TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T82739	Plasma kallikrein	B05HPK	(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-4-[1-(2-methylpropanoyl)piperidin-4-yl]butanoyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-4-piperidin-4-ylbutanamide	Investigative	53345970	C37H55N7O5S	709.9	CC(C)C(=O)N1CCC(CC1)CC[C@H](C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B0AW8R	US8598206, Table 6, 13	Investigative	53345967	C36H54N8O5S	710.9	CN(C)C(=O)N1CCC(CC1)CC[C@H](C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B0B7ZQ	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655489	C24H27N9O5S	553.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)S(=O)(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B0B8NX	(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide	Investigative	10669349	C20H27Cl2N3O2	412.3	C1CCC(CC1)[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3=C(C=CC(=C3)Cl)Cl)N	Ki = 586000 nM	Non binder
T82739	Plasma kallikrein	B0LT9N	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655486	C24H25FN8O3	492.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)F	IC50 = 740000 nM	Non binder
T82739	Plasma kallikrein	B1CDF7	(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]-5-(1-oxidopyridin-1-ium-4-yl)pentanamide	Investigative	53346182	C34H45N7O5S	663.8	C1CNCCC1CC[C@@H](C(=O)NCC2=CC=C(C=C2)C(=N)N)NC(=O)[C@@H](CCCC3=CC=[N+](C=C3)[O-])NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B1GUP7	Mupain-1	Investigative	101862198	C51H73N13O16S2	1188.3	C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N1)N)C(=O)O)CC(=O)O)CC(C)C)CC3=CC=C(C=C3)O)CCCN=C(N)N)CO)CC4=CC=C(C=C4)O	Ki > 1000000 nM	Non binder
T82739	Plasma kallikrein	B1KIC5	N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(Aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide	Investigative	57395841	C38H51N7O7	717.9	CC[C@H](C)[C@@H]1C(=O)N[C@H](/C=C/C(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)N1)CC3=CC(=CC=C3)CN)NC(=O)C)CC4=CC=C(C=C4)O	Ki = 3300000 nM	Non binder
T82739	Plasma kallikrein	B1U8JQ	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(cyanomethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655497	C26H27N9O4	529.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OCC#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B21UTS	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)acetyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	45264998	C29H36ClN3O2	494.1	C1C[C@H](N(C1)C(=O)CC2C3=CC=CC=C3C=CC4=CC=CC=C24)C(=O)NCC5CCC(CC5)N.Cl	Ki = 775000 nM	Non binder
T82739	Plasma kallikrein	B24EPB	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(2-oxopropoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655495	C27H30N8O5	546.6	CC(=O)COC1=CC=C(C=C1)N2CC(=O)N(C2=O)CC3=CC4=CN=C(N=C4N3C)C(=O)N[C@@H](CCCCN)C#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B2JKZ7	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-5-oxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655504	C24H27FN8O2	478.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CN(CC3=O)C4=CC=C(C=C4)F	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B2LT3J	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655491	C25H25N9O3	499.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)C#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B3DSG9	[Amino-[[4-[(4-nitrophenoxy)sulfonylmethyl]phenyl]methylsulfanyl]methylidene]azanium;bromide	Investigative	90655701; 118705719	C15H16BrN3O5S2	462.3	C1=CC(=CC=C1CSC(=[NH2+])N)CS(=O)(=O)OC2=CC=C(C=C2)[N+](=O)[O-].[Br-]	Ki = 320000 nM	Non binder
T82739	Plasma kallikrein	B46YQJ	N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-1-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide	Investigative	57400764	C31H31N5O3	521.6	C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4	IC50 = 680000 nM	Non binder
T82739	Plasma kallikrein	B53VWR	Tert-butyl 3-[3-[5-[[(1S)-5-amino-1-cyanopentyl]carbamoyl]-2-(pyridin-4-ylmethoxy)anilino]-3-oxopropyl]indole-1-carboxylate	Investigative	57390236	C35H40N6O5	624.7	CC(C)(C)OC(=O)N1C=C(C2=CC=CC=C21)CCC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4	IC50 = 910000 nM	Non binder
T82739	Plasma kallikrein	B5W6NO	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44347573	C29H36F3N3O4	547.6	C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O	Ki > 1000000 nM	Non binder
T82739	Plasma kallikrein	B5YW4G	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-4-(4-phenoxyphenyl)piperazin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655506	C31H32N8O4	580.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CC(=O)N(CC3=O)C4=CC=C(C=C4)OC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B6OE5J	US8598206, Table 6, 14	Investigative	53345863	C35H52N8O5S	696.9	CNC(=O)N1CCC(CC1)CC[C@H](C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B6ST8W	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44347533	C28H35F3N4O4	548.6	C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=N3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O	Ki = 767000 nM	Non binder
T82739	Plasma kallikrein	B80EYR	(12Z)-19-Amino-21-methyl-6-(pyrazol-1-ylmethyl)-9,16-dioxa-1,18,24,28-tetrazatetracyclo[24.2.1.03,8.017,22]nonacosa-3(8),4,6,12,17(22),18,20,26(29),27-nonaen-25-one	Investigative	134130030	C28H31N7O3	513.6	CC1=CC(=NC2=C1CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCC/C=C\\CCO2)N=C3)N	IC50 > 3000000 nM	Non binder
T82739	Plasma kallikrein	B8ST4B	US8598206, Table 6, 12	Investigative	53345752	C33H43N7O4S	633.8	C1CNCCC1CC[C@@H](C(=O)NCC2=CC=C(C=C2)C(=N)N)NC(=O)[C@@H](CCC3=CC=NC=C3)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B8UX9T	US8598206, Table 6, 16	Investigative	53345861	C35H51N7O6S	697.9	COC(=O)N1CCC(CC1)CC[C@H](C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	B97YHM	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-carbamoylphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655501	C31H31N9O5	609.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC=CC=C5C(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B9FT3D	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(4-methoxyphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655498	C31H32N8O5	596.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC=C(C=C5)OC	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	B9I3UR	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44347477	C28H35F3N4O4	548.6	C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=NC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O	Ki > 1000000 nM	Non binder
T82739	Plasma kallikrein	BA0CY1	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(3-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655492	C24H27N9O5S	553.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC(=CC=C4)S(=O)(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BARC31	N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[5-oxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655505	C30H32N8O3	552.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CN(CC3=O)C4=CC=C(C=C4)OC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BD8A6V	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-quinolin-6-yloxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655500	C33H31N9O4	617.7	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC6=C(C=C5)N=CC=C6	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BDKG59	N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-2-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide	Investigative	57393799	C31H31N5O3	521.6	C1=CC=C2C=C(C=CC2=C1)CC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4	IC50 = 380000 nM	Non binder
T82739	Plasma kallikrein	BF8ON7	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-3-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44347479	C28H35F3N4O4	548.6	C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CN=CC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O	Ki = 476000 nM	Non binder
T82739	Plasma kallikrein	BFQR09	US8598206, Table 6, 9	Investigative	53346080	C36H53N7O5S	695.9	CC(=O)N1CCC(CC1)CCC[C@H](C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NS(=O)(=O)CC4=CC=CC=C4	Ki > 500000 nM	Non binder
T82739	Plasma kallikrein	BI5U3N	6-Amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide	Investigative	57392333	C42H60N8O7	789	CC[C@H](C)[C@@H]1C(=O)N[C@H](/C=C/C(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)N1)CC3=CC(=CC=C3)CN)NC(=O)CCCCCN)CC4=CC=C(C=C4)O	Ki = 2000000 nM	Non binder
