TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T56367	Phosphodiesterase 1	D0F9GE	Dipyridamole	Approved	3108	C24H40N8O4	504.6	C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	D0Y9ZE	Milrinone	Approved	4197	C12H9N3O	211.22	CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2	IC50 = 198000 nM	Poor binder
T56367	Phosphodiesterase 1	D0T5PO	ROLIPRAM	Phase 2	5092	C16H21NO3	275.34	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	D0BK6B	CI-930	Discontinued in Phase 2	3021729	C14H14N4O	254.29	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B05TXO	5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968471	C17H24ClN3O3	353.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCOCCN	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	B0P4FZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7,8-trimethoxy-2-naphthoic acid methyl ester	Investigative	10651803	C30H35BrN2O9	647.5	COC1=CC2=CC(=C(C(=C2C(=C1OC)OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B14TIW	3,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one	Investigative	10492654	C14H21N5O	275.35	CCCN1C=NC2=C1N(C(=O)N3C2=NCCC3)CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B21MFB	4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9836643	C15H12ClN3OS	317.8	CN1C(=NC2=CC=C(C=C2)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	B2L6WO	6,9-Dipropyltetrazolo[5,1-f]purin-5-one	Investigative	10491646	C11H15N7O	261.279	CCCN1C=NC2=C1C3=NN=NN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B2S3MG	6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one	Investigative	15606258	C17H15N3O2	293.32	COC1=NC2=C3C(=C1)CCN3C(=O)CN=C2C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B39EWD	4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-1-methyl-3,6-dihydro-1H-pyridin-2-one	Investigative	44324296	C20H23NO5	357.4	CN1CC=C(CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B3EAM6	T 0156 Hydrochloride	Investigative	9852041	C31H30ClN5O7	620	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B3MJU1	1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-	Investigative	1348	C20H14ClN3	331.8	C1=CC=C(C=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B3RH6C	4-Propyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one	Investigative	10536740	C10H11N5O	217.23	CCCN1C2=C(C3=NC=CN3C1=O)NC=N2	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B42HIX	1-(2-Thienyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10791038	C25H28N2O6S	484.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC=CS3)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 = 77000 nM	Poor binder
T56367	Phosphodiesterase 1	B4JF8H	8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9880288	C16H22ClN3O2	323.82	CNCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 = 72400 nM	Poor binder
T56367	Phosphodiesterase 1	B57NKZ	2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9880010	C15H12ClN3OS	317.8	CN1C(=NC2=CC=CC=C2O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	B5E7LG	4,5-Dihydro-6-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	14099432	C17H18N4O	294.35	C1CCC2=C(C1)N=CN2C3=CC=C(C=C3)C4=NNC(=O)CC4	IC50 = 140000 nM	Poor binder
T56367	Phosphodiesterase 1	B5E8JU	1-(3-Amino-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10840471	C29H35N3O8	553.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)N)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B5M1ES	4-[[(1,3-Benzodioxol-5-yl)methyl]amino]quinazoline-6-carbonitrile	Investigative	9995187	C17H12N4O2	304.3	C1OC2=C(O1)C=C(C=C2)CNC3=NC=NC4=C3C=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B5QEJ4	[3-Hydroxymethyl-1-(3-methanesulfonyl-4,5-dimethoxy-phenyl)-6,7-dimethoxy-naphthalen-2-yl]-methanol	Investigative	10479468	C23H26O8S	462.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)S(=O)(=O)C)OC)OC)CO)CO	IC50 = 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B5RU1P	5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-N,N-dimethyl-benzamide	Investigative	10575733	C25H29NO7	455.5	CN(C)C(=O)C1=C(C(=CC(=C1)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B6JYK0	[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-[3-hydroxymethyl-6,7-dimethoxy-4-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanone	Investigative	10602534	C29H36N2O8	540.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)CO)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B6N1WC	1-(3,4,5-Trimethoxyphenyl)-3-(methylcarbamoyl)-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10528313	C25H27NO8	469.5	CNC(=O)C1=C(C(=C2C=C(C(=CC2=C1)OC)OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	B7AG1X	1-(1,3-Benzodioxole-5-yl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10792119	C28H30N2O8	522.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC4=C(C=C3)OCO4)C(=O)OC)C(=O)N5CCN(CC5)CCO	IC50 = 55000 nM	Poor binder
T56367	Phosphodiesterase 1	B7E5PT	6-Methoxy-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-12-one	Investigative	10541661	C18H16N2O2	292.3	COC1=CC2=C3C(=C1)C(=NCC(=O)N3CC2)C4=CC=CC=C4	IC50 = 52000 nM	Poor binder
T56367	Phosphodiesterase 1	B7H3NC	5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9966830	C15H11ClFN3S	319.8	CN1C(=NC2=CC(=CC=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	B8F5IL	1-(3,4,5-Trimethoxyphenyl)-3-[(4-oxopiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10650055	C29H31NO9	537.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCC(=O)CC4	IC50 = 88000 nM	Poor binder
T56367	Phosphodiesterase 1	B8OSL6	5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9901606	C15H11ClFN3S	319.8	CN1C(=NC2=CC=C(C=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 85680 nM	Poor binder
T56367	Phosphodiesterase 1	B8Y3NA	[3-Hydroxymethyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanol	Investigative	44274920	C23H26O7	414.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)CO)CO	IC50 = 60000 nM	Poor binder
T56367	Phosphodiesterase 1	B9F7DC	1-(3,4-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10626417	C27H28Cl2N2O6	547.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C=C3)Cl)Cl)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 = 89000 nM	Poor binder
T56367	Phosphodiesterase 1	B9FN2U	3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzonitrile	Investigative	21920370	C16H11ClN4S	326.8	CN1C(=NC2=CC=CC(=C2)C#N)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	B9K6NZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester	Investigative	10232923	C27H28BrClN2O6	591.9	COC1=C(C(=CC(=C1)C2=C3C=CC=C(C3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)Cl)Br)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BA15LJ	5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile	Investigative	44301890	C16H14N4O	278.31	CC1=C(CC(C(=O)N1)C#N)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 130000 nM	Poor binder
T56367	Phosphodiesterase 1	BAW4V2	2-Tert-butyl-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione	Investigative	44386433	C18H24N4O2	328.4	CC(C)CN1C2=C(C3=C(C=C2)NC(=N3)C(C)(C)C)C(=O)N(C1=O)C	IC50 ~ 50000 nM	Poor binder
T56367	Phosphodiesterase 1	BB0N4P	2-[5-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride	Investigative	45263841	C32H27ClN4O5	583	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CN=C(C=C3)N4C(=O)C5=CC=CC=C5C(=N4)C6=CN=CC=C6)CO)CO.Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BB92VR	1,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one	Investigative	10515565	C13H19N5O	261.32	CCCN1C=NC2=C1C3=NCCN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BBG85C	6,7-Dipropyltetrazolo[5,1-f]purin-5-one	Investigative	10563356	C11H15N7O	261.279	CCCN1C=NC2=C1N(C(=O)N3C2=NN=N3)CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BBIO52	3,4-Dipropyl-7,8,9,10-tetrahydro-[1,3]diazepino[2,1-f]purin-5-one	Investigative	10613420	C15H23N5O	289.38	CCCN1C=NC2=C1N(C(=O)N3C2=NCCCC3)CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BBQ31S	(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol	Investigative	10729204	C14H16O4	248.27	COC1=CC2=CC(=C(C=C2C=C1OC)CO)CO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BC09JT	Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4-yl)-amine	Investigative	9994528	C17H15N3O2	293.32	CC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BC0AT9	1-(3,4,5-Trimethoxyphenyl)-3-[(4-methylpiperazino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10673963	C29H34N2O8	538.6	CN1CCN(CC1)C(=O)C2=C(C(=C3C=C(C(=CC3=C2)OC)OC)C4=CC(=C(C(=C4)OC)OC)OC)C(=O)OC	IC50 = 69000 nM	Poor binder
