TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T50773	Dipeptidyl-peptidase 7	D02EYG	Linagliptin	Approved	10096344	C25H28N8O2	472.5	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0L3DK	Vildagliptin	Approved	6918537	C17H25N3O2	303.4	C1C[C@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0NJ5H	Alogliptin	Approved	11450633	C18H21N5O2	339.4	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0T8XB	Anagliptin	Approved	44513473	C19H25N7O2	383.4	CC1=NN2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N	IC50 = 176700 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 59830 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0M3XR	MK-3102	Phase 3	46209133	C17H20F2N4O3S	398.4	CS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 67000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D00FYF	NVP-DPP728	Discontinued in Phase 2	9796290	C15H18N6O	298.34	C1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N	IC50 = 110000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B01ZGN	(2-Cyclopentylidene-2-fluoroethyl)[3-(dimethylamino)propyl]amine	Investigative	23646087	C12H23FN2	214.32	CN(C)CCCNCC(=C1CCCC1)F	IC50 = 53700 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B02HGP	(R)-3-Amino-1-((S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444353	C17H17F6N5O	421.34	C[C@H]1C2=NC(=NN2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F	IC50 = 72000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B04DNO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-8-carboxamide	Investigative	71655627	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=NC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B05ITZ	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	49797350	C18H23F4N3O4	421.4	C[C@@H](C1=CC=C(C=C1)NC(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 70000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B09NLJ	(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3,4-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one	Investigative	23645945	C19H21F2N3O2	361.4	C1CC1C2=NC3=C(O2)CCN(C3)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0CQ9W	2-[(5-Cyanopyridin-2-yl)amino]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	73356495	C15H16N6O2	312.33	C1C[C@H](N(C1)C(=O)CNC(=O)CNC2=NC=C(C=C2)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0DKU3	(3R,4R)-1-(3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	23661718	C19H18F6N6O2	476.4	CC1=NN=C2N1N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 = 74000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0EF5R	N-(1-Napthalenecarbonyl)-Gly-boroPro	Investigative	15951636	C17H19BN2O4	326.2	B([C@@H]1CCCN1C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)(O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0FSW7	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11584650	C25H27F4N5O4	537.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C=CN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0IT9D	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamide	Investigative	71667227	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2N=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0IVO8	Cyclohexyl-(2-pyrrolidino-ethyl)-amine	Investigative	43181622	C12H24N2	196.33	C1CCC(CC1)NCCN2CCCC2	IC50 = 136000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0JN3R	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)acetamide	Investigative	53326713	C20H27F5N2O	406.4	CC(=O)N(CCCC(F)(F)F)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 51000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0KAV6	(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one	Investigative	23647117	C19H25F2N3O2	365.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N)C3CC3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0KFM1	US9346814, Ref. Cmpd No 5	Investigative	78140030	C16H16N4O2	296.32	C1CC(N(C1)C(=O)CNC(=O)C2=CNC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0M5SP	(3R)-3-Amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263683	C17H18ClF6N5O	457.8	C[C@H]1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 74000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0V4GL	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11628195	C25H28F4N6O4	552.5	CC1=NN2C=C(C=CC2=N1)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0WBO6	(3r)-4-[(3r)-3-Amino-4-(2,4,5-Trifluorophenyl)butanoyl]-3-(2,2,2-Trifluoroethyl)-1,4-Diazepan-2-One	Investigative	11592154	C17H19F6N3O2	411.34	C1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC(F)(F)F	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B0YFZ2	1-((2S,4S)-2-(5-Tert-butyl-1,2,4-oxadiazole-3-carbonyl)-4-fluoropyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone	Investigative	44432859	C17H27FN4O4	370.4	CC(C)(C)C1=NC(=NO1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CNC(C)(C)CO)F	IC50 = 70100 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B12BGJ	(2R,3S,5R)-2-(2-Chloro-5-fluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73349220	C16H18ClFN4O	336.79	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)Cl)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B12RTM	2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)ethanone	Investigative	11068388	C18H21N2O4P	360.3	C1CC(N(C1)C(=O)CN)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 = 79000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B16QZU	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797006	C24H27F4N3O5	513.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCOCC3)N.C(=O)(C(F)(F)F)O	IC50 = 77000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B17YAU	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid	Investigative	53353383	C28H33F3N4O6	578.6	C[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1AS7D	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione;hydrochloride	Investigative	56671898	C22H33ClN4O2	421	C1CCN(CC1)C2CCN(CC2)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1B6OU	(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916388	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1BC8W	N-[2-[(2S,4R)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655560	C17H15FN4O2	326.32	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1BN9D	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamide	Investigative	71655625	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=NC3=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1FN5T	1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-	Investigative	10821833	C11H22N2O	198.31	CC[C@H](C)[C@@H](C(=O)N1CCCCC1)N	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1K9VQ	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11526865	C25H28F4N6O4	552.5	CC1=CC(=CN2C1=NC=N2)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1M7LE	(3R,4R)-1-Pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797240	C20H17F6N5O2	473.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CN=C4C=CC=NC4=N3.C(=O)(C(F)(F)F)O	IC50 = 58000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1O7FB	(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797028	C24H26F5N3O4	515.5	CCNC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1QB0E	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693954	C18H16N6O2	348.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1T8CU	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamide	Investigative	90655558	C20H17FN6O2	392.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)N=C(N3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1V6ZI	N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655559	C17H15FN4O2	326.32	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1W3SJ	6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667230	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1W7KO	(2S)-1-(2-Benzamidoacetyl)-N-tert-butylpyrrolidine-2-carboxamide	Investigative	70689751	C18H25N3O3	331.4	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1WXH8	1-[(2S,4S)-4-(4-Cyclopropyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71451939	C24H31N5O2	421.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5CC5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1WY8G	Benzamide, N-(2-oxo-2-(1-pyrrolidinyl)ethyl)-	Investigative	56877	C13H16N2O2	232.28	C1CCN(C1)C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B1X8PE	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797024	C24H26F5N3O5	531.5	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)NCCO)N.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B20ICK	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797110	C23H27F4N3O5	501.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2CO)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B21XNZ	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylacetamide	Investigative	53320181	C18H26F2N2O	324.4	CCN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B23QVT	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-pyridin-4-ylacetamide	Investigative	89705045	C14H16N4O2	272.3	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B28BIY	2-Amino-1-(3-fluoro-pyrrolidin-1-yl)-3-methyl-pentan-1-one	Investigative	44364126	C10H19FN2O	202.27	CCC(C)C(C(=O)N1CCC(C1)F)N	IC50 = 111000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B28IXO	2,2-Bis(4-chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70693949	C21H19Cl2N3O2	416.3	C1C[C@H](N(C1)C(=O)CNC(=O)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B28JTM	(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile	Investigative	46916435	C20H20ClFN4O3	418.8	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2BF5P	2-Amino-1-piperidin-1-yl-butan-1-one	Investigative	12742483	C9H18N2O	170.25	CCC(C(=O)N1CCCCC1)N	IC50 = 88700 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2CZ9O	(2R,3S,5R)-5-(1-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209246	C19H22F2N4O3S	424.5	C1CC1S(=O)(=O)N2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N)C=N2	IC50 = 88000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2DUJ8	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(3-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate	Investigative	45266136	C29H30F4N4O4	574.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)[N+]3=CC=CC=C3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)[O-]	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2EIL4	3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxylic acid	Investigative	53318866	C20H28F2N2O2	366.4	C1CC(CC(C1)N2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)O	IC50 = 85000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2GN3Q	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(3-methylbutyl)quinoline-4-carboxamide	Investigative	90655544	C22H26N4O2	378.5	CC(C)CCN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2GP8T	(3R)-3-Amino-1-(2-cyclopropyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443736	C21H25F3N4O	406.4	CC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C4CC4)C	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2LBR3	(2S,3R)-2-Amino-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127045827	C13H19F3N4O3	336.31	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)NN=C2)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2LX9S	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethyl)-4,6-dihydro-1H-pyrrolo[3,4-d]imidazol-5-yl]oxan-3-amine	Investigative	73355286	C17H17F5N4O	388.33	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)N=C(N4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2M8CF	(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916345	C23H25ClN4O3	440.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC(=CC3)C4=CC=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2N3MR	2,6-Diamino-1-azetidin-1-yl-hexan-1-one	Investigative	44364211	C9H19N3O	185.27	C1CN(C1)C(=O)C(CCCCN)N	IC50 = 159000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2NSL8	Fluoro-Olefin Analogue 10	Investigative	23646089	C18H28FN	277.4	C1CCC(=C(CNC23CC4CC(C2)CC(C4)C3)F)CC1	IC50 = 91300 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2SV1U	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127046626	C29H30F5N5O4S	639.6	CC1=NC2=C(S1)CN(C2)C(=O)[C@H](CC(=O)N3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2UKR4	US9346814, Cmpd No 29 Example 34	Investigative	89712285	C15H15N5O2	297.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=NC=CC23)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2VIJ5	N-[2-[(2S)-2-Cyano-4-ethylpyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691905	C20H21N3O2	335.4	CCC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2W8VT	(2s)-1-[1-(4-Phenylbutanoyl)-L-Prolyl]pyrrolidine-2-Carbonitrile	Investigative	11198569	C20H25N3O2	339.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2WD4Q	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(4-fluorophenyl)-1-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443719	C23H23F3N4O	428.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C4=CC=C(C=C4)F	IC50 = 58000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2WJM8	(2S)-1-(2-{[2-Oxo-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11695535	C18H22N4O2	326.4	C1C[C@H](N(C1)C(=O)CNCC(=O)N2CCC3=CC=CC=C3C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2XOS3	8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667376	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=C(C3=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2Y9VJ	1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	22029894	C21H24N6O2	392.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B2YIT4	(R)-3-Amino-4-(2,5-difluoro-phenyl)-1-[3-(4-fluoro-benzyl)-2-trifluoromethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-butan-1-one	Investigative	44443715	C24H22F6N4O	496.4	C1CN(CC2=C1N=C(N2CC3=CC=C(C=C3)F)C(F)(F)F)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 = 56000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B34ZJO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylbenzamide	Investigative	70681357	C20H19N3O2	333.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC(=C2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B35VON	(2S,3As,6aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712788	C18H20F3N3O	351.4	C1C[C@H]2C[C@H](N([C@H]2C1)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C#N	IC50 = 71680 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B37HXI	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-4-carboxamide	Investigative	71655624	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CN=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B38SRY	US9051329, Example 5	Investigative	71203758	C17H21N7O2	355.4	CC#CCN1C2=C(N=C3N(C(=O)CN3C2=O)C)N=C1N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3AS4R	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid	Investigative	11591936	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NC3=CC=NN3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 = 63000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3C0AY	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796990	C22H21F5N2O5	488.4	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)O)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3C6RZ	3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-methyl-1-phenylethyl)propionamide	Investigative	11702902	C19H26N4O2	342.4	CC(C)(C1=CC=CC=C1)NC(=O)CCNCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3CG1Q	(2S)-1-[2-(4-Naphthalen-1-yltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile	Investigative	90655551	C19H17N5O	331.4	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=CC4=CC=CC=C43)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3DI8L	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-oxazole-5-carboxamide	Investigative	71667510	C12H14N4O3	262.26	CC1=C(OC=N1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3ERG1	Tert-butyl N-[[1-[(3R,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71460901	C27H38N6O4	510.