TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53524	Platelet-derived growth factor receptor alpha	B0Z1FU	Chembl4238023	Investigative	141523094	C25H24N6O6	504.5	C1CN(CC1NC(=O)C2=NC=C(C=C2)C(=O)O)C3=NC4=C(COC4)C(=N3)NC5=CC6=C(C=C5)OCCO6	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B1E0HS	1-[4-(3-Methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-methylphenyl)urea	Investigative	136269119	C21H21N5O2	375.4	CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3CC(=O)NC4=NNC(=C34)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B4K5TJ	4-(3-((4-Hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide	Investigative	44541014	C26H21N3O5	455.5	CN1C=C(C2=C(C=CN=C21)C3=CC=C(C=C3)C(=O)NCCO)/C=C\\4/C(=O)C5=C(C=CC=C5O4)O	IC50 = 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B59SVD	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-ethylbenzo[de]isoquinoline-1,3-dione	Investigative	71741327	C20H26N4O2	354.4	CCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B5J8VH	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexadecylbenzo[de]isoquinoline-1,3-dione	Investigative	71741332	C34H54N4O2	550.8	CCCCCCCCCCCCCCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B5JX9Z	Chembl4246600	Investigative	141523058	C23H28N6O4	452.5	C1CCC(CC1)NC2=NC(=NC3=C2COC3)N4CCC(C4)NC(=O)C5=NC=C(C=C5)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B7SJ2I	1-(2-Fluoro-5-methylphenyl)-3-[4-(3-methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	136269138	C21H20FN5O2	393.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3CC(=O)NC4=NNC(=C34)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	B9G5NX	Chembl4250883	Investigative	141523067	C23H30N6O4	454.5	CCCCCCNC1=NC(=NC2=C1COC2)N3CCC(C3)NC(=O)C4=NC=C(C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BB20UV	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-methylbenzo[de]isoquinoline-1,3-dione	Investigative	71741204	C19H24N4O2	340.4	CN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BCI78A	Chembl4245985	Investigative	141523061	C24H24N6O4	460.5	CC1=CC=C(C=C1)NC2=NC(=NC3=C2COC3)N4CCC(C4)NC(=O)C5=NC=C(C=C5)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BE6WK1	2-Butyl-6-[2-[2-(dimethylamino)ethylamino]ethylamino]benzo[de]isoquinoline-1,3-dione	Investigative	71741328	C22H30N4O2	382.5	CCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BEL89A	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-octylbenzo[de]isoquinoline-1,3-dione	Investigative	45379956	C26H38N4O2	438.6	CCCCCCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BFK14D	1-Cyclohexyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137654848	C20H23N5O	349.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4CCCCC4	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BG2BL4	N-(1,3-Benzodioxol-5-ylmethyl)-4-pyrido[2,3]thieno[2,4-d]pyrimidin-4-ylpiperazine-1-carbothioamide	Investigative	11419895	C22H20N6O2S2	464.6	C1CN(CCN1C2=NC=NC3=C2SC4=C3C=CC=N4)C(=S)NCC5=CC6=C(C=C5)OCO6	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BH62NI	1-Benzyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137655849	C21H19N5O	357.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BI4K5Q	1-Ethyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137660584	C16H17N5O	295.34	CCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BIKV80	3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	44575073	C23H18FN3O2	387.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BJI19Q	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-propylurea	Investigative	137639044	C17H19N5O	309.4	CCCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BM0PQ7	Chembl4247042	Investigative	141523085	C22H28N6O4	440.5	CCCCCNC1=NC(=NC2=C1COC2)N3CCC(C3)NC(=O)C4=NC=C(C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BNH6Q2	1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	122705261	C18H21N7O2	367.4	CCOC(CN1C2=NC=NC(=C2C(=N1)C3=CN=C4C(=C3)C=CN4)N)OCC	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BO2IH0	Chembl4248043	Investigative	141523076	C25H26N6O4	474.5	CCC1=CC=C(C=C1)NC2=NC(=NC3=C2COC3)N4CCC(C4)NC(=O)C5=NC=C(C=C5)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BP34EV	Chembl4239846	Investigative	141523059	C21H26N6O5	442.5	COCCCNC1=NC(=NC2=C1COC2)N3CCC(C3)NC(=O)C4=NC=C(C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BQ1W5F	5-[4-Amino-1-(2,2-dimethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	127045861	C16H17N7O3	355.35	COC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OC	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BQ3OZ4	4-(6,7-Dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	Investigative	11353953	C27H27N9O4S2	605.7	COC1=C(C=C2C(=C1)C3=C(N2)N=CN=C3N4CCN(CC4)C(=S)NC5=CC=C(C=C5)S(=O)(=O)NC6=NC=CC=N6)OC	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BQO39K	4-(6,7-Dimethoxyquinazolin-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	Investigative	59020517	C25H26N8O4S2	566.7	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=S)NC4=CC=C(C=C4)S(=O)(=O)NC5=NC=CC=N5)OC	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BR9T3P	Chembl4242803	Investigative	141523069	C24H32N6O4	468.5	CCCCCCCNC1=NC(=NC2=C1COC2)N3CCC(C3)NC(=O)C4=NC=C(C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BT0V7B	5-[4-Amino-1-(1,3-dioxolan-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	127046862	C16H15N7O3	353.34	C1COC(O1)CN2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)OC(=N5)N)N	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BTR7F5	Chembl4243810	Investigative	141523091	C25H26N6O4	474.5	CC1=C(C=C(C=C1)NC2=NC(=NC3=C2COC3)N4CCC(C4)NC(=O)C5=NC=C(C=C5)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BVG3F6	4-Pyrido[2,3]thieno[2,4-d]pyrimidin-4-yl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	Investigative	59020502	C24H21N9O2S3	563.7	C1CN(CCN1C2=NC=NC3=C2SC4=C3C=CC=N4)C(=S)NC5=CC=C(C=C5)S(=O)(=O)NC6=NC=CC=N6	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BW14ZG	Chembl4250240	Investigative	145983151	C24H24N6O5	476.5	COC1=CC=C(C=C1)NC2=NC(=NC3=C2COC3)N4CCC(C4)NC(=O)C5=NC=C(C=C5)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BXB01F	5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	122163152	C18H21N7O3	383.4	CCOC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OCC	IC50 ~ 100000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BYL30S	Chembl4244068	Investigative	141523068	C22H28N6O5	456.5	CCOCCCNC1=NC(=NC2=C1COC2)N3CCC(C3)NC(=O)C4=NC=C(C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T53524	Platelet-derived growth factor receptor alpha	BZ57ML	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexylbenzo[de]isoquinoline-1,3-dione	Investigative	71741329	C24H34N4O2	410.6	CCCCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder