TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T12541	Phosphatidylinositol-4-kinase beta	B02ATY	3-(3-Bromo-5-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905184	C15H16BrN5O	362.22	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC(=C3)Br)OC)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B18QZD	5-[4-Amino-1-(2-piperidin-3-ylethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-2-chlorophenol	Investigative	52943394	C18H21ClN6O	372.9	C1CC(CNC1)CCN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B23SCK	5-[4-Amino-1-[(3R)-pyrrolidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-fluorophenol	Investigative	24905310	C15H15FN6O	314.32	C1CNC[C@@H]1N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B39BMJ	5-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol	Investigative	24905291	C13H13N5O2	271.27	CN1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)OC)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B3V0RW	5-(4-Amino-1-((R)-tetrahydrofuran-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905318	C15H14ClN5O2	331.76	C1COC[C@@H]1N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B3Z9SW	5-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methylphenol	Investigative	24905290	C13H13N5O	255.28	CC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C)O	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B4HX3I	1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905171	C12H13N7	255.28	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CN=C3)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B5G2JQ	5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chloropheno	Investigative	24905303	C17H19ClN6O	358.8	C1CNCCC1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	B6A0VO	5-(4-Amino-1-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905307	C21H17FN8O	416.4	CC1=NN(N=C1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N)C5=CC=CC=C5	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BD6QZ4	1-Cyclohexyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905298	C20H25N5O2	367.4	CCOC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C4CCCCC4)OC	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BH4DW7	5-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol	Investigative	24905294	C17H19N5O2	325.4	COC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C4CCCC4)O	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BH5YK7	8-[(2R)-1-(3,5-Difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-chromen-4-one	Investigative	66557964	C28H29F2N3O5	525.5	C1C[C@@H](N(C1)C2=CC(=CC(=C2)F)F)C3=CC(=CC4=C3OC(=CC4=O)N5CCOCC5)C(=O)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BJ5PE2	5-(4-Amino-1-((pyrrolidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905305	C16H17ClN6O	344.8	C1CNCC1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BJR40B	5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905301	C17H19FN6O	342.4	C1CNCCC1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BLIS49	Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate	Investigative	24905187	C23H26N6O2	418.5	CC(C)(C)OC(=O)N1C=CC2=C1C=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCC5	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BOVT82	5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905299	C17H19ClN6O	358.8	C1CC(CNC1)CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BR0SG8	5-(4-Amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol	Investigative	24905293	C14H15N5O2	285.3	CCN1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)OC)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BVE73A	5-(4-Amino-1-((pyrrolidin-2-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905304	C16H17ClN6O	344.8	C1CC(NC1)CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BXW73J	5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905308	C21H15FN6O2	402.4	C1=CC=C(C=C1)C2=C(OC=N2)CN3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)F)O)N	IC50 = 100000 nM	Poor binder
T12541	Phosphatidylinositol-4-kinase beta	BXW8A4	5-(4-Amino-1-((S)-pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905309	C15H15FN6O	314.32	C1CNC[C@H]1N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder