TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T20331 Neuropeptide Y receptor type 5 B0JAI2 2-Diphenylacetylamino-5-guanidino-pentanoic acid [1-(4-hydroxy-phenyl)-ethyl]-amide Investigative 44288112 C28H33N5O3 487.6 CC(C1=CC=C(C=C1)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3 IC50 = 75000 nM Poor binder T20331 Neuropeptide Y receptor type 5 B35VLW 2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-2-hydroxy-1-phenyl-ethyl)-amide Investigative 44287971 C28H33N5O3 487.6 C1=CC=C(C=C1)[C@@H](CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3 IC50 = 68000 nM Poor binder T20331 Neuropeptide Y receptor type 5 B75MXH 2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide Investigative 21129772 C27H31N5O3 473.6 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O IC50 = 80000 nM Poor binder T20331 Neuropeptide Y receptor type 5 B9BLS5 2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-carbamoyl-phenyl-methyl)-amide Investigative 44287982 C28H32N6O3 500.6 C1=CC=C(C=C1)[C@H](C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3 IC50 = 163000 nM Poor binder T20331 Neuropeptide Y receptor type 5 BG83PQ N-[4beta-[(2-Naphthylsulfonylamino)methyl]cyclohexane-1alpha-ylmethyl]-2-tetralincarboxamide Investigative 44295140 C29H34N2O3S 490.7 C1CC(CCC1CNC(=O)C2CCC3=CC=CC=C3C2)CNS(=O)(=O)C4=CC5=CC=CC=C5C=C4 Ki ~ 100000 nM Poor binder