TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T94131 HUMAN PI3-kinase gamma D0DF2M PMID28870136-Compound-48 Patented 2153 C7H8N4O2 180.16 CN1C2=C(C(=O)N(C1=O)C)NC=N2 IC50 = 800000 nM Non binder T94131 HUMAN PI3-kinase gamma D0H9IX PMID28870136-Compound-52 Patented 2519 C8H10N4O2 194.19 CN1C=NC2=C1C(=O)N(C(=O)N2C)C IC50 = 1000000 nM Non binder T94131 HUMAN PI3-kinase gamma B0PFB2 3-[4-(Benzyloxy)-3-methoxyphenyl]pentanedioic acid Investigative 347279 C19H20O6 344.4 COC1=C(C=CC(=C1)C(CC(=O)O)CC(=O)O)OCC2=CC=CC=C2 IC50 = 5876000 nM Non binder T94131 HUMAN PI3-kinase gamma B43MQP 2-(7-Oxobenzo[a]phenalen-3-yl)sulfinylacetic acid Investigative 226105 C19H12O4S 336.4 C1=CC=C2C(=C1)C3=C4C(=C(C=C3)S(=O)CC(=O)O)C=CC=C4C2=O IC50 = 1570000 nM Non binder T94131 HUMAN PI3-kinase gamma B4Y2SQ 3-Butyl-2-(7H-purin-6-ylsulfanylmethyl)quinazolin-4-one Investigative 9925404 C18H18N6OS 366.4 CCCCN1C(=NC2=CC=CC=C2C1=O)CSC3=NC=NC4=C3NC=N4 IC50 = 217800 nM Non binder T94131 HUMAN PI3-kinase gamma B4ZEF0 2-Methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile Investigative 14501859 C8H6N4 158.16 CC1=NN2C=CC=NC2=C1C#N IC50 = 773000 nM Non binder T94131 HUMAN PI3-kinase gamma B5KQP3 5-Chloro-2-[2-[3-[(3-fluorosulfonylphenyl)carbamoylamino]anilino]-2-oxoethoxy]benzoic acid Investigative 309591 C22H17ClFN3O7S 521.9 C1=CC(=CC(=C1)NC(=O)NC2=CC(=CC=C2)S(=O)(=O)F)NC(=O)COC3=C(C=C(C=C3)Cl)C(=O)O IC50 = 9157000 nM Non binder T94131 HUMAN PI3-kinase gamma B6MY5D 7-(4-Ethoxyanilino)-4-hydroxynaphthalene-2-sulfonic acid Investigative 235602 C18H17NO5S 359.4 CCOC1=CC=C(C=C1)NC2=CC3=CC(=CC(=C3C=C2)O)S(=O)(=O)O IC50 = 992000 nM Non binder T94131 HUMAN PI3-kinase gamma B7LB5F 2-Propan-2-ylpyrazolo[1,5-a]pyrimidine-3-carbonitrile Investigative 57401565 C10H10N4 186.21 CC(C)C1=NN2C=CC=NC2=C1C#N IC50 = 395000 nM Non binder T94131 HUMAN PI3-kinase gamma B8SKH9 11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione Investigative 122180796 C26H27N5O2S 473.6 COC1=CC=C(C=C1)C2=NC(=C3C4CCCN4C(=S)N(C3=N2)C5=CC=CC=C5)N6CCOCC6 IC50 = 345900 nM Non binder T94131 HUMAN PI3-kinase gamma B9AG6R 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine Investigative 267310 C7H9N5 163.18 CC1=CC(=NC2=NC(=NN12)N)C IC50 > 1600000 nM Non binder T94131 HUMAN PI3-kinase gamma B9BZ6N 3-(3,4-Dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propanoic acid Investigative 270557 C20H24O7 376.4 COC1=C(C=C(C=C1)C(CC(=O)O)C2=CC(=C(C(=C2)OC)OC)OC)OC IC50 = 6074000 nM Non binder T94131 HUMAN PI3-kinase gamma BB31WX 5-(2-Chlorophenylazo)-6-hydroxy-2-naphthalenesulfonic acid Investigative 79972 C16H11ClN2O4S 362.8 C1=CC=C(C(=C1)N=NC2=C(C=CC3=C2C=CC(=C3)S(=O)(=O)O)O)Cl IC50 = 1498000 nM Non binder T94131 HUMAN PI3-kinase gamma BBA1V6 2-Amino-6-chlorobenzoxazole Investigative 40237 C7H5ClN2O 168.58 C1=CC2=C(C=C1Cl)OC(=N2)N IC50 = 380000 nM Non binder T94131 HUMAN PI3-kinase gamma BC8KQ1 6-(6-Methoxynaphthalen-2-yl)-2-methyl-6-oxohexanoic acid Investigative 247414 C18H20O4 300.3 CC(CCCC(=O)C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O IC50 = 5184000 nM Non binder T94131 HUMAN PI3-kinase gamma BCV2S9 4-{5-Oxo-3-pentadecyl-4-[(e)-phenyldiazenyl]-4,5-dihydro-1h-pyrazol-1-yl}benzenesulfonic acid Investigative 274101 C30H42N4O4S 554.7 