TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T04696	Tyrosyl-DNA phosphodiesterase 2	D09YDM	Camptothecin	Phase 3	24360	C20H16N2O4	348.4	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B04SBV	6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,7]naphthyridine-5,11-dione	Investigative	127044408	C18H14N2O4	322.3	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=NC=C4)C(=O)N3C[C@@H](CO)O	IC50 = 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B0L3KX	6-[3-(Dimethylamino)propyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione	Investigative	127044412	C20H19N3O2	333.4	CN(C)CCCN1C2=C(C3=C(C1=O)N=CC=C3)C(=O)C4=CC=CC=C42	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B0SH2B	6-(3-Aminophenyl)-4H-isoquinoline-1,3-dione	Investigative	122483622	C15H12N2O2	252.27	C1C2=C(C=CC(=C2)C3=CC(=CC=C3)N)C(=O)NC1=O	IC50 = 55000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B10OJN	O=C1NC(CC2=CC(=CC=C12)C1=C(C(=O)O)C=CC=C1)=O	Investigative	122483618	C16H11NO4	281.26	C1C2=C(C=CC(=C2)C3=CC=CC=C3C(=O)O)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B14DJA	6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione	Investigative	127044405	C18H14N2O4	322.3	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CC=N4)C(=O)N3C[C@@H](CO)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B14QNI	Chembl4166134	Investigative	121478363	C22H14N2O6	402.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=CC(=C4)NC(=O)C=C	IC50 = 71000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B16UGQ	3-Amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione	Investigative	555805	C12H10N4O2	242.23	C1C2=NN(C(=C2C(=O)NC1=O)N)C3=CC=CC=C3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B27SKI	7-Phenyl-1H-quinazoline-2,4-dione	Investigative	118641028	C14H10N2O2	238.24	C1=CC=C(C=C1)C2=CC3=C(C=C2)C(=O)NC(=O)N3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B2D1ZC	3-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-N-methylsulfonylbenzamide	Investigative	71818443	C20H19NO5S2	417.5	COC1=C(C=C(C=C1)C2=CSC(=C2)C3=CC(=CC=C3)C(=O)NS(=O)(=O)C)OC	EC50 ~ 150000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B2KE1H	N-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-1-methyl-6-oxo-5-phenylmethoxypyrimidine-4-carboxamide	Investigative	71818293	C25H23N3O5S	477.5	CN1C=NC(=C(C1=O)OCC2=CC=CC=C2)C(=O)NC3=CC(=CS3)C4=CC(=C(C=C4)OC)OC	EC50 ~ 150000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B2S5DQ	Chembl4176371	Investigative	121478406	C16H14N2O4	298.29	CCOC(=O)C1=C(N(C2=C1C(=O)C3=C(C2=O)N=CC=C3)C)C	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B3B5YD	6-[(2S)-2,3-Dihydroxypropyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione	Investigative	127044413	C18H14N2O4	322.3	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3C[C@@H](CO)O)N=CC=C4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B3N5FK	Schembl21803658	Investigative	137644721	C23H23ClN4O3	438.9	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5CCNCC5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B3NSQ6	6-(3-Morpholin-4-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione	Investigative	127044239	C22H21N3O3	375.4	C1COCCN1CCCN2C3=C(C4=C(C2=O)N=CC=C4)C(=O)C5=CC=CC=C53	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B40EQP	Chembl4169637	Investigative	14895314	C14H9NO4	255.22	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)C=CC=N3)C(=O)C	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B46DVJ	Chembl4163458	Investigative	121478317	C16H13NO7	331.28	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC[C@@H](CO)O	IC50 = 50000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B4PT5I	Chembl4165069	Investigative	121478304	C19H11ClN2O4	366.8	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)NC4=CC(=CC=C4)Cl	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B4QWZ7	Schembl22364354	Investigative	127044557	C18H17Cl2N3O2	378.2	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CC=N4)C(=O)N3CCCN.Cl.Cl	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B5AKT4	Schembl21803673	Investigative	137637372	C22H22ClN3O3	411.9	CC(C)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)Cl)C(=O)C4=C2N=CC(=C4)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B5QMX9	Schembl21803674	Investigative	137645346	C24H24ClN3O4	453.9	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5CCC(CC5)O)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B5QW9P	Schembl21803651	Investigative	137635992	C23H23FN4O3	422.5	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCNCC5)N=C1	IC50 = 107000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B5T3LP	1,3-Dioxo-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid	Investigative	68699178	