TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94879	HUMAN phosphodiesterase type 5	B0S7MH	6-(2-Isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	54580523	C15H18N4O2	286.33	CC(C)C1=NN2C(=C1C3=NNC(=O)CC3)C=CC=C2OC	IC50 = 225000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B27WAS	(1-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperidin-4-yl)methylphosphonic acid	Investigative	136104513	C24H34N5O7PS	567.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CP(=O)(O)O)OCCC)C	IC50 = 3090000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B28JUZ	2-(4-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperazin-1-yl)ethylphosphonic acid	Investigative	136104511	C24H35N6O7PS	582.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCP(=O)(O)O)OCCC)C	IC50 = 1070000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B29VZX	3-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]propanoic acid	Investigative	135543088	C25H33N5O6S	531.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CCC(=O)O)OCC)C	IC50 = 6610000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B3MWX5	5-[5-[4-(Diethoxyphosphorylmethyl)piperidin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136104510	C28H42N5O7PS	623.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CP(=O)(OCC)OCC)OCCC)C	IC50 = 2950000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B4CD2Z	3-(Cyclopentyloxy)-N-(2-fluorophenyl)-4-methoxybenzamide	Investigative	10087963	C19H20FNO3	329.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B4HE0N	15-Propan-2-yl-3,4,13,14-tetrazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,9,11,14-pentaen-5-one	Investigative	54582528	C15H16N4O	268.31	CC(C)C1=NN2C=CC=C3C2=C1C4=NNC(=O)CC4C3	IC50 = 350000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B4Q7RS	Benzamide,n-(2-chlorophenyl)-3-(cyclopentyloxy)-4-methoxy-	Investigative	10450290	C19H20ClNO3	345.8	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B53YJC	N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]propanamide	Investigative	136044184	C21H27N5O3	397.5	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)NC(=O)CC)OCCC)C	IC50 = 2630000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B5A7NH	5-[5-[4-(2-Diethoxyphosphorylethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136104508	C28H43N6O7PS	638.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCP(=O)(OCC)OCC)OCCC)C	IC50 = 955000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B5BC1H	Proxyphylline	Investigative	4977	C10H14N4O3	238.24	CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 600000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B5W8PZ	3-Cyclopentyloxy-N-(2,5-dichloro-phenyl)-4-methoxy-benzamide	Investigative	10091146	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B5ZL1U	5-[5-[4-(Diethoxyphosphorylmethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136044186	C27H41N6O7PS	624.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CP(=O)(OCC)OCC)OCCC)C	IC50 = 1740000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B67JPX	1-Methyl-5-[6-(4-methylpiperazin-1-yl)sulfonyl-1,3-benzodioxol-4-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	135455996	C21H26N6O5S	474.5	CCCC1=NN(C2=C1N=C(NC2=O)C3=C4C(=CC(=C3)S(=O)(=O)N5CCN(CC5)C)OCO4)C	IC50 = 2344228815 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B6QVD7	1-Methyl-5-[7-(4-methylpiperazin-1-yl)sulfonyl-2,3-dihydro-1,4-benzodioxin-5-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	135475323	C22H28N6O5S	488.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C4C(=CC(=C3)S(=O)(=O)N5CCN(CC5)C)OCCO4)C	IC50 = 126000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B6S2ZY	2-Isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine	Investigative	54585432	C15H16N4O	268.31	CC(C)C1=NN2C=CC=CC2=C1C3=NN=C(C=C3)OC	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B8DCS3	3-(6-Chloro-4-methylpyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine	Investigative	54583497	C15H15ClN4	286.76	CC1=CC(=NN=C1C2=C3C=CC=CN3N=C2C(C)C)Cl	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B8G9IN	1-Benzoyl-5-methylindole-2,3-dione	Investigative	4636426	C16H11NO3	265.26	CC1=CC2=C(C=C1)N(C(=O)C2=O)C(=O)C3=CC=CC=C3	IC50 = 746450 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B8QM0Z	5-[6-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-1,3-benzodioxol-4-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136124415	C22H28N6O6S	504.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C4C(=CC(=C3)S(=O)(=O)N5CCN(CC5)CCO)OCO4)C	IC50 = 3019951720 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B8SPK5	3-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]propanoic acid	Investigative	135452935	C26H35N5O6S	545.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CCC(=O)O)OCCC)C	IC50 = 20000000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	B9DQS1	3-(Cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxybenzamide	Investigative	10249183	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Cl)Cl)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BAL09Z	4-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]butanoic acid	Investigative	136044187	C26H35N5O6S	545.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CCCC(=O)O)OCC)C	IC50 = 4570000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BBK24I	N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]cyclohexanecarboxamide	Investigative	135542972	C25H33N5O3	451.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)NC(=O)C4CCCCC4)OCCC)C	IC50 = 2400000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BC9ML7	3-Cyclopentyloxy-N-(2,6-dibromo-phenyl)-4-methoxy-benzamide	Investigative	10434818	C19H19Br2NO3	469.2	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Br)Br)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BE3W9S	3-[4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]propanoic acid	Investigative	136124412	C24H32N6O6S	532.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCC(=O)O)OCC)C	IC50 = 2450000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BE8J5Y	N-(2-Chloro-6-methyl-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10067044	C20H22ClNO3	359.8	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BEGD54	4-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]butanoic acid	Investigative	136044185	C27H37N5O6S	559.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CCCC(=O)O)OCCC)C	IC50 = 2000000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BF4YQ2	N-(4-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10043209	C19H20ClNO3	345.8	COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)Cl)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BF51SU	3-(Cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxybenzamide	Investigative	9798336	C19H19F2NO3	347.4	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2F)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BG74WU	2-Benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	54580524	C22H24N4O2	376.5	CC(C)C1=NN2C(=C1C3=NN(C(=O)CC3)CC4=CC=CC=C4)C=CC=C2OC	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BG9Y0M	5-[6-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-3,4-dihydro-2H-chromen-8-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136124414	C24H32N6O5S	516.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC(=CC4=C3OCCC4)S(=O)(=O)N5CCN(CC5)CCO)C	IC50 = 79432823472 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BGJ5U0	2-Benzyl-6-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	24751988	C21H22N4O	346.4	CC(C)C1=NN2C=CC=CC2=C1C3=NN(C(=O)CC3)CC4=CC=CC=C4	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BH25NI	2-Methyl-N-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]propanamide	Investigative	136044179	C22H29N5O3	411.5	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)NC(=O)C(C)C)OCCC)C	IC50 = 2880000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BH5ES1	{1-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperidin-4-yl}-phosphonic acid monoethyl ester	Investigative	136104507	C25H36N5O7PS	581.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)P(=O)(O)OCC)OCCC)C	IC50 = 3310000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BI9ZN4	3-Cyclopentyloxy-N-(2,3-dichloro-phenyl)-4-methoxy-benzamide	Investigative	10385088	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C(=CC=C2)Cl)Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BIPO02	7-Methyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one	Investigative	54587403	C14H14N4O	254.29	CC12CCC3=NN4C=CC=CC4=C3C1=NNC(=O)C2	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BJ8NA9	5-[2,3-Dihydro-5-(4-methylpiperazin-1-ylsulfonyl)-7-benzofuryl]-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	135455994	C22H28N6O4S	472.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC(=CC4=C3OCC4)S(=O)(=O)N5CCN(CC5)C)C	IC50 = 4168693835 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BJB62V	5-[5-(4-Diethoxyphosphorylpiperidin-1-yl)sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136104509	C27H40N5O7PS	609.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)P(=O)(OCC)OCC)OCCC)C	IC50 = 2450000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BJI62E	3-Cyclopentyloxy-N-(4-fluoro-phenyl)-4-methoxy-benzamide	Investigative	10404302	C19H20FNO3	329.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BK3S6U	(S)-6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one	Investigative	54586393	C15H18N4O	270.33	C[C@H]1CC(=O)NN=C1C2=C3C=CC=CN3N=C2C(C)C	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BKUS04	1-Benzoyl-5-[(4-methylpiperazin-1-yl)methyl]indole-2,3-dione	Investigative	137635781	C21H21N3O3	363.4	CN1CCN(CC1)CC2=CC3=C(C=C2)N(C(=O)C3=O)C(=O)C4=CC=CC=C4	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BM41PT	N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]butanamide	Investigative	135457489	C22H29N5O3	411.5	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)NC(=O)CCC)OCCC)C	IC50 = 3720000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BN43VK	2-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]acetic acid	Investigative	136044182	C24H31N5O6S	517.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CC(=O)O)OCC)C	IC50 = 3020000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BN9XE6	(2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperazin-1-yl}-ethyl)-phosphonic acid monoethyl ester	Investigative	136104506	C26H39N6O7PS	610.7	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCP(=O)(O)OCC)OCCC)C	IC50 = 3550000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BNAL82	{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperazin-1-ylmethyl}-phosphonic acid monoethyl ester	Investigative	136104505	C25H37N6O7PS	596.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CP(=O)(O)OCC)OCCC)C	IC50 = 5500000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BO5Q4C	Benzamide,n-(2-bromophenyl)-3-(cyclopentyloxy)-4-methoxy-	Investigative	9977675	C19H20BrNO3	390.3	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2Br)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BOU0X1	3-Cyclopentyloxy-4-methoxy-N-phenyl-benzamide	Investigative	10448177	C19H21NO3	311.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BQ4CU7	(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol	Investigative	149784	C14H23N5O	277.37	CCCCCC[C@@H]([C@@H](C)O)N1C=NC2=C(N=CN=C21)N	Ki > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BQGB96	3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanylphenyl)benzamide	Investigative	10338401	C20H23NO3S	357.5	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2SC)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BR4SI8	2-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]acetic acid	Investigative	135530618	C25H33N5O6S	531.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CC(=O)O)OCCC)C	IC50 = 9120000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BRA9H0	4-Benzyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one	Investigative	54580522	C20H18N4O	330.4	C1CC2=NN3C=CC=CC3=C2C4=NN(C(=O)CC41)CC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BTFE37	{1-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperidin-4-ylmethyl}-phosphonic acid monoethyl ester	Investigative	135506388	C26H38N5O7PS	595.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)CP(=O)(O)OCC)OCCC)C	IC50 = 5890000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BTL85D	1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidine-4-carboxylic acid	Investigative	136044183	C23H29N5O6S	503.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)C(=O)O)OCC)C	IC50 = 1950000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BUN05R	1-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperidin-4-ylphosphonic acid	Investigative	136104512	C23H32N5O7PS	553.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)P(=O)(O)O)OCCC)C	IC50 = 1410000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BV1FS2	1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidine-4-carboxylic acid	Investigative	136044180	C24H31N5O6S	517.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCC(CC4)C(=O)O)OCCC)C	IC50 = 6610000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BV1YD3	3-Cyclopentyloxy-4-methoxy-N-(2-trifluoromethyl-phenyl)-benzamide	Investigative	10339653	C20H20F3NO3	379.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2C(F)(F)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BV94BJ	4-Benzyl-7-methyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one	Investigative	54586394	C21H20N4O	344.4	CC12CCC3=NN4C=CC=CC4=C3C1=NN(C(=O)C2)CC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BVMI81	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methylpyridazin-3(2H)-one	Investigative	54580520	C15H16N4O	268.31	CC1=CC(=O)NN=C1C2=C3C=CC=CN3N=C2C(C)C	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BW43LS	5-[5-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-2,3-dihydro-1-benzofuran-7-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136124413	C23H30N6O5S	502.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC(=CC4=C3OCC4)S(=O)(=O)N5CCN(CC5)CCO)C	IC50 = 4897788194 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BW6ZJ3	N-(2-Chloro-6-fluoro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10248176	C19H19ClFNO3	363.8	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Cl)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BW9EM5	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-	Investigative	158962	C10H14N4O3	238.24	C[C@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 600000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BWK5P8	3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide	Investigative	10472374	C21H25NO3	339.4	CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BXD8Z7	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-	Investigative	158961	C10H14N4O3	238.24	C[C@@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 600000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BXS7T4	3-Cyclopentyloxy-4-methoxy-N-o-tolyl-benzamide	Investigative	10449000	C20H23NO3	325.4	CC1=CC=CC=C1NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 1000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BY06RU	3-Cyclopentyloxy-4-methoxy-N-p-tolyl-benzamide	Investigative	9973597	C20H23NO3	325.4	CC1=CC=C(C=C1)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 200000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BY16BA	4-Benzyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,6,10,13,15-hexaen-5-one	Investigative	54587404	C20H16N4O	328.4	C1CC2=NN3C=CC=CC3=C2C4=NN(C(=O)C=C41)CC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BY5QP3	4-Benzyl-15-propan-2-yl-3,4,13,14-tetrazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,9,11,14-pentaen-5-one	Investigative	54582529	C22H22N4O	358.4	CC(C)C1=NN2C=CC=C3C2=C1C4=NN(C(=O)CC4C3)CC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BZA80X	N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]acetamide	Investigative	136044181	C20H25N5O3	383.4	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)NC(=O)C)OCCC)C	IC50 = 1230000000000 nM	Non binder
T94879	HUMAN phosphodiesterase type 5	BZV82K	5-[7-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-2,3-dihydro-1,4-benzodioxin-5-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	136044178	C23H30N6O6S	518.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C4C(=CC(=C3)S(=O)(=O)N5CCN(CC5)CCO)OCCO4)C	IC50 = 158000000000 nM	Non binder