TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99455	HUMAN fusion protein Bcr-Abl	B05AET	[4-(2,4-Dichlorobenzoyl)piperazin-1-yl]-[4-(1,3-thiazol-2-yl)phenyl]methanone	Investigative	122189068	C21H17Cl2N3O2S	446.3	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=NC=CS3)C(=O)C4=C(C=C(C=C4)Cl)Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B0A1SE	4-[5-Bromo-4-[4-(2,5-dichlorothiophen-3-yl)sulfonylpiperazin-1-yl]pyrimidin-2-yl]morpholine	Investigative	134155843	C16H18BrCl2N5O3S2	543.3	C1CN(CCN1C2=NC(=NC=C2Br)N3CCOCC3)S(=O)(=O)C4=C(SC(=C4)Cl)Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B0CAK6	5-Bromo-2-chloro-4-(4-propylsulfonylpiperazin-1-yl)pyrimidine	Investigative	134157397	C11H16BrClN4O2S	383.69	CCCS(=O)(=O)N1CCN(CC1)C2=NC(=NC=C2Br)Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B0VSK1	[4-[6-(4-Tert-butylanilino)pyrimidin-4-yl]phenyl]-[4-(2-chlorobenzoyl)piperazin-1-yl]methanone	Investigative	118722089	C32H32ClN5O2	554.1	CC(C)(C)C1=CC=C(C=C1)NC2=NC=NC(=C2)C3=CC=C(C=C3)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B51ADN	4-[5-Bromo-4-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]pyrimidin-2-yl]morpholine	Investigative	134135339	C17H23BrN6O4S	487.4	CC1=C(C(=NO1)C)S(=O)(=O)N2CCN(CC2)C3=NC(=NC=C3Br)N4CCOCC4	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B5JN8K	[4-[6-(2,4-Dichloroanilino)pyrimidin-4-yl]phenyl]-[4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl]methanone	Investigative	118722091	C29H22Cl2F3N5O2	600.4	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=C(C=C(C=C4)Cl)Cl)C(=O)C5=CC(=CC=C5)C(F)(F)F	IC50 = 266000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	B90VOP	[4-(5-Bromo-2-morpholin-4-ylpyrimidin-4-yl)piperazin-1-yl]-(4-chloro-2-nitrophenyl)methanone	Investigative	134150056	C19H20BrClN6O4	511.8	C1CN(CCN1C2=NC(=NC=C2Br)N3CCOCC3)C(=O)C4=C(C=C(C=C4)Cl)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BA2U4L	[4-[6-(3,4-Difluoroanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722075	C28H22F3N5O2	517.5	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=CC(=C(C=C4)F)F)C(=O)C5=CC=CC=C5F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BBTE37	5-Bromo-2-chloro-4-(4-cyclopropylsulfonylpiperazin-1-yl)pyrimidine	Investigative	134150012	C11H14BrClN4O2S	381.68	C1CC1S(=O)(=O)N2CCN(CC2)C3=NC(=NC=C3Br)Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BCR0N8	[4-[3-(Dimethylamino)benzoyl]piperazin-1-yl]-[4-(6-methylpyridin-3-yl)phenyl]methanone	Investigative	122189058	C26H28N4O2	428.5	CC1=NC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCN(CC3)C(=O)C4=CC(=CC=C4)N(C)C	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BFH01A	[4-[6-(3-Chloro-4-methylanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722084	C29H25ClFN5O2	530	CC1=C(C=C(C=C1)NC2=NC=NC(=C2)C3=CC=C(C=C3)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5F)Cl	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BI80JP	[4-[6-(3,4-Dichloroanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722085	C28H22Cl2FN5O2	550.4	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=CC(=C(C=C4)Cl)Cl)C(=O)C5=CC=CC=C5F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BK4V7H	4-[4-(5-Bromo-2-morpholin-4-ylpyrimidin-4-yl)piperazin-1-yl]sulfonylbenzonitrile	Investigative	134141669	C19H21BrN6O3S	493.4	C1CN(CCN1C2=NC(=NC=C2Br)N3CCOCC3)S(=O)(=O)C4=CC=C(C=C4)C#N	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BL2WY8	[4-[6-(2,4-Dichloroanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722073	C28H22Cl2FN5O2	550.4	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=C(C=C(C=C4)Cl)Cl)C(=O)C5=CC=CC=C5F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BLW4T3	(4-Pyridin-2-ylphenyl)-[4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl]methanone	Investigative	122189041	C24H20F3N3O2	439.4	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC=CC=N3)C(=O)C4=CC(=CC=C4)C(F)(F)F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BN4D2G	[4-[6-(4-Tert-butylanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722070	C32H32FN5O2	537.6	CC(C)(C)C1=CC=C(C=C1)NC2=NC=NC(=C2)C3=CC=C(C=C3)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5F	IC50 = 354000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BP4R7B	[4-[6-(4-Fluoroanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722083	C28H23F2N5O2	499.5	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=CC=C(C=C4)F)C(=O)C5=CC=CC=C5F	IC50 = 277000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BS6HG5	[4-(3-Fluorobenzoyl)piperazin-1-yl]-[4-(1,3-thiazol-2-yl)phenyl]methanone	Investigative	122189064	C21H18FN3O2S	395.5	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=NC=CS3)C(=O)C4=CC(=CC=C4)F	IC50 = 444180 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BU5ZA8	[4-(3-Fluorobenzoyl)piperazin-1-yl]-[4-(6-methylpyridin-3-yl)phenyl]methanone	Investigative	122189056	C24H22FN3O2	403.4	CC1=NC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCN(CC3)C(=O)C4=CC(=CC=C4)F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BUK91J	[4-[6-(3-Bromoanilino)pyrimidin-4-yl]phenyl]-[4-(2-fluorobenzoyl)piperazin-1-yl]methanone	Investigative	118722071	C28H23BrFN5O2	560.4	C1CN(CCN1C(=O)C2=CC=C(C=C2)C3=CC(=NC=N3)NC4=CC(=CC=C4)Br)C(=O)C5=CC=CC=C5F	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BX1DC8	[4-(4-Tert-butylbenzoyl)piperazin-1-yl]-[4-(4-methylpyridin-2-yl)phenyl]methanone	Investigative	122189053	C28H31N3O2	441.6	CC1=CC(=NC=C1)C2=CC=C(C=C2)C(=O)N3CCN(CC3)C(=O)C4=CC=C(C=C4)C(C)(C)C	IC50 > 500000 nM	Non binder
T99455	HUMAN fusion protein Bcr-Abl	BZK73E	[4-(2-Fluorobenzoyl)piperazin-1-yl]-[4-[6-(3-propan-2-ylanilino)pyrimidin-4-yl]phenyl]methanone	Investigative	118722077	C31H30FN5O2	523.6	CC(C)C1=CC(=CC=C1)NC2=NC=NC(=C2)C3=CC=C(C=C3)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5F	IC50 > 500000 nM	Non binder