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3F5EW	Benzyl (2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71450087	C25H27N5O3	445.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3F8SY	(2S)-1-(2-{[3-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11581247	C19H23FN4O2	358.4	C1C[C@H](N(C1)C(=O)CNCCC(=O)N2CCC3=C(C2)C=CC(=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3GC9X	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-phenylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797058	C16H20F4N2O3	364.33	C[C@@H](C1=CC=CC=C1)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3GTS2	trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-ol	Investigative	53322820	C19H28F2N2O	338.4	C1C[C@H](CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3LEO0	(3R,4R)-1-Pyrazino[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797242	C19H16F6N6O2	474.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NC=CN=C4N=C3.C(=O)(C(F)(F)F)O	IC50 = 93000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3M1PO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide	Investigative	71655557	C24H22N4O3	414.5	COC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3MVY5	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]pyridine-4-carboxamide	Investigative	127035740	C22H22F2N6O2	440.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NC(=O)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3OJ9A	(R)-3-Amino-1-(2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	9953181	C16H15F6N5O	407.31	C1CN2C(=NC(=N2)C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 54000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3TG9P	(2S,3R)-2-Amino-3-methyl-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)pentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127046628	C14H20F3N3O3S	367.39	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)SC(=N2)C)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3UMC6	(1R)-2-[2-(1-Adamantylamino)acetyl]cyclopentane-1-carbonitrile	Investigative	11346707	C18H26N2O	286.4	C1C[C@H](C(C1)C(=O)CNC23CC4CC(C2)CC(C4)C3)C#N	IC50 = 133500 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3W0YL	(2S,4S)-1-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	118712775	C15H15F4N3O	329.29	C1[C@@H](CN([C@@H]1C#N)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)F	IC50 = 50620 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3WXE4	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189877	C25H28N8O4	504.5	CC(=CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3XG5Y	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-propan-2-ylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035753	C19H24F2N4O3S	426.5	CC(C)S(=O)(=O)C1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B3ZRL2	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochloride	Investigative	11576569	C22H25ClF2N6O2	478.9	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B45OBY	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylmethanesulfonamide	Investigative	53321487	C17H26F2N2O2S	360.5	CCN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C	IC50 = 68000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B46LRO	(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916343	C22H26FN5O3	427.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B46ZFN	(2S)-2-Amino-4-[4-[(2-chloro-6-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56658021	C25H27ClF4N4O4	559	C1CN(CCN1CC2=C(C=CC=C2Cl)F)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4AS3C	(2S,3S)-3-Amino-2-[4-(3-cyanophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797013	C25H26F4N4O4	522.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=CC(=C2)C#N)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4C7UW	4-Phenyl-1-[(2S,4S)-4-[4-(piperazin-1-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71453723	C26H37N7O2	479.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)CN5CCNCC5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4E9DC	(2S,3S)-2-(4-Acetamidophenyl)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797349	C20H26F4N4O5	478.4	CC(=O)NC1=CC=C(C=C1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4G6QZ	2-[(2H-1,3-Benzodioxol-5-ylmethyl)amino]-1-(pyrrolidin-1-yl)ethan-1-one	Investigative	11277009	C14H18N2O3	262.3	C1CCN(C1)C(=O)CNCC2=CC3=C(C=C2)OCO3	IC50 = 63000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4G7MW	(2R,3S,5R)-2-(2,4-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73350799	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=C(C=C2)F)F)N3CC4=C(C3)NN=C4	IC50 = 70000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4GUY6	(3R,4R)-1-Pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797225	C18H17F6N3O2	421.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CN=CC=C3.C(=O)(C(F)(F)F)O	IC50 = 82000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4GWA5	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(3-methylidenepyrrolidin-1-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127047734	C30H32F8N4O6	696.6	C=C1CCN(C1)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4I9KH	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]ethanesulfonamide	Investigative	127035742	C18H23F2N5O3S	427.5	CCS(=O)(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4JER3	cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine	Investigative	53321497	C19H28F2N2	322.4	C1CCN(CC1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 77000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4LN3G	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-oxo-1H-quinoline-4-carboxamide	Investigative	73354936	C17H16N4O3	324.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=O)NC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4M9AQ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamide	Investigative	71667231	C18H15F3N4O3	392.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OC(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4MH8I	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797252	C19H15F9N6O2	530.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C(=NN=C4C(F)(F)F)C=C3.C(=O)(C(F)(F)F)O	IC50 = 96000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4SQ3V	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-phenylpyridine-4-carboxamide	Investigative	89705195	C19H18N4O2	334.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4T6IR	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-3-hydroxyquinoline-4-carboxamide	Investigative	73347360	C17H16N4O3	324.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C(C=NC3=CC=CC=C32)O)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4UD2V	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-yloxyacetamide	Investigative	73350450	C19H19N3O3	337.4	C1C[C@H](N(C1)C(=O)CNC(=O)COC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4US5K	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1H-pyrazole-4-sulfonamide	Investigative	53325446	C19H26F2N4O2S	412.5	CC1=C(C=NN1)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4UZI7	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797230	C19H16F9N3O2	489.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=C(C=CC=N3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B4WF7G	(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560554	C14H19N5O	273.33	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)N=[N+]=[N-])N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B50ABY	(3R)-3-Amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45266006	C17H18ClF6N5O	457.8	C[C@@H]1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B54CZS	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(1H-imidazol-5-yl)acetamide	Investigative	89705179	C12H15N5O2	261.279	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CN=CN2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B56PFV	(2R,3R)-7-Ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797612	C21H19F6N3O4S	523.5	CCS(=O)(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B58LGR	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354470	C29H35F3N4O6	592.6	CC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5HV8B	2-Amino-1-(2,3-dihydro-1H-isoindol-2-yl)-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)butane-1,4-dione	Investigative	23646033	C23H27N3O4	409.5	COC1=C(C=C2CN(CCC2=C1)C(=O)CC(C(=O)N3CC4=CC=CC=C4C3)N)OC	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5I7BM	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzenesulfonamide	Investigative	70693950	C14H17N3O4S	323.37	COC1=CC(=CC=C1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5JE4R	N-[2-[(2S)-2-Cyano-4-methylpyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70693955	C15H17N3O2	271.31	CC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5L6RD	2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole	Investigative	10383508	C20H26N4O2	354.4	CC(C)(CC(=O)N1CC2=CC=CC=C2C1)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5N9OF	2,6-Diamino-1-azepan-1-yl-hexan-1-one	Investigative	44364212	C12H25N3O	227.35	C1CCCN(CC1)C(=O)C(CCCCN)N	IC50 = 51900 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5NO1K	(2S)-1-[2-[Methyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655546	C18H20N4O	308.4	CN(CC1=CC=NC2=CC=CC=C12)CC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5P4GW	N-(2-Cyclopentylideneethyl)cyclohexanamine	Investigative	23646101	C13H23N	193.33	C1CCC(CC1)NCC=C2CCCC2	IC50 = 62000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5SVJ0	(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11540951	C23H24F4N6O4	524.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC(C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5TW8V	(S)-2-Amino-2-((1S,3R)-3-methoxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44382006	C13H24N2O2	240.34	CO[C@@H]1CCC[C@@H](C1)[C@@H](C(=O)N2CCCC2)N	IC50 = 62000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5US6T	(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	52946866	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2CC(C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5VGF4	(2S,3S)-3-Amino-2-[4-(benzenesulfonamido)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797344	C24H28F4N4O6S	576.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 80000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5X6QY	Benzyl (2S,4S)-4-[4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71455494	C25H34N6O5	498.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)OCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5XOQ9	N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide	Investigative	89705076	C18H18N4O3	338.4	C1C[C@H](N(C1)C(=O)[C@@H](CO)NC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5XTY4	2-(Cyclohexylamino)-1-cyclopentylethanethione	Investigative	44387755	C13H23NS	225.4	C1CCC(CC1)NCC(=S)C2CCCC2	IC50 = 92000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B5YM8H	US9346814, Cmpd No 27 Example 32	Investigative	129010652	C18H18N4O2	322.4	CC1=CC2=NC=CC(=C2C=C1)C(=O)NCC(=O)N3CCC[C@H]3[N+]#[C-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B60QKI	4-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-4-oxobutanamide	Investigative	70685559	C28H31F2N5O3	523.6	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B62DJY	1-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56668673	C31H30F5N3O4	603.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CCC(=O)N4CC5=CC=CC=C5C4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B62MNH	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-thiophen-2-ylacetamide	Investigative	70685557	C13H15N3O2S	277.34	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=CS2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B62XNL	(2S)-1-[(2S,4S)-4-[2-(5,7-Dihydro-4H-thieno[2,3-c]pyridin-6-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938706	C19H22N4O3S	386.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=C(C3)SC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B63GSY	(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one	Investigative	44560397	C15H22N2O	246.35	CC[C@H](C)[C@@H](C(=O)N1CC2=CC=CC(=C2C1)C)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B65YCI	(R)-2-(2,5-Difluorophenyl)-1-(1-(methylsulfonyl)piperidin-4-yl)ethanamine	Investigative	53324155	C14H20F2N2O2S	318.38	CS(=O)(=O)N1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 65000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B67CVZ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanamide	Investigative	70693952	C22H28FN5O3	429.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B67QTG	(3R)-3-Amino-1-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263686	C18H17ClF9N5O	525.8	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC(F)(F)F.Cl	IC50 = 60000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B68GQS	(R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2,4,5-trifluoro-phenyl)-butan-1-one	Investigative	44394073	C21H24F3N3O	391.4	C1CN([C@@H](CN1)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 78000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B69UWH	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(1-methylimidazol-4-yl)sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine	Investigative	127035243	C20H22F2N6O3S	464.5	CN1C=C(N=C1)S(=O)(=O)N2C=C3CN(CC3=N2)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 61000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6EPR5	(2S)-1-[(2S,4S)-5-Oxo-4-[2-oxo-2-[2-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]ethyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916384	C19H21F3N6O3	438.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C=C(N=C4C3)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6GZM1	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-2-yloxyacetamide	Investigative	73350449	C19H19N3O3	337.4	C1C[C@H](N(C1)C(=O)CNC(=O)COC2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6H4NF	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797008	C23H24F5N3O4	501.4	CNC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6HGC1	(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile	Investigative	46917048	C20H20F2N4O3	402.4	C1[C@H](C(=O)N[C@@H]1C(=O)N2CC(C[C@H]2C#N)(F)F)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6IGR3	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-sulfonamide	Investigative	51346970	C20H27F2N3O3S	427.5	CC1=C(C(=NO1)C)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 63000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6L7QG	CID 44123747	Investigative	44123747	C22H25FN6O2	424.5	C[C@]1(CCCN(C1)C2=CC3=C(N2CC4=C(C=CC(=C4)F)C#N)C(=O)N(C(=O)N3C)C)N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6R8UY	(2R,3R)-8-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797631	C20H17F6N3O4S	509.4	CS(=O)(=O)C1=CC2=C(C=C1)N=C3N2C[C@@H]([C@H](C3)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6TEO4	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-sulfonamide	Investigative	73353425	C17H17N3O3S	343.4	C1C[C@H](N(C1)C(=O)CNS(=O)(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B6U5FD	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(5S)-3-oxo-5-(hydroxymethyl)piperazino]xanthine	Investigative	101887273	C25H26N8O4	502.5	CC#CCN1C2=C(N=C1N3C[C@H](NC(=O)C3)CO)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B70EMU	(S)-1-(2-(2-Tert-butyl-1,3,4-oxadiazole-5-carbonyl)pyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone	Investigative	44432942	C17H28N4O4	352.4	CC(C)(C)C1=NN=C(O1)C(=O)[C@@H]2CCCN2C(=O)CNC(C)(C)CO	IC50 = 60000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B70NZC	2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-propan-1-one	Investigative	44328126	C13H18N2O2	234.29	C1CCN(C1)C(=O)C(CC2=CC=C(C=C2)O)N	IC50 = 150000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B70OPQ	3-Methyl-1-oxo-1-piperidin-1-ylpentan-2-aminium	Investigative	24692381	C11H22N2O	198.31	CCC(C)C(C(=O)N1CCCCC1)N	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B70SUP	7-But-2-ynyl-3-methyl-1-[(5-methyl-2-phenyltriazol-4-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189870	C24H27N9O2	473.