TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17345	Dihydrofolate reductase	D0Y4GO	Pemetrexed	Approved	135410875	C20H21N5O6	427.4	.	IC50 = 66000 nM	Poor binder
T17345	Dihydrofolate reductase	B05VWL	2,4-Pyrimidinediamine, 5-[(3,4-dihydro-2(1H)-isoquinolinyl)methyl]-	Investigative	23161237	C14H17N5	255.32	C1CN(CC2=CC=CC=C21)CC3=CN=C(N=C3N)N	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B06RLA	1-Cyclopropyl-7-[4-[[1-[(2,4-diaminopyrimidin-5-yl)methyl]triazol-4-yl]methyl]piperazin-1-yl]-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid	Investigative	57404326	C24H26FN11O3	535.5	C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)N4CCN(CC4)CC5=CN(N=N5)CC6=CN=C(N=C6N)N)F)C(=O)O	IC50 = 50000 nM	Poor binder
T17345	Dihydrofolate reductase	B13YGS	10-[(4-Methoxyphenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride	Investigative	56658456	C15H22ClN5O	323.82	COC1=CC=C(C=C1)CN2C(=NC(=NC23CCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B1H5TD	10-[(4-Methylphenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride	Investigative	56679011	C15H22ClN5	307.82	CC1=CC=C(C=C1)CN2C(=NC(=NC23CCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B2A9IH	5-((1-(3-Chlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine	Investigative	25007427	C21H24ClN5O	397.9	C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)CC4=CC(=CC=C4)Cl	IC50 = 55200 nM	Poor binder
T17345	Dihydrofolate reductase	B2QNO1	5-(3-Chlorobenzyloxy)quinazoline-2,4-diamine	Investigative	11673839	C15H13ClN4O	300.74	C1=CC(=CC(=C1)Cl)COC2=CC=CC3=C2C(=NC(=N3)N)N	IC50 = 98000 nM	Poor binder
T17345	Dihydrofolate reductase	B2SLA9	5-(3,4-Dimethoxy-5-{(1e)-3-Oxo-3-[(1s)-1-Propylphthalazin-2(1h)-Yl]prop-1-En-1-Yl}benzyl)pyrimidine-2,4-Diamine	Investigative	42627761	C27H30N6O3	486.6	CCC[C@H]1C2=CC=CC=C2C=NN1C(=O)/C=C/C3=C(C(=CC(=C3)CC4=CN=C(N=C4N)N)OC)OC	IC50 = 110000 nM	Poor binder
T17345	Dihydrofolate reductase	B2X8DE	5-{[1-(2-Fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine	Investigative	23729147	C21H24FN5O	381.4	C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)CC4=CC=CC=C4F	IC50 ~ 125000 nM	Poor binder
T17345	Dihydrofolate reductase	B3K8HN	5-(((2-Methylpyridin-3-yl)oxy)methyl)quinazoline-2,4-diamine	Investigative	137636390	C15H15N5O	281.31	CC1=C(C=CC=N1)OCC2=C3C(=CC=C2)N=C(N=C3N)N	IC50 ~ 150000 nM	Poor binder
T17345	Dihydrofolate reductase	B46INS	5-[[4-[5-Chloro-2-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]piperazin-1-yl]methyl]pyrimidine-2,4-diamine	Investigative	134154523	C23H24ClF3N6O	492.9	C1CN(CCN1CC2=CN=C(N=C2N)N)C3=C(C=CC(=C3)Cl)OCC4=CC(=CC=C4)C(F)(F)F	IC50 ~ 75000 nM	Poor binder
T17345	Dihydrofolate reductase	B4AOF9	6-Ethyl-6-methyl-1-[(4-methylphenyl)methyl]-1,3,5-triazine-2,4-diamine;hydrochloride	Investigative	56668842	C14H22ClN5	295.81	CCC1(N=C(N=C(N1CC2=CC=C(C=C2)C)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B4K6CP	10-[(3,4-Dichlorophenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride	Investigative	53387837	C14H18Cl3N5	362.7	C1CCC2(C1)N=C(N=C(N2CC3=CC(=C(C=C3)Cl)Cl)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B57WPO	5-[(4-Methylphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56679013	C16H24ClN5	321.8	