TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T55956	Metabotropic glutamate receptor 6	D02VKC	NBQX	Phase 1	3272524	C12H8N4O6S	336.28	C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3	IC50 = 74000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	B1ST5P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid	Investigative	24780092	C12H18NO7PS	351.31	CS(=O)(=O)C1=CC=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	B8M3QP	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methyl-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	57765525	C12H17N2O7P	332.25	CC1=C(C=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	B9H5SN	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-morpholin-4-yl-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	57765549	C15H22N3O8P	403.32	C1COCCN1C2=C(C=C(C=C2)C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BD04NQ	(1R,2S)-1-Amino-2-(phosphonomethyl)cyclopropanecarboxylic acid	Investigative	16748099	C5H10NO5P	195.11	C1[C@@H]([C@]1(C(=O)O)N)CP(=O)(O)O	EC50 = 111000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BGBD73	3-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid	Investigative	24779948	C12H16NO7P	317.23	C1=CC(=CC(=C1)C(=O)O)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BGNL83	2-Amino-4-methyl-5-phenyl-3-thiophenecarbonitrile	Investigative	308248	C12H10N2S	214.29	CC1=C(SC(=C1C#N)N)C2=CC=CC=C2	IC50 = 71000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BKTZ62	Ethyl 4-methyl-2-(morpholinodiazenyl)-5-phenylthiophene-3-carboxylate	Investigative	45483698	C18H21N3O3S	359.4	CCOC(=O)C1=C(SC(=C1C)C2=CC=CC=C2)N=NN3CCOCC3	IC50 = 54000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BN4S1D	(2S)-2-Amino-4-[[amino-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]-hydroxyphosphoryl]butanoic acid	Investigative	58058380	C12H18N3O8P	363.26	COC1=CC(=CC(=C1O)[N+](=O)[O-])C(N)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BNS67U	(2S)-2-Amino-4-[hydroxy-[(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137646034	C11H15N2O7P	318.22	C1=CC(=C(C=C1CP(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BP8AW5	(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137654697	C11H15N2O8P	334.22	C1=CC(=C(C=C1[C@H](O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 = 68400 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BXT6U8	(2S)-2-Amino-4-[[(2-amino-1,3-thiazol-5-yl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	137661492	C8H14N3O5PS	295.26	C1=C(SC(=N1)N)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BZ07DY	2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid	Investigative	6604795	C8H12N2O4	200.19	CC1=C(C(=O)NO1)CC[C@@H](C(=O)O)N	Ki = 58000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	BZ20RS	L-2-Aminoadipic acid	Investigative	92136	C6H11NO4	161.16	C(C[C@@H](C(=O)O)N)CC(=O)O	Ki = 140000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	D07GRG	LY-379268	Investigative	10197984	C7H9NO5	187.15	C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	D0EK6P	(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate	Investigative	5310984	C6H10N2O4	174.15	C1[C@@H](NC[C@]1(C(=O)O)N)C(=O)O	Ki = 110000 nM	Poor binder
T55956	Metabotropic glutamate receptor 6	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder