TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05409	Neutral endopeptidase	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B15SNK	(2S)-5-(Diaminomethylideneamino)-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	122195270	C29H48N12O8	692.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B16HUV	(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-phenyl-propionic acid	Investigative	44275764	C35H37N2O7P	628.6	C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)C(CC2=CC=CC=C2)CP(=O)([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4)O	IC50 ~ 60000 nM	Poor binder
T05409	Neutral endopeptidase	B17YAU	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid	Investigative	53353383	C28H33F3N4O6	578.6	C[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B2OI0M	(2S)-2-[[(2S)-2-[[2-[Benzyl-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	56953765	C29H48N12O8	692.8	C1=CC=C(C=C1)CN(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B2TY4V	(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-5-guanidino-pentanoic acid	Investigative	44275795	C32H40N5O7P	637.7	C1=CC=C(C=C1)C[C@H](NC(=O)OCC2=CC=CC=C2)P(=O)(CC(CC3=CC=CC=C3)C(=O)N[C@H](CCCN=C(N)N)C(=O)O)O	IC50 ~ 60000 nM	Poor binder
T05409	Neutral endopeptidase	B3VCP2	5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acid	Investigative	10467565	C10H10ClN3O3	255.66	C1C2=C(C=CC=C2Cl)NC(=O)N1CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B43FLX	(2S)-5-(Diaminomethylideneamino)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]pentanoic acid	Investigative	70681503	C30H50N12O8	706.8	C[C@H]([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B4F7WP	(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-methyl-butyric acid	Investigative	44275416	C31H37N2O7P	580.6	CC(C)[C@H](C(=O)O)NC(=O)C(CC1=CC=CC=C1)CP(=O)([C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)O	IC50 ~ 60000 nM	Poor binder
T05409	Neutral endopeptidase	B4GV3K	(2S)-5-(Carbamoylamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	122195275	C29H47N11O9	693.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=O)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B4LGA0	2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-4-carbamoyl-butyric acid	Investigative	44275869	C31H36N3O8P	609.6	C1=CC=C(C=C1)C[C@H](NC(=O)OCC2=CC=CC=C2)P(=O)(CC(CC3=CC=CC=C3)C(=O)NC(CCC(=O)N)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B58LGR	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354470	C29H35F3N4O6	592.6	CC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B6DM3H	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-2-phenylacetyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	70689859	C28H46N12O8	678.7	C1=CC=C(C=C1)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B6H4EL	1-(Pyrrolidin-1-yl)-2-(quinoxalin-6-yl)ethanone	Investigative	25015303	C14H15N3O	241.29	C1CCN(C1)C(=O)CC2=CC3=NC=CN=C3C=C2	IC50 ~ 50000 nM	Poor binder
T05409	Neutral endopeptidase	B7BQS2	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56955273	C29H47FN12O8	710.8	C1=CC(=CC=C1C[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B81BUO	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-4-phenylbutanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953762	C30H50N12O8	706.8	C1=CC=C(C=C1)CC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 = 70000 nM	Poor binder
T05409	Neutral endopeptidase	B8QJ1S	(3R,5S)-5-{[(2,5-Difluorobenzyl)amino]methyl}-1-(5-propylpyrimidin-2-yl)pyrrolidine-3-thiol	Investigative	44401169	C19H24F2N4S	378.5	CCCC1=CN=C(N=C1)N2C[C@@H](CC2CNCC3=C(C=CC(=C3)F)F)S	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B8VN0Q	(2R,3S)-2-[[2-Benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-hydroxybutanoic acid	Investigative	56668219	C30H35N2O8P	582.6	C[C@@H]([C@H](C(=O)O)NC(=O)C(CC1=CC=CC=C1)CP(=O)([C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)O)O	IC50 = 50000 nM	Poor binder
T05409	Neutral endopeptidase	B9AE7Y	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354369	C31H39F3N4O6	620.7	CCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	B9TE2I	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	70683617	C38H57N13O9	839.9	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N	IC50 = 51000 nM	Poor binder