CC1=CC=C(C=C1)CN2C(=NC(=NC23CCCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B59JEI	6-[[(4-Acetylphenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone	Investigative	135855760	C20H17N3O2	331.4	CC(=O)C1=CC=C(C=C1)N(CC#C)CC2=CC3=C(C=C2)N=CNC3=O	IC50 = 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B5M7QR	(E)-3-[3-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-1-phenylprop-2-en-1-one;hydrochloride	Investigative	127032512	C20H22ClN5O	383.9	CC1(N=C(N=C(N1C2=CC=CC(=C2)/C=C/C(=O)C3=CC=CC=C3)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B5S1IN	5-[(3,4,5-Trimethoxyphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56658458	C18H28ClN5O3	397.9	COC1=CC(=CC(=C1OC)OC)CN2C(=NC(=NC23CCCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B5YC6A	Chembl4227744	Investigative	145968635	C18H15N5O	317.3	C1=CC=C(C=C1)/C=C/C(=O)/C=C/C2=NC3=C(C=C2)N=C(N=C3N)N	IC50 = 70510 nM	Poor binder
T17345	Dihydrofolate reductase	B68LGH	6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-3H-quinazolin-4-one	Investigative	135855759	C21H21N3O4	379.4	COC1=CC(=CC(=C1OC)OC)N(CC#C)CC2=CC3=C(C=C2)N=CNC3=O	IC50 = 66600 nM	Poor binder
T17345	Dihydrofolate reductase	B72PVU	2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid	Investigative	15616238	C20H21N7O5	439.4	CC1=NC2=NC=C(N=C2C(=N1)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	IC50 ~ 50000 nM	Poor binder
T17345	Dihydrofolate reductase	B7DX0Z	6-Ethyl-1-[(4-methoxyphenyl)methyl]-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride	Investigative	56682331	C14H22ClN5O	311.81	CCC1(N=C(N=C(N1CC2=CC=C(C=C2)OC)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B7L4BW	1,1-Bis(4-hydroxyphenyl)benzo[e]isobenzofuran-3-one	Investigative	16086910	C24H16O4	368.4	C1=CC=C2C(=C1)C=CC3=C2C(OC3=O)(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O	Ki = 110000 nM	Poor binder
T17345	Dihydrofolate reductase	B7M2AC	(3-Chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy)methyl)piperidin-1-yl)methanone	Investigative	25007788	C21H22ClN5O2	411.9	C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)C(=O)C4=CC(=CC=C4)Cl	IC50 ~ 125000 nM	Poor binder
T17345	Dihydrofolate reductase	B8MDG2	5-[(4-Methoxyphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56668844	C16H24ClN5O	337.8	COC1=CC=C(C=C1)CN2C(=NC(=NC23CCCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B95ZTV	1-[(4-Chlorophenyl)methyl]-6-ethyl-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride	Investigative	56675714	C13H19Cl2N5	316.2	CCC1(N=C(N=C(N1CC2=CC=C(C=C2)Cl)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B9SK0J	6,6-Dimethyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,3,5-triazine-2,4-diamine;hydrochloride	Investigative	56668840	C15H24ClN5O3	357.83	CC1(N=C(N=C(N1CC2=CC(=C(C(=C2)OC)OC)OC)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	B9WG8E	2-Amino-5-(4-nitrophenylthio)-6-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one	Investigative	135511915	C13H11N5O3S	317.33	CC1=C(C2=C(N1)N=C(NC2=O)N)SC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 54000 nM	Poor binder
T17345	Dihydrofolate reductase	BA5UO4	4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzonitrile	Investigative	135855753	C19H15N5O	329.4	C#CCN(CC1=CC2=C(C=C1)N=C(NC2=O)N)C3=CC=C(C=C3)C#N	IC50 = 66600 nM	Poor binder
