TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17048	DNA topoisomerase II alpha	D0B7EB	Etoposide	Approved	36462	C29H32O13	588.6	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O	IC50 = 50000 nM	Poor binder
T17048	DNA topoisomerase II alpha	D00VZF	Merbarone	Discontinued in Phase 2	4990817	C11H9N3O3S	263.27	C1=CC=C(C=C1)NC(=O)C2C(=O)NC(=S)NC2=O	IC50 = 120000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B04CRY	(3E)-5-Hydroxy-3-[(3,4,5-trihydroxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	11414937	C15H10O6	286.24	C1=CC2=C(C=C1O)/C(=C\\C3=CC(=C(C(=C3)O)O)O)/C(=O)O2	IC50 = 120000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B0WHM9	(2R,4S,6R)-6-((3R,3Ar,5aS,6S,7S,9bR)-6-(3-hydroxypropyl)-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,5,5a,6,7,8,9b-decahydro-1H-cyclopenta[a]naphthalen-3-yl)-2-methylheptane-1,4-diol	Investigative	10961552	C30H52O3	460.7	C[C@H](C[C@H](C[C@@H](C)[C@H]1CC[C@@]2([C@@]1(CC[C@@H]3C2=CC[C@H]([C@]3(C)CCCO)C(=C)C)C)C)O)CO	IC50 = 50400 nM	Poor binder
T17048	DNA topoisomerase II alpha	B0Y3XW	(E)-N-Methyl-2-(pyridin-2-ylmethylene)hydrazinecarbothioamide	Investigative	5711011	C8H10N4S	194.26	CNC(=S)N/N=C/C1=CC=CC=N1	IC50 = 76000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B1HEQ6	2-(Benzylthio)-4-(3-chlorobenzylthio)-1,3,5-triazine-6(1H)-one	Investigative	54578708	C17H14ClN3OS2	375.9	C1=CC=C(C=C1)CSC2=NC(=NC(=O)N2)SCC3=CC(=CC=C3)Cl	IC50 = 54600 nM	Poor binder
T17048	DNA topoisomerase II alpha	B1LI6T	2-Pyridinecarbaldehyde N-isopropylthiosemicarbazone #	Investigative	9602564	C10H14N4S	222.31	CC(C)NC(=S)N/N=C/C1=CC=CC=N1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B1N0WS	5-Amino-7-[2-(diethylamino)ethylimino]-1,3,6-triphenylpyrimido[4,5-d]pyrimidine-2,4-dithione	Investigative	72206053	C30H31N7S2	553.7	CCN(CC)CCN=C1N=C2C(=C(N1C3=CC=CC=C3)N)C(=S)N(C(=S)N2C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B2S4UZ	N-(2-Morpholin-4-ylethyl)quinolino[4,3-b]quinoxalin-6-amine	Investigative	134130167	C21H21N5O	359.4	C1COCCN1CCNC2=NC3=CC=CC=C3C4=NC5=CC=CC=C5N=C42	IC50 = 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B3NQB2	[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] 7-[[2-[4-hydroxy-3-(hydroxymethyl)anilino]-2-oxoethyl]amino]-7-oxoheptanoate	Investigative	72375750	C31H30N2O12	622.6	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC(=O)CCCCCC(=O)NCC(=O)NC4=CC(=C(C=C4)O)CO)O)O	IC50 = 78900 nM	Poor binder
T17048	DNA topoisomerase II alpha	B4DEZ3	4-Allyl-1-(1-(2-pyridyl)ethylidene)-3-thio-semicarbazide	Investigative	5371064	C11H14N4S	234.32	C/C(=N\\NC(=S)NCC=C)/C1=CC=CC=N1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B4K6PQ	4-[3-(Tert-Butylamino)imidazo[1,2-a]pyridine-2-yl]benzoic acid	Investigative	53380489	C18H19N3O2	309.4	CC(C)(C)NC1=C(N=C2N1C=CC=C2)C3=CC=C(C=C3)C(=O)O	IC50 = 52660 nM	Poor binder
T17048	DNA topoisomerase II alpha	B5BM6Q	Schembl21810455	Investigative	137662151	C23H17N3O4S	431.5	C1=CC=C(C=C1)N2C(=C(C(=O)N(C2=S)C3=CC=CC=C3)C(=O)NC4=CC(=CC=C4)O)O	IC50 = 200000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B5PXJ8	N',N'-Diethyl-N-quinolino[4,3-b]quinoxalin-6-ylethane-1,2-diamine	Investigative	134130860	C21H23N5	345.4	CCN(CC)CCNC1=NC2=CC=CC=C2C3=NC4=CC=CC=C4N=C31	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B63OUV	4-Chloro-10,11-difluoro-5-nitro-14-oxo-8-oxa-1-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2,4,6,9(17),10,12,15-heptaene-15-carboxylic acid	Investigative	134346930	C16H5ClF2N2O6	394.67	C1=C2C3=C(C(=C1F)F)OC4=CC(=C(C=C4N3C=C(C2=O)C(=O)O)Cl)[N+](=O)[O-]	IC50 = 125000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B69JUZ	(2R,6R)-Methyl 6-((3R,3aR,5aS,6S,7S,9bR)-6-(3-methoxy-3-oxopropyl)-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,5,5a,6,7,8,9b-decahydro-1H-cyclopenta[a]naphthalen-3-yl)-2-methyl-4-oxoheptanoate	Investigative	11049543	C32H50O5	514.7	C[C@H](CC(=O)C[C@@H](C)C(=O)OC)[C@H]1CC[C@@]2([C@@]1(CC[C@@H]3C2=CC[C@H]([C@]3(C)CCC(=O)OC)C(=C)C)C)C	IC50 = 67300 nM	Poor binder
T17048	DNA topoisomerase II alpha	B6ZKB2	1-Methyl-3-[(E)-1-pyrazin-2-ylethylideneamino]thiourea	Investigative	5375900	C8H11N5S	209.27	C/C(=N\\NC(=S)NC)/C1=NC=CN=C1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B7M2PE	7-{[2-(Dimethylamino)ethyl]amino}-5-imino-1,6-triphenyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione	Investigative	45029397	C28H27N7S2	525.7	CN(C)CCN=C1N=C2C(=C(N1C3=CC=CC=C3)N)C(=S)N(C(=S)N2C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B7XJ1D	1,3-Dihydroxy-9H-xanthen-9-one	Investigative	5488193	C13H8O4	228.2	C1=CC=C2C(=C1)C(=O)C3=C(C=C(C=C3O2)O)O	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B87LBN	{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioate	Investigative	1385849	C15H17FN6OS2	380.5	C1COCCN1C(=S)SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 = 139000 nM	Poor binder
T17048	DNA topoisomerase II alpha	B8B0DH	6-(4-Methylpiperazin-1-yl)-2-[2-(4-prop-2-ynoxyphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazole	Investigative	58160590	C28H26N6O	462.5	CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)OCC#C	IC50 = 51600 nM	Poor binder
T17048	DNA topoisomerase II alpha	B8HQ6Z	(4S,5S)-5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one	Investigative	137642577	C20H32O5Si	380.5	CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H](CC(=O)O1)CC2=CC(=C(C=C2)OC)OC	IC50 = 137000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BA4MH6	4-Benzylsulfanyl-6-[(2-chlorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54578483	C17H14ClN3OS2	375.9	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=CC=C3Cl	IC50 = 94100 nM	Poor binder
T17048	DNA topoisomerase II alpha	BA7UK3	2-Butyltriazolo[4,5-g]phthalazine-4,9-dione	Investigative	21072879	C12H11N5O2	257.25	CCCCN1N=C2C(=N1)C(=O)C3=CN=NC=C3C2=O	IC50 = 64800 nM	Poor binder
T17048	DNA topoisomerase II alpha	BAC85V	2-Pyridinecarboxaldehyde thiosemicarbazone	Investigative	5382559	C7H8N4S	180.23	C1=CC=NC(=C1)/C=N/NC(=S)N	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BAH0G8	1-[(2S,4S,5S)-5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione	Investigative	137647664	C25H38N2O6Si	490.7	CC1=CN(C(=O)NC1=O)[C@@H]2C[C@@H]([C@H](O2)CO[Si](C)(C)C(C)(C)C)CC3=CC(=C(C=C3)OC)OC	IC50 = 89200 nM	Poor binder
