TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0C9XA	GSK683699	Phase 2	119	C4H9NO2	103.12	C(CC(=O)O)CN	IC50 = 165958.69 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B1GDX4	2,4-Dichloro-N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137639241	C19H19Cl2IN2O	489.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)I	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B24YZS	2-Ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide	Investigative	8181355	C21H26N2O2	338.4	CCOC1=CC=CC=C1C(=O)NC2CCN(CC2)CC3=CC=CC=C3	IC50 = 180000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B2OQ0Z	2,4-Dichloro-N-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137657292	C19H19Cl2N3O3	408.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B36YMB	1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10481573	C28H29Cl2NO4	514.4	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)(C3=CC=C(C=C3)Cl)OCCN4CCCC(C4)C(=O)O	IC50 = 88000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B3T7ZJ	1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10412575	C30H35NO4	473.6	CC1=CC=C(C=C1)C(C2=CC=C(C=C2)C)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O	IC50 = 109000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B5JUH7	2,4-Dichloro-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamide	Investigative	137638838	C23H22Cl2N2O	413.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC4=CC=CC=C4C=C3	IC50 ~ 50000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B5VY1Q	2,4-Dichloro-N-[1-[(2-cyanophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137654858	C20H19Cl2N3O	388.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3C#N	IC50 ~ 50000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B6XF0Q	2,4-Dichloro-N-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]benzamide	Investigative	137638836	C21H22Cl2N2O	389.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)C/C=C/C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B89XQC	Methyl 4-[[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]methyl]benzoate	Investigative	137642163	C21H22Cl2N2O3	421.3	COC(=O)C1=CC=C(C=C1)CN2CCC(CC2)NC(=O)C3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BAU58Z	N-(1-Benzylpiperidin-4-yl)-3-(trifluoromethyl)benzamide	Investigative	17250318	C20H21F3N2O	362.4	C1CN(CCC1NC(=O)C2=CC(=CC=C2)C(F)(F)F)CC3=CC=CC=C3	IC50 = 169824.37 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BD23TL	N-(1-Benzylpiperidin-4-yl)-4-fluorobenzamide	Investigative	702501	C19H21FN2O	312.4	C1CN(CCC1NC(=O)C2=CC=C(C=C2)F)CC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BGL58X	2,4-Dichloro-N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137658990	C20H19Cl2N3O	388.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BI4YL8	N-(1-Benzylpiperidin-4-yl)-2,4-dichlorobenzamide	Investigative	1069892	C19H20Cl2N2O	363.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3	IC50 = 58000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BJHW74	2,4-Dichloro-N-(1-phenacylpiperidin-4-yl)benzamide	Investigative	137638617	C20H20Cl2N2O2	391.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BLOW98	(R,E)-1-(4-(2-Fluorophenyl)-4-o-tolylbut-3-enyl)piperidine-3-carboxylic acid	Investigative	50941729	C23H26FNO2	367.5	CC1=CC=CC=C1/C(=C\\CCN2CCC[C@H](C2)C(=O)O)/C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BPA2B9	2,4-Dichloro-N-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzamide	Investigative	137659917	C22H21Cl2N3O	414.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=NC4=CC=CC=C4C=C3	IC50 ~ 50000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BRMG32	N-(1-Benzylpiperidin-4-yl)-2,3-dimethoxybenzamide	Investigative	13314232	C21H26N2O3	354.4	COC1=CC=CC(=C1OC)C(=O)NC2CCN(CC2)CC3=CC=CC=C3	IC50 = 91000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BX40JU	1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10073933	C28H29F2NO4	481.5	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)OCCN4CCCC(C4)C(=O)O	IC50 = 151000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BXG3Y0	2,4-Dichloro-N-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137638595	C19H19Cl2N3O3	408.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0H7WK	SNAP-5114	Investigative	10458835	C30H35NO6	505.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[C@@H](C4)C(=O)O	IC50 = 71700 nM	Poor binder