TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T28713	Serine/threonine-protein kinase Chk2	B08TNX	2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride	Investigative	24205073	C15H13Cl2N7O2	394.2	C1=CC2=NC(=C(N2C=C1)/C=N/N=C(N)N)C3=CC(=C(C=C3)Cl)[N+](=O)[O-].Cl	IC50 = 79000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B14THE	2-[(Z)-[6-(4-Fluorophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57390270	C14H14ClFN6S	352.8	CC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)F)/C=N\\N=C(N)N.Cl	IC50 ~ 50000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1A7XV	N-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrochloride	Investigative	57392058	C16H15Cl2N7O2S	440.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/NC4=NCCN4.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1D7AU	2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771591	C19H18ClN7O4S	475.9	COC1=CC(=C(C=C1C2=C(N3C4=CC=CC=C4SC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1DH3E	2-[(E)-[2-Chloro-6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770690	C13H11Cl2FN6S	373.2	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)F.Cl	IC50 = 90000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1GEA4	2-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771589	C15H11Cl3N6S2	445.8	C1=CC=C2C(=C1)N3C(=C(N=C3S2)C4=C(SC(=C4)Cl)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1QKM3	2-[(E)-[6-(4-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572662	C16H18ClN7O2S	407.9	CCCC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B1ZUY4	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572544	C13H10Cl3N7O2S	434.7	C1=CSC2=NC(=C(N21)/C=N/N=C(N)N)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B32IMB	(R)-2-(4-(3-(Dimethylamino)pyrrolidin-1-yl)quinazolin-2-yl)-6-fluorophenol	Investigative	136089403	C20H21FN4O	352.4	CN(C)[C@@H]1CCN(C1)C2=NC(=NC3=CC=CC=C32)C4=C(C(=CC=C4)F)O	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B3A6CW	2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393794	C13H11BrClN7O2S	444.7	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Br)/C=N\\N=C(N)N)[N+](=O)[O-].Cl	IC50 = 88500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B3IXZ4	2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395515	C13H11ClFN7O2S	383.79	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])F.Cl	IC50 = 77500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B3O1HQ	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2,3-dimethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572631	C15H14Cl3N7O2S	462.7	CC1=C(SC2=NC(=C(N12)/C=N/N=C(N)N)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])C.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B4AZF8	2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204557	C17H13Cl2N7O2S	450.3	C1=CC=C2C(=C1)N3C(=C(N=C3S2)C4=CC(=C(C=C4)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B4BPE9	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24205071	C13H12Cl2N8O2S	415.3	CC1=NN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 78000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B4I5KM	2-[(Z)-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395511	C13H12ClFN6S	338.79	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B4KR8E	2-[(E)-[2-Methyl-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572534	C14H14ClN7O2S	379.8	CC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 83000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B4MLI1	(R)-5-(8-Chloroisoquinolin-3-Ylamino)-3-(1-(Dimethylamino)propan-2-Yloxy)pyrazine-2-Carbonitrile	Investigative	44203948	C19H19ClN6O	382.8	C[C@H](CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B50OTR	2-[(E)-(2-Chloro-6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	54770688	C13H12Cl2N6S	355.2	C1=CC=C(C=C1)C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B5XJA0	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-ethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	16099329	C15H14Cl3N7O2S	462.7	CCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 59000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B5XOM2	2-[(E)-[6-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572735	C15H16ClN7O4S	425.9	COC1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 = 96000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B65URH	2-[(Z)-[6-(2-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395517	C13H11ClFN7O2S	383.79	C1=CC(=C(C(=C1)[N+](=O)[O-])F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B7JZ0Q	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572656	C16H17Cl2N7O2S	442.3	CCCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 90500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B7R2DJ	2-Amino-1-[(E)-[6-(4-chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24800836	C14H14Cl2N8O2S	429.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N/C(=N/N)/N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B85EIP	N-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrobromide	Investigative	54771593	C17H13BrCl2N6S2	516.299	C1CN=C(N1)N/N=C/C2=C(N=C3N2C4=CC=CC=C4S3)C5=C(SC(=C5)Cl)Cl.Br	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	B9FG4V	5-[(8-Chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile	Investigative	44203849	C19H19ClN6O	382.8	CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl	IC50 = 84000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BCYB54	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204555	C11H9Cl3N6S2	395.7	C1=CSC2=NC(=C(N21)/C=N/N=C(N)N)C3=C(SC(=C3)Cl)Cl.Cl	IC50 = 65000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BDJ35Q	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	Investigative	44427519	C34H35N5O4	577.7	CC(C)(C1=CC2=C(C=C1)NC3=C(C=CC(=C3)C4=CC(=C(C=C4)N)OC)C(=O)N2)C(=O)NC5=CC=C(C=C5)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BDQP14	2-[(E)-[2-Chloro-6-(2,5-dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770686	C11H8Cl4N6S2	430.2	C1=C(SC(=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)Cl)Cl.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BDS73P	2-[(E)-[6-(4-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572239	C13H12ClN7O2S	365.8	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BF4P9V	(4-(2-Amino-5-phenylpyridin-3-yl)phenyl)methanol	Investigative	46229881	C18H16N2O	276.3	C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CC=C(C=C3)CO	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BF8TJ9	4-(2-Amino-5-(benzo[b]thiophen-3-yl)pyridin-3-yl)benzamide	Investigative	46230144	C20H15N3OS	345.4	C1=CC=C2C(=C1)C(=CS2)C3=CC(=C(N=C3)N)C4=CC=C(C=C4)C(=O)N	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BFE78D	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572658	C16H16Cl3N7O2S	476.8	CCCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BFN3E1	2-[(E)-[6-(3-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572660	C16H18ClN7O2S	407.9	CCCC1=CN2C(=C(N=C2S1)C3=CC(=CC=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 69500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BFP53Q	2-[(E)-[6-(3-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57402532	C13H12ClN7O2S	365.8	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(N3C=CSC3=N2)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BG16US	2-[(Z)-[6-(4-Bromo-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57394412	C13H11BrClN7O2S	444.7	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])Br.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BG6TF3	4-(2-Amino-5-phenylpyridin-3-yl)-N-(2-hydroxyethyl)benzamide	Investigative	46229880	C20H19N3O2	333.4	C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CC=C(C=C3)C(=O)NCCO	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BG92IY	2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771821	C17H18ClN7O4	419.8	COC1=CC(=C(C=C1C2=C(N3C=CC=CC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BGC3K4	5-(Isoquinolin-3-ylamino)pyrazine-2-carbonitrile	Investigative	44205165	C14H9N5	247.25	C1=CC=C2C=NC(=CC2=C1)NC3=NC=C(N=C3)C#N	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BI0R8C	2-[(Z)-[6-[3-(Trifluoromethyl)phenyl]imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395519	C14H12ClF3N6S	388.8	C1=CC(=CC(=C1)C(F)(F)F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BIR3H1	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Investigative	135589980	C29H27N3O3	465.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O)O	IC50 ~ 50000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BJ74PZ	Pyrazolo pyridine, 11	Investigative	44246252	C14H19N5O3	305.33	CCOC(=O)C1=CN=C2C(=C1N3CCOC(C3)CN)C=NN2	IC50 = 50000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BJ97CS	2-[(Z)-[6-(2,4,5-Trifluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57399028	C13H10ClF3N6S	374.77	C1=CSC2=NC(=C(N21)/C=N\\N=C(N)N)C3=CC(=C(C=C3F)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BKU7P4	2-[(E)-[6-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572243	C13H11Cl2N7O2S	400.2	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)[N+](=O)[O-])Cl.Cl	IC50 = 81000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BLD86E	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572532	C14H13Cl2N7O2S	414.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 64800 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BLE57S	5-[(8-Chloroisoquinolin-3-yl)amino]pyrazine-2-carbonitrile	Investigative	44205167	C14H8ClN5	281.7	C1=CC2=CC(=NC=C2C(=C1)Cl)NC3=NC=C(N=C3)C#N	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BM2E0V	2-[(E)-[2-Chloro-6-(4-chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572619	C13H10Cl3N7O2S	434.7	C1=CC(=C(C=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)[N+](=O)[O-])Cl.Cl	IC50 = 90000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BNU8F1	2-[(E)-[2-Chloro-6-(4-cyanophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770914	C14H11Cl2N7S	380.3	C1=CC(=CC=C1C#N)C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 = 93500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BO9I8T	2-[(E)-[2-Chloro-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393797	C13H11Cl2N7O2S	400.2	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BP04US	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-3-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572536	C14H13Cl2N7O2S	414.3	CC1=CSC2=NC(=C(N12)/C=N/N=C(N)N)C3=CC(=C(C=C3)Cl)[N+](=O)[O-].Cl	IC50 = 84400 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BQIF85	4-(2-(Methylamino)-5-(thiophen-3-yl)pyridin-3-yl)benzamide	Investigative	46229935	C17H15N3OS	309.4	CNC1=C(C=C(C=N1)C2=CSC=C2)C3=CC=C(C=C3)C(=O)N	IC50 = 85000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BR06PL	2-[(E)-[6-(4-Aminophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393796	C13H14ClN7S	335.82	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)N.Cl	IC50 = 67500 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BS58DG	3-(2-Amino-5-(thiophen-3-yl)pyridin-3-yl)benzamide	Investigative	46229879	C16H13N3OS	295.4	C1=CC(=CC(=C1)C(=O)N)C2=C(N=CC(=C2)C3=CSC=C3)N	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BT4X2J	2-[(Z)-[6-(2,6-Difluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395513	C13H11ClF2N6S	356.78	C1=CC(=C(C(=C1)F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BTDZ39	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572623	C14H12Cl3N7O2S	448.7	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BTV83Z	2-[(Z)-[6-(2-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57400762	C13H12ClFN6S	338.79	C1=CC=C(C(=C1)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BUMF04	2-[(E)-[2-Chloro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572530	C13H11Cl2N7O2S	400.2	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)[N+](=O)[O-].Cl	IC50 = 78750 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BVKC03	2-[(E)-[2-Methyl-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572625	C14H14ClN7O2S	379.8	CC1=CN2C(=C(N=C2S1)C3=CC(=CC=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 59000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BX25RW	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204553	C12H11Cl3N6S2	409.7	CC1=CN2C(=C(N=C2S1)C3=C(SC(=C3)Cl)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BYX1R8	2-[(Z)-[6-(3,4-Difluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57402526	C13H11ClF2N6S	356.78	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BZB36F	1,3-Bis[(E)-[2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	135580407	C29H24Cl3N11O8S2	825.1	COC1=CC(=C(C=C1C2=C(N3C(=N2)SC(=C3)Cl)/C=N/NC(=N)N/N=C/C4=C(N=C5N4C=C(S5)Cl)C6=CC(=C(C=C6OC)[N+](=O)[O-])OC)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T28713	Serine/threonine-protein kinase Chk2	BZR1I9	2-[(Z)-[2-Fluoro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57397343	C13H11ClFN7O2S	383.79	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)F)/C=N\\N=C(N)N)[N+](=O)[O-].Cl	IC50 = 56500 nM	Poor binder