TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T38338	Voltage-gated calcium channel alpha Cav2.2	B0MUQ5	Chembl4224750	Investigative	145970794	C26H23F6N3O4S	587.5	C1=CC(=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NCC4=CC=C(C=C4)OCCCN)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 144000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B18DTZ	(R)-2-(6-(Phenethylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol	Investigative	71459658	C20H28N6O	368.5	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NCCC3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B1A5OJ	Olomoucine II	Investigative	5494414	C19H26N6O2	370.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3O	EC50 = 80000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B3B0XM	Chembl4225787	Investigative	145969009	C26H26F3N5O4S	561.6	C1=CC=C(C=C1)OC2=CC3=C(C=C2)N=C(S3)NCC4=CC=C(C=C4)OCCCN=C(N)N.C(=O)(C(F)(F)F)O	IC50 = 103000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B3ES9G	Chembl4224756	Investigative	145971033	C26H26F3N3O5S	549.6	CN(CC1=CC=C(C=C1)OCCCN)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)O.C(=O)(C(F)(F)F)O	IC50 = 117000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B3OE1Q	Chembl4227450	Investigative	145971143	C29H29F3N4O4S	586.6	CN(C)CCCOC1=CC=C(C=C1)CN(C)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C#N.C(=O)(C(F)(F)F)O	IC50 = 69000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B4I0BA	Chembl4225757	Investigative	145967628	C27H25F6N3O4S	601.6	CN(CC1=CC=C(C=C1)OCCCN)C2=NC3=C(S2)C=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 77000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B59QUG	(2R)-2-[[6-(Benzylamino)-9-methylpurin-2-yl]amino]butan-1-ol	Investigative	71461387	C17H22N6O	326.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NCC3=CC=CC=C3	EC50 ~ 70000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B5JE0Z	Chembl4227653	Investigative	145968873	C28H27F6N3O4S	615.6	CN(C)CCCOC1=CC=C(C=C1)CNC2=NC3=C(S2)C=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 51000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B5N4CS	(2R)-2-[(6-Anilino-9-propylpurin-2-yl)amino]butan-1-ol	Investigative	71455944	C18H24N6O	340.4	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NC3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B62EUK	(2R)-2-[[6-(Benzhydrylamino)-9-propylpurin-2-yl]amino]butan-1-ol	Investigative	71463105	C25H30N6O	430.5	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NC(C3=CC=CC=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B78NFO	Chembl4228579	Investigative	145970259	C25H23F4N3O4S	537.5	C1=CC(=CC=C1CNC2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)F)OCCCN.C(=O)(C(F)(F)F)O	IC50 = 106000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B7JXT0	(2R)-2-[[9-Propyl-6-[[4-(trifluoromethyl)phenyl]methylamino]purin-2-yl]amino]butan-1-ol	Investigative	71459654	C20H25F3N6O	422.4	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NCC3=CC=C(C=C3)C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B7XI2E	Chembl4285527	Investigative	73294550	C24H27ClN2O2	410.9	CC(C)[C@@H]1C[C@@H](CCO1)C2=NN(C(=C2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4OC	IC50 = 55000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B86BQH	(R)-2-(6-(Cyclopropylmethylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol	Investigative	71463104	C16H26N6O	318.42	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3CC3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B93IQM	Chembl4225815	Investigative	145970149	C28H27F3N6O4S	600.6	CN(CC1=CC=C(C=C1)OCCCN=C(N)N)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C#N.C(=O)(C(F)(F)F)O	IC50 = 143000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B9AK1X	(2R)-2-[[9-Methyl-6-[(4-phenylphenyl)methylamino]purin-2-yl]amino]butan-1-ol	Investigative	71461386	C23H26N6O	402.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NCC3=CC=C(C=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B9PR4S	Chembl4227740	Investigative	145968632	C26H23F6N3O4S	587.5	C1=CC(=CC=C1CNC2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F)OCCCN.C(=O)(C(F)(F)F)O	IC50 = 59000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	B9RXA6	(2R)-2-[[6-(Benzhydrylamino)-9-methylpurin-2-yl]amino]butan-1-ol	Investigative	71463102	C23H26N6O	402.