TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T00895	Protein kinase C epsilon	D01XYJ	Zidovudine	Approved	35370	C10H13N5O4	267.24	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	D0R9YR	BETULINIC ACID	Phase 1	64971	C30H48O3	456.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	D0WS1V	L-751250	Preclinical	448991	C20H25ClN6O3	432.9	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=C(C=C3)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	B13BDT	3-Hydroxy-2-[4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dimethylbenzoyl]benzoic acid	Investigative	44322720	C29H27NO8	517.5	CC1=CC(=CC(=C1C(=O)C2=C(C=CC=C2O)C(=O)O)C)C(=O)OC3CCCC3NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	B1BZK4	2-(2,6-Dihydroxy-4-{[(1S,2R)-2-(4-hydroxy-benzoylamino)-cyclopentylmethyl]-carbamoyl}-benzoyl)-3-hydroxy-benzoic acid	Investigative	15297224	C28H26N2O9	534.5	C1C[C@H]([C@@H](C1)NC(=O)C2=CC=C(C=C2)O)CNC(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C=CC=C4O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	B2U1HJ	1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	4877	C19H19N5	317.4	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	B4F1NE	2-[2,6-Dihydroxy-4-[[(3R,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]-methylcarbamoyl]benzoyl]-3-hydroxybenzoic acid	Investigative	71718528	C29H29N3O9	563.6	CN([C@H]1CCCNC[C@H]1NC(=O)C2=CC=C(C=C2)O)C(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C=CC=C4O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	B4U6PG	Platanic acid	Investigative	64980	C29H46O4	458.7	CC(=O)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	B5XGJ1	Betulinic acid 28-O-carboxymethylmethylate	Investigative	10482065	C33H52O5	528.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)OCC(=O)OC	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	B7AYK6	Betulinic acid 3-O-sulfonate potassium salt	Investigative	44575685	C30H47KO6S	574.9	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OS(=O)(=O)[O-])C)C(=O)O.[K+]	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	B93PBH	(1S)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid	Investigative	44322686	C28H32N2O9	540.6	C1CCC([C@H](C1)C(=O)O)C(=O)C2=C(C=C(C=C2O)C(=O)O[C@@H]3CCCNCC3NC(=O)C4=CC=C(C=C4)O)O	IC50 = 97000 nM	Poor binder
T00895	Protein kinase C epsilon	B9EJ0X	Acyclic Balanol Analog 8b	Investigative	5327950	C31H25NO10	571.5	C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)COC(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C=CC=C4O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BA6CV3	[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-(8-hydroxy-4-oxo-3H-phthalazin-1-yl)benzoate	Investigative	136026545	C27H23N3O8	517.5	C1CC(C(C1)OC(=O)C2=CC(=C(C(=C2)O)C3=NNC(=O)C4=C3C(=CC=C4)O)O)NC(=O)C5=CC=C(C=C5)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BB31EG	Modified Benzophenone Carboxylic Acid, Balanol Analog 37	Investigative	5327996	C28H23F3N2O9	588.5	C1C[C@H]([C@@H](C1)OC(=O)C2=CC(=C(C(=C2)O)C(=O)C3=C(C=CC=C3O)NC(=O)C(F)(F)F)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BC82AY	Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	Investigative	644356	C20H16N2O4	348.4	COCC(=O)OC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC4=CC=CC=C4N3	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	BE3V4Z	[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 3,5-dihydroxy-4-(1-hydroxynaphthalene-2-carbonyl)benzoate	Investigative	44322982	C31H28N2O8	556.6	C1C[C@H](C(CNC1)NC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C5=CC=CC=C5C=C4)O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BE8T9F	3-Hydroxy-2-[4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylphenyl]benzoic acid	Investigative	44323003	C25H22N2O7	462.4	C1C(C(CN1)OC(=O)C2=CC=C(C=C2)C3=C(C=CC=C3O)C(=O)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BEC17U	Acyclic Balanol Analog 7b	Investigative	5327949	C25H23NO11S	545.5	CS(=O)(=O)NC(CC1=CC=C(C=C1)O)COC(=O)C2=CC(=C(C(=C2)O)C(=O)C3=C(C=CC=C3O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BLD6S1	2-(2-((Dimethylamino)methyl)-5-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	44570884	C27H25N5OS	467.6	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)C5=C(C=CC(=C5)OC)CN(C)C	IC50 = 95000 nM	Poor binder
T00895	Protein kinase C epsilon	BM1P3R	Acyclic Balanol Analog 13b	Investigative	5327955	C29H23NO11S	593.6	C1=CC=C(C=C1)S(=O)(=O)NC(COC(=O)C2=CC(=C(C(=C2)O)C(=O)C3=C(C=CC=C3O)C(=O)O)O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BM7JY6	Betulinic acid 3-O-succinate	Investigative	10415328	C34H52O6	556.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CCC(=O)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BMJE80	Betulinic acid 3-O-crotonate	Investigative	11756581	C34H52O4	524.8	C/C=C/C(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@@H]4[C@H]5[C@@H](CC[C@@]5(CC[C@]4([C@@]3(CC[C@H]2C1(C)C)C)C)C(=O)O)C(=C)C)C	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BN17KD	4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-1-(4-hydroxy-benzoylamino)-indan-2-yl ester	Investigative	10460643	C31H23NO10	569.5	C1[C@H]([C@@H](C2=CC=CC=C21)NC(=O)C3=CC=C(C=C3)O)OC(=O)C4=CC(=C(C(=C4)O)C(=O)C5=C(C=CC=C5O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BU6GL4	(1S,3As,5aR,5bR,9S,11aR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-propan-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid	Investigative	44337790	C30H50O3	458.7	CC(C)[C@@H]1CC[C@]2(C1C3CCC4[C@]5(CC[C@@H](C(C5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BUY1S6	Purvalanol A	Investigative	456214	C19H25ClN6O	388.9	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	BVS35M	(18S)-18-[(Benzylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione	Investigative	10768554	C33H30N4O3	530.6	C1CN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO[C@@H]1CNCC6=CC=CC=C6)C7=CC=CC=C75)C(=O)NC4=O	IC50 = 57000 nM	Poor binder
T00895	Protein kinase C epsilon	BW4AN3	[2-(1H-Indole-2-carbonyl)-1H-indol-5-yl] acetate	Investigative	5330546	C19H14N2O3	318.3	CC(=O)OC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC4=CC=CC=C4N3	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	BY67VL	Acyclic Balanol Analog 17b	Investigative	5327954	C31H25NO11	587.5	C1=CC(=C(C(=C1)O)C(=O)C2=C(C=C(C=C2O)C(=O)OCC(CC3=CC=C(C=C3)O)NC(=O)C4=CC=C(C=C4)O)O)C(=O)O	IC50 ~ 50000 nM	Poor binder
T00895	Protein kinase C epsilon	BYH31M	2-(N-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]anilino)acetic acid	Investigative	44322889	C27H25N3O9	535.5	C1C(C(CN1)OC(=O)C2=CC(=C(C(=C2)O)C(=O)N(CC(=O)O)C3=CC=CC=C3)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BYI18Q	Betulinic acid 3-O-benzoate	Investigative	10099352	C37H52O4	560.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C6=CC=CC=C6)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	BZ70IQ	3beta-Acetoxybetulinic acid	Investigative	10300534	C32H50O4	498.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T00895	Protein kinase C epsilon	D02XHC	aloisine A	Investigative	448912	C16H17N3O	267.33	CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T00895	Protein kinase C epsilon	D05KJY	BETULIN	Investigative	72326	C30H50O2	442.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO	IC50 ~ 150000 nM	Poor binder