TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T84133	Phosphodiesterase 10A	B0VL2T	2-Amino-4-chlorobenzothiazole	Investigative	29872	C7H5ClN2S	184.65	C1=CC2=C(C(=C1)Cl)N=C(S2)N	Ki = 210000 nM	Non binder
T84133	Phosphodiesterase 10A	B10LIK	6,7-Dimethoxy-4-[(3R)-3-(2-propan-2-ylphenoxy)pyrrolidin-1-yl]quinazoline	Investigative	44452603	C23H27N3O3	393.5	CC(C)C1=CC=CC=C1O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 169824365.3 nM	Non binder
T84133	Phosphodiesterase 10A	B1FQT2	4-[(3R)-3-(4-Tert-butylphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102623	C24H29N3O3	407.5	CC(C)(C)C1=CC=C(C=C1)O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 100000000 nM	Non binder
T84133	Phosphodiesterase 10A	B26BRH	6,7-Dimethoxy-4-[(3R)-3-[2-(trifluoromethoxy)phenoxy]pyrrolidin-1-yl]quinazoline	Investigative	44452447	C21H20F3N3O4	435.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC=C4OC(F)(F)F)OC	Ki = 181970085.9 nM	Non binder
T84133	Phosphodiesterase 10A	B3GW5D	4-[(3R)-3-(3,4-Dimethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102626	C22H25N3O5	411.5	COC1=C(C=C(C=C1)O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC)OC	Ki = 66069344.8 nM	Non binder
T84133	Phosphodiesterase 10A	B3WKS0	6,7-Dimethoxy-4-[(3R)-3-(pyridin-2-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102602	C19H20N4O3	352.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC=N4)OC	Ki = 120226443.5 nM	Non binder
T84133	Phosphodiesterase 10A	B3ZR4B	N,N-Dimethyl-1-[3-(1-quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]piperidin-4-amine	Investigative	58547883	C23H28N6O	404.5	CN(C)C1CCN(CC1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 343000 nM	Non binder
T84133	Phosphodiesterase 10A	B5X2BI	6,7-Dimethoxy-4-[(3R)-3-[(6-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazoline	Investigative	16102628	C25H25N3O4	431.5	COC1=CC2=C(C=C1)C=C(C=C2)O[C@@H]3CCN(C3)C4=NC=NC5=CC(=C(C=C54)OC)OC	Ki = 17782794.1 nM	Non binder
T84133	Phosphodiesterase 10A	B73MPK	6,7-Dimethoxy-4-[(3R)-3-(3-phenylphenoxy)pyrrolidin-1-yl]quinazoline	Investigative	16102599	C26H25N3O3	427.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC(=C4)C5=CC=CC=C5)OC	Ki = 134896288.3 nM	Non binder
T84133	Phosphodiesterase 10A	B7FZS9	6,7-Dimethoxy-4-[(3R)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]quinazoline	Investigative	16102594	C21H23N3O4	381.4	COC1=CC=CC=C1O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 239883291.9 nM	Non binder
T84133	Phosphodiesterase 10A	B7KQP1	6,7-Dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)oxy]pyrrolidin-1-yl]quinazoline	Investigative	16102606	C24H24N4O3	416.5	CC1=NC2=C(C=C1)C=C(C=C2)O[C@@H]3CCN(C3)C4=NC=NC5=CC(=C(C=C54)OC)OC	Ki = 17782794.1 nM	Non binder
T84133	Phosphodiesterase 10A	B8T9XO	4-[(3R)-3-(3-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102625	C22H25N3O4	395.5	CCOC1=CC(=CC=C1)O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 93325430.08 nM	Non binder
T84133	Phosphodiesterase 10A	B8Y3IU	4-[(3R)-3-(4-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102598	C22H25N3O4	395.5	CCOC1=CC=C(C=C1)O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 53703179.64 nM	Non binder
T84133	Phosphodiesterase 10A	BETC35	4-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrile	Investigative	16102622	C21H20N4O3	376.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=C(C=C4)C#N)OC	Ki = 54954087.39 nM	Non binder
T84133	Phosphodiesterase 10A	BF7P3H	6,7-Dimethoxy-4-[(3R)-3-[(7-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazoline	Investigative	16102605	C25H25N3O4	431.5	COC1=CC2=C(C=C1)C=CC(=C2)O[C@@H]3CCN(C3)C4=NC=NC5=CC(=C(C=C54)OC)OC	Ki = 16982436.52 nM	Non binder
T84133	Phosphodiesterase 10A	BG38OE	6,7-Dimethoxy-4-[(3R)-3-(quinolin-6-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102629	C23H22N4O3	402.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC5=C(C=C4)N=CC=C5)OC	Ki = 11748975.55 nM	Non binder
