-1-Cyclohexyl-3-hydroxyheptan-2-yl]-2-(6-methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide	Investigative	44314473	C24H39N5O2	429.6	CCCCC([C@H](CC1CCCCC1)NC(=O)CC2=NN=C3N2C=C(N=C3CCC)C)O	IC50 ~ 100000 nM	Poor binder
T61622	Angiotensinogenase renin	D0Y5IQ	GRASSYSTATIN A	Investigative	44255320	C58H95N9O16	1174.4	C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)OC)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C)O)O	IC50 = 50000 nM	Poor binder