TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88975	Phosphodiesterase 3A	D03QJL	Ibudilast	Phase 2	3671	C14H18N2O	230.31	CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C	IC50 = 299000 nM	Non binder
T88975	Phosphodiesterase 3A	B0S7MH	6-(2-Isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	54580523	C15H18N4O2	286.33	CC(C)C1=NN2C(=C1C3=NNC(=O)CC3)C=CC=C2OC	IC50 = 260000 nM	Non binder
T88975	Phosphodiesterase 3A	B1E8VF	4-(2-Fluoroethoxymethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	122193929	C28H25FN4O2	468.5	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C(=C4)COCCF	IC50 = 306000 nM	Non binder
T88975	Phosphodiesterase 3A	B4HE0N	15-Propan-2-yl-3,4,13,14-tetrazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,9,11,14-pentaen-5-one	Investigative	54582528	C15H16N4O	268.31	CC(C)C1=NN2C=CC=C3C2=C1C4=NNC(=O)CC4C3	IC50 = 210000 nM	Non binder
T88975	Phosphodiesterase 3A	B6S2ZY	2-Isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine	Investigative	54585432	C15H16N4O	268.31	CC(C)C1=NN2C=CC=CC2=C1C3=NN=C(C=C3)OC	IC50 > 400000 nM	Non binder
T88975	Phosphodiesterase 3A	B8DCS3	3-(6-Chloro-4-methylpyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine	Investigative	54583497	C15H15ClN4	286.76	CC1=CC(=NN=C1C2=C3C=CC=CN3N=C2C(C)C)Cl	IC50 > 400000 nM	Non binder
T88975	Phosphodiesterase 3A	B8RJ4T	2-Isopropyl-3-(6-chloropyridazine-3-yl)pyrazolo[1,5-a]pyridine	Investigative	24751991	C14H13ClN4	272.73	CC(C)C1=NN2C=CC=CC2=C1C3=NN=C(C=C3)Cl	IC50 > 400000 nM	Non binder
T88975	Phosphodiesterase 3A	BG74WU	2-Benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	54580524	C22H24N4O2	376.5	CC(C)C1=NN2C(=C1C3=NN(C(=O)CC3)CC4=CC=CC=C4)C=CC=C2OC	IC50 > 400000 nM	Non binder
T88975	Phosphodiesterase 3A	BK3S6U	(S)-6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one	Investigative	54586393	C15H18N4O	270.33	C[C@H]1CC(=O)NN=C1C2=C3C=CC=CN3N=C2C(C)C	IC50 > 400000 nM	Non binder
T88975	Phosphodiesterase 3A	BVMI81	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methylpyridazin-3(2H)-one	Investigative	54580520	C15H16N4O	268.31	CC1=CC(=O)NN=C1C2=C3C=CC=CN3N=C2C(C)C	IC50 > 400000 nM	Non binder