TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05904	Phosphodiesterase 8	D0Z7ZM	Rhucin	Approved	135398744	C22H30N6O4S	474.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C	IC50 = 100000 nM	Poor binder
T05904	Phosphodiesterase 8	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	D0A0ZU	AC1MOZOL	Patented	3403301	C16H18N2OS2	318.5	CCC(C)SC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B1O7SK	(2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087052	C21H19ClN6O3	438.9	C[C@@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B4JE2U	N~2~-(1-Cyclopentyl-4-Oxo-4,7-Dihydro-1h-Pyrazolo[3,4-D]pyrimidin-6-Yl)-N-(4-Methoxyphenyl)-D-Alaninamide	Investigative	135566935	C20H24N6O3	396.4	C[C@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4CCCC4)C(=O)N2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	B9V3TH	N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide	Investigative	2409032	C23H24N4OS	404.5	CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BAN58F	(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one	Investigative	11989102	C24H22F3N7O	481.5	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CN=C(C=C5)C(F)(F)F)NC6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BJ1LG9	(2R)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087050	C21H19ClN6O3	438.9	C[C@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BMLT90	(2S)-2-[(1-Cyclopentyl-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087045	C20H24N6O3	396.4	C[C@@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4CCCC4)C(=O)N2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BOF79I	(6Ar,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-(4-trifluoromethyl-benzyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one	Investigative	11989101	C25H23F3N6O	480.5	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CC=C(C=C5)C(F)(F)F)NC6=CC=CC=C6	Ki = 54000 nM	Poor binder
T05904	Phosphodiesterase 8	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BVA87L	2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136217455	C21H19ClN6O3	438.9	CC(C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 = 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T05904	Phosphodiesterase 8	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder