TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T58937	Glycine transporter-2	B0MSC1	3,4-Dichloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71720525	C21H31Cl2N3O3S	476.5	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC(=C(C=C3)Cl)Cl	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B0TZ4J	N-[[1-(4-Propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide	Investigative	71718685	C22H32F3N3O4S	491.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC(=CC=C3)OC(F)(F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B1KR2G	8-((1S,2S)-2-Phenyl-cyclohexyl)-1-propyl-1,3,8-triaza-spiro[4.5]decan-4-one	Investigative	44406558	C22H33N3O	355.5	CCCN1CNC(=O)C12CCN(CC2)[C@H]3CCCC[C@H]3C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	B29VMP	2,6-Difluoro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	54764172	C21H31F2N3O3S	443.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=CC=C3F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B2UXA5	8-[(1R,2S)-2-Hydroxy-2-pyridin-2-ylcyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406551	C24H30N4O2	406.5	C1CC[C@]([C@@H](C1)N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=CC=N5)O	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	B2VRT5	1-Cyclopentyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one	Investigative	44406577	C24H35N3O	381.6	C1CC[C@@H]([C@@H](C1)C2=CC=CC=C2)N3CCC4(CC3)C(=O)NCN4C5CCCC5	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	B2XR3E	2-Fluoro-4-methoxy-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71719306	C22H34FN3O4S	455.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=C(C=C3)OC)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B3FMW2	4-Fluoro-2-methoxy-6-methylsulfanyl-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71719905	C23H36FN3O4S2	501.7	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=C(C=C3SC)F)OC	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B43RFY	N-[[1-(4-Propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-2-(trifluoromethoxy)benzamide	Investigative	54765031	C22H32F3N3O4S	491.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC=CC=C3OC(F)(F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B5PD9I	2-Chloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-3-(trifluoromethyl)benzamide	Investigative	71719305	C22H31ClF3N3O3S	510	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C(=CC=C3)C(F)(F)F)Cl	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B5Y1OE	2-Amino-6-chloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	54764945	C21H33ClN4O3S	457	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=CC=C3Cl)N	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B61GPF	1-Benzyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one	Investigative	44406626	C26H33N3O	403.6	C1CC[C@@H]([C@@H](C1)C2=CC=CC=C2)N3CCC4(CC3)C(=O)NCN4CC5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	B6ZSG5	4-Fluoro-2-methyl-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	54764173	C22H34FN3O3S	439.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=C(C=C3)F)C	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B7NW1P	4-Chloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71716254	C21H32ClN3O3S	442	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC=C(C=C3)Cl	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B7OYJ8	2,4-Dichloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	54764946	C21H31Cl2N3O3S	476.5	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=C(C=C3)Cl)Cl	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	B7ZL5W	8-(2-Hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one	Investigative	18441735	C25H31N3O2	405.5	C1CCC(C(C1)N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=CC=C5)O	EC50 = 72000 nM	Poor binder
T58937	Glycine transporter-2	B8TZL5	8-[(1R,2R)-2-Hydroxy-2-pyridin-4-ylcyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406458	C24H30N4O2	406.5	C1CC[C@]([C@@H](C1)N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=NC=C5)O	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	BA8CD5	2,6-Dichloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71720526	C21H31Cl2N3O3S	476.5	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=CC=C3Cl)Cl	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	BBX86G	N-[[1-(4-Propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]benzamide	Investigative	71716253	C21H33N3O3S	407.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	BF24PZ	N-[[1-(4-Propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-2-(trifluoromethyl)benzamide	Investigative	54764522	C22H32F3N3O3S	475.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC=CC=C3C(F)(F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	BHC1G6	2-Methoxy-N-[[1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-4,6-bis(trifluoromethyl)benzamide	Investigative	71718694	C24H33F6N3O4S	573.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=C(C=C(C=C3OC)C(F)(F)F)C(F)(F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	BHK42V	8-[(1R,2R)-2-Hydroxy-2-(2-methylphenyl)cyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406604	C26H33N3O2	419.6	CC1=CC=CC=C1[C@@]2(CCCC[C@H]2N3CCC4(CC3)C(=O)NCN4C5=CC=CC=C5)O	EC50 = 70000 nM	Poor binder
T58937	Glycine transporter-2	BLN67T	1-Cyclobutyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one	Investigative	44406546	C23H33N3O	367.5	C1CC[C@@H]([C@@H](C1)C2=CC=CC=C2)N3CCC4(CC3)C(=O)NCN4C5CCC5	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	BS9KW0	8-[(3R,4R)-3-Hydroxy-3-phenyloxan-4-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406685	C24H29N3O3	407.5	C1COC[C@]([C@@H]1N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=CC=C5)O	EC50 ~ 100000 nM	Poor binder
T58937	Glycine transporter-2	BW1NI4	8-[(1R,2R)-2-Hydroxy-2-phenylcyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406538	C25H31N3O2	405.5	C1CC[C@]([C@@H](C1)N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=CC=C5)O	EC50 = 72000 nM	Poor binder
T58937	Glycine transporter-2	BW9H5B	8-[(1R,2R)-2-Hydroxy-2-(4-methoxyphenyl)cyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406539	C26H33N3O3	435.6	COC1=CC=C(C=C1)[C@@]2(CCCC[C@H]2N3CCC4(CC3)C(=O)NCN4C5=CC=CC=C5)O	EC50 = 67000 nM	Poor binder
T58937	Glycine transporter-2	BX8NK7	N-[[1-(4-Propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-4-(trifluoromethoxy)benzamide	Investigative	71718079	C22H32F3N3O4S	491.6	CCCS(=O)(=O)N1CCN(CC1)C2(CCCCC2)CNC(=O)C3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 75000 nM	Poor binder
T58937	Glycine transporter-2	BY92LT	8-[(1R,2R)-2-(4-Fluorophenyl)-2-hydroxycyclohexyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	44406603	C25H30FN3O2	423.5	C1CC[C@]([C@@H](C1)N2CCC3(CC2)C(=O)NCN3C4=CC=CC=C4)(C5=CC=C(C=C5)F)O	EC50 = 57000 nM	Poor binder