C10H7NO4	205.17	C1C2=C(C=CC(=C2)C(=O)O)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B64YVH	Schembl21803662	Investigative	137661166	C23H22ClN3O4	439.9	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5CCOCC5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B68ORQ	Schembl21803683	Investigative	137646143	C22H22FN3O3	395.4	CC(C)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B71PYC	Chembl4169597	Investigative	145955087	C13H9N3O4	271.23	CCOC(=O)C1=C2C(=NN1)C(=O)C3=C(C2=O)C=CC=N3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B78WPY	Chembl4161672	Investigative	121478349	C13H9N3O4	271.23	CCOC(=O)C1=C2C(=NN1)C(=O)C3=C(C2=O)N=CC=C3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B7MJ1A	6-(3-Phenylphenyl)-4H-isoquinoline-1,3-dione	Investigative	122483623	C21H15NO2	313.3	C1C2=C(C=CC(=C2)C3=CC=CC(=C3)C4=CC=CC=C4)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B7O4UF	7-(2-Furyl)-2-hydroxy-4H-isoquinoline-1,3-dione	Investigative	57400600	C13H9NO4	243.21	C1C2=C(C=C(C=C2)C3=CC=CO3)C(=O)N(C1=O)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B7WTM9	[1-[4-(3,4-Dimethoxyphenyl)thiophene-2-carbonyl]piperidin-3-yl]-dimethoxyphosphorylmethanone	Investigative	71818296	C21H26NO7PS	467.5	COC1=C(C=C(C=C1)C2=CSC(=C2)C(=O)N3CCCC(C3)C(=O)P(=O)(OC)OC)OC	EC50 ~ 150000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B89XED	6-(3-Morpholin-4-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione	Investigative	127044402	C22H21N3O3	375.4	C1COCCN1CCCN2C3=C(C4=C(C2=O)C=CC=N4)C(=O)C5=CC=CC=C53	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B8BP2U	6-[(2S)-2,3-Dihydroxypropyl]-3-iodoindeno[1,2-c]isoquinoline-5,11-dione	Investigative	122179149	C19H14INO4	447.2	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)I)C(=O)N3C[C@@H](CO)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B8FJX6	6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione	Investigative	122179164	C21H16N4O2	356.4	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=NC=C4)C(=O)N3CCCN5C=CN=C5	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B8WA2P	6-[3-(Dimethylamino)propyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione	Investigative	127044404	C20H19N3O2	333.4	CN(C)CCCN1C2=C(C3=C(C1=O)C=CC=N3)C(=O)C4=CC=CC=C42	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B9FX7O	6-(Furan-2-yl)benzo[de]isoquinoline-1,3-dione	Investigative	127029757	C16H9NO3	263.25	C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)C4=CC=CO4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B9JB0O	6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione	Investigative	127044560	C21H16N4O2	356.4	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CN=C4)C(=O)N3CCCN5C=CN=C5	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B9VJ2C	3-Amino-2-(4-fluorophenyl)-7H-pyrazolo[4,3-c]pyridine-4,6-dione	Investigative	60103948	C12H9FN4O2	260.22	C1C2=NN(C(=C2C(=O)NC1=O)N)C3=CC=C(C=C3)F	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	B9X1YC	Schembl21803696	Investigative	137652438	C22H17FN4O3	404.4	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5C=CN=C5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BA2KC5	6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione	Investigative	127044559	C22H21N3O3	375.4	C1COCCN1CCCN2C3=C(C4=C(C2=O)C=CN=C4)C(=O)C5=CC=CC=C53	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BANW81	C(C1=CC=CC=C1)C=1C=C2CC(NC(C2=CC=1)=O)=O	Investigative	122483613	C16H13NO2	251.28	C1C2=C(C=CC(=C2)CC3=CC=CC=C3)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BB8Z2X	Schembl21803682	Investigative	137643195	C25H27N5O6	493.5	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCN5CCN(CC5)CCO)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BC6E4U	Chembl4159314	Investigative	145957109	C26H15NO6	437.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=C(C=C4)C(=O)C5=CC=CC=C5	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BC8R5T	Schembl21803653	Investigative	137651075	C21H20ClN3O3	397.9	CCNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)Cl)C(=O)C4=C2N=CC(=C4)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BCJ4H7	Schembl21803687	Investigative	137653301	C23H22FN3O3	407.4	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCCC5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BD3NF8	Chembl4167695	Investigative	121478296	C20H18N4O6	410.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OCCC4=CN(N=N4)CCCO	IC50 = 66000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BE74UK	4-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-N-methylsulfonylbenzamide	Investigative	71818444	C20H19NO5S2	417.5	COC1=C(C=C(C=C1)C2=CSC(=C2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C)OC	EC50 ~ 150000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BE76SX	NC=1C=C(C=CC=1)C1=CC=C2CC(NC(C2=C1)=O)=O	Investigative	122483611	C15H12N2O2	252.27	C1C2=C(C=C(C=C2)C3=CC(=CC=C3)N)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BE80ZW	Chembl4161031	Investigative	121478405	C21H15NO5	361.