T82739	Plasma kallikrein	BK2PW0	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoyl-4-phenoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655502	C31H31N9O5	609.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC(=C(C=C4)OC5=CC=CC=C5)C(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BL3G5E	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[3-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44347623	C29H35F3N4O6	592.6	C1C[C@H](N(C1)C(=O)CC(C2=CC3=C(C=C2)OCO3)C4=CN=CC=C4)C(=O)NCC5CCC(CC5)N.C(=O)(C(F)(F)F)O	Ki = 1000000 nM	Non binder
T82739	Plasma kallikrein	BLRQ02	(S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-amino)-acetyl]-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide	Investigative	10744643	C26H38Cl2N4O3	525.5	CCN(CC)C(=O)CN[C@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NCC3=C(C=CC(=C3)Cl)Cl	Ki = 399000 nM	Non binder
T82739	Plasma kallikrein	BMBF42	Methyl (2S,4S)-4-amino-2-[[(2S,4S)-4-amino-2-[3-[(1R,3R)-3-[[(2S,4S)-4-amino-2-[[(2S,4S)-4-amino-5-(1H-indol-3-yl)-3-oxo-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-2-oxocyclohexyl]propanoylamino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-5-(4-hydroxyphenyl)-3-oxopentanoate	Investigative	44404049	C68H74N12O14	1283.4	COC(=O)[C@H](C(=O)[C@H](CC1=CC=C(C=C1)O)N)NC(=O)[C@H](C(=O)[C@H](CC2=CNC3=CC=CC=C32)N)NC(=O)CC[C@H]4CCC[C@H](C4=O)NC(=O)[C@H](C(=O)[C@H](CC5=CNC6=CC=CC=C65)N)NC(=O)[C@H](C(=O)[C@H](CC7=CNC8=CC=CC=C87)N)NC(=O)OCC9=CC=CC=C9	IC50 > 400000 nM	Non binder
T82739	Plasma kallikrein	BMIN51	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655493	C25H27N9O4	517.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=CC(=C4)C(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BNP38W	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[3-carbamoyl-4-(pyridin-4-ylmethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655503	C31H32N10O5	624.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC(=C(C=C4)OCC5=CC=NC=C5)C(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BP3MV4	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655487	C25H28N8O4	504.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BP9GX7	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655490	C25H27N9O4	517.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)C(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BPAD98	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	86302628	C30H30N8O4	566.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BRL69O	US8598206, Table 6, 1	Investigative	53345654	C30H42N10O4S	638.8	C1CNCCC1CC[C@@H](C(=O)NCC2=CC=C(C=C2)C(=N)N)NC(=O)[C@@H](CCCN3C=NN=N3)NS(=O)(=O)CC4=CC=CC=C4	Ki > 200000 nM	Non binder
T82739	Plasma kallikrein	BRT12F	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-propylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655488	C27H32N8O3	516.6	CCCC1=CC=C(C=C1)N2CC(=O)N(C2=O)CC3=CC4=CN=C(N=C4N3C)C(=O)N[C@@H](CCCCN)C#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BRWO92	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(pyridin-4-ylmethoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655499	C30H31N9O4	581.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OCC5=CC=NC=C5	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BUHW20	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-amino-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655496	C26H29N9O5	547.6	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OCC(=O)N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BV3U9R	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655494	C25H25N9O3	499.5	CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=CC(=C4)C#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BVLI64	N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[(3-methyl-2,5-dioxoimidazolidin-1-yl)methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide	Investigative	90655485	C19H24N8O3	412.4	CN1CC(=O)N(C1=O)CC2=CC3=CN=C(N=C3N2C)C(=O)N[C@@H](CCCCN)C#N	IC50 > 1000000 nM	Non binder
T82739	Plasma kallikrein	BWE90T	(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2-carbamoylmethoxy-5-chloro-benzylamide	Investigative	10742217	C22H31ClN4O4	451	C1CCC(CC1)[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3=C(C=CC(=C3)Cl)OCC(=O)N)N	Ki = 816000 nM	Non binder