TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T34429	Neuronal acetylcholine receptor alpha-7	D0Q9HF	Acetylcholine	Approved	187	C7H16NO2+	146.21	CC(=O)OCC[N+](C)(C)C	EC50 = 69000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D0T8GD	Nicotine	Approved	89594	C10H14N2	162.23	CN1CCC[C@H]1C2=CN=CC=C2	EC50 = 83000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D0U7BW	Carbachol	Approved	2551	C6H15N2O2+	147.2	C[N+](C)(C)CCOC(=O)N	Ki = 66000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D0X4ZR	Bupropion	Approved	444	C13H18ClNO	239.74	CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C	IC50 = 50000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D04HYP	ABT-594	Discontinued in Phase 2	3075702	C9H11ClN2O	198.65	C1CN[C@H]1COC2=CN=C(C=C2)Cl	EC50 = 56000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B01DYG	6-Methoxy-1,2-propano-1,2,3,4-tetrahydroisoquinoline	Investigative	11106445	C13H17NO	203.28	COC1=CC2=C(C=C1)C3CCCN3CC2	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B0LQ8K	[(2S)-1-Methylpyrrolidin-2-yl]methyl quinoline-3-carboxylate	Investigative	73347339	C16H18N2O2	270.33	CN1CCC[C@H]1COC(=O)C2=CC3=CC=CC=C3N=C2	IC50 = 97300 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B1J3FS	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(pyridin-2-yl)methanone	Investigative	66211794	C12H15N3O	217.27	C1C2CN(CC2CN1)C(=O)C3=CC=CC=N3	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B1UF2Z	6,7-Dimethoxy-2-methyl-2-propyl-3,4-dihydro-1H-isoquinolin-2-ium;iodide	Investigative	137636378	C15H24INO2	377.26	CCC[N+]1(CCC2=CC(=C(C=C2C1)OC)OC)C.[I-]	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B2F3UX	1,2,3,5,6,10b-Hexahydropyrrolo[2,1-a]isoquinoline	Investigative	12272373	C12H15N	173.25	C1CC2C3=CC=CC=C3CCN2C1	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B3BNZ7	[(2S)-1-Methylpyrrolidin-2-yl]methyl 6-chloropyridine-3-carboxylate	Investigative	73353403	C12H15ClN2O2	254.71	CN1CCC[C@H]1COC(=O)C2=CN=C(C=C2)Cl	IC50 = 58500 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B3G6CN	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1S,2S)-2-methylcyclopropyl]methanone	Investigative	71682672	C11H18N2O	194.27	C[C@H]1C[C@@H]1C(=O)N2CC3CNCC3C2	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B4DUO0	(1R,16R)-16-Methoxy-5-oxa-10-azatetracyclo[8.7.0.01,13.02,7]heptadeca-2(7),13-dien-4-one	Investigative	44354684	C16H21NO3	275.34	CO[C@@H]1CC=C2CCN3[C@@]2(C1)C4=C(CC3)COC(=O)C4	IC50 = 98000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B52KGQ	1-Ethyl-4-phenylthiomorpholin-1-ium;trifluoromethanesulfonate	Investigative	137637992	C13H18F3NO3S2	357.4	CC[S+]1CCN(CC1)C2=CC=CC=C2.C(F)(F)(F)S(=O)(=O)[O-]	IC50 = 73000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B5D2PQ	O-Methylcorypalline	Investigative	27694	C12H17NO2	207.27	CN1CCC2=CC(=C(C=C2C1)OC)OC	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B6DS0X	[20-[[Dimethyl-[(4-nitrophenyl)methyl]azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-[(4-nitrophenyl)methyl]azanium;dibromide	Investigative	17758335	C38H40Br2N6O4	804.6	C[N+](C)(CC1=CC=C(C=C1)[N+](=O)[O-])CC2=C3CN4C(=C(C5=CC=CC=C54)C[N+](C)(C)CC6=CC=C(C=C6)[N+](=O)[O-])CN3C7=CC=CC=C72.[Br-].