TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67684	Muscarinic acetylcholine receptor M3	B02WDC	Xanomeline	Investigative	60809	C14H23N3OS	281.42	CCCCCCOC1=NSN=C1C2=CCCN(C2)C	EC50 = 39800000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B0LCK4	4-[4-(4-Hydroxy-4,4-diphenylbutyl)-4-methylpiperazin-4-ium-1-yl]-1,1-diphenylbutan-1-ol;iodide	Investigative	44448499	C37H45IN2O2	676.7	C[N+]1(CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)CCCC(C4=CC=CC=C4)(C5=CC=CC=C5)O.[I-]	Ki = 182000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B19XTZ	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	Investigative	44448383	C44H58I2N2O2	900.8	C[N+]1(CCC(CC1)C2CC[N+](CC2)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCC(C5=CC=CC=C5)(C6=CC=CC=C6)O.[I-].[I-]	Ki = 2690000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B1KPY8	4-[4-(1,1-Dimethylpiperidin-1-ium-4-yl)-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	Investigative	44448379	C29H44I2N2O	690.5	C[N+]1(CCC(CC1)C2CC[N+](CC2)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)C.[I-].[I-]	Ki = 275000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B2DO3R	1-Azabicyclo[2.2.2]octan-2-yl(diphenyl)methanol;hydrobromide	Investigative	49797556	C20H24BrNO	374.3	C1CN2CCC1CC2C(C3=CC=CC=C3)(C4=CC=CC=C4)O.Br	IC50 = 6599000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B2TJ5E	4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797390	C36H46Cl2N2O2	609.7	CN(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCN(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 2630000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B47IWT	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Investigative	4995951	C23H24N2O4	392.4	CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C	Ki = 1380000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B4QG5Z	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)piperidin-4-yl]piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797389	C42H54Cl2N2O2	689.8	C1CN(CCC1C2CCN(CC2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCC(C5=CC=CC=C5)(C6=CC=CC=C6)O.Cl.Cl	Ki = 1380000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B57EYL	3-Methoxy-4-[12-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecoxy]-1,2,5-thiadiazole	Investigative	11071537	C23H37N5O3S2	495.7	CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCCCCOC3=NSN=C3OC	EC50 = 2510000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B5DKA3	(4-Hydroxy-4,4-diphenylbutyl)-[3-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]propyl]-dimethylazanium;diiodide	Investigative	44448418	C39H52I2N2O2	834.6	C[N+](C)(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCC[N+](C)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-].[I-]	Ki = 81300000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B72EXB	3-[4-[Hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-1-yl]propan-1-ol;bromide	Investigative	42625939	C23H30BrNO2	432.4	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCO.[Br-]	IC50 = 29509000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B75OCY	4-[Hydroxy(diphenyl)methyl]-1-propyl-1-azoniabicyclo[2.2.2]octane bromide	Investigative	11531768	C23H30BrNO	416.4	CCC[N+]12CCC(CC1)(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]	IC50 = 208000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B8JN9T	1,1-Diphenyl-4-piperazin-1-ylbutan-1-ol;dihydrochloride	Investigative	49797395	C20H28Cl2N2O	383.4	C1CN(CCN1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl.Cl	Ki = 1510000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B8LSW9	Diphenyl-[1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl]methanol;bromide	Investigative	42625858	C28H32BrNO	478.5	C1C[N+]2(CCC1C(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCC5=CC=CC=C5.[Br-]	IC50 = 2824000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B9C0OK	4-[3-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]propyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797388	C37H48Cl2N2O2	623.7	CN(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCCN(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 575000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	B9VT7Z	4-[Hydroxy(diphenyl)methyl]-1-[3-(methyloxy)propyl]-1-azoniabicyclo[2.2.2]octane Bromide	Investigative	42625941	C24H32BrNO2	446.4	COCCC[N+]12CCC(CC1)(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]	IC50 = 829000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BA1SK9	4-[Hydroxy(diphenyl)methyl]-1-(2-hydroxyethyl)-1-azoniabicyclo[2.2.2]octane Bromide	Investigative	11517306	C22H28BrNO2	418.4	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCO.[Br-]	IC50 = 486000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BA86IS	2-[2-[4-[Hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-1-yl]ethoxymethyl]benzonitrile;bromide	Investigative	42626014	C30H33BrN2O2	533.5	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5C#N.[Br-]	IC50 = 5403000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BCA76V	(4-Hydroxy-4,4-diphenylbutyl)-[2-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]ethyl]-dimethylazanium;diiodide	Investigative	44448456	C38H50I2N2O2	820.6	C[N+](C)(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CC[N+](C)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-].[I-]	Ki = 22900000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BCAJ53	1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride	Investigative	49797392	C26H31ClN2O	423	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C4=CC=CC=C4.Cl	Ki = 14100000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BE7M1V	4-(4,4-Dimethylpiperazin-4-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448537	C22H31IN2O	466.4	C[N+]1(CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C.[I-]	Ki = 245000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BEZJ94	4-(1-Methyl-4-phenylpiperazin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448495	C27H33IN2O	528.5	C[N+]1(CCN(CC1)C2=CC=CC=C2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-]	Ki = 132000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BF9AE0	1-Azabicyclo[2.2.2]octan-4-yl(diphenyl)methanol;hydrobromide	Investigative	49797557	C20H24BrNO	374.3	C1CN2CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.Br	IC50 = 1068000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BG61NE	[1-(2-Aminoethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide	Investigative	42625937	C22H29BrN2O	417.4	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCN.[Br-]	IC50 = 850000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BK2WI3	alpha,alpha-Diphenyl-3-quinuclidinemethanol hydrobromide	Investigative	3044806	C20H24BrNO	374.3	C1CN2CCC1C(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.Br	IC50 = 1104000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BM6Q1Z	Diphenidol hydrochloride	Investigative	66266	C21H28ClNO	345.9	C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl	Ki = 891000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BMIW49	12-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecyl acetate;hydrochloride	Investigative	10226456	C22H38ClN3O3S	460.1	CC(=O)OCCCCCCCCCCCCOC1=NSN=C1C2=CCCN(C2)C.Cl	EC50 = 25100000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BMT8I2	[1-(5-Phenoxypentyl)-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide	Investigative	42626010	C31H38BrNO2	536.5	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCCCOC5=CC=CC=C5.[Br-]	IC50 = 306000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BO9G4H	12-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecan-1-ol;hydrochloride	Investigative	9909907	C20H36ClN3O2S	418	CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCCCCO.Cl	EC50 = 100000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BP2VC7	4-[4-(4-Hydroxy-4,4-diphenylbutyl)piperazin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797391	C36H44Cl2N2O2	607.6	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)CCCC(C4=CC=CC=C4)(C5=CC=CC=C5)O.Cl.Cl	Ki = 11500000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BRC7N9	4-(4-Methylpiperazin-1-yl)-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797394	C21H30Cl2N2O	397.4	CN1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl.Cl	Ki = 135000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BWV9F3	4-[Hydroxy(diphenyl)methyl]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide	Investigative	42625933	C21H26BrNO	388.3	C[N+]12CCC(CC1)(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]	IC50 = 935000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BX84RC	4-(1-Methylpiperidin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448645	C22H30INO	451.4	C[N+]1(CCCCC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.[I-]	Ki = 3630000000000000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BZ0UQ2	1-(Cyclopropylmethyl)-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane Bromide	Investigative	42625935	C24H30BrNO	428.4	C1CC1C[N+]23CCC(CC2)(CC3)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Br-]	IC50 = 1956000 nM	Non binder
T67684	Muscarinic acetylcholine receptor M3	BZD1R6	4-[4-(1-Methylpiperidin-4-yl)piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797387	C27H40Cl2N2O	479.5	CN1CCC(CC1)C2CCN(CC2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 191000000000000 nM	Non binder