T17345	Dihydrofolate reductase	BAZ24W	5-[(4-Chlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine	Investigative	56665414	C15H20ClN5	305.8	C1CCC2(CC1)N=C(N=C(N2CC3=CC=C(C=C3)Cl)N)N	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BBL27Q	3,3-Bis(3-fluoro-4-hydroxy-phenyl)benzo[g]isobenzofuran-1-one	Investigative	16086917	C24H14F2O4	404.4	C1=CC=C2C(=C1)C=CC3=C2C(=O)OC3(C4=CC(=C(C=C4)O)F)C5=CC(=C(C=C5)O)F	Ki = 109000 nM	Poor binder
T17345	Dihydrofolate reductase	BC0J1H	(E)-3-[4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-1-phenylprop-2-en-1-one;hydrochloride	Investigative	127033994	C20H22ClN5O	383.9	CC1(N=C(N=C(N1C2=CC=C(C=C2)/C=C/C(=O)C3=CC=CC=C3)N)N)C.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BCS56B	2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid	Investigative	135436405	C21H25N5O6	443.5	C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BEL65U	(2-Chlorophenyl)-[4-(2,4-diaminoquinazolin-5-yloxymethyl)piperidin-1-yl]methanone	Investigative	25002412	C21H22ClN5O2	411.9	C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)C(=O)C4=CC=CC=C4Cl	IC50 ~ 125000 nM	Poor binder
T17345	Dihydrofolate reductase	BFTS78	3-(5-((2,4-Diaminopyrimidin-5-yl)methyl)-3-hydroxy-2-methoxyphenyl)-1-(1-propylphthalazin-2(1H)-yl)prop-2-en-1-one	Investigative	45267934	C26H28N6O3	472.5	CCCC1C2=CC=CC=C2C=NN1C(=O)/C=C/C3=C(C(=CC(=C3)CC4=CN=C(N=C4N)N)O)OC	IC50 = 110000 nM	Poor binder
T17345	Dihydrofolate reductase	BGW85K	Chembl4169358	Investigative	21705470	C16H14ClN5O	327.77	C1=CC(=CC=C1COC2=CC=C(C=C2)C3=NC(=NC(=N3)N)N)Cl	IC50 = 83300 nM	Poor binder
T17345	Dihydrofolate reductase	BI68LM	5-((1-(2-Fluorophenylsulfonyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine	Investigative	25002763	C20H22FN5O3S	431.5	C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)S(=O)(=O)C4=CC=CC=C4F	IC50 ~ 125000 nM	Poor binder
T17345	Dihydrofolate reductase	BIM7X6	Chembl4229201	Investigative	145989276	C16H13N5O	291.31	C1=CC=C(C=C1)C(=O)/C=C/C2=NC3=C(C=C2)N=C(N=C3N)N	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BJ36XB	(2S)-2-[[4-[Acetyl-[(2,4-diamino-5-formyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid	Investigative	71462050	C23H27N7O7	513.5	CC(=O)N(CC1CCC2=C(N1C=O)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BJPX80	5-[(3,4-Dichlorophenyl)methyl]-1,3,5-triazaspiro[5.6]dodeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56665415	C16H22Cl3N5	390.7	C1CCCC2(CC1)N=C(N=C(N2CC3=CC(=C(C=C3)Cl)Cl)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BLJR30	6-Phenyl-7H-pyrimido[4,5-b][1,4]oxazine-2,4-diamine	Investigative	12517705	C12H11N5O	241.25	C1C(=NC2=C(N=C(N=C2O1)N)N)C3=CC=CC=C3	IC50 = 168000 nM	Poor binder
T17345	Dihydrofolate reductase	BM2W4J	1,8-Naphthalein derivative, 9	Investigative	23648073	C24H14I2O4	620.2	C1=CC2=C3C(=C1)C(=O)OC(C3=CC=C2)(C4=CC(=C(C=C4)O)I)C5=CC(=C(C=C5)O)I	Ki = 94000 nM	Poor binder
T17345	Dihydrofolate reductase	BMA9X7	2,4-Pyrimidinediamine, 6-methyl-5-(1-naphthalenyl)-	Investigative	12214236	C15H14N4	250.3	CC1=C(C(=NC(=N1)N)N)C2=CC=CC3=CC=CC=C32	Ki = 56000 nM	Poor binder
T17345	Dihydrofolate reductase	BN5QZ6	PF-DcpSi	Investigative	132574708	C16H12FN5O	309.3	C1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=CC(=CC(=C3)C#N)F	IC50 = 52000 nM	Poor binder