[Br-]	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B6JL1Y	6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline	Investigative	41221	C11H15NO	177.24	CN1CCC2=C(C1)C=CC(=C2)OC	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B6XO7L	(10Bs)-8,9-dimethoxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline	Investigative	24823533	C14H19NO2	233.31	COC1=C(C=C2[C@@H]3CCCN3CCC2=C1)OC	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B7K9GP	Polygodial	Investigative	72503	C15H22O2	234.33	C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B84VPY	(E)-3-(2,4-Dihydroxyphenyl)-1-(2,4,5-trihydroxyphenyl)prop-2-en-1-one	Investigative	118714574	C15H12O6	288.25	C1=CC(=C(C=C1O)O)/C=C/C(=O)C2=CC(=C(C=C2O)O)O	EC50 = 67000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B8JBZ3	[(2S)-1-Methylpyrrolidin-2-yl]methyl 6-phenylmethoxypyridine-3-carboxylate	Investigative	73350433	C19H22N2O3	326.4	CN1CCC[C@H]1COC(=O)C2=CN=C(C=C2)OCC3=CC=CC=C3	IC50 = 59100 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	B9JT0Z	(E)-3-(2,4-Dihydroxyphenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one	Investigative	78210299	C15H12O5	272.25	C1=CC(=C(C=C1O)O)/C=C/C(=O)C2=C(C=CC(=C2)O)O	EC50 = 125000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BA7ZD4	4,2',5'-Trihydroxychalcone	Investigative	5980988	C15H12O4	256.25	C1=CC(=CC=C1/C=C/C(=O)C2=C(C=CC(=C2)O)O)O	EC50 = 56000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BAJ7Q3	Nornicotine	Investigative	412	C9H12N2	148.2	C1CC(NC1)C2=CN=CC=C2	Ki = 138000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BBU0Y2	(+)-Crispine A	Investigative	11673094	C14H19NO2	233.31	COC1=C(C=C2[C@H]3CCCN3CCC2=C1)OC	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BCE79Z	8,9-Dimethoxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline	Investigative	10263398	C14H19NO2	233.31	COC1=C(C=C2C3CCCN3CCC2=C1)OC	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BE1W2K	Trimethyl-[[20-[(trimethylazaniumyl)methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl]azanium;diiodide	Investigative	44408895	C26H34I2N4	656.4	C[N+](C)(C)CC1=C2CN3C(=C(C4=CC=CC=C43)C[N+](C)(C)C)CN2C5=CC=CC=C51.[I-].[I-]	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BEIN65	1,1-Diethyl-4-phenylpiperazin-1-ium	Investigative	11581017	C14H23N2+	219.35	CC[N+]1(CCN(CC1)C2=CC=CC=C2)CC	IC50 = 55000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BEM50L	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(furan-3-yl)methanone	Investigative	24945123	C11H14N2O2	206.24	C1C2CN(CC2CN1)C(=O)C3=COC=C3	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BF38WZ	(1S)-16-Methoxy-5-oxa-10-azatetracyclo[8.7.0.01,13.02,7]heptadeca-2(7),13-dien-4-one	Investigative	73759679	C16H21NO3	275.34	COC1CC=C2CCN3[C@]2(C1)C4=C(CC3)COC(=O)C4	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BHL28J	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-methoxyphenyl)methanone	Investigative	66213161	C14H18N2O2	246.3	COC1=CC=C(C=C1)C(=O)N2CC3CNCC3C2	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BIX8Z4	1-[(1R,5S)-8-Azabicyclo[3.2.1]oct-2-en-2-yl]ethanone	Investigative	11332920	C9H13NO	151.21	CC(=O)C1=CC[C@@H]2CC[C@H]1N2	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BK2E1J	[20-[[Dimethyl(prop-2-enyl)azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-prop-2-enylazanium;dibromide	Investigative	44408940	C30H38Br2N4	614.5	C[N+](C)(CC=C)CC1=C2CN3C(=C(C4=CC=CC=C43)C[N+](C)(C)CC=C)CN2C5=CC=CC=C51.[Br-].