T05409	Neutral endopeptidase	B9X2JB	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(4-methylphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953763	C30H50N12O8	706.8	CC1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BB01LM	(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-pentanedioic acid	Investigative	44275871	C31H35N2O9P	610.6	C1=CC=C(C=C1)C[C@H](NC(=O)OCC2=CC=CC=C2)P(=O)(CC(CC3=CC=CC=C3)C(=O)N[C@H](CCC(=O)O)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BBO18S	{[(S)-1-Benzylcarbamoyl-4-(2-fluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acid	Investigative	10715413	C19H20FN2O4P	390.3	C1=CC=C(C=C1)CNC(=O)[C@H](CC#CC2=CC=CC=C2F)NCP(=O)(O)O	IC50 = 55000 nM	Poor binder
T05409	Neutral endopeptidase	BC29HE	(2S)-2-[[(2S)-2-[[(2S)-3-(4-Benzoylphenyl)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	56953764	C36H52N12O9	796.9	C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BC79LV	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(4-iodophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953635	C29H47IN12O8	818.7	C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)I	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BCV1L8	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(2,3,4,5,6-pentafluorophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953636	C29H43F5N12O8	782.7	C(C[C@@H](C(=O)N[C@@H](CC1=C(C(=C(C(=C1F)F)F)F)F)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)N)CN=C(N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BD2V9Y	N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide	Investigative	54589400	C20H27N5O4	401.5	CNC(=O)[C@H](CC1=CN=CN1)NC(=O)CN(CCCC2=CC=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BD56ZJ	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56955272	C29H47FN12O8	710.8	C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BE9L5Y	(2S)-2-[[(2S)-3-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	122195276	C37H61N13O13	896	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1OC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)CO)O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BGD1N9	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953637	C29H48N12O8	692.8	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BH1PU8	(2S)-5-(Diaminomethylideneamino)-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]pentanoic acid	Investigative	122195271	C29H48N12O7S	708.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BHU24K	2,3-Dihydro-1,4-benzodioxin-5-yl (2S,4R)-4-benzoylsulfanyl-2-[(2,4,5-trifluorophenyl)methoxymethyl]pyrrolidine-1-carboxylate	Investigative	11192220	C28H24F3NO6S	559.6	C1COC2=C(O1)C=CC=C2OC(=O)N3C[C@@H](C[C@H]3COCC4=CC(=C(C=C4F)F)F)SC(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BJ56HI	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	70681347	C27H45N11O7	635.7	C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N	IC50 ~ 70000 nM	Poor binder
T05409	Neutral endopeptidase	BJ63ZY	6-Amino-2-{2-benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-hexanoic acid	Investigative	44275713	C32H40N3O7P	609.6	C1=CC=C(C=C1)C[C@H](NC(=O)OCC2=CC=CC=C2)P(=O)(CC(CC3=CC=CC=C3)C(=O)NC(CCCCN)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BJU2E4	2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-methyl-butyric acid	Investigative	44275937	C31H37N2O7P	580.6	CC(C)C(C(=O)O)NC(=O)C(CC1=CC=CC=C1)CP(=O)([C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BK23JG	(2S)-2-[[(2S)-2-[[(2S)-3-(4-Chlorophenyl)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	56955274	C29H47ClN12O8	727.2	C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)Cl	IC50 = 70000 nM	Poor binder
T05409	Neutral endopeptidase	BLG5D0	(2S)-2-[[(2S)-3-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	122195277	C37H61N13O13	896	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)CO)O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BLM0B4	(2S)-3-Hydroxy-2-[(2-methoxycarbonyl-4-methylpentanoyl)amino]propanoic acid	Investigative	90668205	C11H19NO6	261.269	CC(C)CC(C(=O)N[C@@H](CO)C(=O)O)C(=O)OC	IC50 = 50118.72 nM	Poor binder
T05409	Neutral endopeptidase	BLM71O	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(3-fluorophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56955271	C29H47FN12O8	710.8	C1=CC(=CC(=C1)F)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BLW9G8	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354365	C30H37F3N4O6	606.6	CCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BML01J	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(Carbamoylamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	122195274	C29H47N11O9	693.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](CCC(=O)N)N	IC50 = 90000 nM	Poor binder
T05409	Neutral endopeptidase	BOF17Z	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(3R)-3-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	56953638	C29H48N12O8	692.8	C1=CC=C(C=C1)[C@@H](CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BORB10	Isopropyl (2S,4R)-2-{[(2,5-difluorobenzyl)amino]methyl}-4-mercaptopyrrolidine-1-carboxylate	Investigative	44400838	C16H22F2N2O2S	344.4	CC(C)OC(=O)N1C[C@@H](CC1CNCC2=C(C=CC(=C2)F)F)S	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BPO6Y5	(2S)-3-Hydroxy-2-[[(3S)-3-methoxycarbonyl-5-methylhexanoyl]amino]propanoic acid	Investigative	90668200	C12H21NO6	275.3	CC(C)C[C@@H](CC(=O)N[C@@H](CO)C(=O)O)C(=O)OC	IC50 = 79432.82 nM	Poor binder
T05409	Neutral endopeptidase	BQS5F1	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	70692015	C29H48N12O9	708.8	C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)O	IC50 = 70000 nM	Poor binder
T05409	Neutral endopeptidase	BRTJ30	Opiorphin (1-4)	Investigative	70683616	C23H36N8O7	536.6	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BT1Q5P	(5-Chloro-3,4-dihydro-1H-2,1,3-benzothiadiazine-3-acetohydroxamic acid)2,2-dioxide	Investigative	10732349	C9H10ClN3O4S	291.71	C1C2=C(C=CC=C2Cl)NS(=O)(=O)N1CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BTA9Y6	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	70696244	C28H46N12O8	678.7	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)N)N	IC50 = 130000 nM	Poor binder
T05409	Neutral endopeptidase	BTE6Q8	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	122195272	C29H48N10O8	664.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)N	IC50 = 50000 nM	Poor binder
T05409	Neutral endopeptidase	BUB5S9	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid	Investigative	70681348	C23H44N12O8	616.7	C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BV7JE6	Opiorphin (2-5)	Investigative	70696243	C24H40N10O6	564.6	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N	IC50 = 180000 nM	Poor binder
T05409	Neutral endopeptidase	BWQ3U8	(2S)-2-[[(2S,3R)-3-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Investigative	122195278	C38H63N13O13	910	C[C@H]([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	BY2P7N	Methyl 2-(2-{N-methyl-1-[(4R)-1-(naphthalene-2-sulfonyl)-4-sulfanylpyrrolidin-2-yl]formamido}acetamido)benzoate	Investigative	44388021	C26H27N3O6S2	541.6	CN(CC(=O)NC1=CC=CC=C1C(=O)OC)C(=O)C2C[C@H](CN2S(=O)(=O)C3=CC4=CC=CC=C4C=C3)S	IC50 = 81900 nM	Poor binder
T05409	Neutral endopeptidase	BZU41M	(2S,4R)-4-Acetylsulfanyl-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid 2,3-dihydro-benzo[1,4]dioxin-5-yl ester	Investigative	10141595	C23H22F3NO6S	497.5	CC(=O)S[C@@H]1C[C@H](N(C1)C(=O)OC2=CC=CC3=C2OCCO3)COCC4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	D07APP	LY-292223	Investigative	131255	C13H13NO3	231.25	C1COCCN1C2=CC(=O)C3=CC=CC=C3O2	IC50 ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	D0B3UN	RXP470.1	Investigative	44580458	C35H35BrClN4O10P	818	C1=CC(=CC(=C1)Cl)C2=CC=C(C=C2)C3=NOC(=C3)C[C@H](CP(=O)(C4=CC=C(C=C4)Br)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T05409	Neutral endopeptidase	D0N8YA	Bb-3497	Investigative	159596	C16H31N3O4	329.43	CCCC[C@H](CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C	IC50 = 50000 nM	Poor binder
T05409	Neutral endopeptidase	D0P4KL	S136492	Investigative	135411330	C17H13NO	247.29	C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC=CC=C3O	IC50 ~ 100000 nM	Poor binder