TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T78198	Purine nucleoside phosphorylase	D06IAR	Adenosine	Approved	60961	C10H13N5O4	267.24	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	Ki = 2000000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B2H6ZK	1,2-Dibenzylbenzimidazole-4,7-dione	Investigative	493154	C21H16N2O2	328.4	C1=CC=C(C=C1)CC2=NC3=C(N2CC4=CC=CC=C4)C(=O)C=CC3=O	Ki = 350000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B3EU0A	1-Benzylbenzimidazole-4,7-dione	Investigative	493146	C14H10N2O2	238.24	C1=CC=C(C=C1)CN2C=NC3=C2C(=O)C=CC3=O	Ki = 580000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B3FYQ4	[(2R,3S,4R,5S)-3,4-Dihydroxy-5-(7-oxo-1,7a-dihydropyrazolo[4,3-d]pyrimidin-3-yl)oxolan-2-yl]methyl 4-fluorosulfonylbenzoate	Investigative	90663690	C17H15FN4O8S	454.4	C1=CC(=CC=C1C(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)C3=NNC4C3=NC=NC4=O)O)O)S(=O)(=O)F	Ki > 300000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B4Q6ZO	{Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihydro-purin-9-yl)-pentyl]-phosphinoylmethyl}-phosphonic acid	Investigative	44264323	C11H18N4O7P2	380.23	C1=NC2=C(N1CCCCCP(=O)(CP(=O)(O)O)O)NC(=O)NC2=O	Ki = 270000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B5BFP8	4,7-Benzimidazoledione	Investigative	260064	C7H4N2O2	148.12	C1=CC(=O)C2=C(C1=O)NC=N2	Ki = 550000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B6N0QB	1-[(4-Fluorophenyl)methyl]benzimidazole-4,7-dione	Investigative	493147	C14H9FN2O2	256.23	C1=CC(=CC=C1CN2C=NC3=C2C(=O)C=CC3=O)F	Ki = 780000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B7T0IA	2,5-Diaminothiazolo[4,5-d]pyrimidin-7(6H)-one	Investigative	135554446	C5H5N5OS	183.19	C12=C(N=C(NC1=O)N)N=C(S2)N	IC50 ~ 330000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B8V4XJ	1-[(3-Fluorophenyl)methyl]benzimidazole-4,7-dione	Investigative	493148	C14H9FN2O2	256.23	C1=CC(=CC(=C1)F)CN2C=NC3=C2C(=O)C=CC3=O	Ki = 520000 nM	Non binder
T78198	Purine nucleoside phosphorylase	B9VAB2	2-Aminoformycin	Investigative	126915	C10H14N6O4	282.26	C([C@@H]1[C@H]([C@H]([C@@H](O1)C2=C3C(=NN2)C(=NC(=N3)N)N)O)O)O	Ki = 1680000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BA15JL	(2S,3S,4R,5S)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Investigative	46233579	C11H14N4O4	266.25	C1=CN(C2=NC=NC(=C21)N)[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O	IC50 = 300000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BB9O7U	2-Amino-7-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-pyrrolo[2,3-d]pyrimidine-4(7H)-thione	Investigative	46233580	C11H14N4O4S	298.32	C1=CN(C2=C1C(=S)N=C(N2)N)[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O	IC50 = 315000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BD42XJ	3-Deazaguanosine	Investigative	124316	C11H14N4O5	282.25	C1=C(NC(=O)C2=C1N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	IC50 > 300000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BJ17WM	1-Benzyl-2-methyl-benzimidazole-4,7-dione	Investigative	493153	C15H12N2O2	252.27	CC1=NC2=C(N1CC3=CC=CC=C3)C(=O)C=CC2=O	Ki = 300000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BOQ45E	Allopurinol riboside	Investigative	135407110	C10H12N4O5	268.23	C1=NN(C2=C1C(=O)NC=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O	Ki = 1800000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BS15HA	3-((2R,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin-7(4H)-one	Investigative	135537118	C10H12N4O5	268.23	C1=NC2=C(NN=C2C(=O)N1)[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O	IC50 = 300000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BSA6O2	1-Butylbenzimidazole-4,7-dione	Investigative	493152	C11H12N2O2	204.22	CCCCN1C=NC2=C1C(=O)C=CC2=O	Ki = 560000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BTD9O8	1-[(2-Fluorophenyl)methyl]benzimidazole-4,7-dione	Investigative	493149	C14H9FN2O2	256.23	C1=CC=C(C(=C1)CN2C=NC3=C2C(=O)C=CC3=O)F	Ki = 1480000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BTYE54	1-Methylbenzimidazole-4,7-dione	Investigative	493151	C8H6N2O2	162.15	CN1C=NC2=C1C(=O)C=CC2=O	Ki = 2210000 nM	Non binder
T78198	Purine nucleoside phosphorylase	BVA1U5	[[4-[[2-Amino-6-oxo-1H-purin-9(6H)-yl]methyl]phenoxy]methyl]phosphonic acid	Investigative	135678234	C13H14N5O5P	351.25	C1=CC(=CC=C1CN2C=NC3=C2N=C(NC3=O)N)OCP(=O)(O)O	Ki = 270000 nM	Non binder
T78198	Purine nucleoside phosphorylase	D04AWP	Guanosine-5'-Monophosphate	Investigative	135398631	C10H14N5O8P	363.22	C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)N	Ki = 1500000 nM	Non binder