T56367	Phosphodiesterase 1	BC3KY5	1-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-2,3-naphthalenedicarboxylic acid dimethyl ester	Investigative	44274868	C25H26O9	470.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BC40DN	6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one	Investigative	135531470	C8H9N7O	219.2	CCCN1C2=C(C3=NN=NN3C1=O)NC=N2	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BC80NT	1-(2-Bromo-4-pyridyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	44274658	C26H28BrN3O6	558.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=NC=C3)Br)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 = 75000 nM	Poor binder
T56367	Phosphodiesterase 1	BCL5X0	[4-(3-Amino-4,5-dimethoxyphenyl)-6,7-diethoxy-3-(hydroxymethyl)naphthalen-2-yl]methanol;hydrochloride	Investigative	45261098	C24H30ClNO6	463.9	CCOC1=CC2=CC(=C(C(=C2C=C1OCC)C3=CC(=C(C(=C3)OC)OC)N)CO)CO.Cl	IC50 = 50000 nM	Poor binder
T56367	Phosphodiesterase 1	BD0XY9	8-Chloro-5-[2-hydroxy-3-(methylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9924709	C17H24ClN3O3	353.8	CNCC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	BD3T2P	1,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one	Investigative	10492653	C14H21N5O	275.35	CCCN1C=NC2=C1C3=NCCCN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BE0P1Q	N-(1,3-Benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine	Investigative	1713	C17H15N3O3	309.32	COC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BE9LP0	N-(1,3-Benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine	Investigative	6610310	C16H12ClN3O2	313.74	C1OC2=C(O1)C=C(C=C2)CNC3=NC=NC4=C3C=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BEG1A9	1-Butyl-3-propyl-5,7-dihydro-4H-purine-2,6-dione	Investigative	44339609	C12H20N4O2	252.31	CCCCN1C(=O)C2C(N=CN2)N(C1=O)CCC	IC50 = 149000 nM	Poor binder
T56367	Phosphodiesterase 1	BEN3V1	[7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-naphtho[2,3-d][1,3]dioxol-6-yl]-methanol	Investigative	10692240	C22H22O7	398.4	COC1=CC(=CC(=C1OC)OC)C2=C3C=C4C(=CC3=CC(=C2CO)CO)OCO4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BF48VA	8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10109572	C18H26ClN3O3	367.9	CN(C)CC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	BG1T9L	1-Butyl-4-(7-ethoxy-2,3-bis-hydroxymethyl-5-methoxy-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324391	C24H31NO5	413.5	CCCCN1CC=C(CC1=O)C2=C(C(=CC3=C2C=C(C=C3OC)OCC)CO)CO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BG5X3F	2-[4-[2,3-Bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride	Investigative	45259281	C30H23ClN4O3	523	C1=CC=C2C(=C1)C=C(C(=C2C3=CC(=NC=C3)N4C(=O)C5=CC=CC=C5C(=N4)C6=CN=CC=C6)CO)CO.Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BGK0J1	8-(4-Methyl-piperazin-1-yl)-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester	Investigative	44315107	C31H35N5O6	573.6	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)N4CCN(CC4)C)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BH4JT6	8-Chloro-5-[3-(dimethylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968370	C18H26ClN3O2	351.9	CN(C)CCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 ~ 101000 nM	Poor binder
T56367	Phosphodiesterase 1	BI42VD	Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyrimidin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride	Investigative	45260805	C31H30ClN5O7	620	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)N=C(C=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BI85PY	6,7-Dimethoxy-2-methyl-4-(3,4,5-trimethoxy-phenyl)-benzo[f]isoindole-1,3-dione	Investigative	10550927	C24H23NO7	437.4	CN1C(=O)C2=C(C1=O)C(=C3C=C(C(=CC3=C2)OC)OC)C4=CC(=C(C(=C4)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BIT6E2	4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324507	C24H31NO6	429.5	CCOC1=CC2=CC(=C(C(=C2C=C1OCC)C3=CCN(C(=O)C3)CCOC)CO)CO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BJ01WX	1-Butyl-4-(6,7-diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324390	C25H33NO5	427.5	CCCCN1CC=C(CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OCC)OCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BJG4Y3	4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324373	C22H27NO6	401.5	COCCN1CC=C(CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BJO5E0	4,5-Dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	20146320	C16H18N4O	282.34	CCC1=NC(=CN1C2=CC=C(C=C2)C3=NNC(=O)CC3)C	IC50 = 80000 nM	Poor binder
