TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T10670 Neuropeptide Y receptor type 2 B5T2OL 2-[[2-(4-Chlorophenyl)-2-phenylacetyl]amino]-5-(diaminomethylideneamino)-N-[(1S)-2,3-dihydro-1H-inden-1-yl]pentanamide Investigative 44288395 C29H32ClN5O2 518 C1CC2=CC=CC=C2[C@H]1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl IC50 = 59000 nM Poor binder T10670 Neuropeptide Y receptor type 2 B75MXH 2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide Investigative 21129772 C27H31N5O3 473.6 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O IC50 ~ 100000 nM Poor binder T10670 Neuropeptide Y receptor type 2 B9ZLC4 2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-1-phenyl-ethyl)-amide Investigative 44287999 C28H33N5O2 471.6 C[C@H](C1=CC=CC=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3 IC50 = 177000 nM Poor binder T10670 Neuropeptide Y receptor type 2 BS2AT1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-guanidino-pentanoic acid benzylamide Investigative 44288390 C27H30ClN5O2 492 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl IC50 = 97000 nM Poor binder T10670 Neuropeptide Y receptor type 2 BT23NZ N-[1-(7-Hydroxy-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-1-oxo-5-[[N'-(3-phenylpropyl)carbamimidoyl]amino]pentan-2-yl]-2-(4-phenylphenyl)acetamide Investigative 44287938 C39H45N5O3 631.8 C1CC2=C(CN(C1)C(=O)C(CCCNC(=NCCCC3=CC=CC=C3)N)NC(=O)CC4=CC=C(C=C4)C5=CC=CC=C5)C=CC(=C2)O IC50 = 78000 nM Poor binder