TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T47107 Protein kinase C gamma D0WS1V L-751250 Preclinical 448991 C20H25ClN6O3 432.9 CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=C(C=C3)C(=O)O)Cl IC50 ~ 100000 nM Poor binder T47107 Protein kinase C gamma B1LGZ6 3,13-Diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tetracosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20,23-decaene-12,14-dione Investigative 9797847 C22H12N2O2 336.3 C1=CC=C2C(=C1)C=CC3=C2C4=C(C5=C3NC6=CC=CC=C65)C(=O)NC4=O IC50 = 56500 nM Poor binder T47107 Protein kinase C gamma B2U1HJ 1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Investigative 4877 C19H19N5 317.4 CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N IC50 ~ 100000 nM Poor binder T47107 Protein kinase C gamma B4F1NE 2-[2,6-Dihydroxy-4-[[(3R,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]-methylcarbamoyl]benzoyl]-3-hydroxybenzoic acid Investigative 71718528 C29H29N3O9 563.6 CN([C@H]1CCCNC[C@H]1NC(=O)C2=CC=C(C=C2)O)C(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C=CC=C4O)C(=O)O)O IC50 ~ 50000 nM Poor binder T47107 Protein kinase C gamma B5QG6J 5-(Methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol Investigative 3568 C16H18O8 338.31 COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O IC50 = 50000 nM Poor binder T47107 Protein kinase C gamma BQ9Y5W 2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide Investigative 44427518 C32H31N5O4 549.6 COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)CC(=O)NC5=CC=C(C=C5)N6CCOCC6)N IC50 ~ 50000 nM Poor binder T47107 Protein kinase C gamma BQL63Y Hippolide A Investigative 53262772 C25H37NO4 415.6 CC(=CCC/C(=C/CC/C(=C/CCC1=CC[C@@H](O[C@@H]1O)[C@@H]2CC(=O)NC2=O)/C)/C)C IC50 = 61970 nM Poor binder T47107 Protein kinase C gamma BSR32G (3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-imidazol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one Investigative 135678111 C19H15N3O3 333.3 COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=NC=CN4)/C(=O)N3)O IC50 ~ 50000 nM Poor binder T47107 Protein kinase C gamma BYI18Q Betulinic acid 3-O-benzoate Investigative 10099352 C37H52O4 560.8 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C6=CC=CC=C6)C)C(=O)O IC50 = 74000 nM Poor binder T47107 Protein kinase C gamma D02XHC aloisine A Investigative 448912 C16H17N3O 267.33 CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O IC50 ~ 100000 nM Poor binder T47107 Protein kinase C gamma D0D6DH A-432411 Investigative 10125830 C20H16N2O3 332.4 COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=CC=CN4)/C(=O)N3)O IC50 ~ 50000 nM Poor binder