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NN(N=C4C)C5=CC=CC=C5)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B71MKZ	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide	Investigative	71655554	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B72UBN	US9051329, Example 2	Investigative	71203783	C21H22N8O2	418.5	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B75EWK	7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione	Investigative	122189871	C23H25N9O2	459.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=NC=N5)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B76RDZ	N-[2-[(2S)-2-(2-Chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655562	C18H18ClN3O3	359.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C(=O)CCl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B78ELA	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one	Investigative	23647119	C18H24F3N3O3	387.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CCO	IC50 = 78000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7BHD4	1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-	Investigative	9796352	C10H20N2O	184.28	CC[C@H](C)[C@@H](C(=O)N1CCCC1)N	IC50 = 110000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7DV5T	(3R)-3-Amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265953	C18H20ClF6N5O	471.8	CCC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7GCH2	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-ethyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443711	C19H21F5N4O	416.4	CCN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 76000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7JV8T	2-(3,4-Difluorophenyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	23646029	C15H13F2N	245.27	C1CN(CC2=CC=CC=C21)C3=CC(=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7JY1F	(2S)-1-(2-{[3-(2,3-Dihydro-1H-isoindol-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11573417	C18H22N4O2	326.4	C1C[C@H](N(C1)C(=O)CNCCC(=O)N2CC3=CC=CC=C3C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7O6VW	7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione	Investigative	122189865	C22H22N6O3	418.4	CCOC1=NC2=C(N1CC#CC)C(=O)N(C(=O)N2C)CC3=NC4=CC=CC=C4C(=N3)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7R3FX	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methylquinoline-4-carboxamide	Investigative	89705096	C18H18N4O2	322.4	CC1=C2C(=CC=NC2=CC=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7R6DT	4-Phenyl-1-[(2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71451900	C27H31N5O2	457.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7VEZ3	1-[(2S,4S)-4-[4-[(Dimethylamino)methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71462597	C24H34N6O2	438.6	CN(C)CC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7VOK6	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one	Investigative	23646451	C21H23F3N4O2	420.4	C1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC3=CC=CC=N3	IC50 = 89000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7XHO5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(2-methoxyethyl)quinoline-4-carboxamide	Investigative	90655543	C20H22N4O3	366.4	COCCN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7Z1KR	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpivalamide	Investigative	53326706	C20H30F2N2O	352.5	CC(C)(C)C(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 81000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7ZKD1	2-[(2H-1,3-Benzodioxol-5-ylmethyl)amino]-1-(piperidin-1-yl)ethan-1-one	Investigative	10084828	C15H20N2O3	276.33	C1CCN(CC1)C(=O)CNCC2=CC3=C(C=C2)OCO3	IC50 = 52000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B7ZO4N	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70691903	C14H14N6O2	298.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC=C2)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B80DMZ	(3R,4R)-1-Pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797233	C17H16F6N4O2	422.32	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=CC=N3.C(=O)(C(F)(F)F)O	IC50 = 54000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B83VCM	N-(N-(Phenyl)butyryl-L-prolyl)pyrrolidine	Investigative	3081017	C19H26N2O2	314.4	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B83YZH	(R)-1-(2-(Quinoline-4-carboxamido)acetyl)pyrrolidin-2-ylboronic acid	Investigative	89705109	C16H18BN3O4	327.1	B([C@@H]1CCCN1C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)(O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B84UYE	(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide	Investigative	71621488	C17H14F2N4O2	344.31	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B85INZ	CID 89705098	Investigative	89705098	C13H13N7O2	299.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=NC=NN23)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B89OCN	(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916433	C21H21F3N4O3	434.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B89PFI	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(1,1,2,2,2-pentafluoroethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645927	C19H19F7N4O	452.4	CN1C(=C2CN(CCC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(C(F)(F)F)(F)F	IC50 = 92000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8ADP0	2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70693951	C26H29F2N5O2	481.5	C1C[C@H](N(C1)C(=O)CNC(=O)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8BJ7Z	Fluoro-Olefin Analogue 11	Investigative	23646090	C14H18FN	219.3	C1CCC(=C(CNC2=CC=CC=C2)F)CC1	IC50 = 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8C1GN	(2S,3S)-3-Amino-4-(1,1-dioxo-1,3-thiazolidin-3-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797029	C23H25F4N3O6S	547.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCS(=O)(=O)C3)N.C(=O)(C(F)(F)F)O	IC50 = 75000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8CN3T	(2S)-1-(2-{[4-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11545508	C21H27FN4O2	386.5	CC(C)(CC(=O)N1CCC2=C(C1)C=CC(=C2)F)NCC(=O)N3CCC[C@H]3C#N	IC50 = 50146 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8EB0N	1-[(2S,4S)-4-[4-(2,4-Difluorophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71451901	C27H29F2N5O2	493.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=C(C=C(C=C5)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8GN5O	(3R)-3-Amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263674	C24H21ClF9N5O	601.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4C(F)(F)F.Cl	IC50 = 83000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8IRZ9	(3R)-3-Amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263688	C19H20ClF6N5O	483.8	C=CCC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 = 62000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8NRQ4	1-[(2S,4S)-4-(4-Cyclohexyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71453762	C27H37N5O2	463.6	C1CCC(CC1)C2=CN(N=N2)[C@H]3C[C@H](N(C3)C(=O)CCCC4=CC=CC=C4)C(=O)N5CCCC5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8RXS7	5-Cyano-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655563	C18H13F2N5O2	369.3	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC(=C23)C#N)C#N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8S4DO	(2R,3S,5R)-5-(2-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209244	C21H26F2N4O3S	452.5	C1CCC(C1)S(=O)(=O)N2C=C3CN(CC3=N2)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 56000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8V3WD	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645918	C17H17F5N4O	388.33	C1CN(CC2=C1NN=C2C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 71000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8VQU9	(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4,3-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one	Investigative	23645944	C19H21F2N3O2	361.4	C1CC1C2=NC3=C(O2)CN(CC3)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 = 56000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8Y3OT	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanesulfonamide	Investigative	127035744	C19H23F2N5O3S	439.5	C1CC1S(=O)(=O)NC2=NNC3=C2CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8Y6QH	(3R)-3-Amino-1-(1-methyl-4-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443727	C18H18F6N4O	420.4	CN1C=NC2=C1CCN(C2C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 76000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B8ZLX7	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride	Investigative	11418876	C16H17ClF5N5O	425.78	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B90STW	(2S,3S)-3-Amino-N-cyclopropyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797023	C25H26F5N3O4	527.5	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)NC4CC4)N.C(=O)(C(F)(F)F)O	IC50 = 55000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B90XAK	(2R,3S,5R)-5-(1-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	89488720	C21H26F2N4O3S	452.5	C1CCC(C1)S(=O)(=O)N2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N)C=N2	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B91XGN	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189875	C14H16N6O3	316.32	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B92INU	(2S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]propan-1-one;2,2,2-trifluoroacetic acid	Investigative	49796973	C21H21F5N2O3	444.4	C1CN(C[C@H]1F)C(=O)[C@H](CC2=CC=C(C=C2)C3=CC=C(C=C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B93QUX	Tert-butyl N-[[1-[(3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]-1-(4-phenylbutanoyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71457236	C28H37N7O4	535.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B94LTU	(2S)-1-[2-[2-Methoxyethyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655545	C20H24N4O2	352.4	COCCN(CC1=CC=NC2=CC=CC=C12)CC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B95THZ	(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56664958	C31H32ClF3N4O4	617.1	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B97IYO	(3S)-2-[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile	Investigative	44390794	C21H20N4O	344.4	C1[C@H](N(CC2=CC=CC=C21)C(=O)[C@H](CC3=CNC4=CC=CC=C43)N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B98DCM	(2R,3R)-2-Amino-N,N-dimethyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49797599	C22H20F6N4O3	502.4	CN(C)C(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 98000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B98KFX	(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanone	Investigative	23646031	C12H22N2O	210.32	C1CCC(CC1)[C@@H](C(=O)N2CCCC2)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9A2LO	trans-4-((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)-4-oxobutanoic acid	Investigative	53324144	C19H26F2N2O3	368.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9AE7Y	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354369	C31H39F3N4O6	620.7	CCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9CJ4F	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(3-methylsulfonylphenyl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797039	C25H29F4N3O6S	575.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)S(=O)(=O)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 81000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9EJH2	3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-phenylpropyl)propionamide	Investigative	11580945	C19H26N4O2	342.4	CCC(C1=CC=CC=C1)NC(=O)CCNCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9F6DL	(1R,2S,5S)-3-[(2S,3R)-2-Amino-3-methylpentanoyl]-3-azabicyclo[3.1.0]hexane-2-carbonitrile;2,2,2-trifluoroacetic acid	Investigative	127046632	C14H20F3N3O3	335.32	CC[C@@H](C)[C@@H](C(=O)N1C[C@H]2C[C@H]2[C@H]1C#N)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9FH4L	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443709	C18H19F5N4O	402.4	CN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 80000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9FUR8	2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide	Investigative	46916346	C18H20N4O3	340.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)NC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9HI5Y	Benzyl (2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71460903	C24H26N6O3	446.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=N5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9I4LK	(2S,3R)-2-Amino-3-methyl-1-(3-methylidenepyrrolidin-1-yl)pentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127046590	C13H21F3N2O3	310.31	CC[C@@H](C)[C@@H](C(=O)N1CCC(=C)C1)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9JG6X	2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-one	Investigative	447256	C9H18N2O	170.25	CC(C)[C@@H](C(=O)N1CCCC1)N	IC50 = 153000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9JP6T	2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-3H-isoindol-1-one	Investigative	73347698	C19H18F2N2O2	344.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9KAW6	US9346814, Ref. Cmpd No 4	Investigative	129010653	C16H16N4O2	296.32	C1CC(N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9NY2Z	(2S,3S)-2-Amino-N-cyclopentyl-3-methylpentanamide	Investigative	10821834	C11H22N2O	198.31	CC[C@H](C)[C@@H](C(=O)NC1CCCC1)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9OZE8	3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	47370344	C11H14N6O3	278.27	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9QBJ7	8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667375	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=C(C3=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9QW0J	(S)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11309656	C7H14N2O2	158.2	C1CCN(C1)C(=O)[C@H](CO)N	IC50 = 65000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9QY7C	(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)propan-1-one	Investigative	11037548	C22H25N4O4P	440.4	C1CC(N(C1)C(=O)[C@H](CC2=CN=CN2)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 60000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9SH1O	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-phenylquinoline-4-carboxamide	Investigative	89705273	C23H20N4O2	384.