TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T78709	5-HT 1A receptor	D03TNA	ABT-724	Discontinued in Phase 2	5025739	C17H19N5	293.4	C1CN(CCN1CC2=NC3=CC=CC=C3N2)C4=CC=CC=N4	Ki = 2780000 nM	Non binder
T78709	5-HT 1A receptor	B03TRB	Chembl4174981	Investigative	2962174	C22H17F3N4O	410.4	C1=CC=C(C=C1)CN2C(=NC(C2=O)(C(F)(F)F)NC3=CC=CC=N3)C4=CC=CC=C4	Ki = 284100 nM	Non binder
T78709	5-HT 1A receptor	B1TZ2X	2{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(4''-fluorophenyl)piperazine	Investigative	25158436	C27H31FN2O2	434.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki = 783000 nM	Non binder
T78709	5-HT 1A receptor	B2GSC7	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(2''-pyrimidyl)piperazine	Investigative	25157257	C26H32N4O2	432.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=NC=CC=N4	Ki = 331000 nM	Non binder
T78709	5-HT 1A receptor	B3ZES5	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(3''-trifluoromethyl)piperazine	Investigative	25158434	C28H31F3N2O2	484.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki = 1409000 nM	Non binder
T78709	5-HT 1A receptor	B5T8BE	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-(3,4-dihydroisoquinoline)	Investigative	25157546	C26H29NO2	387.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCC4=CC=CC=C4C3	Ki = 1310000 nM	Non binder
T78709	5-HT 1A receptor	B67VFR	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(3,4-dihydroisoquinoline)	Investigative	25156416	C27H31NO2	401.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCC4=CC=CC=C4C3	Ki = 1124000 nM	Non binder
T78709	5-HT 1A receptor	B6GSB4	8-(3,6-Dihydro-2H-pyridin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	Investigative	44306007	C14H13N3S	255.34	C1CN(CC=C1)C2=NC3=C(N4C2=CC=C4)SC=C3	IC50 = 457088.19 nM	Non binder
T78709	5-HT 1A receptor	B6MZ5S	Chembl4283960	Investigative	145992567	C34H36N4O3	548.7	CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=CC6=CC=CC=C65	Ki = 413200 nM	Non binder
T78709	5-HT 1A receptor	B6NC4G	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25156966	C30H35F3N2O2	512.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	B6RYK2	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2''-pyrimidyl)piperazine	Investigative	25156413	C27H34N4O2	446.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=NC=CC=N4	Ki = 558000 nM	Non binder
T78709	5-HT 1A receptor	B6UO4K	6,7-Dimethoxy-2-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-3,4-dihydro-1H-isoquinoline	Investigative	25156685	C28H33NO4	447.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	B8IH3A	6,7-Dimethoxy-2-[4-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]butyl]-3,4-dihydro-1H-isoquinoline	Investigative	25156686	C30H37NO4	475.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	B8N5YX	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(N-methyl)piperazine	Investigative	25157543	C24H34N2O2	382.5	CN1CCN(CC1)CCCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	B8XI7A	8-(4-Benzylpiperazin-1-yl)-4-phenyl-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene	Investigative	10526362	C26H24N4S	424.6	C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(C=C(S4)C5=CC=CC=C5)N6C3=CC=C6	IC50 = 389045.14 nM	Non binder
T78709	5-HT 1A receptor	B8ZBW1	Chembl4166092	Investigative	145954503	C21H20F2N2O2	370.4	C1CN(CC2=C1ON=C2C3=CC(=C(C=C3)F)F)CC[C@H](C4=CC=CC=C4)O	Ki = 330400 nM	Non binder
T78709	5-HT 1A receptor	B94WDN	1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone	Investigative	11596869	C22H19N5O4	417.4	CC1=C(C=CC(=C1O)C(=O)C)OCC2=CC=C(C=C2)OC3=NC=CC(=C3)C4=NNN=N4	Ki > 3020000 nM	Non binder
T78709	5-HT 1A receptor	B98SDE	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25158433	C29H35ClN2O2	479.1	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki = 1308000 nM	Non binder
T78709	5-HT 1A receptor	B9TLU8	6,7-Dimethoxy-2-[3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propyl]-3,4-dihydro-1H-isoquinoline	Investigative	25157845	C29H35NO4	461.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	B9XGS1	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(4''-fluorophenyl)piperazine	Investigative	25157253	C29H35FN2O2	462.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BAY41H	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(3''-chlorophenyl)piperazine	Investigative	25156688	C27H31ClN2O2	451	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki = 686000 nM	Non binder