CCCCCCCCCCCCCCCC1=NN(C(=O)C1N=NC2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)O IC50 = 241000 nM Non binder T94131 HUMAN PI3-kinase gamma BF3U6P (2S)-4-(1,3-Benzodioxol-5-yl)-4-oxo-2-[(3,4,5-trimethoxyphenyl)methyl]butanoic acid Investigative 92172785 C21H22O8 402.4 COC1=CC(=CC(=C1OC)OC)C[C@@H](CC(=O)C2=CC3=C(C=C2)OCO3)C(=O)O IC50 = 575000 nM Non binder T94131 HUMAN PI3-kinase gamma BGUS85 11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione Investigative 122180795 C26H27N5O2S 473.6 COC1=CC=CC(=C1)C2=NC(=C3C4CCCN4C(=S)N(C3=N2)C5=CC=CC=C5)N6CCOCC6 IC50 = 465500 nM Non binder T94131 HUMAN PI3-kinase gamma BIUS43 {2-[(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4-nitrophenoxy}acetic acid Investigative 6053578 C14H12N2O6S2 368.4 CCN1C(=O)/C(=C\\C2=C(C=CC(=C2)[N+](=O)[O-])OCC(=O)O)/SC1=S IC50 = 612000 nM Non binder T94131 HUMAN PI3-kinase gamma BO0WH3 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine Investigative 520127 C6H5ClN4 168.58 CC1=NC2=NC=NN2C(=C1)Cl IC50 > 1670000 nM Non binder T94131 HUMAN PI3-kinase gamma BO5C4T 3-(2,3,10,11-Tetramethoxyisoquinolino[2,1-b]isoquinolin-7-ium-8-yl)propanoic acid Investigative 426449 C24H24NO6+ 422.4 COC1=CC2=CC3=[N+](C=CC4=CC(=C(C=C43)OC)OC)C(=C2C=C1OC)CCC(=O)O IC50 = 7333000 nM Non binder T94131 HUMAN PI3-kinase gamma BQ2BT1 13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione Investigative 122180839 C24H30N6O2S 466.6 C1CC2C3=C(N=C(N=C3N(C(=S)N2C1)C4=CC=CC=C4)CN5CCOCC5)N6CCOCC6 IC50 = 781500 nM Non binder T94131 HUMAN PI3-kinase gamma BTI9F4 4-[(4-Carboxy-2,5-dimethyl-phenyl)disulfanyl]-2,5-dimethyl-benzoic acid Investigative 275065 C18H18O4S2 362.5 CC1=CC(=C(C=C1SSC2=CC(=C(C=C2C)C(=O)O)C)C)C(=O)O IC50 = 1460000 nM Non binder T94131 HUMAN PI3-kinase gamma BV56MY 6-Hydroxy-5-[[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]diazenyl]naphthalene-2-sulfonic acid Investigative 165595 C24H20N4O4S 460.5 CC1=CC=CC=C1N=NC2=CC(=C(C=C2)N=NC3=C(C=CC4=C3C=CC(=C4)S(=O)(=O)O)O)C IC50 = 2415000 nM Non binder T94131 HUMAN PI3-kinase gamma BW59KC 6-Hydroxy-5-[[2-methoxy-4-[(4-sulfophenyl)diazenyl]phenyl]diazenyl]naphthalene-2-sulfonic acid Investigative 414938 C23H18N4O8S2 542.5 COC1=C(C=CC(=C1)N=NC2=CC=C(C=C2)S(=O)(=O)O)N=NC3=C(C=CC4=C3C=CC(=C4)S(=O)(=O)O)O IC50 = 2437000 nM Non binder T94131 HUMAN PI3-kinase gamma BWL19S 5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-amine Investigative 28063903 C8H10N4 162.19 CC1=CC(=NC2=CC(=NN12)N)C IC50 = 915000 nM Non binder T94131 HUMAN PI3-kinase gamma BY0J9C 4-(1,3-Benzodioxol-5-yl)-2-(3,4-dimethoxyphenyl)-4-oxobutanoic acid Investigative 291727 C19H18O7 358.3 COC1=C(C=C(C=C1)C(CC(=O)C2=CC3=C(C=C2)OCO3)C(=O)O)OC IC50 = 234000 nM Non binder T94131 HUMAN PI3-kinase gamma BZ42BQ 13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione Investigative 122180840 C25H32N6O2S 480.6 CC(C1=NC(=C2C3CCCN3C(=S)N(C2=N1)C4=CC=CC=C4)N5CCOCC5)N6CCOCC6 IC50 = 967700 nM Non binder T94131 HUMAN PI3-kinase gamma BZ7O3R n,o-Bis[(benzyloxy)carbonyl]tyrosine Investigative 263480 C25H23NO7 449.5 C1=CC=C(C=C1)COC(=O)NC(CC2=CC=C(C=C2)OC(=O)OCC3=CC=CC=C3)C(=O)O IC50 = 324000 nM Non binder T94131 HUMAN PI3-kinase gamma D09ZNV CGP-029482 Investigative 447682 C17H12N2O3 292.29 C1=CC=C2C(=C1)C(=C3N2C4=CC=CC=C4C(=O)N3)CC(=O)O IC50 > 200000 nM Non binder