T17345	Dihydrofolate reductase	BO14FE	1,1-Bis(3,5-dibromo-4-hydroxy-phenyl)benzo[e]isobenzofuran-3-one	Investigative	16086914	C24H12Br4O4	684	C1=CC=C2C(=C1)C=CC3=C2C(OC3=O)(C4=CC(=C(C(=C4)Br)O)Br)C5=CC(=C(C(=C5)Br)O)Br	Ki = 69000 nM	Poor binder
T17345	Dihydrofolate reductase	BO2CR9	Chembl4162075	Investigative	129906767	C16H14ClN5O	327.77	C1=CC(=CC(=C1)Cl)COC2=CC=C(C=C2)C3=NC(=NC(=N3)N)N	IC50 = 72490 nM	Poor binder
T17345	Dihydrofolate reductase	BOMZ50	2,4-Diaminofuro[2,3-d]pyrimidine, 12	Investigative	44246329	C19H24N4O2	340.4	CC(C)CC(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 = 62700 nM	Poor binder
T17345	Dihydrofolate reductase	BON5D9	5-[(2,4-Difluorophenoxy)methyl]quinazoline-2,4-diamine	Investigative	11645134	C15H12F2N4O	302.28	C1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=C(C=C(C=C3)F)F	IC50 ~ 50000 nM	Poor binder
T17345	Dihydrofolate reductase	BPF4D3	7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one	Investigative	135469335	C12H13N5O	243.26	CC1=C2C=NC3=C(C2=C(N1C)C)C(=O)NC(=N3)N	IC50 ~ 95000 nM	Poor binder
T17345	Dihydrofolate reductase	BQ10MG	5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-isoquinolin-2-ylmethyl]-pyrimidine-2,4-diamine	Investigative	10884015	C21H22N6O3	406.4	COC1=CC2=C(C=C1)C(CN(C2)CC3=CN=C(N=C3N)N)C4=CC(=CC=C4)[N+](=O)[O-]	IC50 = 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BQ35WH	5-(4-Morpholin-4-YL-phenylsulfanyl)-2,4-quinazolinediamine	Investigative	3534	C18H19N5OS	353.4	C1COCCN1C2=CC=C(C=C2)SC3=CC=CC4=C3C(=NC(=N4)N)N	IC50 = 70000 nM	Poor binder
T17345	Dihydrofolate reductase	BR7P1L	2,4-Diamino-6-[N-(3',5'-dimethoxybenzyl)amino]pyrido-[2,3-d]pyrimidine	Investigative	479418	C16H18N6O2	326.35	COC1=CC(=CC(=C1)CNC2=CC3=C(N=C(N=C3N=C2)N)N)OC	IC50 = 160000 nM	Poor binder
T17345	Dihydrofolate reductase	BS4AV9	5-[(3-Fluorophenoxy)methyl]quinazoline-2,4-diamine	Investigative	137637328	C15H13FN4O	284.29	C1=CC(=CC(=C1)F)OCC2=C3C(=CC=C2)N=C(N=C3N)N	IC50 ~ 50000 nM	Poor binder
T17345	Dihydrofolate reductase	BSIO95	2,4-Diaminofuro[2,3-d]pyrimidine, 11	Investigative	44246328	C19H24N4O2	340.4	CCCCC(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 = 93900 nM	Poor binder
T17345	Dihydrofolate reductase	BT8LR2	2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-2-yl)-benzoylamino]-pentanedioic acid	Investigative	135545819	C21H18N6O6	450.4	C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N2C=C3C=NC4=C(C3=C2)C(=O)NC(=N4)N	IC50 ~ 80000 nM	Poor binder
T17345	Dihydrofolate reductase	BTQ70E	5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52946619	C19H22N4O2	338.4	CC(C)CC(=CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 = 86500 nM	Poor binder
T17345	Dihydrofolate reductase	BU2K3W	5-[(4-Methylphenyl)methyl]-1,3,5-triazaspiro[5.6]dodeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56682333	C17H26ClN5	335.9	CC1=CC=C(C=C1)CN2C(=NC(=NC23CCCCCC3)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BUP4T3	5-[(3,4-Dichlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	44529841	C15H20Cl3N5	376.7	C1CCC2(CC1)N=C(N=C(N2CC3=CC(=C(C=C3)Cl)Cl)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BUQI14	2-Amino-5-(3,4-dichlorophenylthio)-6-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one	Investigative	135543610	C13H10Cl2N4OS	341.2	CC1=C(C2=C(N1)N=C(NC2=O)N)SC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 62000 nM	Poor binder