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)C4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9WR4C	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-thiazole-5-carboxamide	Investigative	71667381	C12H14N4O2S	278.33	CC1=C(SC=N1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	B9Y6PH	Tert-butyl N-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71457237	C27H38N6O4	510.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA10GO	(2S)-1-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-methylamino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655547	C15H21N5O2	303.36	CN(CC(=O)N1CCC[C@H]1C#N)CC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA27WY	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-c][1,2]oxazol-5-yl]butan-1-one	Investigative	23645931	C17H16F5N3O2	389.32	C1CN(CC2=C(ON=C21)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 54000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA6CS8	N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide	Investigative	15951642	C14H15N3O2	257.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA6RE2	2,6-Dichloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70687705	C14H13Cl2N3O2	326.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C(C=CC=C2Cl)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA8GF2	2-{(R)-4-[(R)-3-Amino-4-(2-fluoro-phenyl)-butyryl]-3-benzyl-piperazin-1-yl}-acetamide	Investigative	10304855	C23H29FN4O2	412.5	C1CN([C@@H](CN1CC(=O)N)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 = 66000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA93PR	N-[2-[(2S,4S)-2-Cyano-4-(trifluoromethyl)pyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691906	C19H16F3N3O2	375.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BA9RN4	(2S,3S)-2-Amino-3-methyl-1-(5-nitroisoindolin-2-yl)pentan-1-one	Investigative	44560553	C14H19N3O3	277.32	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)[N+](=O)[O-])N	IC50 = 66000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAE30K	(3S)-3-Amino-4-(2-diphenoxyphosphorylpyrrolidin-1-yl)-4-oxo-butanamide	Investigative	10982631	C20H24N3O5P	417.4	C1CC(N(C1)C(=O)[C@H](CC(=O)N)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAGB25	(3R)-3-Amino-N-[1,1-dioxo-4-(1,3-thiazol-2-yl)thian-4-yl]-4-(2-fluorophenyl)butanamide	Investigative	44589935	C18H22FN3O3S2	411.5	C1CS(=O)(=O)CCC1(C2=NC=CS2)NC(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 = 85200 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAJ0Z7	(2S,4S)-1-[(2S)-2-Amino-3-(2-cyanophenyl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	72697498	C15H15FN4O	286.3	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@H](CC2=CC=CC=C2C#N)N)F	IC50 = 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAS40I	(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one	Investigative	44560555	C13H19N3O	233.31	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)N=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAV26G	1-(Quinoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887277	C24H25N7O2	443.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C=C4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BAX50B	(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one	Investigative	23647114	C18H25F2N3O2	353.4	CCN1CCCN([C@@H](C1=O)C)C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB02TU	Benzoic acid 1-(2-amino-3-methyl-pentanoyl)-pyrrolidin-3-yl ester	Investigative	44364446	C17H24N2O3	304.4	CCC(C)C(C(=O)N1CCC(C1)OC(=O)C2=CC=CC=C2)N	IC50 = 158000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB0E9I	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-isobutyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443713	C21H25F5N4O	444.4	CC(C)CN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 85000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB3P5E	(3R,4R)-1-Pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797241	C19H16F6N6O2	474.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NC=NC=C4N=C3.C(=O)(C(F)(F)F)O	IC50 = 87000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB6LD1	(R)-2,4-Diamino-1-piperidin-1-yl-butan-1-one	Investigative	10058240	C9H19N3O	185.27	C1CCN(CC1)C(=O)[C@@H](CCN)N	IC50 = 130000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB7XV5	(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one	Investigative	46916387	C18H21N3O3S	359.4	C1CSCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB8P1W	2-(1,3-Benzodioxol-5-ylmethylamino)-1-cyclopentylethanethione	Investigative	44387765	C15H19NO2S	277.4	C1CCC(C1)C(=S)CNCC2=CC3=C(C=C2)OCO3	IC50 = 67000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BB9AT8	7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189864	C19H23N7O3S	429.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CSC(=N4)CO)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBA72Y	(2S)-1-[(2R)-1-(4-Phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	70685696	C20H25N3O2	339.4	C1C[C@H](N(C1)C(=O)[C@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBL8H4	(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188904	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBQ08T	(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431316	C19H20F6N4	418.4	C1CC([C@H](C[C@H]1N2CCN3C(=NC=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBT45Y	(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11389441	C7H14N2O	142.2	C[C@@H](C(=O)N1CCCC1)N	IC50 = 179000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBU16R	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine	Investigative	101887274	C24H26N8O3	474.5	CC#CCN1C2=C(N=C1NCCNC(=O)C)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBZ0Y3	4-Phenyl-1-[(2S,4R)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71455456	C27H31N5O2	457.6	C1CCN(C1)C(=O)[C@@H]2C[C@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BBZ48I	(3R)-3-Amino-1-[8-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263677	C25H20ClF12N5O	669.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC0L9S	(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide	Investigative	44590696	C22H27FN6O2	426.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(C=C2)N=CN3)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC0LG5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[(2,2,2-trifluoroacetyl)amino]benzamide	Investigative	90655557	C16H15F3N4O3	368.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)NC(=O)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC0PO2	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-3-oxopiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;dihydrochloride	Investigative	90664693	C29H30Cl2F2N4O3	591.5	C1CN(C(=O)CN1C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC2LJ5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylimidazole-4-carboxamide	Investigative	89705223	C12H15N5O2	261.279	CN1C=NC=C1C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC35UT	(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916385	C16H22N4O3	318.37	C1CCN(C1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC3O6M	2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile	Investigative	122189869	C28H27N7O2	493.6	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)C5=CC=CC=C5C#N)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC8U5R	2-(Cyclohexylamino)-1-(piperidin-1-yl)ethan-1-one	Investigative	10242745	C13H24N2O	224.34	C1CCC(CC1)NCC(=O)N2CCCCC2	IC50 = 177000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC9O7A	(3R,6S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one	Investigative	23647125	C18H24F3N3O2	371.4	CC[C@@H]1C(=O)NC[C@@H](CN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 = 61000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BC9YH5	(R)-3-Amino-1-(2-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10429788	C18H20F3N5O	379.4	C1CC1C2=NN3CCN(CC3=N2)C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCE3S8	7-But-2-ynyl-3-methyl-1-(naphthalen-2-ylmethyl)-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189868	C25H26N6O2	442.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC5=CC=CC=C5C=C4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCF37O	(R)-3-Amino-1-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444344	C15H16F3N5O	339.32	C1CN2C(=NC=N2)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCI0G4	(2S,4S)-1-[(3R)-3-Amino-4-(2-chlorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	118712765	C15H17ClFN3O	309.76	C1[C@@H](CN([C@@H]1C#N)C(=O)C[C@@H](CC2=CC=CC=C2Cl)N)F	IC50 = 129710 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCI98M	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-3-carboxamide	Investigative	71655555	C16H16N4O2	296.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CNC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCJM04	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]oxan-3-amine	Investigative	73353756	C17H18F5N5O	403.35	C1CN2C(=NN=C2C(F)(F)F)CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCSR15	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-2-carboxamide	Investigative	73350448	C16H16N4O2	296.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCT71P	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride	Investigative	45265711	C17H17ClF7N5O	475.8	C1CN2C(=NN=C2C(C(F)(F)F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCU5K0	(2R,3R)-7-Methoxy-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797614	C20H17F6N3O3	461.4	COC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 73000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCU72K	1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887271	C24H26N8O3	474.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BCY75P	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide	Investigative	89712515	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NNN=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BD40BK	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11570138	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BD70UI	(2R,3S,5R)-2-(2-Chlorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73353758	C16H19ClN4O	318.8	C1[C@H](CO[C@@H]([C@H]1N)C2=CC=CC=C2Cl)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BD7Z9M	N-[2-[(2S)-2-Cyano-4-methylidenepyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70683455	C19H17N3O2	319.4	C=C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BD8HB2	(2S,3S)-3-Amino-N,N-dimethyl-4-oxo-4-pyrrolidin-1-yl-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11678025	C24H27F3N6O4	520.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCCC4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BDE0S4	(2S,4R)-1-((2S,3R)-2-Amino-3-methylpentanoyl)-4-azidopyrrolidine-2-carbonitrile	Investigative	44560989	C11H18N6O	250.3	CC[C@@H](C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C#N)N=[N+]=[N-])N	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BDJQ81	(R)-1-(4-(1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)ethanone	Investigative	53317581	C15H20F2N2O	282.33	CC(=O)N1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 66000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BDTL57	5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71655623	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Br)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BDX83I	trans-(S)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide	Investigative	53325453	C20H29F2N3O	365.5	C1C[C@@H](CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)N	IC50 = 80000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE0UJ8	(2-Cyclohexylidene-2-fluoroethyl)[3-(dimethylamino)propyl]amine	Investigative	23646100	C13H25FN2	228.35	CN(C)CCCNCC(=C1CCCCC1)F	IC50 = 54600 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE5W0N	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyridine-4-carboxamide	Investigative	71667379	C21H22N4O4	394.4	COC1=C(C=C(C=C1)C2=NC=CC(=C2)C(=O)NCC(=O)N3CCC[C@H]3C#N)OC	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE60LN	Benzyl (S)-1-(2-((bis(4-acetamidophenoxy))phosphoryl)pyrrolidin-1-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	44435314	C34H42N5O8P	679.7	CC(=O)NC1=CC=C(C=C1)OP(=O)(C2CCCN2C(=O)[C@H](CCCCN)NC(=O)OCC3=CC=CC=C3)OC4=CC=C(C=C4)NC(=O)C	IC50 = 77000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE63DS	(2S)-1-(2-{[3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11689866	C21H28N4O4	400.5	COC1=C(C=C2CN(CCC2=C1)C(=O)CCNCC(=O)N3CCC[C@H]3C#N)OC	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE6UQ3	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine	Investigative	101887276	C28H27N9O3	537.6	CC#CCN1C2=C(N=C1NCCNC(=O)C3=CC=NC=C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE8I5O	2-[7-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide;hydrochloride	Investigative	45263693	C20H23ClF6N6O2	528.9	CN(C)C(=O)CC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BE9V5A	(R)-1-(1-(4-Fluorobenzyl)-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,5-difluorophenyl)butan-1-one	Investigative	44443714	C24H22F6N4O	496.4	C1CN(CC2=C1N(C(=N2)C(F)(F)F)CC3=CC=C(C=C3)F)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 = 64000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEB4N3	(R)-3-Amino-4-(2-fluorophenyl)-1-(piperazin-1-yl)butan-1-one	Investigative	9835053	C14H20FN3O	265.33	C1CN(CCN1)C(=O)C[C@@H](CC2=CC=CC=C2F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEC2Z5	Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(4-trimethylsilyltriazol-1-yl)pyrrolidine-1-carboxylate	Investigative	71462641	C22H31N5O3Si	441.6	C[Si](C)(C)C1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)OCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEF9T1	Allo-Ile-Isoindoline	Investigative	24784416	C14H20N2O	232.32	CC[C@@H](C)[C@@H](C(=O)N1CC2=CC=CC=C2C1)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEG8V0	(2S)-1-[(2S,4S)-4-Azido-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	71462596	C20H24N6O2	380.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-])C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEJ2I4	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-2,2,2-trifluoroethanesulfonamide	Investigative	127035743	C18H20F5N5O3S	481.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NS(=O)(=O)CC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEK3T0	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyrazin-2-ylmethyl)-1,4-diazepan-2-one	Investigative	44418114	C20H22F3N5O2	421.4	C1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC3=NC=CN=C3	IC50 = 75000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEK64B	Tert-butyl 4-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]piperazine-1-carboxylate	Investigative	71451902	C31H45N7O4	579.7	CC(C)(C)OC(=O)N1CCN(CC1)CC2=CN(N=N2)[C@H]3C[C@H](N(C3)C(=O)CCCC4=CC=CC=C4)C(=O)N5CCCC5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEMP08	(3R)-3-Amino-1-[8-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265945	C24H24ClF6N5O2	563.9	COC1=CC=C(C=C1)CC2C3=NN=C(N3CCN2C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F.Cl	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEMP29	N-Benzyl-2-(1-pyrrolidinyl)ethanamine	Investigative	3318661	C13H20N2	204.31	C1CCN(C1)CCNCC2=CC=CC=C2	IC50 = 55300 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEO4P7	(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938499	C24H32N4O4	440.5	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BEX29D	(3R)-3-Amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777804	C17H18ClF6N5O	457.8	C[C@@H]1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF0D1S	US9051329, Example 1	Investigative	71203752	C21H21F4N7O2	479.