T17048	DNA topoisomerase II alpha	BAR83W	6-Phenethylsulfanyl-7H-purin-2-amine	Investigative	943044	C13H13N5S	271.34	C1=CC=C(C=C1)CCSC2=NC(=NC3=C2NC=N3)N	IC50 = 85000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BB2C6A	2'-Phenyl-[2,4']bibenzooxazolyl	Investigative	44338931	C20H12N2O2	312.3	C1=CC=C(C=C1)C2=NC3=C(C=CC=C3O2)C4=NC5=CC=CC=C5O4	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BB50SO	2-Ethyltriazolo[4,5-g]phthalazine-4,9-dione	Investigative	21072878	C10H7N5O2	229.19	CCN1N=C2C(=N1)C(=O)C3=CN=NC=C3C2=O	IC50 = 61500 nM	Poor binder
T17048	DNA topoisomerase II alpha	BBI18H	3-Ethyltriazolo[4,5-g]phthalazine-4,9-dione	Investigative	21072873	C10H7N5O2	229.19	CCN1C2=C(C(=O)C3=CN=NC=C3C2=O)N=N1	IC50 = 55600 nM	Poor binder
T17048	DNA topoisomerase II alpha	BBP70N	Chembl4226061	Investigative	132576592	C23H36O5S2Si	484.7	CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H](CC(=O)O1)C2(SCCCS2)C3=CC(=C(C=C3)OC)OC	IC50 = 55300 nM	Poor binder
T17048	DNA topoisomerase II alpha	BBT15G	1-Benzyl-3-[(E)-2-pyridylmethyleneamino]thiourea	Investigative	6892730	C14H14N4S	270.35	C1=CC=C(C=C1)CNC(=S)N/N=C/C2=CC=CC=N2	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BD1BP9	4-(2,4-Dihydroxy-6-pentylbenzoyl)oxy-2-hydroxybenzoic acid	Investigative	76336671	C19H20O7	360.4	CCCCCC1=C(C(=CC(=C1)O)O)C(=O)OC2=CC(=C(C=C2)C(=O)O)O	IC50 = 125000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BD4FZ8	3-(2-(Methylthio)thiazolo[5,4-b]quinolin-9-ylamino)phenol	Investigative	44456349	C17H13N3OS2	339.4	CSC1=NC2=C(C3=CC=CC=C3N=C2S1)NC4=CC(=CC=C4)O	IC50 = 64340 nM	Poor binder
T17048	DNA topoisomerase II alpha	BDBH92	5-Amino-7-[3-(dimethylamino)propylimino]-1,3,6-triphenylpyrimido[4,5-d]pyrimidine-2,4-dithione	Investigative	72206054	C29H29N7S2	539.7	CN(C)CCCN=C1N=C2C(=C(N1C3=CC=CC=C3)N)C(=S)N(C(=S)N2C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BDF4B3	1H-[1,2,3]Triazolo[4,5-g]phthalazine-4,9-dione	Investigative	21072874	C8H3N5O2	201.14	C1=C2C(=CN=N1)C(=O)C3=NNN=C3C2=O	IC50 = 52800 nM	Poor binder
T17048	DNA topoisomerase II alpha	BDMZ21	Methyl 2'-(2-hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylate	Investigative	127748	C22H14N2O5	386.4	COC(=O)C1=C2C(=CC=C1)OC(=N2)C3=C4C(=CC=C3)OC(=N4)C5=CC=CC=C5O	IC50 = 50000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BE0XH8	1-[(2R,4S,5S)-5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione	Investigative	137636616	C25H38N2O6Si	490.7	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[Si](C)(C)C(C)(C)C)CC3=CC(=C(C=C3)OC)OC	IC50 = 99100 nM	Poor binder
T17048	DNA topoisomerase II alpha	BEHV02	1-[(2R,4S,5S)-4-[2-(3,4-Dimethoxyphenyl)-1,3-dithian-2-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione	Investigative	101233649	C22H28N2O6S2	480.6	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)C3(SCCCS3)C4=CC(=C(C=C4)OC)OC	IC50 = 64500 nM	Poor binder