[Br-]	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BKHT98	2,5-Difluoro-N-[[1-(2-phenylethyl)piperidin-4-ylidene]amino]aniline	Investigative	90666446	C19H21F2N3	329.4	C1CN(CCC1=NNC2=C(C=CC(=C2)F)F)CCC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BLAF56	(3Ar,6aS)-5-(5-ethoxypyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole;dihydrochloride	Investigative	44190223	C13H21Cl2N3O	306.23	CCOC1=CN=CC(=C1)N2C[C@H]3CNC[C@H]3C2.Cl.Cl	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BLP30N	3-(1,4-Diazabicyclo[3.2.2]nonane-4-yl)dibenzothiophene 5,5-dioxide	Investigative	57334716	C19H20N2O2S	340.4	C1CN2CCC1N(CC2)C3=CC4=C(C=C3)C5=CC=CC=C5S4(=O)=O	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BMOH90	(3Ar,6aS)-5-(5-phenylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole;2,2,2-trifluoroacetic acid	Investigative	44592539	C19H20F3N3O2	379.4	C1[C@@H]2CN(C[C@@H]2CN1)C3=CN=CC(=C3)C4=CC=CC=C4.C(=O)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BP10FV	Thiacloprid	Investigative	115224	C10H9ClN4S	252.72	C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl	IC50 = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BQ8FG7	[1-[(3-Hydroxyphenyl)methyl]indol-3-yl]methyl-trimethylazanium;iodide	Investigative	76322102	C19H23IN2O	422.3	C[N+](C)(C)CC1=CN(C2=CC=CC=C21)CC3=CC(=CC=C3)O.[I-]	Ki = 145000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BQHX70	(+)-Pyrido[3,4-b]homotropane	Investigative	13996231	C11H14N2	174.24	C1CC2C3=C(CCC1N2)C=CN=C3	Ki ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BR89DI	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(4-methoxyphenyl)methanone	Investigative	71455499	C15H20N2O2	260.329	COC1=CC=C(C=C1)C(=O)N2CC3CC(C2)CNC3	Ki = 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BRUZ59	Corypalline	Investigative	280225	C11H15NO2	193.24	CN1CCC2=CC(=C(C=C2C1)O)OC	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BTP26N	(1R,3Ar,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1-((pyridin-3-yloxy)methyl)octahydropyrrolo[3,4-c]pyrrole	Investigative	46225231	C23H25N5O	387.5	CN1C[C@@H]2CN(C[C@@H]2[C@@H]1COC3=CN=CC=C3)C4=NN=C(C=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BW9L6R	Dendocarbin A	Investigative	10911949	C15H22O3	250.33	C[C@]12CCCC([C@@H]1CC=C3[C@@H]2[C@@H](OC3=O)O)(C)C	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BWJ0O7	[3-(2,3,4,5-Tetrahydropyridin-6-yl)phenyl]methanol	Investigative	127027055	C12H15NO	189.25	C1CCN=C(C1)C2=CC=CC(=C2)CO	EC50 = 60000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BXSM15	Hydrohydrastinine	Investigative	22301	C11H13NO2	191.23	CN1CCC2=CC3=C(C=C2C1)OCO3	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BY1NU5	6,7-Dimethoxy-2-methyl-2-prop-2-enyl-3,4-dihydro-1H-isoquinolin-2-ium;bromide	Investigative	137639518	C15H22BrNO2	328.24	C[N+]1(CCC2=CC(=C(C=C2C1)OC)OC)CC=C.[Br-]	IC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	BZT06E	3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole	Investigative	24894145	C18H19ClN4O	342.8	CC1=C(C=NN1C2CCNCC2)C3=CC(=NO3)C4=CC=CC=C4Cl	EC50 ~ 100000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D08XRH	DMPP	Investigative	1316	C12H19N2+	191.29	C[N+]1(CCN(CC1)C2=CC=CC=C2)C	EC50 = 95000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D0LH4L	BOLDINE	Investigative	10154	C19H21NO4	327.4	CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)O)OC)O	Ki = 67000 nM	Poor binder
T34429	Neuronal acetylcholine receptor alpha-7	D0V0AW	TC-2559	Investigative	9823180	C12H18N2O	206.28	CCOC1=CN=CC(=C1)/C=C/CCNC	Ki = 71000 nM	Poor binder