T56367	Phosphodiesterase 1	BL6IY3	4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one	Investigative	135442775	C10H13N5O	219.24	CCCN1C2=NC=NC2=C3NCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BL8I9U	1-[2-(2-Oxo-1,2-dihydropyridine-1-yl)-4-pyridinyl]-6,7-dimethoxynaphthalene-2,3-dimethanol	Investigative	10669693	C24H22N2O5	418.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=NC=C3)N4C=CC=CC4=O)CO)CO	IC50 = 50000 nM	Poor binder
T56367	Phosphodiesterase 1	BMIV96	4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one	Investigative	135528334	C11H15N5O	233.27	CCCN1C2=NC=NC2=C3NCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BML09C	1-Isoamyl-3-isobutylxanthine	Investigative	152034	C14H22N4O2	278.35	CC(C)CCN1C(=O)C2=C(N=CN2)N(C1=O)CC(C)C	IC50 = 86000 nM	Poor binder
T56367	Phosphodiesterase 1	BNO4D2	1-[(1-Butyl-2-oxo-1,2-dihydropyridin)-4-yl]-6,7-dimethoxynaphthalene-2,3-dimethanol	Investigative	10763354	C23H27NO5	397.5	CCCCN1C=CC(=CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BO3HN8	[1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl]-methanol	Investigative	11794425	C22H24O6	384.4	COC1=C(C=C(C=C1)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC)OC	IC50 = 70000 nM	Poor binder
T56367	Phosphodiesterase 1	BOR72W	1-(2-Methyl-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	44274717	C30H36N2O8	552.6	CC1=CC(=C(C=C1C2=C3C=C(C(=CC3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)OC)OC)OC)OC	IC50 = 97000 nM	Poor binder
T56367	Phosphodiesterase 1	BOWD63	2-(Methoxymethyl)-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione	Investigative	44387117	C16H20N4O3	316.35	CC(C)CN1C2=C(C3=C(C=C2)NC(=N3)COC)C(=O)N(C1=O)C	IC50 = 54000 nM	Poor binder
T56367	Phosphodiesterase 1	BP1Q9U	1-(3,4,5-Trimethoxyphenyl)-3-[(4-hydroxypiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	11800567	C29H33NO9	539.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCC(CC4)O	IC50 = 74000 nM	Poor binder
T56367	Phosphodiesterase 1	BPC5O6	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester	Investigative	10579873	C30H35BrN2O8	631.5	CCOC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 = 61000 nM	Poor binder
T56367	Phosphodiesterase 1	BQES71	N-[5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-phenyl]-acetamide	Investigative	10646809	C24H27NO7	441.5	CC(=O)NC1=C(C(=CC(=C1)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC)OC)OC	IC50 = 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BS4MT6	4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one	Investigative	135456675	C12H17N5O	247.3	CCCN1C2=NC=NC2=C3NCCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BT5Y3C	3,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one	Investigative	9881656	C13H19N5O	261.32	CCCN1C=NC2=C1N(C(=O)N3C2=NCC3)CCC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BU1AK8	1-(3,5-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10840332	C27H28Cl2N2O6	547.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=CC(=C3)Cl)Cl)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BU7AX8	1-(3-Nitrophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10506218	C27H29N3O8	523.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BW1M0I	1-(3,4,5-Trimethoxyphenyl)-3-(morpholinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10625920	C28H31NO9	525.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BW2G9J	6-(6,7-Bis-hydroxymethyl-2,3-dimethoxy-naphthalen-1-yl)-1-methyl-3,6-dihydro-1H-pyridin-2-one	Investigative	44324251	C20H23NO5	357.4	CN1C(C=CCC1=O)C2=C(C(=CC3=CC(=C(C=C32)CO)CO)OC)OC	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BXAD50	4-(6-Ethoxy-2,3-bis-hydroxymethyl-7-methoxy-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324252	C23H29NO6	415.5	CCOC1=CC2=CC(=C(C(=C2C=C1OC)C3=CCN(C(=O)C3)CCOC)CO)CO	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	BZ5W4G	Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quinazolin-4-yl)-amine	Investigative	10471556	C17H15N3O2S	325.4	CSC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T56367	Phosphodiesterase 1	D00YPO	TETRAHYDROBENXIMIDAZOLE	Investigative	14032753	C18H20N4O	308.4	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=NC4=C3CCCC4	IC50 = 75000 nM	Poor binder