TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T46040	Coagulation factor XI	D0I7OF	Hexamethylene amiloride	Preclinical	1794	C12H18ClN7O	311.77	C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N	IC50 ~ 50000 nM	Poor binder
T46040	Coagulation factor XI	B05OSA	Disodium;[2-[2-[3,5-dicyano-6-nitro-4-(4-phenoxyphenyl)pyridin-2-yl]sulfanylacetyl]-6-sulfonatooxyphenyl] sulfate	Investigative	90655982	C27H14N4Na2O12S3	728.6	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=C(C(=NC(=C3C#N)SCC(=O)C4=C(C(=CC=C4)OS(=O)(=O)[O-])OS(=O)(=O)[O-])[N+](=O)[O-])C#N.[Na+].[Na+]	IC50 = 109000 nM	Poor binder
T46040	Coagulation factor XI	B1CLK9	[4-[4-Oxo-3-[5-[5-[[4-oxo-2-(4-sulfooxyphenyl)quinazolin-3-yl]methyl]triazol-1-yl]pentyl]quinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71600263	C36H31N7O10S2	785.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC=C(C=C3)OS(=O)(=O)O)CCCCCN4C(=CN=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC=C(C=C7)OS(=O)(=O)O	IC50 = 90000 nM	Poor binder
T46040	Coagulation factor XI	B1PMC4	Chembl4217043	Investigative	135393474	C17H23N9O2	385.4	COC1=NC=C(C=N1)C2=C(N=C(C(=N2)C(=O)N=C(N)N)N)N3CCCCCC3	IC50 ~ 50000 nM	Poor binder
T46040	Coagulation factor XI	B37VHD	[3-[3-[4-[4-[[2-(3-Hydroxy-5-sulfooxyphenyl)-4-oxoquinazolin-3-yl]methyl]triazol-1-yl]butyl]-4-oxoquinazolin-2-yl]-5-sulfooxyphenyl] acetate	Investigative	71718753	C37H31N7O13S2	845.8	CC(=O)OC1=CC(=CC(=C1)C2=NC3=CC=CC=C3C(=O)N2CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC(=CC(=C7)OS(=O)(=O)O)O)OS(=O)(=O)O	IC50 = 153000 nM	Poor binder
T46040	Coagulation factor XI	B3A0MQ	(3E,6S,9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-6-phenyl-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),3,17(22),18,20-pentaene-7,10,13-trione	Investigative	52948297	C35H43ClN4O3	603.2	CC(C)C[C@H]1C(=O)NCC2=C(C/C=C/C[C@H](C(=O)N[C@@H](C(=O)N1)C3CCCCC3)C4=CC=CC=C4)NC5=C2C=C(C=C5)Cl	IC50 = 135800 nM	Poor binder
T46040	Coagulation factor XI	B3H8WP	N-[[(3S,3Ar)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzothiazin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713018	C20H18ClN3O5S2	480	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CS3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T46040	Coagulation factor XI	B3Q2VK	(9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-7,7-dioxo-7lambda6-thia-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),17(22),18,20-tetraene-10,13-dione	Investigative	52943592	C28H41ClN4O4S	565.2	CC(C)C[C@H]1C(=O)NCC2=C(CCCCCS(=O)(=O)N[C@@H](C(=O)N1)C3CCCCC3)NC4=C2C=C(C=C4)Cl	IC50 = 175900 nM	Poor binder
T46040	Coagulation factor XI	B4UJA1	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137637214	C117H160N32O28S3	2558.9	C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](CSCC3=CC4=CC(=C3)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@@H](CSC4)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC7=CNC8=CC=CC=C87)CC9=CNC1=CC=CC=C19)CC(=O)N)CC1=CNC2=CC=CC=C21)[C@@H](C)O)CC(=O)N)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)CC(C)C	Ki ~ 50000 nM	Poor binder
T46040	Coagulation factor XI	B4W3NK	N-[(6-Amino-2-methylpyridin-3-yl)methyl]-1-[[4-(pyrazol-1-ylmethyl)phenyl]methyl]pyrazole-4-carboxamide	Investigative	134130781	C22H23N7O	401.5	CC1=C(C=CC(=N1)N)CNC(=O)C2=CN(N=C2)CC3=CC=C(C=C3)CN4C=CC=N4	IC50 = 106000 nM	Poor binder