T17048	DNA topoisomerase II alpha	BEOP64	5H-Quinolino[4,3-b]quinoxalin-6-one	Investigative	110273100	C15H9N3O	247.25	C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C(=O)N2	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BEVW64	4H-1-Benzopyran-3-carboxaldehyde, 2-(methylphenylamino)-4-oxo-	Investigative	11425952	C17H13NO3	279.29	CN(C1=CC=CC=C1)C2=C(C(=O)C3=CC=CC=C3O2)C=O	IC50 = 67860 nM	Poor binder
T17048	DNA topoisomerase II alpha	BFXT89	4-Benzylsulfanyl-6-[(2-fluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54768947	C17H14FN3OS2	359.4	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=CC=C3F	IC50 = 72500 nM	Poor binder
T17048	DNA topoisomerase II alpha	BFY04V	5-Amino-1,3,6-triphenyl-7-(2-pyridin-2-ylethylimino)pyrimido[4,5-d]pyrimidine-2,4-dithione	Investigative	72206407	C31H25N7S2	559.7	C1=CC=C(C=C1)N2C(=C3C(=NC2=NCCC4=CC=CC=N4)N(C(=S)N(C3=S)C5=CC=CC=C5)C6=CC=CC=C6)N	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BG05HP	6-[2-(Dimethylamino)ethyl]-3-methylpyridazino[4,3-c]quinolin-5-one	Investigative	134130551	C16H18N4O	282.34	CC1=CC2=C(C3=CC=CC=C3N(C2=O)CCN(C)C)N=N1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BH0J2N	Methyl 3-[(3R,3aR,5aS,6S,7S,9bR)-3a,6,9b-trimethyl-3-[(2R)-1-[(2R,4R)-4-methyl-5-oxooxolan-2-yl]propan-2-yl]-7-prop-1-en-2-yl-1,2,3,4,5,5a,7,8-octahydrocyclopenta[a]naphthalen-6-yl]propanoate	Investigative	637031	C31H48O4	484.7	C[C@@H]1C[C@H](OC1=O)C[C@@H](C)[C@H]2CC[C@@]3([C@@]2(CC[C@@H]4C3=CC[C@H]([C@]4(C)CCC(=O)OC)C(=C)C)C)C	IC50 = 75700 nM	Poor binder
T17048	DNA topoisomerase II alpha	BH8UX1	5-Amino-1,3,6-triphenyl-7-(2-pyridin-4-ylethylimino)pyrimido[4,5-d]pyrimidine-2,4-dithione	Investigative	72206408	C31H25N7S2	559.7	C1=CC=C(C=C1)N2C(=C3C(=NC2=NCCC4=CC=NC=C4)N(C(=S)N(C3=S)C5=CC=CC=C5)C6=CC=CC=C6)N	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BHWS36	Schembl21810443	Investigative	137662271	C25H21N3O6S	491.5	COC1=CC(=CC(=C1O)OC)NC(=O)C2=C(N(C(=S)N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4)O	IC50 = 120000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BJ5Q1P	1-Pyrrolidinecarbothioic acid (2-pyridylmethylene) hydrazide	Investigative	9577310	C11H14N4S	234.32	C1CCN(C1)C(=S)N/N=C/C2=CC=CC=N2	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BK3R7M	4-Benzylsulfanyl-6-[(4-fluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54768949	C17H14FN3OS2	359.4	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=C(C=C3)F	IC50 = 146600 nM	Poor binder
T17048	DNA topoisomerase II alpha	BKQ0M1	Schembl21810417	Investigative	137636431	C23H17N3O4S	431.5	C1=CC=C(C=C1)N2C(=C(C(=O)N(C2=S)C3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)O)O	IC50 = 150000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BKT89X	2-Propan-2-yltriazolo[4,5-g]phthalazine-4,9-dione	Investigative	44452369	C11H9N5O2	243.22	CC(C)N1N=C2C(=N1)C(=O)C3=CN=NC=C3C2=O	IC50 = 54500 nM	Poor binder
T17048	DNA topoisomerase II alpha	BL15MG	5-(2-Morpholin-4-ylethyl)quinolino[4,3-b]quinoxalin-6-one	Investigative	134131206	C21H20N4O2	360.4	C1COCCN1CCN2C3=CC=CC=C3C4=NC5=CC=CC=C5N=C4C2=O	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BLGU51	N-Tert-butyl-2-(4-chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-amine	Investigative	122178382	C23H22ClN3	375.9	CC(C)(C)NC1=C(N=C2N1C=C(C=C2)C3=CC=CC=C3)C4=CC=C(C=C4)Cl	IC50 = 55370 nM	Poor binder