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OCCC4=CC=CC=C4	IC50 = 53000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BEH0A5	Chembl4172896	Investigative	145949905	C19H10N2O4	330.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C4=NC5=CC=CC=C5O4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BEVO64	5-Fluoro-14-methoxy-9-(3-morpholin-4-ylpropyl)-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione	Investigative	137638718	C23H22FN3O4	423.4	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCOCC5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BF0QY6	6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dione	Investigative	56837840	C13H9NO4	243.21	C1C2=C(C=CC(=C2)C3=CC=CO3)C(=O)N(C1=O)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BF7DC5	Chembl4163092	Investigative	121478438	C20H11NO7	377.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC5=C(C=C4)OCO5	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BF7S5I	3-Amino-2-pyridin-3-yl-7H-pyrazolo[4,3-c]pyridine-4,6-dione	Investigative	127030613	C11H9N5O2	243.22	C1C2=NN(C(=C2C(=O)NC1=O)N)C3=CN=CC=C3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BGB32X	Chembl4167718	Investigative	14895315	C15H11NO5	285.25	CCOC(=O)C1=C(OC2=C1C(=O)C3=C(C2=O)N=CC=C3)C	IC50 = 54000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BH8OX0	Chembl4169093	Investigative	145955773	C24H20N2O7	448.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=C(C=C4)NC(=O)OC(C)(C)C	IC50 = 88000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BHRN64	Schembl21803655	Investigative	137656446	C22H17ClN4O3	420.8	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5C=CN=C5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BI45FC	Chembl4175970	Investigative	145972895	C15H12N2O4	284.27	CCNC(=O)C1=C(OC2=C1C(=O)C3=C(C2=O)N=CC=C3)C	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BJ6YZ7	Schembl21803677	Investigative	137635101	C22H19FN4O3S	438.5	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCNC5=NCCS5)N=C1	IC50 = 61600 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BJ7A6C	Chembl4169561	Investigative	145953711	C26H24N2O7	476.5	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=C(C=C4)OCCCN5CCOCC5	IC50 = 51000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BK98OT	Chembl4166710	Investigative	121478403	C19H12N2O4	332.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)NC4=CC=CC=C4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BL3E4B	Chembl4176758	Investigative	121478292	C20H10N2O5	358.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=CC=C4C#N	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BM34XR	Chembl4166527	Investigative	121478332	C23H13NO5	383.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC5=CC=CC=C5C=C4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BN0VT2	Schembl22364356	Investigative	127044409	C18H17Cl2N3O2	378.2	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=NC=C4)C(=O)N3CCCN.Cl.Cl	IC50 = 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BN36LF	Chembl4161227	Investigative	145959663	C14H12NO6P	321.22	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)P(=O)(OC)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BNM90W	Chembl4161640	Investigative	121478368	C22H14N2O6	402.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=C(C=C4)NC(=O)C=C	IC50 = 68000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BNU6A1	6-Bromobenzo[de]isoquinoline-1,3-dione	Investigative	304992	C12H6BrNO2	276.08	C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)Br	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BO3MJ8	6-Quinolin-3-yl-4H-isoquinoline-1,3-dione	Investigative	122483608	C18H12N2O2	288.3	C1C2=C(C=CC(=C2)C3=CC4=CC=CC=C4N=C3)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BOD15A	6-(3-Imidazol-1-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione	Investigative	127044411	C21H16N4O2	356.4	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3CCCN5C=CN=C5)N=CC=C4	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BP72VM	Chembl4174619	Investigative	121478306	C19H12N2O5	348.