T84133	Phosphodiesterase 10A	BGM83X	6,7-Dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]quinazoline	Investigative	16102593	C21H20F3N3O3	419.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC=C4C(F)(F)F)OC	Ki = 794328234.7 nM	Non binder
T84133	Phosphodiesterase 10A	BIAB25	2-[4-Fluoro-3-[7-methyl-12-(trifluoromethyl)-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl]phenyl]propan-2-ol	Investigative	89968385	C19H15F4N5O	405.3	CC1=NC2=C(N=C(C=C2)C(F)(F)F)N3C1=NN=C3C4=C(C=CC(=C4)C(C)(C)O)F	IC50 = 7980000 nM	Non binder
T84133	Phosphodiesterase 10A	BK9YQ4	4-[(3R)-3-(2-Chlorophenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102621	C20H20ClN3O3	385.8	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC=C4Cl)OC	Ki = 194984460 nM	Non binder
T84133	Phosphodiesterase 10A	BL6G1I	6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	11955614	C22H21N5O3	403.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=NC5=CC=CC=C5N=C4)OC	Ki = 3981071.71 nM	Non binder
T84133	Phosphodiesterase 10A	BMCF65	6,7-Dimethoxy-4-[(3R)-3-(quinolin-7-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102630	C23H22N4O3	402.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC5=C(C=CC=N5)C=C4)OC	Ki = 11748975.55 nM	Non binder
T84133	Phosphodiesterase 10A	BN18MF	4-[(3R)-3-(Isoquinolin-3-yloxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline	Investigative	16102607	C23H22N4O3	402.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC5=CC=CC=C5C=N4)OC	Ki = 18620871.37 nM	Non binder
T84133	Phosphodiesterase 10A	BN4L5M	6,7-Dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102627	C19H20N4O3	352.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CN=CC=C4)OC	Ki = 125892541.2 nM	Non binder
T84133	Phosphodiesterase 10A	BOK36T	(R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline	Investigative	16102600	C23H25N3O3	391.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC5=C(CCC5)C=C4)OC	Ki = 67608297.54 nM	Non binder
T84133	Phosphodiesterase 10A	BPFD30	6,7-Dimethoxy-4-[(3r)-3-(2-Naphthyloxy)pyrrolidin-1-Yl]quinazoline	Investigative	15991588	C24H23N3O3	401.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC5=CC=CC=C5C=C4)OC	Ki = 11748975.55 nM	Non binder
T84133	Phosphodiesterase 10A	BQ02WT	2-[3-(3-Pyridin-2-ylpyrazin-2-yl)oxyazetidin-1-yl]quinoline	Investigative	58547818	C21H17N5O	355.4	C1C(CN1C2=NC3=CC=CC=C3C=C2)OC4=NC=CN=C4C5=CC=CC=N5	IC50 = 350000 nM	Non binder
T84133	Phosphodiesterase 10A	BQW3I2	2-(4-Methyl-1,3-thiazol-2-yl)pyridine	Investigative	21259157	C9H8N2S	176.24	CC1=CSC(=N1)C2=CC=CC=N2	IC50 = 324000 nM	Non binder
T84133	Phosphodiesterase 10A	BTO2L3	6,7-Dimethoxy-4-[(3R)-3-(pyridin-4-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102603	C19H20N4O3	352.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=NC=C4)OC	Ki = 109647819.6 nM	Non binder
T84133	Phosphodiesterase 10A	BWF04C	5-(Furan-2-yl)-3-methyl-1H-pyrazole	Investigative	700124	C8H8N2O	148.16	CC1=CC(=NN1)C2=CC=CO2	IC50 = 851000 nM	Non binder
T84133	Phosphodiesterase 10A	BWH5K8	2-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrile	Investigative	16102596	C21H20N4O3	376.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC=C4C#N)OC	Ki = 128824955.2 nM	Non binder
T84133	Phosphodiesterase 10A	BXJ17O	6,7-Dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrolidin-1-yl]quinazoline	Investigative	16102604	C24H23N3O3	401.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=CC=CC5=CC=CC=C54)OC	Ki = 208929613.1 nM	Non binder
T84133	Phosphodiesterase 10A	BXR57W	(R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazoline	Investigative	16102620	C21H23N3O3	365.4	CC1=CC=CC=C1O[C@@H]2CCN(C2)C3=NC=NC4=CC(=C(C=C43)OC)OC	Ki = 323593656.9 nM	Non binder
T84133	Phosphodiesterase 10A	BY7U5W	(R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline	Investigative	16102601	C18H18ClN5O3	387.8	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=NC=C(C=N4)Cl)OC	Ki = 43651583.22 nM	Non binder