T17048	DNA topoisomerase II alpha	BLJ52C	3'-(3,4-Dihydroxybenzyl)-3'-deoxythymidine	Investigative	101233647	C17H20N2O6	348.3	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)CC3=CC(=C(C=C3)O)O	IC50 = 176000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BM5O6U	3-[3-(Butylamino)-2-hydroxypropoxy]-1-hydroxyxanthen-9-one	Investigative	73357046	C20H23NO5	357.4	CCCCNCC(COC1=CC(=C2C(=C1)OC3=CC=CC=C3C2=O)O)O	IC50 = 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BMR18U	17-[2-(Dimethylamino)ethoxy]-11,12-diazapentacyclo[11.8.0.02,10.04,9.014,19]henicosa-1,4,6,8,10,12,14(19),15,17,20-decaen-3-one	Investigative	137646471	C23H19N3O2	369.4	CN(C)CCOC1=CC2=C(C=C1)C3=NN=C4C5=CC=CC=C5C(=O)C4=C3C=C2	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BN7O9K	2-Pyridinecarbaldehyde 4-allyl(thiosemicarbazone)	Investigative	7694997	C10H12N4S	220.3	C=CCNC(=S)N/N=C/C1=CC=CC=N1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BO6D0P	5-[3-(Dimethylamino)propyl]quinolino[4,3-b]quinoxalin-6-one	Investigative	134130865	C20H20N4O	332.4	CN(C)CCCN1C2=CC=CC=C2C3=NC4=CC=CC=C4N=C3C1=O	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BOA4M6	1-Ethyl-3-[(E)-2-pyridylmethyleneamino]thiourea	Investigative	7728685	C9H12N4S	208.29	CCNC(=S)N/N=C/C1=CC=CC=N1	IC50 = 94000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BP3BR2	5-[2-(Diethylamino)ethyl]quinolino[4,3-b]quinoxalin-6-one	Investigative	134130052	C21H22N4O	346.4	CCN(CC)CCN1C2=CC=CC=C2C3=NC4=CC=CC=C4N=C3C1=O	IC50 = 87580 nM	Poor binder
T17048	DNA topoisomerase II alpha	BP81HN	N2-(2-(Diethylamino)ethyl)-N9-phenylthiazolo[5,4-b]quinoline-2,9-diamine	Investigative	10318315	C22H25N5S	391.5	CCN(CC)CCNC1=NC2=C(C3=CC=CC=C3N=C2S1)NC4=CC=CC=C4	IC50 = 168900 nM	Poor binder
T17048	DNA topoisomerase II alpha	BPN8G4	Bis[2-[2-(6-chloro-8-oxo-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-14-yl)ethyl-methylamino]ethyl] butanedioate	Investigative	25164921	C42H38Cl2N6O6	793.7	CN(CCN1C2=CC=CC3=C2C(=N1)C4=C(C3=O)C(=CC=C4)Cl)CCOC(=O)CCC(=O)OCCN(C)CCN5C6=CC=CC7=C6C(=N5)C8=C(C7=O)C(=CC=C8)Cl	IC50 = 50000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BQA4L6	[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] 7-[(2-anilino-2-oxoethyl)amino]-7-oxoheptanoate	Investigative	72375652	C30H28N2O10	576.5	C1=CC=C(C=C1)NC(=O)CNC(=O)CCCCCC(=O)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O	IC50 = 149000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BQWE80	(2R)-2beta,4beta,8-Trimethyl-11-fluoro-1,2,4,4abeta-tetrahydrospiro[3,10-dioxa-9,11b-diaza-3H-cyclopenta[b]phenanthrene-5(6H),5'(2'H)-pyrimidine]-2',4',6'(1'H,3'H)-trione	Investigative	45381704	C19H19FN4O5	402.4	C[C@@H]1CN2[C@H]([C@@H](O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5C)C(=O)NC(=O)NC3=O	IC50 = 50000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BR06GD	2-Methyltriazolo[4,5-g]phthalazine-4,9-dione	Investigative	11629881	C9H5N5O2	215.17	CN1N=C2C(=N1)C(=O)C3=CN=NC=C3C2=O	IC50 = 55600 nM	Poor binder