T78709	5-HT 1A receptor	BCD2S8	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(2''-pyrimidil)piperazine	Investigative	25156412	C25H30N4O2	418.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=NC=CC=N4	Ki = 656000 nM	Non binder
T78709	5-HT 1A receptor	BF3QK7	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(3''-chlorophenyl)piperazine	Investigative	25155851	C30H37ClN2O2	493.1	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BG1D6T	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(2''-pyrimidyl)piperazine	Investigative	25157850	C28H36N4O2	460.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=NC=CC=N4	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BI3LQ7	Chembl4288077	Investigative	145990093	C24H29FN4O3	440.5	CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)CC3=CC=CC=C3)O)C4=CC=C(C=C4)F	Ki = 377500 nM	Non binder
T78709	5-HT 1A receptor	BISD74	1-[3-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]propyl]-4-methylpiperazine	Investigative	25156414	C23H32N2O2	368.5	CN1CCN(CC1)CCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BJ0YT5	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25156129	C29H33F3N2O2	498.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki = 2874000 nM	Non binder
T78709	5-HT 1A receptor	BJ1O0D	6,7-Dimethoxy-2-[5-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]pentyl]-3,4-dihydro-1H-isoquinoline	Investigative	25157848	C31H39NO4	489.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BM68LY	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(N-methyl)piperazine	Investigative	25157260	C22H30N2O2	354.5	CN1CCN(CC1)CCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BMS76X	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(N-methyl)piperazine	Investigative	25156415	C25H36N2O2	396.6	CN1CCN(CC1)CCCCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BOL9J8	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(2''-methoxyphenyl)piperazine	Investigative	25156131	C29H36N2O3	460.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC=CC=C4OC	Ki = 756000 nM	Non binder
T78709	5-HT 1A receptor	BPUG28	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(4''-fluorophenyl)piperazine	Investigative	25156133	C28H33FN2O2	448.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki = 800000 nM	Non binder
T78709	5-HT 1A receptor	BQ2ST7	8-[4-[(4-Chlorophenyl)-phenylmethyl]piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	Investigative	10718731	C26H23ClN4S	459	C1CN(CCN1C2=NC3=C(N4C2=CC=C4)SC=C3)C(C5=CC=CC=C5)C6=CC=C(C=C6)Cl	IC50 = 204173.79 nM	Non binder
T78709	5-HT 1A receptor	BQFS49	2{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(2''-methoxyphenyl)piperazine	Investigative	25156130	C28H34N2O3	446.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=CC=C4OC	Ki = 1241000 nM	Non binder
T78709	5-HT 1A receptor	BSI5O1	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(3''-chlorophenyl)piperazine	Investigative	25155850	C28H33ClN2O2	465	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki = 1130000 nM	Non binder
T78709	5-HT 1A receptor	BT3GN6	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(2''-methoxyphenyl)piperazine	Investigative	25156132	C31H40N2O3	488.7	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC=CC=C4OC	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BTDU07	5-Fluoro-2alpha-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperidino]indan-1beta-ol	Investigative	10926737	C22H24FNO3	369.4	C1CN(CCC1C2=C3C(=CC=C2)OCCO3)[C@@H]4CC5=C([C@H]4O)C=CC(=C5)F	Ki = 436515832.2 nM	Non binder
T78709	5-HT 1A receptor	BU38KS	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-(3,4-dihydroisoquinoline)	Investigative	25156684	C28H33NO2	415.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCC4=CC=CC=C4C3	Ki = 1331000 nM	Non binder
T78709	5-HT 1A receptor	BV2B4A	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-(3,4-dihydroisoquinoline)	Investigative	25157549	C29H35NO2	429.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCC4=CC=CC=C4C3	Ki > 5000000 nM	Non binder
T78709	5-HT 1A receptor	BXQ53G	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2''-methoxyphenyl)piperazine	Investigative	25158435	C30H38N2O3	474.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC=CC=C4OC	Ki = 1092000 nM	Non binder
T78709	5-HT 1A receptor	BZV25H	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(4''-fluorophenyl)piperazine	Investigative	25156411	C30H37FN2O2	476.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki > 5000000 nM	Non binder