T46040	Coagulation factor XI	B79EXU	Sodium;[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl]oxymethyl]-1H-indol-5-yl] sulfate	Investigative	118723908	C38H36NNaO16S	817.7	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OCC5=C(C6=C(N5)C=CC(=C6)OS(=O)(=O)[O-])C(=O)OCC)C(=O)OCC)OC)C.[Na+]	IC50 = 86900 nM	Poor binder
T46040	Coagulation factor XI	B7AF4Q	1-[2-(2-Tert-butylphenoxy)pyridin-3-yl]-3-[4-[2-[(dimethylamino)methyl]phenyl]-2-fluorophenyl]urea	Investigative	71625797	C31H33FN4O2	512.6	CC(C)(C)C1=CC=CC=C1OC2=C(C=CC=N2)NC(=O)NC3=C(C=C(C=C3)C4=CC=CC=C4CN(C)C)F	Ki ~ 55000 nM	Poor binder
T46040	Coagulation factor XI	B89BJS	N-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide	Investigative	44411556	C14H23N5O2S	325.43	CC(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C1=NC=CS1	IC50 = 123000 nM	Poor binder
T46040	Coagulation factor XI	B91EPI	4-Aminomethylphenylboronic acid hydrochloride	Investigative	2734311	C7H11BClNO2	187.43	B(C1=CC=C(C=C1)CN)(O)O.Cl	IC50 = 77300 nM	Poor binder
T46040	Coagulation factor XI	B95MFL	[3-[4-Oxo-3-[[1-[4-[4-oxo-2-(4-sulfooxyphenyl)quinazolin-3-yl]butyl]triazol-4-yl]methyl]quinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71600943	C35H29N7O10S2	771.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC=C(C=C3)OS(=O)(=O)O)CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC(=CC=C7)OS(=O)(=O)O	IC50 = 159000 nM	Poor binder
T46040	Coagulation factor XI	B96DXB	[2-Methoxy-4-[4-oxo-3-[4-[4-[[4-oxo-2-(3-sulfooxyphenyl)quinazolin-3-yl]methyl]triazol-1-yl]butyl]quinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71601211	C36H31N7O11S2	801.8	COC1=C(C=CC(=C1)C2=NC3=CC=CC=C3C(=O)N2CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC(=CC=C7)OS(=O)(=O)O)OS(=O)(=O)O	IC50 = 182000 nM	Poor binder
T46040	Coagulation factor XI	B98KPM	Sodium;[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl]oxymethyl]-6-methoxy-1-benzofuran-5-yl]oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate	Investigative	71734497	C52H49NaO23S	1097	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OCC5=C(C6=CC(=C(C=C6O5)OC)OCC7=C(C8=CC(=C(C=C8O7)OC)OS(=O)(=O)[O-])C(=O)OCC)C(=O)OCC)C(=O)OCC)OC)C.[Na+]	IC50 = 99000 nM	Poor binder
T46040	Coagulation factor XI	B9XQT1	(2S)-N-[(5-Chloro-2-prop-2-enyl-1H-indol-3-yl)methyl]-2-[[(2R)-2-cyclohexyl-2-(pent-4-enoylamino)acetyl]amino]-4-methylpentanamide	Investigative	50908869	C31H43ClN4O3	555.1	CC(C)C[C@@H](C(=O)NCC1=C(NC2=C1C=C(C=C2)Cl)CC=C)NC(=O)[C@@H](C3CCCCC3)NC(=O)CCC=C	IC50 = 103100 nM	Poor binder
T46040	Coagulation factor XI	BB2S8T	6-Chloro-2-hydroxyquinoline	Investigative	326646	C9H6ClNO	179.6	C1=CC2=C(C=CC(=O)N2)C=C1Cl	Ki = 70000 nM	Poor binder
T46040	Coagulation factor XI	BC1X6P	304L Stainless Steel powder	Investigative	45261246	C27H36ClN5O3	514.1	CC[C@@H]1CC(N2[C@@H]1[C@H](C[C@](C2=O)(CC3=CC=CC=C3)N)OC)C(=O)NCC4=CC=C(C=C4)C(=N)N.Cl	IC50 ~ 133000 nM	Poor binder
T46040	Coagulation factor XI	BC7FE4	[2-Methoxy-4-[3-[[1-[4-[2-(3-methoxy-4-sulfooxyphenyl)-4-oxoquinazolin-3-yl]butyl]triazol-4-yl]methyl]-4-oxoquinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71600941	C37H33N7O12S2	831.8	COC1=C(C=CC(=C1)C2=NC3=CC=CC=C3C(=O)N2CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC(=C(C=C7)OS(=O)(=O)O)OC)OS(=O)(=O)O	IC50 = 139000 nM	Poor binder
T46040	Coagulation factor XI	BC96JP	[4-[4-Oxo-3-[[1-[4-[4-oxo-2-(3-sulfooxyphenyl)quinazolin-3-yl]butyl]triazol-4-yl]methyl]quinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71601066	C35H29N7O10S2	771.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC(=CC=C3)OS(=O)(=O)O)CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC=C(C=C7)OS(=O)(=O)O	IC50 = 91000 nM	Poor binder
T46040	Coagulation factor XI	BCA2D3	Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[4-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate	Investigative	137647340	C38H18Na8O38S8	1523	C1=CC(=CC=C1COC2=CC(=CC3=C2C(=O)C(=C(O3)C4=CC(=C(C=C4)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COC5=CC(=CC6=C5C(=O)C(=C(O6)C7=CC(=C(C=C7)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]	IC50 = 180000 nM	Poor binder
T46040	Coagulation factor XI	BD9IW4	[3-[4-Oxo-3-[[1-[4-[4-oxo-2-(3-sulfooxyphenyl)quinazolin-3-yl]butyl]triazol-4-yl]methyl]quinazolin-2-yl]phenyl] hydrogen sulfate	Investigative	71600679	C35H29N7O10S2	771.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC(=CC=C3)OS(=O)(=O)O)CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC(=CC=C7)OS(=O)(=O)O	IC50 = 102000 nM	Poor binder
T46040	Coagulation factor XI	BDAJ86	N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	76685067	C20H18ClN3O6S	463.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T46040	Coagulation factor XI	BHAG94	(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid	Investigative	137654508	C76H105N19O19S3	1685	C[C@H]1CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSC3)C(=O)N1)CCCCNC(=N)N)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)CO)NC(=O)C)C(=O)O)CC(C)C)CC(=O)O)CCC(=O)N)CC7=CN=CN7	Ki ~ 50000 nM	Poor binder
T46040	Coagulation factor XI	BHVF86	(1R,6S,8S,8As)-6-amino-N-[(4-carbamimidoylphenyl)methyl]-1-ethyl-8-methoxy-6-(2-methylprop-2-enyl)-5-oxo-1,2,3,7,8,8a-hexahydroindolizine-3-carboxamide;(E)-but-2-enedioic acid	Investigative	46905372	C28H39N5O7	557.6	CC[C@@H]1CC(N2[C@@H]1[C@H](C[C@](C2=O)(CC(=C)C)N)OC)C(=O)NCC3=CC=C(C=C3)C(=N)N.C(=C/C(=O)O)\\C(=O)O	IC50 ~ 133000 nM	Poor binder
T46040	Coagulation factor XI	BI90NG	2-[4-(Sulfooxy)phenyl]-3-[6-[4-[2-[4-(sulfooxy)phenyl]-4-oxo-3,4-dihydroquinazoline-3-ylmethyl]-1H-1,2,3-triazole-1-yl]hexyl]quinazoline-4(3H)-one	Investigative	71601210	C37H33N7O10S2	799.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC=C(C=C3)OS(=O)(=O)O)CCCCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC=C(C=C7)OS(=O)(=O)O	IC50 = 52000 nM	Poor binder
T46040	Coagulation factor XI	BI97QF	Chembl2332610	Investigative	71716976	C64H93N17O16S3	1452.7	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](CCCCN)C(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T46040	Coagulation factor XI	BIXT64	Naphthalene-2-sulfonic acid [(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide	Investigative	44411677	C19H21N5O3S2	431.5	C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)C3=NC=CS3	IC50 = 86000 nM	Poor binder
T46040	Coagulation factor XI	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T46040	Coagulation factor XI	BK8QS2	2-[4-(Sulfooxy)phenyl]-3-[4-[4-[2-[4-(sulfooxy)phenyl]-4-oxo-3,4-dihydroquinazoline-3-ylmethyl]-1H-1,2,3-triazole-1-yl]butyl]quinazoline-4(3H)-one	Investigative	71601065	C35H29N7O10S2	771.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC=C(C=C3)OS(=O)(=O)O)CCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC=C(C=C7)OS(=O)(=O)O	IC50 = 82000 nM	Poor binder
T46040	Coagulation factor XI	BLYR94	2-[4-(Sulfooxy)phenyl]-3-[5-[4-[2-[4-(sulfooxy)phenyl]-4-oxo-3,4-dihydroquinazoline-3-ylmethyl]-1H-1,2,3-triazole-1-yl]pentyl]quinazoline-4(3H)-one	Investigative	71601067	C36H31N7O10S2	785.8	C1=CC=C2C(=C1)C(=O)N(C(=N2)C3=CC=C(C=C3)OS(=O)(=O)O)CCCCCN4C=C(N=N4)CN5C(=NC6=CC=CC=C6C5=O)C7=CC=C(C=C7)OS(=O)(=O)O	IC50 = 59000 nM	Poor binder
T46040	Coagulation factor XI	BM6ND8	Chembl2332604	Investigative	71716975	C59H82N16O15S3	1351.6	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)CN)C(=O)NCC(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T46040	Coagulation factor XI	BMZC64	Sodium;[2-[(2-benzyl-3-ethoxycarbonyl-6-methoxy-1-benzofuran-5-yl)oxymethyl]-3-ethoxycarbonyl-1H-indol-5-yl] sulfate	Investigative	118723904	C31H28NNaO11S	645.6	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=C(N3)C=CC(=C4)OS(=O)(=O)[O-])C(=O)OCC)OC)CC5=CC=CC=C5.[Na+]	IC50 = 118000 nM	Poor binder
T46040	Coagulation factor XI	BNY76B	5-Chloro-N-(((3S,3aS)-1-oxo-7-(3-oxomorpholino)-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-3-yl)methyl)thiophene-2-carboxamide	Investigative	118713026	C21H20ClN3O5S	461.9	C1CC2=C(C=CC(=C2)N3CCOCC3=O)N4[C@@H]1[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T46040	Coagulation factor XI	BQ0F9L	(2S)-N-[(5-Chloro-2-prop-2-enyl-1H-indol-3-yl)methyl]-2-[[(2R)-2-cyclohexyl-2-[[(2S)-2-phenylpent-4-enoyl]amino]acetyl]amino]-4-methylpentanamide	Investigative	52942903	C37H47ClN4O3	631.2	CC(C)C[C@@H](C(=O)NCC1=C(NC2=C1C=C(C=C2)Cl)CC=C)NC(=O)[C@@H](C3CCCCC3)NC(=O)[C@@H](CC=C)C4=CC=CC=C4	IC50 = 145900 nM	Poor binder
T46040	Coagulation factor XI	BQ0ZY6	Benzamidine hydrochloride	Investigative	80289	C7H9ClN2	156.61	C1=CC=C(C=C1)C(=N)N.Cl	IC50 = 120000 nM	Poor binder
T46040	Coagulation factor XI	BR5VK9	Sodium;[2-[[6-methoxy-3-[(2-methylpropan-2-yl)oxycarbonyl]-1-benzofuran-5-yl]oxymethyl]-1,3-benzothiazol-6-yl] sulfate	Investigative	118723894	C22H20NNaO9S2	529.5	CC(C)(C)OC(=O)C1=COC2=CC(=C(C=C21)OCC3=NC4=C(S3)C=C(C=C4)OS(=O)(=O)[O-])OC.[Na+]	IC50 = 124000 nM	Poor binder
T46040	Coagulation factor XI	BVC8S1	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3,3a,4,5-tetrahydro-[1,3]oxazolo[3,4-a]quinoxalin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713029	C20H19ClN4O5S	462.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CN3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T46040	Coagulation factor XI	BVMQ63	Disodium;[4-[[3-[1,3-dioxo-5-[(4-sulfonatooxyphenyl)carbamoyl]isoindol-2-yl]benzoyl]amino]phenyl] sulfate	Investigative	90655984	C28H17N3Na2O12S2	697.6	C1=CC(=CC(=C1)N2C(=O)C3=C(C2=O)C=C(C=C3)C(=O)NC4=CC=C(C=C4)OS(=O)(=O)[O-])C(=O)NC5=CC=C(C=C5)OS(=O)(=O)[O-].[Na+].[Na+]	IC50 = 122000 nM	Poor binder
T46040	Coagulation factor XI	BYE5M2	(1R,6S,8S,8As)-6-amino-N-[(4-carbamimidoylphenyl)methyl]-6-(cyclohexen-1-ylmethyl)-1-ethyl-8-methoxy-5-oxo-1,2,3,7,8,8a-hexahydroindolizine-3-carboxamide;hydrochloride	Investigative	45261220	C27H40ClN5O3	518.1	CC[C@@H]1CC(N2[C@@H]1[C@H](C[C@](C2=O)(CC3=CCCCC3)N)OC)C(=O)NCC4=CC=C(C=C4)C(=N)N.Cl	IC50 ~ 133000 nM	Poor binder