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF0LN1	(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916386	C18H20F3N7O3	439.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C(=NN=C4C(F)(F)F)C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF1PL7	(2R,3S,5R)-5-(3H-1,2-Benzoxazol-2-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73350798	C18H18F2N2O2	332.3	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CC=CC=C4O3	IC50 = 65000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF32PB	(S)-2-Amino-4-methyl-1-(pyrrolidin-1-yl)pentan-1-one	Investigative	22690988	C10H20N2O	184.28	CC(C)C[C@@H](C(=O)N1CCCC1)N	IC50 = 122000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF3IO2	(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one	Investigative	23647123	C17H22F3N3O2	357.37	C[C@@H]1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 = 71000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF3OS1	(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(3-ethyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride	Investigative	23645410	C17H22ClF2N5O	385.8	CCC1=NN=C2N1CCN(C2)C(=O)C[C@@H](CC3=CC(=C(C=C3)F)F)N.Cl	IC50 = 64000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF4DX7	US9346814, Ref. Cmpd No 3 (Example 5)	Investigative	71667225	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF5C8N	8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione	Investigative	122189874	C18H26N6O2	358.4	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF5N2S	(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796938	C27H38F3N3O7	573.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C(C3CCCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF81CI	(3R)-3-Amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263687	C22H21ClF6N6O	534.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=N4.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BF9C4K	(3R)-3-Amino-4-(3,4-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride	Investigative	11487118	C16H17ClF5N5O	425.78	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3)F)F)N.Cl	IC50 = 98000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFA87K	(6S)-1-[(2S)-2-Amino-4-oxo-4-[2-thiophen-2-yl-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]butyl]-5,5-difluoro-6-hydroxypiperidin-2-one	Investigative	59550101	C21H22F5N5O3S	519.5	C1CC([C@@H](N(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C4=CC=CS4)N)O)(F)F	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFAI67	(2S,3S)-2-Amino-3-methyl-1-(5-methylisoindolin-2-yl)pentan-1-one	Investigative	44560454	C15H22N2O	246.35	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFO8H4	5-Bromo-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	89705152	C17H13BrF2N4O2	423.2	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Br)C#N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFQT80	(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560549	C18H28N2O	288.4	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(C)(C)C)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFR59B	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylpropanamide	Investigative	70683454	C16H19N3O2	285.34	C1C[C@H](N(C1)C(=O)CNC(=O)CCC2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFX7G6	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine	Investigative	127035239	C17H17F5N4O3S	452.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CN(N=C4C3)S(=O)(=O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BFZ06R	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide	Investigative	16040457	C18H17N3O2	307.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG0TM6	(2S)-1-(2-{[3-Oxo-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11717090	C19H24N4O2	340.4	C1C[C@H](N(C1)C(=O)CNCCC(=O)N2CCC3=CC=CC=C3C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG1L0U	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(6S)-1,4-diazabicyclo[4.3.0]nonane-4-yl]xanthine	Investigative	101887278	C27H30N8O2	498.6	CC#CCN1C2=C(N=C1N3CCN4CCC[C@H]4C3)N(C(=O)N(C2=O)CC5=NC6=CC=CC=C6C(=N5)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG26SJ	(3R)-3-Amino-1-(4-ethyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443723	C20H22F6N4O	448.4	CCC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C(F)(F)F)C	IC50 = 93000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG36ZY	Phe-Pro-CN	Investigative	23645371	C14H17N3O	243.3	C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)N)C#N	IC50 = 84430 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG3ES9	N-[(2S)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamide	Investigative	90655538	C18H18N4O2	322.4	C[C@@H](C(=O)N1CCC[C@H]1C#N)NC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG53WY	2-(4-Cyanophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	71667380	C20H17N5O2	359.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)C3=CC=C(C=C3)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG8CU2	Benzyl (S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate	Investigative	688304	C17H22N2O3	302.37	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BG9E0F	7-Anilino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	89705100	C23H21N5O2	399.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)NC4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGCW21	3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramide	Investigative	11624893	C21H30N4O2	370.5	CC(C)(CC(=O)NC(C)(C)C1=CC=CC=C1)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGE8N2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridazine-4-carboxamide	Investigative	90655555	C12H13N5O2	259.26	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CN=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGQ0I1	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11649741	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 = 61000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGT19Y	(2S)-1-(2-Naphthalen-2-yloxyacetyl)pyrrolidine-2-carbonitrile	Investigative	73345857	C17H16N2O2	280.32	C1C[C@H](N(C1)C(=O)COC2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGTC64	1-Isoleucyl-1,2,5,6-tetrahydropyridine	Investigative	10774283	C11H20N2O	196.29	CC[C@H](C)[C@@H](C(=O)N1CCC=CC1)N	IC50 = 52000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BGU6X1	2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid	Investigative	49796940	C25H27F4N3O6S	573.6	C1[C@H](N(CS1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)CC(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH0K1R	(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one	Investigative	23647124	C17H22F3N3O2	357.37	C[C@H]1CCN([C@@H](C(=O)N1)C)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 73000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH0S9T	(2S,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193503	C16H18F2N4O	320.34	C1[C@H](CO[C@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH26MI	cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)cyclohexyl)ethanamine	Investigative	53317579	C20H24F5N5	429.4	C1CC(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)N3CCN4C(=NN=C4C(F)(F)F)C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH2RU0	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(4-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate	Investigative	45266135	C29H30F4N4O4	574.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)[N+]3=CC=CC=C3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)[O-]	IC50 = 89000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH2YG8	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796945	C25H26F7N3O4	565.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 55000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH3XE8	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-ylacetamide	Investigative	73356494	C19H19N3O2	321.4	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH4AD7	N'-[Bis(4-fluorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]butanediamide	Investigative	70687706	C24H24F2N4O3	454.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH50EA	(2S,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193504	C16H18F2N4O	320.34	C1[C@H](CO[C@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BH50KZ	(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	23628283	C21H23ClF3N3O2	441.9	C1CCN(N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(=O)C3=CC=CC=C3.Cl	IC50 = 72000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHC67B	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645925	C18H17F7N4O	438.3	C1CN(CC2=C1NN=C2C(C(F)(F)F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 67000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHC7X8	7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methylpyrimido[1,2-b]pyridazin-4-one;2,2,2-trifluoroacetic acid	Investigative	49797248	C21H19F6N5O3	503.4	CC1=CC(=O)N2C(=N1)C=CC(=N2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHE3O7	Pyrrolidine, 1-[(2S,3R)-2-amino-3-methyl-1-oxopentyl]-	Investigative	9794073	C10H20N2O	184.28	CC[C@@H](C)[C@@H](C(=O)N1CCCC1)N	IC50 = 145000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHE45S	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)piperidine-4-carboxamide	Investigative	89704942	C13H20N4O2	264.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2CCNCC2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHO3P0	Ala-Pro-CN	Investigative	44328300	C8H13N3O	167.21	C[C@@H](C(=O)N1CCC[C@H]1C#N)N	IC50 = 110000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHPD40	cis-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide	Investigative	53317580	C20H29F2N3O	365.5	C1CC(CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)N	IC50 = 54000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHW27S	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione	Investigative	122189872	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CN=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BHXZ75	7-Benzyl-1-[(4-methoxyquinazolin-2-yl)methyl]-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189879	C27H26N8O4	526.5	CN1C2=C(C(=O)N(C1=O)CC3=NC4=CC=CC=C4C(=N3)OC)N(C(=N2)N5CCNC(=O)C5)CC6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI01GZ	(R)-2-(2,5-Difluorophenyl)-1-(1-(6-fluoropyridin-3-yl)piperidin-4-yl)ethanamine	Investigative	53318865	C18H20F3N3	335.4	C1CN(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)C3=CN=C(C=C3)F	IC50 = 52000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI1ZT8	(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-(tetrazol-1-yl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797001	C23H23F5N6O3	526.5	C1CN(C[C@H]1F)C(=O)[C@H]([C@@H](CN2C=NN=N2)C3=CC=C(C=C3)C4=CC=C(C=C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI42VJ	Thiazolopiperidine 76	Investigative	9983092	C23H23F2N3O3S2	491.6	CS(=O)(=O)C1=CC=C(C=C1)C2=NC3=C(S2)CCN(C3)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 = 51000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI4BM3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-[4-(3,4-difluorophenyl)triazol-1-yl]acetamide	Investigative	70693953	C17H16F2N6O2	374.3	C1C[C@H](N(C1)C(=O)CNC(=O)CN2C=C(N=N2)C3=CC(=C(C=C3)F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI6H3W	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443720	C19H21F5N4O	416.4	CC1C2=C(CCN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N(C(=N2)C(F)(F)F)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI6W8U	(2E)-2-[2-(Adamantan-1-ylamino)-1-fluoroethylidene]cyclopentane-1-carbonitrile	Investigative	11784400	C18H25FN2	288.4	C1CC(/C(=C(\\CNC23CC4CC(C2)CC(C4)C3)/F)/C1)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI7JG0	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propan-2-ylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035242	C19H24F2N4O3S	426.5	CC(C)S(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI9J3L	US9051329, Example 7	Investigative	71203742	C21H23F2N7O2	443.4	CCN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI9O1C	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887269	C24H24N8O3	472.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BI9R7K	(2Z)-2-[2-(Adamantan-1-ylamino)-1-fluoroethylidene]cyclopentane-1-carbonitrile	Investigative	11101478	C18H25FN2	288.4	C1CC(/C(=C(/CNC23CC4CC(C2)CC(C4)C3)\\F)/C1)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BIA7D0	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443708	C18H19F5N4O	402.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 92000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BID3T2	(3R)-3-Amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265943	C23H22ClF6N5O	533.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4.Cl	IC50 = 52000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BIG1T8	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide	Investigative	71655556	C18H18N4O3	338.4	CC1=NC2=CC=CC=C2C(=C1O)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BIG41S	trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-yl carbamate	Investigative	53318864	C20H29F2N3O2	381.5	C1C[C@H](CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)OC(=O)N	IC50 = 72000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BILY34	(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-methyl-piperazin-1-yl)-butan-1-one	Investigative	9835382	C15H22FN3O	279.35	C[C@@H]1CNCCN1C(=O)C[C@@H](CC2=CC=CC=C2F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BIM9C6	(11R,12R)-11-(2,4,5-Trifluorophenyl)-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-amine;hydrochloride	Investigative	45270905	C16H14ClF3N4	354.76	C1[C@@H]([C@H](CN2C1=NC3=C2C=CN=C3)N)C4=CC(=C(C=C4F)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BIN9Y2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	71667226	C13H14N4O2	258.279	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJ1ZB7	(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938602	C20H24N4O4	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJ4O8E	Sitagliptin Hydrochloride	Investigative	11476287	C16H16ClF6N5O	443.77	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJ4X3T	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	11374531	C24H26N8O2	458.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJB0L9	(3R)-3-Amino-1-[(4R)-4-methyl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	70681315	C19H20ClF6N3O	455.8	C[C@@H]1CN(CC2=CC=C(N12)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJF84U	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796942	C22H29F4N7O4	531.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCCCCC3=NNN=N3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJG76B	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(thiazolidin-3-yl)butan-1-one	Investigative	44394103	C13H16F2N2OS	286.34	C1CSCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 77560 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJH79B	1-[(2S,4S)-4-[4-(Morpholin-4-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71457240	C26H36N6O3	480.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)CN5CCOCC5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJN02P	2-Amino-1-piperidin-1-yl-pentan-1-one	Investigative	43650152	C10H20N2O	184.28	CCCC(C(=O)N1CCCCC1)N	IC50 = 57100 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJU0F1	(2R,3R)-7-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797605	C20H17F6N3O4S	509.4	CS(=O)(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 88000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJV7P3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-2-carboxamide	Investigative	70691901	C18H17N3O2	307.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJXK70	(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46893990	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BJZ56I	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-[3-(trifluoromethyl)phenyl]sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine	Investigative	127035375	C23H21F5N4O3S	528.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CN(N=C4C3)S(=O)(=O)C5=CC=CC(=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BK3A1B	(R)-3-Amino-4-(2,4-difluoro-phenyl)-1-thiazolidin-3-yl-butan-1-one	Investigative	44394024	C13H16F2N2OS	286.34	C1CSCN1C(=O)C[C@@H](CC2=C(C=C(C=C2)F)F)N	IC50 = 56050 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BK47RM	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127047762	C28H29F5N6O4	608.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=C(C4)NN=C5)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BK6NP9	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-methylquinoline-4-carboxamide	Investigative	89705081	C18H18N4O2	322.4	CC1=CC2=NC=CC(=C2C=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BK86NO	(3R)-3-Amino-1-[8-[(4-fluorophenyl)-hydroxymethyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263680	C23H21ClF7N5O2	567.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(C4=CC=C(C=C4)F)O.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BKA5O2	N'-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-[(4-fluorophenyl)methyl]butanediamide	Investigative	70691902	C18H21FN4O3	360.4	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NCC2=CC=C(C=C2)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BKB15R	(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431317	C18H19F6N5	419.4	C1CC([C@H](C[C@@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BKCX95	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,2,3,4-tetrahydroacridine-9-carboxamide	Investigative	73347359	C21H22N4O2	362.4	C1CCC2=NC3=CC=CC=C3C(=C2C1)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BKT8C2	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H,5H,6H,7H-pyrido[4,3-d][1,3]thiazol-5-yl}butan-1-one	Investigative	23645938	C17H19F2N3OS	351.4	CC1=NC2=C(S1)CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 80000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BKTP80	(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one	Investigative	46938802	C19H23N3O3	341.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BL0B8W	2,4-Diamino-1-piperidin-1-yl-butan-1-one	Investigative	24906298	C9H19N3O	185.27	C1CCN(CC1)C(=O)C(CCN)N	IC50 = 191000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BL3AK0	(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	44590735	C29H34F5N3O7	631.6	CC(C)[C@@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BL7B5H	6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-one;2,2,2-trifluoroacetic acid	Investigative	49797249	C19H18F6N6O3	492.4	CN1C(=O)N2C(=N1)C=CC(=N2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 = 57000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BL82NA	1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189876	C21H22N8O4	450.5	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLK68G	(R)-3-Amino-1-[(R)-2-(4-fluoro-benzyl)-piperazin-1-yl]-4-(2-fluoro-phenyl)-butan-1-one	Investigative	9947730	C21H25F2N3O	373.4	C1CN([C@@H](CN1)CC2=CC=C(C=C2)F)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLO83A	7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667378	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLP38T	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-1,2-oxazole-5-carboxamide	Investigative	53324153	C19H23F2N3O2	363.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C3=CC=NO3	IC50 = 58000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLUG68	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamide	Investigative	71667081	C18H18N4O2	322.4	CC1=NC2=CC=CC=C2C(=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLW9G8	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354365	C30H37F3N4O6	606.6	CCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLX1I6	(2S,4S)-1-[(2S)-2-Amino-3-[2-(trifluoromethyl)phenyl]propanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	72697499	C15H15F4N3O	329.29	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@H](CC2=CC=CC=C2C(F)(F)F)N)F	IC50 = 102000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BLXQ31	Unii-Z82X63Q1Z5	Investigative	122189866	C27H30N8O3	514.6	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)NC(=O)C)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BM04GD	(2R,3S,5R)-5-(2-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209134	C19H22F2N4O3S	424.5	C1CC1S(=O)(=O)N2C=C3CN(CC3=N2)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 87000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BM2E9X	((2S,4S)-4-(Dinaphthalen-2-ylamino)pyrrolidin-2-yl)(isoindolin-2-yl)methanone	Investigative	44560746	C33H29N3O	483.6	C1[C@@H](CN[C@@H]1C(=O)N2CC3=CC=CC=C3C2)N(C4=CC5=CC=CC=C5C=C4)C6=CC7=CC=CC=C7C=C6	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BM4SN0	4-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	90655556	C14H16N4O2	272.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BM52VH	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)methanesulfonamide	Investigative	53324293	C19H27F5N2O2S	442.5	CS(=O)(=O)N(CCCC(F)(F)F)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 86000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BM76YO	N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]-6-methoxyquinoline-4-carboxamide	Investigative	89705275	C18H16F2N4O3	374.3	COC1=CC2=C(C=CN=C2C=C1)C(=O)NCC(=O)N3CC(C[C@H]3C#N)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BMA24I	N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	66561555	C18H16FN3O2	325.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BMOE12	4-Phenyl-1-[(2S,4S)-4-[4-(phenylmethoxymethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71457239	C29H35N5O3	501.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)COCC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BMU92D	2-[[(2S,4S)-1-[(1,1-Dimethyl-2-hydroxyethylamino)acetyl]-4-fluoro-2-pyrrolidinyl]carbonyl]-5-tert-butyl-1,3,4-oxadiazole	Investigative	23655077	C17H27FN4O4	370.4	CC(C)(C)C1=NN=C(O1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CNC(C)(C)CO)F	IC50 = 145800 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BMX32J	3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile	Investigative	22029457	C22H23N7O2	417.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC(=CC=C4)C#N)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN07TD	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylbutanamide	Investigative	70681470	C12H19N3O2	237.3	CC(C)CC(=O)NCC(=O)N1CCC[C@H]1C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN25GB	(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797016	C23H24F5N3O4	501.4	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC(C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 58000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN2B0U	2-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655552	C13H13ClN4O2	292.72	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN2VT4	(2S,3S)-3-Amino-4-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797022	C23H25F4N3O4	483.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN3A9U	2-Amino-3-hydroxy-1-pyrrolidin-1-yl-propan-1-one	Investigative	21949259	C7H14N2O2	158.2	C1CCN(C1)C(=O)C(CO)N	IC50 = 65000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN4IH8	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-(tetrazol-1-yl)butanamide;2,2,2-trifluoroacetic acid	Investigative	49797018	C23H22F5N7O4	555.5	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)NN4C=NN=N4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN67GJ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-pyrrolo[2,3-b]pyridine-4-carboxamide	Investigative	89705136	C15H15N5O2	297.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CNC3=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN71KS	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-ethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443710	C19H21F5N4O	416.4	CCN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BN9WM6	2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide	Investigative	122189867	C22H22N8O3	446.5	CC#CCN1C2=C(N=C1NCC(=O)N)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNC3J6	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49796998	C24H26F5N3O5	531.5	CN(C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N)OC.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNCD53	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-(trifluoromethoxy)benzamide	Investigative	70696068	C15H14F3N3O3	341.28	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)OC(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNI7A8	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11577431	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C=NN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNM78Q	2-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655553	C13H13BrN4O2	337.17	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNO3Q4	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645920	C18H19F5N4O	402.4	CN1C(=C2CN(CCC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(F)(F)F	IC50 = 51000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNPH45	3-Amino-4-oxo-4-pyrrolidin-1-yl-butyramide	Investigative	9855673	C8H15N3O2	185.22	C1CCN(C1)C(=O)C(CC(=O)N)N	IC50 = 152000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNQ4J0	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-propan-2-ylbutanamide;2,2,2-trifluoroacetic acid	Investigative	49797017	C25H28F5N3O4	529.5	CC(C)NC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 76000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNV4S9	US9051329, Example 8	Investigative	71203746	C22H23F4N7O2	493.5	CCN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNW2R8	4-Phenyl-1-[(2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71459091	C26H30N6O2	458.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=N5	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNX0V1	N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797607	C20H18F6N4O4S	524.4	CS(=O)(=O)NC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 74000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNZ48S	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797015	C24H26F5N3O4	515.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 94000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BNZ7Y3	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one	Investigative	23645935	C18H19F5N4O	402.4	CN1C(=C2CCN(CC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(F)(F)F	IC50 = 85000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO0XA5	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797243	C20H16F9N5O2	529.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=C(N=C4C=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 64000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO34KM	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl)oxan-3-amine	Investigative	73355285	C17H19F2N3O2	335.35	CC1=NC2=C(O1)CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO3K8F	(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile	Investigative	46917047	C20H21FN4O3	384.4	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO3W0D	N-[1-[(2S)-2-Cyanopyrrolidine-1-carbonyl]cyclopropyl]quinoline-4-carboxamide	Investigative	90655539	C19H18N4O2	334.4	C1C[C@H](N(C1)C(=O)C2(CC2)NC(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO45VH	(3R,4R)-1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797250	C18H16F6N6O2	462.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=NN=C4C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO4R1X	US9346814, Cmpd No 37 Example 42	Investigative	89704955	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NC=NN2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BO61MP	1-(Quinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887270	C23H24N8O2	444.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C=N4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOB84S	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035240	C18H22F2N4O3S	412.5	CCS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOF67R	(S)-2-Amino-2-((1S,3R)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44381811	C11H20N2O2	212.29	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@H](C2)O)N	IC50 = 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOI3X9	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(5-fluoro-1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56675536	C31H30F6N4O4	636.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=C(C4)C=C(C=C5)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOR15Y	trans-N-(2-(3-Chlorophenyl)cyclopropyl)-3-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethylamino)-3-methylbutanamide	Investigative	46891534	C22H26ClFN2O2	404.9	CC(C)(CC(=O)N[C@H]1C[C@@H]1C2=CC(=CC=C2)Cl)CC(=O)N3C[C@H](C[C@H]3C#C)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOU3F6	(R)-3-Amino-4-(4-fluoro-phenyl)-1-thiazolidin-3-yl-butan-1-one	Investigative	44394244	C13H17FN2OS	268.35	C1CSCN1C(=O)C[C@@H](CC2=CC=C(C=C2)F)N	IC50 = 67630 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOW40S	Fluoro-Olefin Analogue 1	Investigative	23646080	C13H22FN	211.32	C1CCC(CC1)NCC(=C2CCCC2)F	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOY06Z	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-carboxamide	Investigative	53324145	C21H25F2N3O	373.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C3=CN=CC=C3	IC50 = 58000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BOZ83J	(2S,3S)-2-Amino-1-(3-fluoropyrrolidin-1-yl)-3-methylpentan-1-one	Investigative	10584272	C10H19FN2O	202.27	CC[C@H](C)[C@@H](C(=O)N1CCC(C1)F)N	IC50 = 111000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BP27EJ	2-[(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid	Investigative	23647116	C18H23F2N3O4	383.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BP4L3F	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one	Investigative	23647118	C17H22F3N3O2	357.37	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BP65UJ	(2S)-1-[2-(4-Phenyltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile	Investigative	90655548	C15H15N5O	281.31	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BP8NB6	(2S)-1-(2-Naphthalen-1-yloxyacetyl)pyrrolidine-2-carbonitrile	Investigative	73353424	C17H16N2O2	280.32	C1C[C@H](N(C1)C(=O)COC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPA24C	2-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655554	C13H15N5O2	273.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPM60Y	2-(4-Chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70685558	C15H16ClN3O2	305.76	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=C(C=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPN72Y	(3R,4R)-1-([1,2,4]Triazolo[4,3-a]pyrimidin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	23661708	C18H16F6N6O2	462.