TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T12005	Coronavirus Main proteinase	D02UOE	Miltirone	Terminated	160142	C19H22O2	282.4	CC(C)C1=CC2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O	IC50 = 60200 nM	Poor binder
T12005	Coronavirus Main proteinase	B0ZT9K	2-[4-(Dimethoxymethyl)-6-hydroxy-pyrimidin-2-yl]sulfanyl-N-[4-(trifluoromethyl)phenyl]acetamide	Investigative	135411086	C16H16F3N3O4S	403.4	COC(C1=CC(=O)NC(=N1)SCC(=O)NC2=CC=C(C=C2)C(F)(F)F)OC	IC50 = 200000 nM	Poor binder
T12005	Coronavirus Main proteinase	B1HWB0	2-[4-[2-[(2-Chlorophenoxy)methyl]thiazol-4-yl]pyrimidin-2-yl]sulfanyl-N-(4-isopropylphenyl)acetamide	Investigative	2744870	C25H23ClN4O2S2	511.1	CC(C)C1=CC=C(C=C1)NC(=O)CSC2=NC=CC(=N2)C3=CSC(=N3)COC4=CC=CC=C4Cl	IC50 = 200000 nM	Poor binder
T12005	Coronavirus Main proteinase	B2ESP0	N-(4-Acetylphenyl)-2-[[5-cyano-4-(3-methoxyphenyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]butanamide	Investigative	136106200	C24H22N4O4S	462.5	CCC(C(=O)NC1=CC=C(C=C1)C(=O)C)SC2=NC(=C(C(=O)N2)C#N)C3=CC(=CC=C3)OC	IC50 = 60000 nM	Poor binder
T12005	Coronavirus Main proteinase	B31EOU	N-(5-Chloro-2-phenoxyphenyl)-2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide	Investigative	135408428	C19H16ClN3O3S	401.9	CC1=CC(=O)NC(=N1)SCC(=O)NC2=C(C=CC(=C2)Cl)OC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T12005	Coronavirus Main proteinase	B48NHS	N-((3S,6R)-6-((S,E)-4-Ethoxycarbonyl-1-((S)-2-oxopyrrolidin-3-YL)but-3-EN-2-ylcarbamoyl)-2,9-dimethyl-4-oxodec-8-EN-3-YL)-5-methylisoxazole-3-carboxamide	Investigative	10062715	C29H42N4O7	558.7	CCOC(=O)/C=C/[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC=C(C)C)CC(=O)[C@H](C(C)C)NC(=O)C2=NOC(=C2)C	IC50 = 70000 nM	Poor binder
T12005	Coronavirus Main proteinase	B4IPS1	Cryptotanshinone	Investigative	160254	C19H20O3	296.4	C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C	IC50 = 87600 nM	Poor binder
T12005	Coronavirus Main proteinase	B50VHK	2-[(5-Cyano-6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide	Investigative	135411087	C20H13F3N4O2S	430.4	C1=CC=C(C=C1)C2=C(C(=O)NC(=N2)SCC(=O)NC3=CC=CC(=C3)C(F)(F)F)C#N	IC50 = 200000 nM	Poor binder
T12005	Coronavirus Main proteinase	B5MXA9	Tanshinone II-b	Investigative	318797	C19H18O4	310.3	CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)CO	IC50 = 52000 nM	Poor binder
T12005	Coronavirus Main proteinase	B9ZHU8	1-Benzyl-5-iodoindoline-2,3-dione	Investigative	10642441	C15H10INO2	363.15	C1=CC=C(C=C1)CN2C3=C(C=C(C=C3)I)C(=O)C2=O	IC50 = 50000 nM	Poor binder
T12005	Coronavirus Main proteinase	BAH5D0	1-Butyl-5-iodoindoline-2,3-dione	Investigative	11515424	C12H12INO2	329.13	CCCCN1C2=C(C=C(C=C2)I)C(=O)C1=O	Ki = 66000 nM	Poor binder
T12005	Coronavirus Main proteinase	BIYH93	N-[4-(4-Chlorophenoxy)phenyl]-2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetamide	Investigative	135410963	C19H16ClN3O3S	401.9	CC1=CC(=O)NC(=N1)SCC(=O)NC2=CC=C(C=C2)OC3=CC=C(C=C3)Cl	IC50 = 200000 nM	Poor binder
T12005	Coronavirus Main proteinase	BS06BK	N-(4-Acetylphenyl)-2-{[5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}acetamide	Investigative	135411084	C22H18N4O4S	434.5	CC(=O)C1=CC=C(C=C1)NC(=O)CSC2=NC(=C(C(=O)N2)C#N)C3=CC(=CC=C3)OC	IC50 = 60000 nM	Poor binder
T12005	Coronavirus Main proteinase	BTD50B	N-(4-Butyl-2-methylphenyl)-2-[(5-cyano-4-cyclohexyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide	Investigative	135419065	C24H30N4O2S	438.6	CCCCC1=CC(=C(C=C1)NC(=O)CSC2=NC(=C(C(=O)N2)C#N)C3CCCCC3)C	IC50 = 200000 nM	Poor binder
T12005	Coronavirus Main proteinase	BTQP38	1-Methyl-2,3-dioxoindoline-5-carboxamide	Investigative	515954	C10H8N2O3	204.18	CN1C2=C(C=C(C=C2)C(=O)N)C(=O)C1=O	IC50 = 71000 nM	Poor binder
T12005	Coronavirus Main proteinase	BUE4O3	Tanshinone IIA	Investigative	164676	C19H18O3	294.3	CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C	IC50 = 89100 nM	Poor binder