T17048	DNA topoisomerase II alpha	BS6E8V	4-Methyl-1-(1-(2-pyridyl)ethylidene)-3-thiosemicarbazide	Investigative	5996579	C9H12N4S	208.29	C/C(=N\\NC(=S)NC)/C1=CC=CC=N1	IC50 = 92000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BSL65F	(3E)-3-[(3,4,5-Trihydroxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	44401922	C15H10O5	270.24	C1=CC=C2C(=C1)/C(=C\\C3=CC(=C(C(=C3)O)O)O)/C(=O)O2	IC50 = 63000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BT08NK	4-[(4-Benzylsulfanyl-6-oxo-1H-1,3,5-triazin-2-yl)sulfanylmethyl]benzonitrile	Investigative	54769407	C18H14N4OS2	366.5	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=C(C=C3)C#N	IC50 = 153400 nM	Poor binder
T17048	DNA topoisomerase II alpha	BU19OR	Indeno[1,2-c]cinnolin-11-one	Investigative	11776102	C15H8N2O	232.24	C1=CC=C2C(=C1)C3=C(C2=O)C4=CC=CC=C4N=N3	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BU5NJ7	N-[(5S,5As,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl]-4-[3-(trifluoromethyl)diazirin-3-yl]benzamide	Investigative	46229825	C30H24F3N3O8	611.5	COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)NC(=O)C6=CC=C(C=C6)C7(N=N7)C(F)(F)F	IC50 = 114000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BUN0D9	N'-Benzyl-N'-methyl-N-quinolino[4,3-b]quinoxalin-6-ylpentane-1,5-diamine	Investigative	134131490	C28H29N5	435.6	CN(CCCCCNC1=NC2=CC=CC=C2C3=NC4=CC=CC=C4N=C31)CC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BUZ69I	4-Ethyl-1-(1-(2-pyridyl)ethylidene)-3-thiosemicarbazide	Investigative	5920829	C10H14N4S	222.31	CCNC(=S)N/N=C(\\C)/C1=CC=CC=N1	IC50 = 79000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BVZ7G6	6-[3-(Dimethylamino)propyl]-3-methylpyridazino[4,3-c]quinolin-5-one	Investigative	134130152	C17H20N4O	296.37	CC1=CC2=C(C3=CC=CC=C3N(C2=O)CCCN(C)C)N=N1	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BX3B7N	5-Imino-1,6-triphenyl-7-[(pyridin-2-ylmethyl)amino]-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione	Investigative	45029396	C30H23N7S2	545.7	C1=CC=C(C=C1)N2C(=C3C(=NC2=NCC4=CC=CC=N4)N(C(=S)N(C3=S)C5=CC=CC=C5)C6=CC=CC=C6)N	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BX4RU1	N,N-Diethyl-2-quinolino[4,3-b]quinoxalin-6-yloxyethanamine	Investigative	134129981	C21H22N4O	346.4	CCN(CC)CCOC1=NC2=CC=CC=C2C3=NC4=CC=CC=C4N=C31	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BXE8Y1	(5S)-5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]oxolan-2-one	Investigative	137656647	C23H36O5S2Si	484.7	CC(C)(C)[Si](C)(C)OC[C@@H]1C(CC(=O)O1)C2(SCCCS2)C3=CC(=C(C=C3)OC)OC	IC50 = 55700 nM	Poor binder
T17048	DNA topoisomerase II alpha	BXN4R6	Bengacarboline	Investigative	10741986	C29H27N5	445.6	C1CNC(C2=C1C3=CC=CC=C3N2)(C4=CNC5=CC=CC=C54)C6=C(C7=CC=CC=C7N6)CCN	IC50 ~ 100000 nM	Poor binder
T17048	DNA topoisomerase II alpha	BZ45LU	17-[3-(Dimethylamino)propoxy]-11,12-diazapentacyclo[11.8.0.02,10.04,9.014,19]henicosa-1,4,6,8,10,12,14(19),15,17,20-decaen-3-one	Investigative	137653544	C24H21N3O2	383.4	CN(C)CCCOC1=CC2=C(C=C1)C3=NN=C4C5=CC=CC=C5C(=O)C4=C3C=C2	IC50 = 52890 nM	Poor binder