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NN=CN4C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPO3Y7	(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one	Investigative	23647126	C18H24F3N3O2	371.4	CC[C@@H]1C(=O)NC[C@H](CN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPQ2K7	4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-5-methyl-1,4-diazepan-2-one	Investigative	21045424	C16H20F3N3O2	343.34	CC1CCNC(=O)CN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BPS6R2	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11533932	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NN3C=CN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ13ZS	1-[(2S,4R)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71450086	C19H25N5O2	355.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ3DE2	Tert-butyl 4-[1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]triazol-4-yl]piperazine-1-carboxylate	Investigative	70685560	C20H30N8O4	446.5	CC(C)(C)OC(=O)N1CCN(CC1)C2=CN(N=N2)CC(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ3WH4	Benzoic acid 1-(2,6-diamino-hexanoyl)-pyrrolidin-3-yl ester	Investigative	44364172	C17H25N3O3	319.4	C1CN(CC1OC(=O)C2=CC=CC=C2)C(=O)C(CCCCN)N	IC50 = 78100 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ4F1G	(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-isopropyl-piperazin-1-yl)-butan-1-one	Investigative	9836210	C17H26FN3O	307.4	CC(C)[C@@H]1CNCCN1C(=O)C[C@@H](CC2=CC=CC=C2F)N	IC50 = 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ4PJ9	(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanamide	Investigative	11229192	C8H15N3O2	185.22	C1CCN(C1)C(=O)[C@H](CC(=O)N)N	IC50 = 152000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ6LG5	(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-thiazol-4-ylmethyl-piperazin-1-yl)-butan-1-one	Investigative	44394028	C18H23FN4OS	362.5	C1CN([C@@H](CN1)CC2=CSC=N2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ7M5N	(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938705	C21H24N4O3	380.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ8H1L	N-[(4-Chlorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655542	C24H21ClN4O2	432.9	C1C[C@H](N(C1)C(=O)CN(CC2=CC=C(C=C2)Cl)C(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQ94KU	(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938799	C17H24N4O3	332.4	C1CCN(CC1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQI0J4	(2S,4S)-1-[(3R)-3-Amino-4-(4-fluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	118712768	C15H17F2N3O	293.31	C1[C@@H](CN([C@@H]1C#N)C(=O)C[C@@H](CC2=CC=C(C=C2)F)N)F	IC50 = 192790 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQK9T2	(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916389	C20H21FN4O3	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQU62W	US9346814, Ref. Cmpd No 2	Investigative	73224265	C18H17N3O2	307.3	C1CC(N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQUC03	5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71655622	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BQYB16	(2S)-1-[2-[4-(4-Fluorophenyl)triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655549	C15H14FN5O	299.3	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BR3B2S	2-Amino-1-(3,6-dihydro-2H-pyridin-1-yl)-3-methyl-pentan-1-one	Investigative	44364213	C11H20N2O	196.29	CCC(C)C(C(=O)N1CCC=CC1)N	IC50 = 52000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BR9JX7	(S)-2-Amino-2-cyclohexyl-1-(3,4-dihydroisoquinolin-2(1H)-YL)ethanone	Investigative	23646027	C17H24N2O	272.4	C1CCC(CC1)[C@@H](C(=O)N2CCC3=CC=CC=C3C2)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BR9NL3	N-(2-Oxo-2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide	Investigative	90655561	C16H17N3O2	283.32	C1CCN(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRF0W5	3,4-Dihydro-1H-isoquinolin-2-yl-[(2S)-pyrrolidin-2-yl]methanone	Investigative	22691359	C14H18N2O	230.31	C1C[C@H](NC1)C(=O)N2CCC3=CC=CC=C3C2	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRG2H8	(2Z)-2-(1-Fluoro-2-{[(4-fluorophenyl)methyl]amino}ethylidene)cyclopentane-1-carbonitrile	Investigative	11079321	C15H16F2N2	262.3	C1CC(/C(=C(/CNCC2=CC=C(C=C2)F)\\F)/C1)C#N	IC50 = 87300 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRI61C	(3R)-3-Amino-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	23645411	C15H17ClF3N5O	375.77	C1CN2C=NN=C2CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRIK86	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-cyclopropylquinoline-4-carboxamide	Investigative	90655541	C20H20N4O2	348.4	C1C[C@H](N(C1)C(=O)CN(C2CC2)C(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRK80C	1-[(2S,4S)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71455458	C19H25N5O2	355.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRM8Z0	Bis(4-acetamidophenyl) 1-((S)-2,6-diaminohexanoyl)pyrrolidin-2-ylphosphonate	Investigative	44435313	C26H36N5O6P	545.6	CC(=O)NC1=CC=C(C=C1)OP(=O)(C2CCCN2C(=O)[C@H](CCCCN)N)OC3=CC=C(C=C3)NC(=O)C	IC50 = 85000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRO20H	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide;2,2,2-trifluoroacetic acid	Investigative	49797011	C24H27F5N4O4	530.5	CN(C)NC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRT85J	Pyrrolidine, 1-(N-phenylalanyl)-	Investigative	7020797	C13H18N2O	218.29	C1CCN(C1)C(=O)[C@H](CC2=CC=CC=C2)N	IC50 = 79000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRXF01	1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887279	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=CC=N4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BRZ71D	(3R,4R)-1-Pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797224	C18H17F6N3O2	421.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CC=CC=N3.C(=O)(C(F)(F)F)O	IC50 = 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BS09KC	4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one	Investigative	10426457	C16H21F2N3O2	325.35	CC1C(=O)NCCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BS17BQ	(3R,4R)-1-Pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797235	C17H16F6N4O2	422.32	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BS4JE3	4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one	Investigative	23646448	C15H18F3N3O2	329.32	C1CNC(=O)CN(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BS74YE	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,7-naphthyridine-4-carboxamide	Investigative	89705103	C16H15N5O2	309.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CN=CC3=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSEC19	1-[(2S,4S)-4-[4-(4-Bromophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71457238	C27H30BrN5O2	536.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=C(C=C5)Br	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSG5J2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-methylquinoline-4-carboxamide	Investigative	90655540	C18H18N4O2	322.4	CN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSJ8D4	N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]acetamide;2,2,2-trifluoroacetic acid	Investigative	49797650	C21H18F6N4O3	488.4	CC(=O)NC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 54000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSP3F8	(3R)-3-Amino-1-[(5S,8S)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777439	C18H20ClF6N5O	471.8	C[C@H]1CN([C@H](C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSQ63I	1-[(2s,4s)-4-[4-(4-Fluorophenyl)-1,2,3-Triazol-1-Yl]-2-Pyrrolidin-1-Ylcarbonyl-Pyrrolidin-1-Yl]-4-Phenyl-Butan-1-One	Investigative	70789754	C27H30FN5O2	475.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSUJ28	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-methylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035752	C17H20F2N4O3S	398.4	CS(=O)(=O)C1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSV86X	N-[2-[(2S,4R)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691904	C18H16N6O2	348.4	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BSX80I	(R)-3-Amino-1-((R)-2-benzylpiperazin-1-yl)-4-(2-fluorophenyl)butan-1-one	Investigative	10144962	C21H26FN3O	355.4	C1CN([C@@H](CN1)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT04CA	1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887275	C24H26N8O2	458.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=CC=N5)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT1C8X	(2S)-1-[(2S)-2-Amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile	Investigative	23646026	C26H29F2N5O2	481.5	C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT41RH	(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916347	C21H26N6O3	410.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=NC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT5Y2N	(2S)-1-[2-[4-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655550	C20H22N6O2	378.4	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)CCC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT78ZL	Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(triazol-1-yl)pyrrolidine-1-carboxylate	Investigative	71460904	C19H23N5O3	369.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=CN=N4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT8LH1	(1S,2R,5S)-5-(2-Cyclopropyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	15949507	C21H23F3N4	388.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=CN=C(N=C3C2)C4CC4)N)C5=CC(=C(C=C5F)F)F	IC50 = 61000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT94PM	(2S)-2-Amino-2-phenyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one	Investigative	22691666	C17H18N2O	266.34	C1CN(CC2=CC=CC=C21)C(=O)[C@H](C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT97SU	(3R)-3-Amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777691	C17H18ClF6N5O	457.8	C[C@H]1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BT9IG8	(R)-1-((R)-8-(4-Fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444371	C23H20F7N5O	515.4	C1CN2C(=NC(=N2)C(F)(F)F)[C@H](N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=C(C=C4)F	IC50 = 60000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BTC89V	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797229	C19H16F9N3O2	489.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=CC(=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 77000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BTL19H	(3R)-3-Amino-1-[(3R)-3-benzylmorpholin-4-yl]-4-(2-fluorophenyl)butan-1-one	Investigative	10183667	C21H25FN2O2	356.4	C1COC[C@H](N1C(=O)C[C@@H](CC2=CC=CC=C2F)N)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BTN0W1	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-N,4-dimethylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797346	C27H32F4N4O5	568.6	CC1=CC=C(C=C1)C(=O)N(C)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BTWO97	(R)-3-Amino-1-((S)-2-benzyl-piperidin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one	Investigative	44394210	C22H27FN2O	354.5	C1CCN([C@@H](C1)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU1R5L	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]methanesulfonamide	Investigative	127035741	C17H21F2N5O3S	413.4	CS(=O)(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU1VT2	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11577331	C24H28F4N4O5	528.5	CN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU3ZH9	(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one	Investigative	44426070	C17H19F6N3O2	411.34	C[C@@H]1C(=O)N[C@@H](CCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU4RE6	(1S,2R,5S)-5-(5H-Pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	15949418	C18H19F3N4	348.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=CN=CN=C3C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU6NL8	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1-pyridin-4-ylmethanesulfonamide	Investigative	127035745	C22H24F2N6O3S	490.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NS(=O)(=O)CC5=CC=NC=C5	IC50 = 88000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU75NX	CID 89704940	Investigative	89704940	C21H20N6O3	404.4	COC1=CC=C(C=C1)C2=NC3=NC=CC(=C3N2)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BU7V1J	(2S,3S)-2-[4-[Acetyl(methyl)amino]phenyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797351	C21H28F4N4O5	492.5	CC(=O)N(C)C1=CC=C(C=C1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUD5P3	Thioamide Analogue 38	Investigative	10014539	C13H24N2S	240.41	C1CCC(CC1)NCC(=S)N2CCCCC2	IC50 = 69000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUE29R	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide	Investigative	127035376	C19H23F2N5O2	391.4	CCC(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUKI39	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzamide	Investigative	70681469	C15H17N3O3	287.31	COC1=CC=CC(=C1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUM9W1	(3R)-3-Amino-1-[(4S)-4-methyl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	70689716	C19H20ClF6N3O	455.8	C[C@H]1CN(CC2=CC=C(N12)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUNE86	Talabostat	Investigative	6918572	C9H19BN2O3	214.07	B([C@@H]1CCCN1C(=O)[C@H](C(C)C)N)(O)O	Ki = 125000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUS09Q	(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193502	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUSB92	(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acid	Investigative	44418251	C14H17BN2O4	288.11	B([C@@H]1CCCN1C(=O)CN2CC3=CC=CC=C3C2=O)(O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BUTA21	1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887272	C24H24N8O4	488.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV03PS	(2S)-1-{2-[(3-{4-[(3,5-Difluorophenyl)carbonyl]piperazin-1-yl}-3-oxopropyl)amino]acetyl}pyrrolidine-2-carbonitrile	Investigative	11604454	C21H25F2N5O3	433.5	C1C[C@H](N(C1)C(=O)CNCCC(=O)N2CCN(CC2)C(=O)C3=CC(=CC(=C3)F)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV0F1D	(2S)-2-Amino-4-[(3S)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56671893	C32H33F5N4O4	632.6	C[C@H]1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV2UR3	(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46938704	C20H21ClN4O3	400.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV3G9D	4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49796939	C25H26F5N3O6	559.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC(=C(C=C2)F)F)N)C(=O)NCC3=CC=C(C=C3)C(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV58QF	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-thiophen-2-ylbenzamide	Investigative	70696069	C18H17N3O2S	339.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)C3=CC=CS3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BV7Q2F	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796955	C29H31F8N3O7	685.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C(=C(C(=C3F)F)F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVA8L1	Benzyl (2S,4S)-4-azido-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71459092	C17H21N5O3	343.