TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T53588 Bacterial NADH-dependent enoyl-ACP reductase B0Y1PV 3-[(4-Methylphenyl)methyl]-5-thiophen-3-yl-1,2,4-oxadiazole Investigative 6539917 C14H12N2OS 256.32 CC1=CC=C(C=C1)CC2=NOC(=N2)C3=CSC=C3 IC50 = 51000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B25FJK 4-[(4-Methylphenyl)methyl]-2-thiophen-3-yl-1,3-oxazole Investigative 6539916 C15H13NOS 255.3 CC1=CC=C(C=C1)CC2=COC(=N2)C3=CSC=C3 IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B2RW3L 1-Benzyl-4-[4-(trifluoromethyl)phenyl]imidazole Investigative 6539912 C17H13F3N2 302.29 C1=CC=C(C=C1)CN2C=C(N=C2)C3=CC=C(C=C3)C(F)(F)F IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B2XQF4 Evernic acid Investigative 10829 C17H16O7 332.3 CC1=CC(=CC(=C1C(=O)OC2=CC(=C(C(=C2)C)C(=O)O)O)O)OC IC50 = 90000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B3OSQ9 (4R)-4-Benzyl-2-thiophen-3-yl-4,5-dihydro-1,3-oxazole Investigative 6539918 C14H13NOS 243.33 C1[C@H](N=C(O1)C2=CSC=C2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B70ZKR Disubstituted imidazole 22 Investigative 6539904 C15H12N2O2S 284.3 C1=CC(=CC(=C1)C(=O)O)CN2C=C(N=C2)C3=CSC=C3 IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B8HET9 1,2,3,4-Tetrahydropyrido[3,4-b]indole 15 Investigative 6539930 C26H22N2O4 426.5 C1CN(CC2=C1C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)O)C(=O)C5=CC=C(C=C5)O IC50 ~ 50000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase B9OX7E 1-[(2-Methylphenyl)methyl]-4-thiophen-3-ylimidazole Investigative 6539908 C15H14N2S 254.4 CC1=CC=CC=C1CN2C=C(N=C2)C3=CSC=C3 IC50 = 65400 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BDE0K8 5-[(4-Methylphenyl)methyl]-3-thiophen-3-yl-1,2,4-oxadiazole Investigative 6539919 C14H12N2OS 256.32 CC1=CC=C(C=C1)CC2=NC(=NO2)C3=CSC=C3 IC50 = 50700 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BHG9Q5 Vulpinic acid Investigative 54690323 C19H14O5 322.3 COC(=O)/C(=C/1\\C(=C(C(=O)O1)C2=CC=CC=C2)O)/C3=CC=CC=C3 IC50 = 84000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BIV59Y (4S)-4-Benzyl-2-thiophen-3-yl-4,5-dihydro-1,3-oxazole Investigative 6539915 C14H13NOS 243.33 C1[C@@H](N=C(O1)C2=CSC=C2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BLJ40Z 5-Ethyl-2-[2-(methylamino)phenoxy]phenol Investigative 59191298 C15H17NO2 243.3 CCC1=CC(=C(C=C1)OC2=CC=CC=C2NC)O IC50 = 112000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BM5NV7 1,2,3,4-Tetrahydro pyrido[3,4-b]indole 36 Investigative 6539951 C27H26N2O4 442.5 CC1=CC(=C(C(=C1C(=O)N2CCC3=C(C2)N(C4=CC=CC=C34)CC5=CC=C(C=C5)O)O)C)O IC50 ~ 50000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BN6H2W 2-(6-Fluoropyridin-2-yl)oxy-5-(imidazol-1-ylmethyl)phenol Investigative 59191276 C15H12FN3O2 285.27 C1=CC(=NC(=C1)F)OC2=C(C=C(C=C2)CN3C=CN=C3)O IC50 = 56000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BNA7S2 1,2,3,4-Tetrahydro pyrido[3,4-b]indole 24 Investigative 6539939 C27H24N2O4 440.5 COC(=O)C1=CC=C(C=C1)C(=O)N2CCC3=C(C2)N(C4=CC=CC=C34)CC5=CC=C(C=C5)O IC50 ~ 50000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BP86DV 1,2,3,4-Tetrahydro pyrido[3,4-b]indole 28 Investigative 6539943 C25H22N2O3 398.5 C1CN(CC2=C1C3=CC=CC=C3N2CC4=CC=C(C=C4)O)C(=O)C5=CC(=CC=C5)O IC50 ~ 50000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BQ0V5G 1-Methyl-4-(thiophen-3-yl)-1H-imidazole Investigative 6539906 C8H8N2S 164.23 CN1C=C(N=C1)C2=CSC=C2 IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BQJ06O 5-(4-Methoxyphenyl)-2-[(4-methylphenyl)methyl]-1H-imidazole Investigative 6539914 C18H18N2O 278.3 CC1=CC=C(C=C1)CC2=NC=C(N2)C3=CC=C(C=C3)OC IC50 = 66200 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BU61RZ Epigallocatechin Investigative 72277 C15H14O7 306.27 C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O IC50 ~ 100000 nM Poor binder T53588 Bacterial NADH-dependent enoyl-ACP reductase BW14MO 1,2,3,4-Tetrahydro pyrido[3,4-b]indole 21 Investigative 6539936 C29H30N2O2 438.6 CCCCC1=CC=C(C=C1)C(=O)N2CCC3=C(C2)N(C4=CC=CC=C34)CC5=CC=C(C=C5)O IC50 ~ 50000 nM Poor binder