TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T21357	Phosphodiesterase 3B	D05MQK	Tadalafil	Approved	110635	C22H19N3O4	389.4	CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36	IC50 ~ 50000 nM	Poor binder
T21357	Phosphodiesterase 3B	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	B0KNS3	(2R,8R)-2-(2,4-Dichlorophenyl)-6-ethyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione	Investigative	50925469	C22H19Cl2N3O2	428.3	CCN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=C(C=C(C=C4)Cl)Cl)NC5=CC=CC=C35	IC50 ~ 50000 nM	Poor binder
T21357	Phosphodiesterase 3B	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	B3VWM4	4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193709	C31H31FN4O4	542.6	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C(=C3)OCCOCCOCCF)C5=CC=NC=C5	IC50 = 61900 nM	Poor binder
T21357	Phosphodiesterase 3B	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	B4PA8F	3-Methoxy-2-[[4-[4-(4-pyridyl)-1-methyl-1H-pyrazole-3-yl]phenoxy]methyl]quinoline	Investigative	90665374	C26H22N4O2	422.5	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3OC)C5=CC=NC=C5	IC50 = 82700 nM	Poor binder
T21357	Phosphodiesterase 3B	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	B9FXI0	4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193931	C31H31FN4O4	542.6	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)OCCOCCOCCF	IC50 = 51800 nM	Poor binder
T21357	Phosphodiesterase 3B	BQI63Y	6-Fluoro-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193935	C25H19FN4O	410.4	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=C(C=C4)C=C(C=C5)F	IC50 = 151000 nM	Poor binder
T21357	Phosphodiesterase 3B	BQIK50	4-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193703	C25H19FN4O	410.4	CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C(=C3)F)C5=CC=NC=C5	IC50 = 103000 nM	Poor binder
T21357	Phosphodiesterase 3B	BS8V1A	(10R,15S)-10-(2,4-Dichlorophenyl)-13-ethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione	Investigative	50925470	C21H17Cl2N3O2	414.3	CCN1C(=O)[C@@H]2CC3=C([C@H](N2C1=O)C4=C(C=C(C=C4)Cl)Cl)NC5=CC=CC=C35	IC50 ~ 50000 nM	Poor binder
T21357	Phosphodiesterase 3B	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T21357	Phosphodiesterase 3B	BZ5MY4	4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193930	C29H27FN4O3	498.5	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)OCCOCCF	IC50 = 50100 nM	Poor binder