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVAE17	(R)-3-Amino-4-phenyl-1-thiazolidin-3-yl-butan-1-one	Investigative	44393611	C13H18N2OS	250.36	C1CSCN1C(=O)C[C@@H](CC2=CC=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVCP74	4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one	Investigative	44426068	C16H20F3N3O2	343.34	CC1C(=O)NCCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVD9U0	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-(naphthalen-2-ylmethyl)piperazin-1-yl]butane-1,4-dione;dihydrochloride	Investigative	90664579	C27H32Cl2N4O2	515.5	C1CN(CCN1CC2=CC3=CC=CC=C3C=C2)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVFS57	(R)-3-Amino-1-((R)-2-benzyl-4-methyl-piperazin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one	Investigative	10304081	C22H28FN3O	369.5	CN1CCN([C@@H](C1)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVHL24	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11541277	C25H28F4N6O4	552.5	CC1=C(C=CC2=NC=NN12)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BVKQ09	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanecarboxamide	Investigative	127035377	C20H23F2N5O2	403.4	C1CC1C(=O)NC2=NNC3=C2CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW05BP	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797347	C26H29F5N4O5	572.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)N(C)C(=O)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW14UT	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-cyclopentyloxy-4-methoxybenzamide	Investigative	70689750	C20H25N3O4	371.4	COC1=C(C=C(C=C1)C(=O)NCC(=O)N2CCC[C@H]2C#N)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW1B4G	2-(Tert-butylamino)-1-((2S,4S)-4-fluoro-2-(2-tert-pentyl-1,3,4-oxadiazole-5-carbonyl)pyrrolidin-1-yl)ethanone	Investigative	44432929	C18H29FN4O3	368.4	CCC(C)(C)C1=NN=C(O1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CNC(C)(C)C)F	IC50 = 97200 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW1L0O	(3R)-3-Amino-1-[5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263673	C18H20ClF6N5O	471.8	CC1CN(C(C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW1P0Q	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1,3-thiazole-2-carboxamide	Investigative	127035378	C20H20F2N6O2S	446.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NC(=O)C5=NC=CS5	IC50 = 70000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW2SM9	(3R)-3-Amino-1-[(5R,8R)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777568	C18H20ClF6N5O	471.8	C[C@@H]1CN([C@@H](C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW38TS	(R)-3-Amino-1-thiazolidin-3-yl-4-o-tolyl-butan-1-one	Investigative	44394239	C14H20N2OS	264.39	CC1=CC=CC=C1C[C@H](CC(=O)N2CCSC2)N	IC50 = 92060 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW4OD5	cis-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide	Investigative	53317575	C17H24F2N2O	310.4	CC(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 83000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW5OL0	(2R,3S,5R)-5-[2-(Benzenesulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	127035244	C22H22F2N4O3S	460.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CN(N=C4C3)S(=O)(=O)C5=CC=CC=C5	IC50 = 95000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW5XD0	(R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2,5-difluoro-phenyl)-butan-1-one	Investigative	44394001	C21H25F2N3O	373.4	C1CN([C@@H](CN1)CC2=CC=CC=C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 65000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW7AS9	(3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797232	C17H16F6N4O2	422.32	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=NC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW8D1L	3-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpropanamide	Investigative	53322758	C18H27F2N3O	339.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)CCN	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BW8ZI9	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one	Investigative	10450114	C16H20F3N3O2	343.34	C[C@@H]1C(=O)NCCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWIO37	(3R,4R)-1-(3-Ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797251	C20H20F6N6O2	490.4	CCC1=NN=C2N1N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 = 90000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWJ1G7	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,2-dimethylpropanamide	Investigative	53322814	C19H28F2N2O	338.4	CC(C)C(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWKU19	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-[methyl-(4-methylphenyl)sulfonylamino]phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797345	C26H32F4N4O6S	604.6	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWL13O	N-[4-[(4-Acetamidophenoxy)-[2-[(2S,3R)-2-amino-3-methylpentanoyl]-1,3-dihydroisoindol-1-yl]phosphoryl]oxyphenyl]acetamide	Investigative	23657547	C30H35N4O6P	578.6	CC[C@@H](C)[C@@H](C(=O)N1CC2=CC=CC=C2C1P(=O)(OC3=CC=C(C=C3)NC(=O)C)OC4=CC=C(C=C4)NC(=O)C)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWO5L8	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443707	C17H17F5N4O	388.33	C1CN(CC2=C1N=C(N2)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWSN83	Methyl 2-[(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetate	Investigative	23647115	C19H25F2N3O4	397.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N)CC(=O)OC	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWYJ26	2-Amino-3-hydroxy-1-piperidin-1-yl-propan-1-one	Investigative	21949272	C8H16N2O2	172.22	C1CCN(CC1)C(=O)C(CO)N	IC50 = 62000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BWZC31	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione	Investigative	122189873	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=NC=C4)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX05ZO	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-d][1,3]thiazol-5-yl]butan-1-one	Investigative	23645939	C17H16F5N3OS	405.4	C1CN(CC2=C1N=C(S2)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 63000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX0H4O	(2S,3As,6aS)-1-[(3R)-3-amino-4-(4-fluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712781	C18H22FN3O	315.4	C1C[C@H]2C[C@H](N([C@H]2C1)C(=O)C[C@@H](CC3=CC=C(C=C3)F)N)C#N	IC50 = 77030 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX4I2J	(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride	Investigative	23644660	C15H18ClF2N5O	357.78	C1CN2C=NN=C2CN1C(=O)C[C@@H](CC3=CC(=C(C=C3)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX4WD0	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189878	C26H30N8O4	518.6	CC(=CCCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX5EA9	(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	11538992	C18H19F6N5	419.4	C1C[C@@H]([C@H](C[C@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX65PY	(3R)-3-Amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265965	C23H21ClF7N5O	551.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4F.Cl	IC50 = 76000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX68NU	(S)-2-Amino-1-(pyrrolidin-1-yl)hexan-1-one	Investigative	44560851	C10H20N2O	184.28	CCCC[C@@H](C(=O)N1CCCC1)N	IC50 = 60000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BX95WV	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}butan-1-one	Investigative	23645917	C17H20F2N4O	334.36	CC1=C2CN(CCC2=NN1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 71000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXC8H5	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035241	C19H24F2N4O3S	426.5	CCCS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXE8K4	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-c][1,2]oxazol-6-yl]butan-1-one	Investigative	23645936	C17H16F5N3O2	389.32	C1CN(CC2=NOC(=C21)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXF60I	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797035	C22H22F5N3O4	487.4	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)N)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXH5N6	(2R)-1-[2-[2-[3-(3,4-Dimethoxyphenyl)-2-oxoimidazolidin-1-yl]ethylamino]acetyl]pyrrolidine-2-carbonitrile;oxalic acid	Investigative	49859910	C22H29N5O8	491.5	COC1=C(C=C(C=C1)N2CCN(C2=O)CCNCC(=O)N3CCC[C@@H]3C#N)OC.C(=O)(C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXM2Y3	3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-phenylpropionamide	Investigative	11680991	C16H20N4O2	300.36	C1C[C@H](N(C1)C(=O)CNCCC(=O)NC2=CC=CC=C2)C#N	IC50 = 57176 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXP65Y	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one	Investigative	11269712	C17H16F5N3OS	405.4	C1CN(CC2=C1SC(=N2)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 95000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXR38A	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one	Investigative	23645933	C18H19F5N4O	402.4	CN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=N1)C(F)(F)F	IC50 = 67000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXT1B4	(2S,3S,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193505	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXZ1N3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methoxyquinoline-4-carboxamide	Investigative	89705244	C18H18N4O3	338.4	COC1=CC=CC2=NC=CC(=C21)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BXZ92E	7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid	Investigative	23661716	C20H17F6N5O3	489.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=CC(=O)N=C4C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY0NR5	2-Amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one	Investigative	3021908	C13H18N2O	218.29	C1CCN(C1)C(=O)C(CC2=CC=CC=C2)N	IC50 = 79000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY1AK2	2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Methyl-6,9-Dioxo-5,6,7,9-Tetrahydro-1h-Imidazo[1,2-A]purin-1-Yl}methyl)-4-Fluorobenzonitrile	Investigative	71203748	C21H21FN8O2	436.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY24JE	(1S,2R,5S)-5-(Isoindolin-2-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	11523077	C20H21F3N2	346.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=CC=CC=C3C2)N)C4=CC(=C(C=C4F)F)F	IC50 = 68000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY5QC9	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-5-phenylquinoline-4-carboxamide	Investigative	89704970	C23H20N4O2	384.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC(=C23)C4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY6Q7W	(4-{[4-(Ethoxycarbonylmethyl-carbamoyl)-phenoxy]-[1-(pyrrolidine-2-carbonyl)-pyrrolidin-2-yl]-phosphinoyloxy}-benzoylamino)-acetic acid ethyl ester	Investigative	44266022	C31H39N4O10P	658.6	CCOC(=O)CNC(=O)C1=CC=C(C=C1)OP(=O)(C2CCCN2C(=O)C3CCCN3)OC4=CC=C(C=C4)C(=O)NCC(=O)OCC	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY6TK4	(3R)-3-Amino-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	11306467	C17H16ClF8N5O	493.8	C1CN2C(=NN=C2C(C(F)(F)F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 78000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY7FR1	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-5-carboxamide	Investigative	71655626	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=CN=C3)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY7N5B	(R)-3-Amino-1-thiazolidin-3-yl-4-(2-trifluoromethyl-phenyl)-butan-1-one	Investigative	44394195	C14H17F3N2OS	318.36	C1CSCN1C(=O)C[C@@H](CC2=CC=CC=C2C(F)(F)F)N	IC50 = 82120 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY8A7O	(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	49797616	C20H15F6N3O4	475.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=CC(=C3)C(=O)O)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY90ZF	(3S)-2-[(2S)-2-Amino-2-cyclohexylacetyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile	Investigative	24784664	C18H23N3O	297.4	C1CCC(CC1)[C@@H](C(=O)N2CC3=CC=CC=C3C[C@H]2C#N)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BY93LZ	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797048	C17H18F8N2O3	450.32	C[C@@H](C1=C(C=C(C=C1)F)C(F)(F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYH49E	N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693956	C19H19N3O2	321.4	C1CCN([C@@H](C1)C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYI91W	N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	66561556	C14H13F2N3O2	293.27	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYO83J	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797244	C19H15F9N6O2	530.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C(=NC(=N4)C(F)(F)F)C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYQE45	(3R)-3-Amino-1-[5,5-dimethyl-3-(trifluoromethyl)-6,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777686	C18H20ClF6N5O	471.8	CC1(CN(CC2=NN=C(N21)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C.Cl	IC50 = 77000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYT61V	Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid	Investigative	49796933	C26H29F4N3O6S	587.6	COC(=O)CC1=CC=C(C=C1)CNC(=O)[C@@H]2CSCN2C(=O)CC(CC3=CC=CC=C3F)N.C(=O)(C(F)(F)F)O	IC50 = 59000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BYTD83	(2S,4S)-1-[(3R)-3-Amino-4-(3-fluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	118712767	C15H17F2N3O	293.31	C1[C@@H](CN([C@@H]1C#N)C(=O)C[C@@H](CC2=CC(=CC=C2)F)N)F	IC50 = 59100 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZ08GA	US9051329, Example 3	Investigative	71203769	C20H21F2N7O2	429.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZ4YN5	2-((R)-2-Amino-4-oxo-4-thiazolidin-3-yl-butyl)-benzonitrile	Investigative	44394194	C14H17N3OS	275.37	C1CSCN1C(=O)C[C@@H](CC2=CC=CC=C2C#N)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZ7B5O	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one	Investigative	23647121	C18H21F6N3O2	425.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC(F)(F)F	IC50 = 56000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZAY29	(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-pyridin-3-ylmethyl-piperazin-1-yl)-butan-1-one	Investigative	44394029	C20H25FN4O	356.4	C1CN([C@@H](CN1)CC2=CN=CC=C2)C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZC1J3	N-((R)-1-((S)-2-Cyanopyrrolidine-1-yl)-1-oxopropan-2-yl)quinoline-4-carboxamide	Investigative	89705242	C18H18N4O2	322.4	C[C@H](C(=O)N1CCC[C@H]1C#N)NC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZD8S1	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylimidazole-4-sulfonamide	Investigative	53324142	C19H26F2N4O2S	412.5	CN1C=C(N=C1)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZEX51	(3R)-3-Amino-1-(4-cyclopropyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443729	C21H22F6N4O	460.4	CN1C2=C(C(N(CC2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C4CC4)N=C1C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZF7J0	2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-4-methyl-1-oxopentyl]-1,2,3,4-tetrahydroisoquinoline	Investigative	11494684	C22H30N4O2	382.5	CC(C)[C@@H](CC(=O)N1CCC2=CC=CC=C2C1)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZI1R7	7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione	Investigative	89668929	C25H27N7O2	457.5	CC#CCN1C2=C(N=C1N3CCCCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	BZYP13	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796953	C29H34F5N3O7	631.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D03DNV	ARI-3099	Investigative	71655266	C13H18BN3O4	291.11	B([C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)C2=CC=NC=C2)(O)O	IC50 ~ 100000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0CP1J	1G244	Investigative	56658139	C29H30F2N4O2	504.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N	IC50 ~ 50000 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0N1FU	N-isoleucylthiazolidine	Investigative	6918465	C9H18N2OS	202.32	CC[C@H](C)[C@@H](C(=O)N1CCSC1)N	IC50 = 68985 nM	Poor binder
T50773	Dipeptidyl-peptidase 7	D0T2EW	Cyclohexylglycine-(2S)-cyanopyrrolidine	Investigative	11075394	C13H21N3O	235.33	C1CCC(CC1)[C@@H](C(=O)N2CCC[C@H]2C#N)N	IC50 = 102000 nM	Poor binder