T17345	Dihydrofolate reductase	BV40NF	5-[(4-Fluorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56665411	C15H21ClFN5	325.81	C1CCC2(CC1)N=C(N=C(N2CC3=CC=C(C=C3)F)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BV7X3N	1-[(4-Chlorophenyl)methyl]-6-cyclopropyl-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride	Investigative	56658454	C14H19Cl2N5	328.2	CC1(N=C(N=C(N1CC2=CC=C(C=C2)Cl)N)N)C3CC3.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BV89OJ	3-Chloro-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-1-benzothiophene-2-carboxamide	Investigative	71520360	C21H10ClNO4S	407.8	C1=CC=C2C(=C1)C(=C(S2)C(=O)NC3=CC4=C5C(=C3)C=CC=C5C(=O)OC4=O)Cl	Ki ~ 55000 nM	Poor binder
T17345	Dihydrofolate reductase	BV9WU8	N-(2,4-Dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-3-nitrobenzamide	Investigative	71521660	C19H10N2O6	362.3	C1=CC2=CC(=CC3=C2C(=C1)C(=O)OC3=O)NC(=O)C4=CC(=CC=C4)[N+](=O)[O-]	Ki ~ 110000 nM	Poor binder
T17345	Dihydrofolate reductase	BVY59J	6-N-[(3,4,5-Trimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine	Investigative	479412	C17H20N6O3	356.4	COC1=CC(=CC(=C1OC)OC)CNC2=CC3=C(N=C(N=C3N=C2)N)N	IC50 = 76000 nM	Poor binder
T17345	Dihydrofolate reductase	BX4L6O	(E)-1-[4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-3-phenylprop-2-en-1-one;hydrochloride	Investigative	127032513	C20H22ClN5O	383.9	CC1(N=C(N=C(N1C2=CC=C(C=C2)C(=O)/C=C/C3=CC=CC=C3)N)N)C.Cl	IC50 = 56400 nM	Poor binder
T17345	Dihydrofolate reductase	BX51IL	N-(4-((3-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid	Investigative	135407589	C19H24N6O6	432.4	C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCCCC2=C(N=C(NC2=O)N)N	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BY7E5Z	4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzamide	Investigative	135855764	C19H17N5O2	347.4	C#CCN(CC1=CC2=C(C=C1)N=C(NC2=O)N)C3=CC=C(C=C3)C(=O)N	IC50 = 72600 nM	Poor binder
T17345	Dihydrofolate reductase	BYLK08	2-Amino-6-phenyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one	Investigative	12242322	C12H10N4O2	242.23	C1C(=NC2=C(O1)N=C(NC2=O)N)C3=CC=CC=C3	IC50 = 57000 nM	Poor binder
T17345	Dihydrofolate reductase	BZ20MA	5-(1,3,4,9-Tetrahydro-beta-carbolin-2-ylmethyl)-pyrimidine-2,4-diamine	Investigative	11822511	C16H18N6	294.35	C1CN(CC2=C1C3=CC=CC=C3N2)CC4=CN=C(N=C4N)N	IC50 = 180000 nM	Poor binder
T17345	Dihydrofolate reductase	BZ85YV	5-[(4-Chlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride	Investigative	56665413	C15H21Cl2N5	342.3	C1CCC2(CC1)N=C(N=C(N2CC3=CC=C(C=C3)Cl)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	BZ8E9Y	10-[(4-Chlorophenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride	Investigative	56665409	C14H19Cl2N5	328.2	C1CCC2(C1)N=C(N=C(N2CC3=CC=C(C=C3)Cl)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	D06ERH	CHALCONE	Investigative	637760	C15H12O	208.25	C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T17345	Dihydrofolate reductase	D0ZG7W	Abbott 14c	Investigative	11441554	C23H28N6O2	420.5	CC(C)(C)NC(=O)NC1=CC=C(C=C1)C2=C(N=C(N=C2N)N)COCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder