TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T41955 Long transient receptor potential channel 8 B5CEM7 2-[Benzoyl-[(3-methoxyphenyl)methyl]amino]-2-phenylacetic acid Investigative 134132806 C23H21NO4 375.4 COC1=CC=CC(=C1)CN(C(C2=CC=CC=C2)C(=O)O)C(=O)C3=CC=CC=C3 IC50 = 59000 nM Poor binder T41955 Long transient receptor potential channel 8 B6YMX7 (3S)-N-Ethyl-3-hydroxy-3-phenyl-N-(thiophen-2-ylmethyl)propanamide Investigative 137639123 C16H19NO2S 289.4 CCN(CC1=CC=CS1)C(=O)C[C@@H](C2=CC=CC=C2)O EC50 = 52023 nM Poor binder T41955 Long transient receptor potential channel 8 B86AIV N-[(1S)-2-Amino-2-oxo-1-phenylethyl]-N-[(3-methoxyphenyl)methyl]thiophene-2-carboxamide Investigative 118247023 C21H20N2O3S 380.5 COC1=CC=CC(=C1)CN([C@@H](C2=CC=CC=C2)C(=O)N)C(=O)C3=CC=CS3 IC50 = 54000 nM Poor binder T41955 Long transient receptor potential channel 8 BBF6L9 N-[(1R)-2-(Dimethylamino)-2-oxo-1-phenylethyl]-N-[(3-methoxyphenyl)methyl]benzamide Investigative 134133658 C25H26N2O3 402.5 CN(C)C(=O)[C@@H](C1=CC=CC=C1)N(CC2=CC(=CC=C2)OC)C(=O)C3=CC=CC=C3 IC50 = 86000 nM Poor binder T41955 Long transient receptor potential channel 8 BBVI53 Menthol Investigative 1254 C10H20O 156.26 CC1CCC(C(C1)O)C(C)C IC50 = 92000 nM Poor binder T41955 Long transient receptor potential channel 8 BD1F4C N-[(1R)-2-Amino-2-oxo-1-phenylethyl]-N-[[4-[(4-fluorophenyl)methoxy]-3-methoxyphenyl]methyl]thiophene-2-carboxamide Investigative 134148902 C28H25FN2O4S 504.6 COC1=C(C=CC(=C1)CN([C@H](C2=CC=CC=C2)C(=O)N)C(=O)C3=CC=CS3)OCC4=CC=C(C=C4)F IC50 ~ 100000 nM Poor binder T41955 Long transient receptor potential channel 8 BR24GH N-[(2R)-1-Amino-1-oxopropan-2-yl]-N-[(3-methoxyphenyl)methyl]benzamide Investigative 134145004 C18H20N2O3 312.4 C[C@H](C(=O)N)N(CC1=CC(=CC=C1)OC)C(=O)C2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T41955 Long transient receptor potential channel 8 BTYI65 2-(4-Methylphenoxy)-N-(1-methylpyrazol-4-yl)-N-(thiophen-2-ylmethyl)acetamide Investigative 137641021 C18H19N3O2S 341.4 CC1=CC=C(C=C1)OCC(=O)N(CC2=CC=CS2)C3=CN(N=C3)C EC50 = 63000 nM Poor binder