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NC(C3=CC=CC=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BB4G8D	(2R)-2-[[6-(Cyclopropylmethylamino)-9-methylpurin-2-yl]amino]butan-1-ol	Investigative	71452435	C14H22N6O	290.36	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NCC3CC3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BB96GM	Chembl4289288	Investigative	90200902	C23H25ClN2O2	396.9	C[C@H]1CC(C[C@@H](O1)C)C2=NN(C(=C2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4OC	IC50 = 61000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BC5D8A	(2R)-2-[[9-Propyl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol	Investigative	71455942	C18H25N7O	355.4	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NCC3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BCOE96	Chembl4225288	Investigative	145970126	C27H25F6N5O4S	629.6	C1=CC(=CC=C1CNC2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F)OCCCN=C(N)N.C(=O)(C(F)(F)F)O	IC50 = 167000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BD1M4W	Chembl4225492	Investigative	145971063	C27H28F3N5O4S	575.6	CN(CC1=CC=C(C=C1)OCCCN=C(N)N)C2=NC3=C(S2)C=C(C=C3)OC4=CC=CC=C4.C(=O)(C(F)(F)F)O	IC50 = 113000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BE63JC	N-[(1S)-1-[4-[[4-(1H-Imidazole-4-ylmethylamino)phenyl](isoamyl)amino]piperidinocarbonyl]-3-methylbutyl]hexahydro-1H-azepine-1-carboxamide	Investigative	44461094	C33H53N7O2	579.8	CC(C)CCN(C1CCN(CC1)C(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)C3=CC=C(C=C3)NCC4=CN=CN4	IC50 = 120000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BEL85Z	(R)-2-(9-Isopropyl-6-(3-(trifluoromethyl)benzylamino)-9H-purin-2-ylamino)butan-1-ol	Investigative	71459652	C20H25F3N6O	422.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC(=CC=C3)C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BER0H3	Chembl4225227	Investigative	145971053	C27H27F4N5O4S	593.6	CN(CC1=CC=C(C=C1)OCCCN=C(N)N)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)F.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BG3AL5	(2R)-2-[[6-[(4-Phenylphenyl)methylamino]-9-propylpurin-2-yl]amino]butan-1-ol	Investigative	71459657	C25H30N6O	430.5	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NCC3=CC=C(C=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BG64FP	(2R)-2-[(6-Anilino-9-methylpurin-2-yl)amino]butan-1-ol	Investigative	71463103	C16H20N6O	312.37	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NC3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BG6AD3	(2R)-2-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol	Investigative	10247627	C18H25N7O	355.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BGB40I	Chembl4226924	Investigative	145967892	C26H25F4N3O4S	551.6	CN(CC1=CC=C(C=C1)OCCCN)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)F.C(=O)(C(F)(F)F)O	IC50 = 98000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BH8GF5	Chembl4225354	Investigative	145968992	C27H25F6N5O4S	629.6	C1=CC(=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NCC4=CC=C(C=C4)OCCCN=C(N)N)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 130000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BHU85E	(R)-2-(6-(Benzhydrylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol	Investigative	71459656	C25H30N6O	430.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC(C3=CC=CC=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BHYJ63	(R)-2-(9-Methyl-6-(phenethylamino)-9H-purin-2-ylamino)butan-1-ol	Investigative	71459653	C18H24N6O	340.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NCCC3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BIC50V	(2R)-2-[[6-(Cyclopropylmethylamino)-9-propylpurin-2-yl]amino]butan-1-ol	Investigative	71457748	C16H26N6O	318.42	CCCN1C=NC2=C(N=C(N=C21)N[C@H](CC)CO)NCC3CC3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BLQF23	Chembl4226823	Investigative	145967661	C28H27F3N4O4S	572.6	CN(C)CCCOC1=CC=C(C=C1)CNC2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C#N.C(=O)(C(F)(F)F)O	IC50 = 105000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BM3Z8U	(R)-2-(9-Isopropyl-6-(phenethylamino)-9H-purin-2-ylamino)butan-1-ol	Investigative	71459655	C20H28N6O	368.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCCC3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BN4Y2R	Chembl4226080	Investigative	145970156	C28H27F6N5O4S	643.6	CN(CC1=CC=C(C=C1)OCCCN=C(N)N)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 = 185000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BQ1T3G	(2R)-2-[[9-Methyl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol	Investigative	71455943	C16H21N7O	327.38	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C)NCC3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BRN8B1	6-Azepan-1-ylmethyl-2-methyl-1,2,3,4-tetrahydro-isoquinolin-5-ol	Investigative	44317301	C17H26N2O	274.4	CN1CCC2=C(C1)C=CC(=C2O)CN3CCCCCC3	IC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BV69QR	(R)-2-(6-(Biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol	Investigative	10137573	C25H30N6O	430.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T38338	Voltage-gated calcium channel alpha Cav2.2	BVO3W9	Chembl4226597	Investigative	145969264	C27H25F3N4O4S	558.6	CN(CC1=CC=C(C=C1)OCCCN)C2=NC3=C(S2)C=C(C=C3)OC4=CC=C(C=C4)C#N.C(=O)(C(F)(F)F)O	IC50 = 65000 nM	Poor binder