TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T70977	Glycogen synthase kinase-3 beta	B1W2QI	1-(4-Amino-1,2,5-oxadiazol-3-yl)-N-methyl-5-(piperidin-1-ylmethyl)-N-(2-pyridin-4-ylethyl)triazole-4-carboxamide	Investigative	10862509	C19H25N9O2	411.5	CN(CCC1=CC=NC=C1)C(=O)C2=C(N(N=N2)C3=NON=C3N)CN4CCCCC4	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B2DX1V	Lithium ion	Investigative	28486	Li+	7	[Li+]	IC50 = 2000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B2RVT1	1-(4-Amino-1,2,5-oxadiazol-3-yl)-5-[(2-methylpropylamino)methyl]-N-(pyridin-4-ylmethyl)triazole-4-carboxamide	Investigative	44341125	C16H21N9O2	371.4	CC(C)CNCC1=C(N=NN1C2=NON=C2N)C(=O)NCC3=CC=NC=C3	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B2U5EN	6-Methoxy-4-phenyl-[1]benzofuro[2,3-b]pyridin-3-ol	Investigative	71451532	C18H13NO3	291.3	COC1=CC2=C(C=C1)OC3=NC=C(C(=C23)C4=CC=CC=C4)O	Ki > 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B2YON3	Ditert-butyl 9-bromo-6-oxo-7H-indolo[3,2-d][1]benzazepine-5,12-dicarboxylate	Investigative	5331131	C26H27BrN2O5	527.4	CC(C)(C)OC(=O)N1C(=O)CC2=C(C3=CC=CC=C31)N(C4=C2C=C(C=C4)Br)C(=O)OC(C)(C)C	IC50 = 639734.84 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B4THA7	5-Methyl-2-thiophen-2-yl-2,3-dihydro-1,5-benzothiazepin-4-one	Investigative	71457865	C14H13NOS2	275.4	CN1C(=O)CC(SC2=CC=CC=C21)C3=CC=CS3	IC50 = 480000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B4YKH8	(2S)-2-(1H-Indol-3-ylmethyl)-2,4-dihydro-1H-pyrido[2,3-b]pyrazin-3-one	Investigative	134157982	C16H14N4O	278.31	C1=CC=C2C(=C1)C(=CN2)C[C@H]3C(=O)NC4=C(N3)C=CC=N4	IC50 = 322000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B5B0TD	2-[4-({[5-(Pyridin-2-yl)-1,3,4-thiadiazol-2-yl]sulfanyl}methyl)phenyl]acetic acid	Investigative	6539729	C16H13N3O2S2	343.4	C1=CC=NC(=C1)C2=NN=C(S2)SCC3=CC=C(C=C3)CC(=O)O	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B5F3WS	Schembl22374664	Investigative	118707111	C25H21F3N2O3	454.4	CC1=C2C(=C(C=C(C2=NC=C1)NCC3=CC=C(C=C3)O)OC)OC4=CC=CC(=C4)C(F)(F)F	IC50 = 240000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B85ICD	Paullone Analogue 61	Investigative	6538750	C15H10ClN3O	283.71	C1C2=C(C3=C(NC1=O)N=CC=C3)NC4=C2C=C(C=C4)Cl	IC50 = 500034.53 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B8IJG3	10-Pyridin-2-yl-8-thiophen-2-yl-5,7-dihydrobenzo[d][1]benzazepine-6-thione	Investigative	44346075	C23H16N2S2	384.5	C1C2=C(C=C(C=C2C3=CC=CS3)C4=CC=CC=N4)C5=CC=CC=C5NC1=S	IC50 = 349945.17 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	B95LFI	6-Methoxy-4-methyl-N-(quinolin-8-ylmethyl)-5-[3-(trifluoromethyl)phenoxy]quinolin-8-amine	Investigative	118707115	C28H22F3N3O2	489.5	CC1=C2C(=C(C=C(C2=NC=C1)NCC3=CC=CC4=C3N=CC=C4)OC)OC5=CC=CC(=C5)C(F)(F)F	IC50 = 400000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BCUE86	8-[(4-Hydroxyphenyl)methylamino]-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-6-ol	Investigative	118707118	C24H19F3N2O3	440.4	CC1=C2C(=C(C=C(C2=NC=C1)NCC3=CC=C(C=C3)O)O)OC4=CC=CC(=C4)C(F)(F)F	IC50 = 750000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BD0TF1	Propyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate	Investigative	44818785	C20H18N2O3	334.4	CCCOC(=O)C1=CC2=C(C=C1)NC3=C2CC(=O)NC4=CC=CC=C43	IC50 = 700000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BDUA81	Pentyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate	Investigative	44818787	C22H22N2O3	362.4	CCCCCOC(=O)C1=CC2=C(C=C1)NC3=C2CC(=O)NC4=CC=CC=C43	IC50 = 600000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BEP1H3	1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea	Investigative	53388146	C15H15N7O2	325.33	COC1=CC=C(C=C1)CNC(=O)NC2=NC=CC(=C2)C3=NNN=N3	IC50 = 510000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BFV09X	2-(2-Thienyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one	