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)NC4=CC=CC=C4O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BPJ97Y	Chembl4171508	Investigative	145950046	C14H12NO6P	321.22	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)C=CC=N3)P(=O)(OC)OC	IC50 = 99000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BPQ9I6	Chembl4165352	Investigative	145952847	C19H11ClN2O4	366.8	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)C=CC=N3)C(=O)NC4=CC(=CC=C4)Cl	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BQ70XZ	N-(4,6-Dioxo-2-phenyl-7H-pyrazolo[4,3-c]pyridin-3-yl)acetamide	Investigative	60104019	C14H12N4O3	284.27	CC(=O)NC1=C2C(=NN1C3=CC=CC=C3)CC(=O)NC2=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BQS1B6	5-Fluoro-14-methoxy-9-[3-(4-methylpiperazin-1-yl)propyl]-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione	Investigative	137633472	C24H25FN4O3	436.5	CN1CCN(CC1)CCCN2C3=C(C4=C(C2=O)C=C(C=C4)F)C(=O)C5=C3N=CC(=C5)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BQYR60	Schembl22364348	Investigative	127044414	C18H17Cl2N3O2	378.2	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3CCCN)N=CC=C4.Cl.Cl	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BR4PH6	2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,7-naphthyridine-1-one	Investigative	122179163	C20H19N3O2	333.4	CN(C)CCCN1C2=C(C3=C(C1=O)C=NC=C3)C(=O)C4=CC=CC=C42	IC50 = 80000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BS9T8G	Schembl21803678	Investigative	137638583	C23H22ClN3O3	423.9	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5CCCC5)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BSD6Z1	Chembl4171800	Investigative	121478298	C20H14N2O5	362.3	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)NC4=CC=C(C=C4)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BSN0I8	Chembl4160844	Investigative	145958644	C24H15N4NaO7	494.4	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OC4=CC=CC(=C4)C5=CN(N=N5)CCC(=O)[O-].[Na+]	IC50 = 50000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BSV47G	Schembl21803652	Investigative	137639878	C20H18FN3O3	367.4	CNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC	IC50 = 108000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BSYZ76	Schembl21803664	Investigative	137652086	C21H20FN3O3	381.4	CCNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC	IC50 = 104000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BTU65B	Chembl4173499	Investigative	121478299	C15H12N2O4	284.27	CCNC(=O)C1=C(OC2=C1C(=O)C3=C(C2=O)C=CC=N3)C	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BTX9V0	O1C(=CC=C1)C1=C2CC(NC(C2=CC=C1)=O)=O	Investigative	122483599	C13H9NO3	227.21	C1C2=C(C=CC=C2C(=O)NC1=O)C3=CC=CO3	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BU2N9K	Chembl4175665	Investigative	121478293	C15H9NO7	315.23	CC1=C(C2=C(O1)C(=O)C3=C(C2=O)N=CC=C3)C(=O)OCC(=O)O	IC50 = 51000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BUN5C6	Schembl21803665	Investigative	137660083	C24H24FN3O4	437.5	COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCC(CC5)O)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BUQ6L5	Chembl4170681	Investigative	145950454	C15H12N2O4	284.27	CCOC(=O)C1=C(NC2=C1C(=O)C3=C(C2=O)N=CC=C3)C	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BV8GK2	Schembl21803669	Investigative	137650951	C20H18ClN3O3	383.8	CNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)Cl)C(=O)C4=C2N=CC(=C4)OC	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BVR70X	6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,6]naphthyridine-5,11-dione	Investigative	127043728	C18H14N2O4	322.3	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CN=C4)C(=O)N3C[C@@H](CO)O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BW9A4G	6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione	Investigative	122179162	C22H21N3O3	375.4	C1COCCN1CCCN2C3=C(C4=C(C2=O)C=NC=C4)C(=O)C5=CC=CC=C53	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BWE06B	6-(3-Imidazol-1-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione	Investigative	127044403	C21H16N4O2	356.4	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CC=N4)C(=O)N3CCCN5C=CN=C5	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BWY20B	C1(=CC=CC=C1)C=1C=C2CC(NC(C2=CC=1)=O)=O	Investigative	122483634	C15H11NO2	237.25	C1C2=C(C=CC(=C2)C3=CC=CC=C3)C(=O)NC1=O	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BYJ7T6	O1C(=CC=C1)C1=CC=C2CC(NC(C2=C1)=O)=O	Investigative	122483636	C13H9NO3	227.21	C1C2=C(C=C(C=C2)C3=CC=CO3)C(=O)NC1=O	IC50 = 50000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BZ6O1S	Chembl4165089	Investigative	145960096	C13H9NO3	227.21	CC1=CC2=C(C(=O)C3=C(C2=O)OC=C3C)N=C1	IC50 ~ 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	BZGX32	Schembl22364355	Investigative	127044406	C18H17Cl2N3O2	378.2	C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CN=C4)C(=O)N3CCCN.Cl.Cl	IC50 = 111000 nM	Poor binder
T04696	Tyrosyl-DNA phosphodiesterase 2	D0J1KH	NSC-95397	Investigative	262093	C14H14O4S2	310.4	C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO	IC50 = 71000 nM	Poor binder