Investigative	4380991	C13H11NOS2	261.399	C1C(SC2=CC=CC=C2NC1=O)C3=CC=CS3	IC50 = 830000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BFX87R	3-({[5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)benzoic acid	Investigative	963534	C15H11N3O3S	313.3	C1=CC(=CC(=C1)C(=O)O)CSC2=NN=C(O2)C3=CC=NC=C3	IC50 = 235000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BHIU24	Octyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate	Investigative	44818789	C25H28N2O3	404.5	CCCCCCCCOC(=O)C1=CC2=C(C=C1)NC3=C2CC(=O)NC4=CC=CC=C43	IC50 > 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BJ09SR	8-Methoxy-12-phenyl-13-phenylmethoxy-17-oxa-15-azatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11,13,15-octaene	Investigative	90667796	C29H21NO3	431.5	COC1=CC2=C(C3=CC=CC=C31)OC4=NC=C(C(=C24)C5=CC=CC=C5)OCC6=CC=CC=C6	Ki > 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BJ4D9E	N-(5,6-Diphenyl-1H-indazol-3-yl)butyramide	Investigative	22319512	C23H21N3O	355.4	CCCC(=O)NC1=NNC2=CC(=C(C=C21)C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 1720000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BKW31Z	4-(1H-Indol-3-yl)pyrimidin-2-amine	Investigative	400433	C12H10N4	210.23	C1=CC=C2C(=C1)C(=CN2)C3=NC(=NC=C3)N	IC50 = 350000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BL09OD	3,6-Dimethoxy-4-phenyl-[1]benzofuro[2,3-b]pyridine	Investigative	71462252	C19H15NO3	305.3	COC1=CC2=C(C=C1)OC3=NC=C(C(=C23)C4=CC=CC=C4)OC	Ki > 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BM2L4K	N-(5,6-Bis(4-phenoxyphenyl)-1H-indazol-3-yl)butyramide	Investigative	46881730	C35H29N3O3	539.6	CCCC(=O)NC1=NNC2=CC(=C(C=C21)C3=CC=C(C=C3)OC4=CC=CC=C4)C5=CC=C(C=C5)OC6=CC=CC=C6	IC50 > 10000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BM9DH6	4-(1H-Indol-2-yl)pyrimidin-2-amine	Investigative	10965763	C12H10N4	210.23	C1=CC=C2C(=C1)C=C(N2)C3=NC(=NC=C3)N	IC50 = 420000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BNTU62	Paullone Analogue 69	Investigative	6538758	C18H15N3O2S	337.4	CN1C2=C(C=C(C=C2)[N+](=O)[O-])C3=C1C4=CC=CC=C4N=C(C3)SC	IC50 = 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BPCL31	2-[4-({[5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)phenyl]acetic acid	Investigative	6539727	C16H14N4O2S	326.4	C1=CC(=CC=C1CC(=O)O)CSC2=NNC(=N2)C3=CC=NC=C3	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BQ42DJ	2-[4-({[5-(Pyridin-3-yl)-1,3,4-thiadiazol-2-yl]sulfanyl}methyl)phenyl]acetic acid	Investigative	6539728	C16H13N3O2S2	343.4	C1=CC(=CN=C1)C2=NN=C(S2)SCC3=CC=C(C=C3)CC(=O)O	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BQL98K	1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea	Investigative	56675716	C15H14N4O2	282.3	COC1=CC=C(C=C1)CNC(=O)NC2=NC=CC(=C2)C#N	IC50 = 1430000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BSEB16	2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile	Investigative	91936970	C22H28N6O	392.5	C1CCC(C1)N2C(=CC(=N2)NC3=NC=CC(=C3)C#N)C4CCN(CC4)C5COC5	IC50 = 682000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BSZ98H	1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea	Investigative	56668847	C16H14N4O4S	358.4	COC1=CC=C(C=C1)CNC(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]	IC50 = 3640000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BT9MD2	2-({[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl}sulfanyl)-5-(pyridin-4-yl)-1,3,4-oxadiazole	Investigative	6539736	C17H13N5O2S	351.4	CC1=NC(=NO1)C2=CC=CC(=C2)CSC3=NN=C(O3)C4=CC=NC=C4	IC50 > 250000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	BW9M0A	4-(5-Bromo-1H-indol-2-yl)pyrimidin-2-amine	Investigative	11822355	C12H9BrN4	289.13	C1=CC2=C(C=C1Br)C=C(N2)C3=NC(=NC=C3)N	IC50 > 1000000 nM	Non binder
T70977	Glycogen synthase kinase-3 beta	D07WXT	Lithium chloride	Investigative	433294	ClLi	42.4	[Li+].[Cl-]	EC50 > 3000000 nM	Non binder